| 1 | Thu Apr 7 | vs Pirates | W9-0 | 1-0 | 1.000 | Busch Stadium · St. Louis, MO |
| 2 | Sat Apr 9 | vs Pirates | W6-2 | 2-0 | 1.000 | Busch Stadium · St. Louis, MO |
| 3 | Sun Apr 10 | vs Pirates | L4-9 | 2-1 | .667 | Busch Stadium · St. Louis, MO |
| 4 | Tue Apr 12 | vs Royals | W6-5 | 3-1 | .750 | Busch Stadium · St. Louis, MO |
| 5 | Thu Apr 14 | at Brewers | L1-5 | 3-2 | .600 | American Family Field · Milwaukee, WI |
| 6 | Fri Apr 15 | at Brewers | W10-1 | 4-2 | .667 | American Family Field · Milwaukee, WI |
| 7 | Sat Apr 16 | at Brewers | W2-1 | 5-2 | .714 | American Family Field · Milwaukee, WI |
| 8 | Sun Apr 17 | at Brewers | L5-6 | 5-3 | .625 | American Family Field · Milwaukee, WI |
| 9 | Tue Apr 19 | at Marlins | W5-1 | 6-3 | .667 | LoanDepot Park · Miami, FL |
| 10 | Wed Apr 20 | at Marlins | W2-0 | 7-3 | .700 | LoanDepot Park · Miami, FL |
| 11 | Thu Apr 21 | at Marlins | L0-5 | 7-4 | .636 | LoanDepot Park · Miami, FL |
| 12 | Fri Apr 22 | at Reds | W4-2 | 8-4 | .667 | Great American Ball Park · Cincinnati, OH |
| 13 | Sat Apr 23 | at Reds | W5-0 | 9-4 | .692 | Great American Ball Park · Cincinnati, OH |
| 14 | Sun Apr 24 | at Reds | L1-4 | 9-5 | .643 | Great American Ball Park · Cincinnati, OH |
| 15 | Mon Apr 25 | vs Mets | L2-5 | 9-6 | .600 | Busch Stadium · St. Louis, MO |
| 16 | Tue Apr 26 | vs Mets | L0-3 | 9-7 | .563 | Busch Stadium · St. Louis, MO |
| 17 | Wed Apr 27 | vs Mets | W10-5 | 10-7 | .588 | Busch Stadium · St. Louis, MO |
| 18 | Thu Apr 28 | vs D-backs | W8-3 | 11-7 | .611 | Busch Stadium · St. Louis, MO |
| 19 | Fri Apr 29 | vs D-backs | L2-6 | 11-8 | .579 | Busch Stadium · St. Louis, MO |
| 20 | Sat Apr 30 | vs D-backs | L0-2 | 11-9 | .550 | Busch Stadium · St. Louis, MO |
| 21 | Sun May 1 | vs D-backs | W7-5 | 12-9 | .571 | Busch Stadium · St. Louis, MO |
| 22 | Mon May 2 | vs Royals | W1-0 | 13-9 | .591 | Busch Stadium · St. Louis, MO |
| 23 | Tue May 3 | at Royals | L1-7 | 13-10 | .565 | Kauffman Stadium · Kansas City, MO |
| 24 | Wed May 4 | at Royals | W10-0 | 14-10 | .583 | Kauffman Stadium · Kansas City, MO |
| 25 | Thu May 5 | at Giants | W7-1 | 15-10 | .600 | Oracle Park · San Francisco, CA |
| 26 | Fri May 6 | at Giants | W3-2 | 16-10 | .615 | Oracle Park · San Francisco, CA |
| 27 | Sat May 7 | at Giants | L7-13 | 16-11 | .593 | Oracle Park · San Francisco, CA |
| 28 | Sun May 8 | at Giants | L3-4 | 16-12 | .571 | Oracle Park · San Francisco, CA |
