| 1 | Thu Apr 1 | at Reds | W11-6 | 1-0 | 1.000 | Great American Ball Park · Cincinnati, OH |
| 2 | Sat Apr 3 | at Reds | L6-9 | 1-1 | .500 | Great American Ball Park · Cincinnati, OH |
| 3 | Sun Apr 4 | at Reds | L1-12 | 1-2 | .333 | Great American Ball Park · Cincinnati, OH |
| 4 | Mon Apr 5 | at Marlins | W4-1 | 2-2 | .500 | LoanDepot Park · Miami, FL |
| 5 | Tue Apr 6 | at Marlins | W4-2 | 3-2 | .600 | LoanDepot Park · Miami, FL |
| 6 | Wed Apr 7 | at Marlins | W7-0 | 4-2 | .667 | LoanDepot Park · Miami, FL |
| 7 | Thu Apr 8 | vs Brewers | W3-1 | 5-2 | .714 | Busch Stadium · St. Louis, MO |
| 8 | Sat Apr 10 | vs Brewers | L5-9 | 5-3 | .625 | Busch Stadium · St. Louis, MO |
| 9 | Sun Apr 11 | vs Brewers | L3-9 | 5-4 | .556 | Busch Stadium · St. Louis, MO |
| 10 | Mon Apr 12 | vs Nationals | L2-5 | 5-5 | .500 | Busch Stadium · St. Louis, MO |
| 11 | Tue Apr 13 | vs Nationals | W14-3 | 6-5 | .545 | Busch Stadium · St. Louis, MO |
| 12 | Wed Apr 14 | vs Nationals | L0-6 | 6-6 | .500 | Busch Stadium · St. Louis, MO |
| 13 | Fri Apr 16 | at Phillies | L2-9 | 6-7 | .462 | Citizens Bank Park · Philadelphi, PA |
| 14 | Sat Apr 17 | at Phillies | W9-4 | 7-7 | .500 | Citizens Bank Park · Philadelphi, PA |
| 15 | Sun Apr 18 | at Phillies | L0-2 | 7-8 | .467 | Citizens Bank Park · Philadelphi, PA |
| 16 | Mon Apr 19 | at Nationals | W12-5 | 8-8 | .500 | Nationals Park · Washington, D.C. |
| 17 | Tue Apr 20 | at Nationals | L2-3 | 8-9 | .471 | Nationals Park · Washington, D.C. |
| 18 | Wed Apr 21 | at Nationals | L0-1 | 8-10 | .444 | Nationals Park · Washington, D.C. |
| 19 | Fri Apr 23 | vs Reds | W5-4 | 9-10 | .474 | Busch Stadium · St. Louis, MO |
| 20 | Sat Apr 24 | vs Reds | W2-0 | 10-10 | .500 | Busch Stadium · St. Louis, MO |
| 21 | Sun Apr 25 | vs Reds | W5-2 | 11-10 | .524 | Busch Stadium · St. Louis, MO |
| 22 | Mon Apr 26 | vs Phillies | L1-2 | 11-11 | .500 | Busch Stadium · St. Louis, MO |
| 23 | Tue Apr 27 | vs Phillies | W5-2 | 12-11 | .522 | Busch Stadium · St. Louis, MO |
| 24 | Wed Apr 28 | vs Phillies | L3-5 | 12-12 | .500 | Busch Stadium · St. Louis, MO |
| 25 | Thu Apr 29 | vs Phillies | W4-3 (10) | 13-12 | .520 | Busch Stadium · St. Louis, MO |
| 26 | Fri Apr 30 | at Pirates | W7-3 | 14-12 | .538 | PNC Park · Pittsburgh, PA |
| 27 | Sat May 1 | at Pirates | W12-5 | 15-12 | .556 | PNC Park · Pittsburgh, PA |
| 28 | Sun May 2 | at Pirates | W3-0 | 16-12 | .571 | PNC Park · Pittsburgh, PA |
| 29 | Mon May 3 | vs Mets | W6-5 | 17-12 | .586 | Busch Stadium · St. Louis, MO |
| 30 | Wed May 5 | vs Mets | W4-1 | 18-12 | .600 | Busch Stadium · St. Louis, MO |
| 31 | Wed May 5 | vs Mets | L2-7 | 18-13 | .581 | Busch Stadium · St. Louis, MO |
| 32 | Thu May 6 | vs Mets | L1-4 | 18-14 | .563 | Busch Stadium · St. Louis, MO |
| 33 | Fri May 7 | vs Rockies | W5-0 | 19-14 | .576 | Busch Stadium · St. Louis, MO |