| 29 | Tue May 10 | vs Orioles | L3-5 | 16-13 | .552 | Busch Stadium · St. Louis, MO |
| 30 | Wed May 11 | vs Orioles | W10-1 | 17-13 | .567 | Busch Stadium · St. Louis, MO |
| 31 | Thu May 12 | vs Orioles | L2-3 | 17-14 | .548 | Busch Stadium · St. Louis, MO |
| 32 | Fri May 13 | vs Giants | L2-8 | 17-15 | .531 | Busch Stadium · St. Louis, MO |
| 33 | Sat May 14 | vs Giants | W4-0 | 18-15 | .545 | Busch Stadium · St. Louis, MO |
| 34 | Sun May 15 | vs Giants | W15-6 | 19-15 | .559 | Busch Stadium · St. Louis, MO |
| 35 | Tue May 17 | at Mets | L1-3 | 19-16 | .543 | Citi Field · Queens, NY |
| 36 | Tue May 17 | at Mets | W4-3 | 20-16 | .556 | Citi Field · Queens, NY |
| 37 | Wed May 18 | at Mets | L4-11 | 20-17 | .541 | Citi Field · Queens, NY |
| 38 | Thu May 19 | at Mets | L6-7 (10) | 20-18 | .526 | Citi Field · Queens, NY |
| 39 | Fri May 20 | at Pirates | W5-3 | 21-18 | .538 | PNC Park · Pittsburgh, PA |
| 40 | Sat May 21 | at Pirates | W5-4 | 22-18 | .550 | PNC Park · Pittsburgh, PA |
| 41 | Sun May 22 | at Pirates | W18-4 | 23-18 | .561 | PNC Park · Pittsburgh, PA |
| 42 | Mon May 23 | vs Blue Jays | W7-3 (10) | 24-18 | .571 | Busch Stadium · St. Louis, MO |
| 43 | Tue May 24 | vs Blue Jays | L1-8 | 24-19 | .558 | Busch Stadium · St. Louis, MO |
| 44 | Thu May 26 | vs Brewers | L3-4 | 24-20 | .545 | Busch Stadium · St. Louis, MO |
| 45 | Fri May 27 | vs Brewers | W4-2 | 25-20 | .556 | Busch Stadium · St. Louis, MO |
| 46 | Sat May 28 | vs Brewers | W8-3 | 26-20 | .565 | Busch Stadium · St. Louis, MO |
| 47 | Sun May 29 | vs Brewers | L0-8 | 26-21 | .553 | Busch Stadium · St. Louis, MO |
| 48 | Mon May 30 | vs Padres | W6-3 | 27-21 | .563 | Busch Stadium · St. Louis, MO |
| 49 | Tue May 31 | vs Padres | W3-2 (10) | 28-21 | .571 | Busch Stadium · St. Louis, MO |
| 50 | Wed Jun 1 | vs Padres | W5-2 | 29-21 | .580 | Busch Stadium · St. Louis, MO |
| 51 | Thu Jun 2 | at Cubs | L5-7 | 29-22 | .569 | Wrigley Field · Chicago, IL |
| 52 | Fri Jun 3 | at Cubs | W14-5 | 30-22 | .577 | Wrigley Field · Chicago, IL |
| 53 | Sat Jun 4 | at Cubs | L1-6 | 30-23 | .566 | Wrigley Field · Chicago, IL |
| 54 | Sat Jun 4 | at Cubs | W7-4 (10) | 31-23 | .574 | Wrigley Field · Chicago, IL |
| 55 | Sun Jun 5 | at Cubs | W5-3 (11) | 32-23 | .582 | Wrigley Field · Chicago, IL |
| 56 | Tue Jun 7 | at Rays | L2-4 (10) | 32-24 | .571 | Tropicana Field · St. Petersburg, FL |
| 57 | Wed Jun 8 | at Rays | L3-11 | 32-25 | .561 | Tropicana Field · St. Petersburg, FL |