| 34 | Sat May 8 | vs Rockies | W9-8 | 20-14 | .588 | Busch Stadium · St. Louis, MO |
| 35 | Sun May 9 | vs Rockies | W2-0 | 21-14 | .600 | Busch Stadium · St. Louis, MO |
| 36 | Tue May 11 | at Brewers | W6-1 (11) | 22-14 | .611 | American Family Field · Milwaukee, WI |
| 37 | Wed May 12 | at Brewers | L1-4 | 22-15 | .595 | American Family Field · Milwaukee, WI |
| 38 | Thu May 13 | at Brewers | W2-0 | 23-15 | .605 | American Family Field · Milwaukee, WI |
| 39 | Fri May 14 | at Padres | L4-5 | 23-16 | .590 | Petco Park · San Diego, CA |
| 40 | Sat May 15 | at Padres | L3-13 | 23-17 | .575 | Petco Park · San Diego, CA |
| 41 | Sun May 16 | at Padres | L3-5 | 23-18 | .561 | Petco Park · San Diego, CA |
| 42 | Tue May 18 | vs Pirates | W5-2 | 24-18 | .571 | Busch Stadium · St. Louis, MO |
| 43 | Wed May 19 | vs Pirates | W8-5 | 25-18 | .581 | Busch Stadium · St. Louis, MO |
| 44 | Fri May 21 | vs Cubs | L3-12 | 25-19 | .568 | Busch Stadium · St. Louis, MO |
| 45 | Sat May 22 | vs Cubs | W2-1 | 26-19 | .578 | Busch Stadium · St. Louis, MO |
| 46 | Sun May 23 | vs Cubs | L1-2 (10) | 26-20 | .565 | Busch Stadium · St. Louis, MO |
| 47 | Mon May 24 | at White Sox | L1-5 | 26-21 | .553 | Guaranteed Rate Field · Chicago, IL |
| 48 | Tue May 25 | at White Sox | L3-8 | 26-22 | .542 | Guaranteed Rate Field · Chicago, IL |
| 49 | Wed May 26 | at White Sox | W4-0 | 27-22 | .551 | Guaranteed Rate Field · Chicago, IL |
| 50 | Thu May 27 | at D-backs | W5-4 (10) | 28-22 | .560 | Chase Field · Phoenix, AZ |
| 51 | Fri May 28 | at D-backs | W8-6 | 29-22 | .569 | Chase Field · Phoenix, AZ |
| 52 | Sat May 29 | at D-backs | W7-4 | 30-22 | .577 | Chase Field · Phoenix, AZ |
| 53 | Sun May 30 | at D-backs | L2-9 | 30-23 | .566 | Chase Field · Phoenix, AZ |
| 54 | Mon May 31 | at Dodgers | L4-9 | 30-24 | .556 | Dodger Stadium · Los Angeles, CA |
| 55 | Tue Jun 1 | at Dodgers | W3-2 | 31-24 | .564 | Dodger Stadium · Los Angeles, CA |
| 56 | Wed Jun 2 | at Dodgers | L3-14 | 31-25 | .554 | Dodger Stadium · Los Angeles, CA |
| 57 | Thu Jun 3 | vs Reds | L2-4 | 31-26 | .544 | Busch Stadium · St. Louis, MO |
| 58 | Fri Jun 4 | vs Reds | L4-6 | 31-27 | .534 | Busch Stadium · St. Louis, MO |
| 59 | Sat Jun 5 | vs Reds | L2-5 | 31-28 | .525 | Busch Stadium · St. Louis, MO |
| 60 | Sun Jun 6 | vs Reds | L7-8 | 31-29 | .517 | Busch Stadium · St. Louis, MO |
| 61 | Tue Jun 8 | vs Guardians | L1-10 | 31-30 | .508 | Busch Stadium · St. Louis, MO |
| 62 | Wed Jun 9 | vs Guardians | W8-2 | 32-30 | .516 | Busch Stadium · St. Louis, MO |
| 63 | Fri Jun 11 | at Cubs | L5-8 | 32-31 | .508 | Wrigley Field · Chicago, IL |
| 64 | Sat Jun 12 | at Cubs | L2-7 | 32-32 | .500 | Wrigley Field · Chicago, IL |
| 65 | Sun Jun 13 | at Cubs | L0-2 | 32-33 | .492 | Wrigley Field · Chicago, IL |