| 58 | Thu Jun 9 | at Rays | L1-2 | 32-26 | .552 | Tropicana Field · St. Petersburg, FL |
| 59 | Fri Jun 10 | vs Reds | W2-0 | 33-26 | .559 | Busch Stadium · St. Louis, MO |
| 60 | Sat Jun 11 | vs Reds | W5-4 | 34-26 | .567 | Busch Stadium · St. Louis, MO |
| 61 | Sun Jun 12 | vs Reds | L6-7 | 34-27 | .557 | Busch Stadium · St. Louis, MO |
| 62 | Mon Jun 13 | vs Pirates | W7-5 | 35-27 | .565 | Busch Stadium · St. Louis, MO |
| 63 | Tue Jun 14 | vs Pirates | W3-1 | 36-27 | .571 | Busch Stadium · St. Louis, MO |
| 64 | Tue Jun 14 | vs Pirates | W9-1 | 37-27 | .578 | Busch Stadium · St. Louis, MO |
| 65 | Wed Jun 15 | vs Pirates | L4-6 | 37-28 | .569 | Busch Stadium · St. Louis, MO |
| 66 | Fri Jun 17 | at Red Sox | L5-6 | 37-29 | .561 | Fenway Park · Boston, MA |
| 67 | Sat Jun 18 | at Red Sox | W11-2 | 38-29 | .567 | Fenway Park · Boston, MA |
| 68 | Sun Jun 19 | at Red Sox | L4-6 | 38-30 | .559 | Fenway Park · Boston, MA |
| 69 | Mon Jun 20 | at Brewers | L0-2 | 38-31 | .551 | American Family Field · Milwaukee, WI |
| 70 | Tue Jun 21 | at Brewers | W6-2 | 39-31 | .557 | American Family Field · Milwaukee, WI |
| 71 | Wed Jun 22 | at Brewers | W5-4 | 40-31 | .563 | American Family Field · Milwaukee, WI |
| 72 | Thu Jun 23 | at Brewers | L4-6 | 40-32 | .556 | American Family Field · Milwaukee, WI |
| 73 | Fri Jun 24 | vs Cubs | L0-3 | 40-33 | .548 | Busch Stadium · St. Louis, MO |
| 74 | Sat Jun 25 | vs Cubs | W5-3 | 41-33 | .554 | Busch Stadium · St. Louis, MO |
| 75 | Sun Jun 26 | vs Cubs | L5-6 (10) | 41-34 | .547 | Busch Stadium · St. Louis, MO |
| 76 | Mon Jun 27 | vs Marlins | W9-0 | 42-34 | .553 | Busch Stadium · St. Louis, MO |
| 77 | Tue Jun 28 | vs Marlins | W5-3 | 43-34 | .558 | Busch Stadium · St. Louis, MO |
| 78 | Wed Jun 29 | vs Marlins | L3-4 | 43-35 | .551 | Busch Stadium · St. Louis, MO |
| 79 | Fri Jul 1 | at Phillies | L3-5 | 43-36 | .544 | Citizens Bank Park · Philadelphi, PA |
| 80 | Sat Jul 2 | at Phillies | W7-6 | 44-36 | .550 | Citizens Bank Park · Philadelphi, PA |
| 81 | Sun Jul 3 | at Phillies | L0-4 | 44-37 | .543 | Citizens Bank Park · Philadelphi, PA |
| 82 | Mon Jul 4 | at Braves | L3-6 | 44-38 | .537 | Truist Park · Cumberland, GA |
| 83 | Tue Jul 5 | at Braves | L1-7 | 44-39 | .530 | Truist Park · Cumberland, GA |
| 84 | Wed Jul 6 | at Braves | L0-3 | 44-40 | .524 | Truist Park · Cumberland, GA |
| 85 | Thu Jul 7 | at Braves | W3-2 (11) | 45-40 | .529 | Truist Park · Cumberland, GA |
| 86 | Fri Jul 8 | vs Phillies | L0-2 | 45-41 | .523 | Busch Stadium · St. Louis, MO |