| 66 | Mon Jun 14 | vs Marlins | W4-2 | 33-33 | .500 | Busch Stadium · St. Louis, MO |
| 67 | Tue Jun 15 | vs Marlins | W2-1 | 34-33 | .507 | Busch Stadium · St. Louis, MO |
| 68 | Wed Jun 16 | vs Marlins | W1-0 | 35-33 | .515 | Busch Stadium · St. Louis, MO |
| 69 | Thu Jun 17 | at Braves | L0-4 | 35-34 | .507 | Truist Park · Cumberland, GA |
| 70 | Fri Jun 18 | at Braves | L1-9 | 35-35 | .500 | Truist Park · Cumberland, GA |
| 71 | Sun Jun 20 | at Braves | W9-1 | 36-35 | .507 | Truist Park · Cumberland, GA |
| 72 | Sun Jun 20 | at Braves | L0-1 | 36-36 | .500 | Truist Park · Cumberland, GA |
| 73 | Tue Jun 22 | at Tigers | L2-8 | 36-37 | .493 | Comerica Park · Detroit, MI |
| 74 | Wed Jun 23 | at Tigers | L2-6 | 36-38 | .486 | Comerica Park · Detroit, MI |
| 75 | Thu Jun 24 | vs Pirates | L2-8 | 36-39 | .480 | Busch Stadium · St. Louis, MO |
| 76 | Fri Jun 25 | vs Pirates | L4-5 | 36-40 | .474 | Busch Stadium · St. Louis, MO |
| 77 | Sat Jun 26 | vs Pirates | W3-1 | 37-40 | .481 | Busch Stadium · St. Louis, MO |
| 78 | Sun Jun 27 | vs Pirates | L2-7 | 37-41 | .474 | Busch Stadium · St. Louis, MO |
| 79 | Mon Jun 28 | vs D-backs | W7-1 | 38-41 | .481 | Busch Stadium · St. Louis, MO |
| 80 | Tue Jun 29 | vs D-backs | W3-2 | 39-41 | .487 | Busch Stadium · St. Louis, MO |
| 81 | Wed Jun 30 | vs D-backs | W7-4 | 40-41 | .494 | Busch Stadium · St. Louis, MO |
| 82 | Thu Jul 1 | at Rockies | L2-5 | 40-42 | .488 | Coors Field · Denver, CO |
| 83 | Fri Jul 2 | at Rockies | W9-3 (10) | 41-42 | .494 | Coors Field · Denver, CO |
| 84 | Sat Jul 3 | at Rockies | L2-3 | 41-43 | .488 | Coors Field · Denver, CO |
| 85 | Sun Jul 4 | at Rockies | L2-3 | 41-44 | .482 | Coors Field · Denver, CO |
| 86 | Mon Jul 5 | at Giants | W5-3 | 42-44 | .488 | Oracle Park · San Francisco, CA |
| 87 | Tue Jul 6 | at Giants | W6-5 | 43-44 | .494 | Oracle Park · San Francisco, CA |
| 88 | Wed Jul 7 | at Giants | L2-5 | 43-45 | .489 | Oracle Park · San Francisco, CA |
| 89 | Fri Jul 9 | at Cubs | L5-10 | 43-46 | .483 | Wrigley Field · Chicago, IL |
| 90 | Sat Jul 10 | at Cubs | W6-0 | 44-46 | .489 | Wrigley Field · Chicago, IL |
| 91 | Fri Jul 16 | vs Giants | L2-7 | 44-47 | .484 | Busch Stadium · St. Louis, MO |
| 92 | Sat Jul 17 | vs Giants | W3-1 | 45-47 | .489 | Busch Stadium · St. Louis, MO |
| 93 | Sun Jul 18 | vs Giants | W2-1 | 46-47 | .495 | Busch Stadium · St. Louis, MO |
| 94 | Mon Jul 19 | vs Cubs | W8-3 | 47-47 | .500 | Busch Stadium · St. Louis, MO |
| 95 | Tue Jul 20 | vs Cubs | L6-7 | 47-48 | .495 | Busch Stadium · St. Louis, MO |
| 96 | Wed Jul 21 | vs Cubs | W3-2 (10) | 48-48 | .500 | Busch Stadium · St. Louis, MO |
| 97 | Thu Jul 22 | vs Cubs | W3-2 | 49-48 | .505 | Busch Stadium · St. Louis, MO |
| 98 | Fri Jul 23 | at Reds | L5-6 | 49-49 | .500 | Great American Ball Park · Cincinnati, OH |
| 99 | Sat Jul 24 | at Reds | L3-5 | 49-50 | .495 | Great American Ball Park · Cincinnati, OH |
| 100 | Sun Jul 25 | at Reds | W10-6 | 50-50 | .500 | Great American Ball Park · Cincinnati, OH |
| 101 | Tue Jul 27 | at Guardians | W4-2 | 51-50 | .505 | Progressive Field · Cleveland, OH |
| 102 | Wed Jul 28 | at Guardians | L2-7 | 51-51 | .500 | Progressive Field · Cleveland, OH |
| 103 | Fri Jul 30 | vs Twins | W5-1 | 52-51 | .505 | Busch Stadium · St. Louis, MO |
| 104 | Sat Jul 31 | vs Twins | L1-8 | 52-52 | .500 | Busch Stadium · St. Louis, MO |
| 105 | Sun Aug 1 | vs Twins | W7-3 | 53-52 | .505 | Busch Stadium · St. Louis, MO |
| 106 | Tue Aug 3 | vs Braves | L1-6 | 53-53 | .500 | Busch Stadium · St. Louis, MO |
| 107 | Wed Aug 4 | vs Braves | L4-7 | 53-54 | .495 | Busch Stadium · St. Louis, MO |
| 108 | Thu Aug 5 | vs Braves | L4-8 | 53-55 | .491 | Busch Stadium · St. Louis, MO |
| 109 | Fri Aug 6 | vs Royals | W4-2 | 54-55 | .495 | Busch Stadium · St. Louis, MO |
| 110 | Sat Aug 7 | vs Royals | W5-2 | 55-55 | .500 | Busch Stadium · St. Louis, MO |
| 111 | Sun Aug 8 | vs Royals | L5-6 | 55-56 | .495 | Busch Stadium · St. Louis, MO |
| 112 | Tue Aug 10 | at Pirates | W4-1 | 56-56 | .500 | PNC Park · Pittsburgh, PA |
| 113 | Wed Aug 11 | at Pirates | W4-0 | 57-56 | .504 | PNC Park · Pittsburgh, PA |
| 114 | Thu Aug 12 | at Pirates | W7-6 | 58-56 | .509 | PNC Park · Pittsburgh, PA |
| 115 | Fri Aug 13 | at Royals | W6-0 | 59-56 | .513 | Kauffman Stadium · Kansas City, MO |
| 116 | Sat Aug 14 | at Royals | W9-4 | 60-56 | .517 | Kauffman Stadium · Kansas City, MO |
| 117 | Sun Aug 15 | at Royals | W7-2 | 61-56 | .521 | Kauffman Stadium · Kansas City, MO |
| 118 | Tue Aug 17 | vs Brewers | L0-2 | 61-57 | .517 | Busch Stadium · St. Louis, MO |
| 119 | Wed Aug 18 | vs Brewers | L4-6 (10) | 61-58 | .513 | Busch Stadium · St. Louis, MO |
| 120 | Thu Aug 19 | vs Brewers | W8-4 | 62-58 | .517 | Busch Stadium · St. Louis, MO |
| 121 | Fri Aug 20 | vs Pirates | L0-4 | 62-59 | .512 | Busch Stadium · St. Louis, MO |
| 122 | Sat Aug 21 | vs Pirates | L4-5 | 62-60 | .508 | Busch Stadium · St. Louis, MO |
| 123 | Sun Aug 22 | vs Pirates | W3-0 | 63-60 | .512 | Busch Stadium · St. Louis, MO |
| 124 | Tue Aug 24 | vs Tigers | L3-4 | 63-61 | .508 | Busch Stadium · St. Louis, MO |
| 125 | Wed Aug 25 | vs Tigers | W3-2 (10) | 64-61 | .512 | Busch Stadium · St. Louis, MO |
| 126 | Thu Aug 26 | at Pirates | L7-11 | 64-62 | .508 | PNC Park · Pittsburgh, PA |
| 127 | Fri Aug 27 | at Pirates | W4-3 | 65-62 | .512 | PNC Park · Pittsburgh, PA |
| 128 | Sat Aug 28 | at Pirates | W13-0 | 66-62 | .516 | PNC Park · Pittsburgh, PA |
| 129 | Sun Aug 29 | at Pirates | L3-4 | 66-63 | .512 | PNC Park · Pittsburgh, PA |
| 130 | Mon Aug 30 | at Reds | W3-1 | 67-63 | .515 | Great American Ball Park · Cincinnati, OH |
| 131 | Wed Sep 1 | at Reds | W5-4 | 68-63 | .519 | Great American Ball Park · Cincinnati, OH |