| 87 | Sat Jul 9 | vs Phillies | L0-1 | 45-42 | .517 | Busch Stadium · St. Louis, MO |
| 88 | Sun Jul 10 | vs Phillies | W4-3 | 46-42 | .523 | Busch Stadium · St. Louis, MO |
| 89 | Mon Jul 11 | vs Phillies | W6-1 | 47-42 | .528 | Busch Stadium · St. Louis, MO |
| 90 | Tue Jul 12 | vs Dodgers | W7-6 | 48-42 | .533 | Busch Stadium · St. Louis, MO |
| 91 | Wed Jul 13 | vs Dodgers | L6-7 | 48-43 | .527 | Busch Stadium · St. Louis, MO |
| 92 | Thu Jul 14 | vs Dodgers | L0-4 | 48-44 | .522 | Busch Stadium · St. Louis, MO |
| 93 | Fri Jul 15 | vs Reds | W7-3 | 49-44 | .527 | Busch Stadium · St. Louis, MO |
| 94 | Sat Jul 16 | vs Reds | W11-3 | 50-44 | .532 | Busch Stadium · St. Louis, MO |
| 95 | Fri Jul 22 | at Reds | L5-9 | 50-45 | .526 | Great American Ball Park · Cincinnati, OH |
| 96 | Sat Jul 23 | at Reds | W6-3 | 51-45 | .531 | Great American Ball Park · Cincinnati, OH |
| 97 | Sun Jul 24 | at Reds | L3-6 | 51-46 | .526 | Great American Ball Park · Cincinnati, OH |
| 98 | Tue Jul 26 | at Blue Jays | L3-10 | 51-47 | .520 | Rogers Centre · Toronto, ON |
| 99 | Wed Jul 27 | at Blue Jays | W6-1 | 52-47 | .525 | Rogers Centre · Toronto, ON |
| 100 | Fri Jul 29 | at Nationals | W6-2 | 53-47 | .530 | Nationals Park · Washington, D.C. |
| 101 | Sat Jul 30 | at Nationals | L6-7 | 53-48 | .525 | Nationals Park · Washington, D.C. |
| 102 | Sun Jul 31 | at Nationals | W5-0 | 54-48 | .529 | Nationals Park · Washington, D.C. |
| 103 | Tue Aug 2 | vs Cubs | W6-0 | 55-48 | .534 | Busch Stadium · St. Louis, MO |
| 104 | Thu Aug 4 | vs Cubs | W4-3 | 56-48 | .538 | Busch Stadium · St. Louis, MO |
| 105 | Thu Aug 4 | vs Cubs | W7-2 | 57-48 | .543 | Busch Stadium · St. Louis, MO |
| 106 | Fri Aug 5 | vs Yankees | W4-3 | 58-48 | .547 | Busch Stadium · St. Louis, MO |
| 107 | Sat Aug 6 | vs Yankees | W1-0 | 59-48 | .551 | Busch Stadium · St. Louis, MO |
| 108 | Sun Aug 7 | vs Yankees | W12-9 | 60-48 | .556 | Busch Stadium · St. Louis, MO |
| 109 | Tue Aug 9 | at Rockies | L5-16 | 60-49 | .550 | Coors Field · Denver, CO |
| 110 | Wed Aug 10 | at Rockies | W9-5 | 61-49 | .555 | Coors Field · Denver, CO |
| 111 | Thu Aug 11 | at Rockies | L6-8 | 61-50 | .550 | Coors Field · Denver, CO |
| 112 | Fri Aug 12 | vs Brewers | W3-1 | 62-50 | .554 | Busch Stadium · St. Louis, MO |
| 113 | Sat Aug 13 | vs Brewers | L2-3 (10) | 62-51 | .549 | Busch Stadium · St. Louis, MO |
| 114 | Sun Aug 14 | vs Brewers | W6-3 | 63-51 | .553 | Busch Stadium · St. Louis, MO |