| 132 | Wed Sep 1 | at Reds | L2-12 | 68-64 | .515 | Great American Ball Park · Cincinnati, OH |
| 133 | Fri Sep 3 | at Brewers | W15-4 | 69-64 | .519 | American Family Field · Milwaukee, WI |
| 134 | Sat Sep 4 | at Brewers | L0-4 | 69-65 | .515 | American Family Field · Milwaukee, WI |
| 135 | Sun Sep 5 | at Brewers | L5-6 | 69-66 | .511 | American Family Field · Milwaukee, WI |
| 136 | Mon Sep 6 | vs Dodgers | L1-5 | 69-67 | .507 | Busch Stadium · St. Louis, MO |
| 137 | Tue Sep 7 | vs Dodgers | L2-7 | 69-68 | .504 | Busch Stadium · St. Louis, MO |
| 138 | Wed Sep 8 | vs Dodgers | W5-4 | 70-68 | .507 | Busch Stadium · St. Louis, MO |
| 139 | Thu Sep 9 | vs Dodgers | W2-1 | 71-68 | .511 | Busch Stadium · St. Louis, MO |
| 140 | Fri Sep 10 | vs Reds | L2-4 | 71-69 | .507 | Busch Stadium · St. Louis, MO |
| 141 | Sat Sep 11 | vs Reds | W6-4 | 72-69 | .511 | Busch Stadium · St. Louis, MO |
| 142 | Sun Sep 12 | vs Reds | W2-0 | 73-69 | .514 | Busch Stadium · St. Louis, MO |
| 143 | Mon Sep 13 | at Mets | W7-0 | 74-69 | .517 | Citi Field · Queens, NY |
| 144 | Tue Sep 14 | at Mets | W7-6 (11) | 75-69 | .521 | Citi Field · Queens, NY |
| 145 | Wed Sep 15 | at Mets | W11-4 | 76-69 | .524 | Citi Field · Queens, NY |
| 146 | Fri Sep 17 | vs Padres | W8-2 | 77-69 | .527 | Busch Stadium · St. Louis, MO |
| 147 | Sat Sep 18 | vs Padres | W3-2 | 78-69 | .531 | Busch Stadium · St. Louis, MO |
| 148 | Sun Sep 19 | vs Padres | W8-7 | 79-69 | .534 | Busch Stadium · St. Louis, MO |
| 149 | Mon Sep 20 | at Brewers | W5-2 | 80-69 | .537 | American Family Field · Milwaukee, WI |
| 150 | Tue Sep 21 | at Brewers | W2-1 | 81-69 | .540 | American Family Field · Milwaukee, WI |
| 151 | Wed Sep 22 | at Brewers | W10-2 | 82-69 | .543 | American Family Field · Milwaukee, WI |
| 152 | Thu Sep 23 | at Brewers | W8-5 | 83-69 | .546 | American Family Field · Milwaukee, WI |
| 153 | Fri Sep 24 | at Cubs | W8-5 | 84-69 | .549 | Wrigley Field · Chicago, IL |
| 154 | Fri Sep 24 | at Cubs | W12-4 | 85-69 | .552 | Wrigley Field · Chicago, IL |
| 155 | Sat Sep 25 | at Cubs | W8-5 | 86-69 | .555 | Wrigley Field · Chicago, IL |
| 156 | Sun Sep 26 | at Cubs | W4-2 | 87-69 | .558 | Wrigley Field · Chicago, IL |
| 157 | Tue Sep 28 | vs Brewers | W6-2 | 88-69 | .561 | Busch Stadium · St. Louis, MO |
| 158 | Wed Sep 29 | vs Brewers | L0-4 | 88-70 | .557 | Busch Stadium · St. Louis, MO |
| 159 | Thu Sep 30 | vs Brewers | W4-3 | 89-70 | .560 | Busch Stadium · St. Louis, MO |
| 160 | Fri Oct 1 | vs Cubs | W4-3 | 90-70 | .563 | Busch Stadium · St. Louis, MO |
| 161 | Sat Oct 2 | vs Cubs | L5-6 | 90-71 | .559 | Busch Stadium · St. Louis, MO |
| 162 | Sun Oct 3 | vs Cubs | L2-3 | 90-72 | .556 | Busch Stadium · St. Louis, MO |
| 163 | Wed Oct 6 | at Dodgers | L1-3 | 0-1 | .000 | Dodger Stadium · Los Angeles, CA |