| 115 | Tue Aug 16 | vs Rockies | W5-4 | 64-51 | .557 | Busch Stadium · St. Louis, MO |
| 116 | Wed Aug 17 | vs Rockies | W5-1 | 65-51 | .560 | Busch Stadium · St. Louis, MO |
| 117 | Thu Aug 18 | vs Rockies | W13-0 | 66-51 | .564 | Busch Stadium · St. Louis, MO |
| 118 | Fri Aug 19 | at D-backs | W5-1 | 67-51 | .568 | Chase Field · Phoenix, AZ |
| 119 | Sat Aug 20 | at D-backs | W16-7 | 68-51 | .571 | Chase Field · Phoenix, AZ |
| 120 | Sun Aug 21 | at D-backs | W6-4 | 69-51 | .575 | Chase Field · Phoenix, AZ |
| 121 | Mon Aug 22 | at Cubs | W1-0 | 70-51 | .579 | Wrigley Field · Chicago, IL |
| 122 | Tue Aug 23 | at Cubs | L0-2 | 70-52 | .574 | Wrigley Field · Chicago, IL |
| 123 | Tue Aug 23 | at Cubs | W13-3 | 71-52 | .577 | Wrigley Field · Chicago, IL |
| 124 | Wed Aug 24 | at Cubs | L1-7 | 71-53 | .573 | Wrigley Field · Chicago, IL |
| 125 | Thu Aug 25 | at Cubs | W8-3 | 72-53 | .576 | Wrigley Field · Chicago, IL |
| 126 | Fri Aug 26 | vs Braves | L4-11 | 72-54 | .571 | Busch Stadium · St. Louis, MO |
| 127 | Sat Aug 27 | vs Braves | W6-5 | 73-54 | .575 | Busch Stadium · St. Louis, MO |
| 128 | Sun Aug 28 | vs Braves | W6-3 | 74-54 | .578 | Busch Stadium · St. Louis, MO |
| 129 | Mon Aug 29 | at Reds | W13-4 | 75-54 | .581 | Great American Ball Park · Cincinnati, OH |
| 130 | Tue Aug 30 | at Reds | L1-5 | 75-55 | .577 | Great American Ball Park · Cincinnati, OH |
| 131 | Wed Aug 31 | at Reds | W5-3 (13) | 76-55 | .580 | Great American Ball Park · Cincinnati, OH |
| 132 | Fri Sep 2 | vs Cubs | W8-0 | 77-55 | .583 | Busch Stadium · St. Louis, MO |
| 133 | Sat Sep 3 | vs Cubs | W8-4 | 78-55 | .586 | Busch Stadium · St. Louis, MO |
| 134 | Sun Sep 4 | vs Cubs | W2-0 | 79-55 | .590 | Busch Stadium · St. Louis, MO |
| 135 | Mon Sep 5 | vs Nationals | L0-6 | 79-56 | .585 | Busch Stadium · St. Louis, MO |
| 136 | Tue Sep 6 | vs Nationals | W4-1 | 80-56 | .588 | Busch Stadium · St. Louis, MO |
| 137 | Wed Sep 7 | vs Nationals | W6-5 | 81-56 | .591 | Busch Stadium · St. Louis, MO |
| 138 | Thu Sep 8 | vs Nationals | L6-11 | 81-57 | .587 | Busch Stadium · St. Louis, MO |
| 139 | Fri Sep 9 | at Pirates | L2-8 | 81-58 | .583 | PNC Park · Pittsburgh, PA |
| 140 | Sat Sep 10 | at Pirates | W7-5 | 82-58 | .586 | PNC Park · Pittsburgh, PA |
| 141 | Sun Sep 11 | at Pirates | W4-3 | 83-58 | .589 | PNC Park · Pittsburgh, PA |
| 142 | Tue Sep 13 | vs Brewers | L4-8 | 83-59 | .585 | Busch Stadium · St. Louis, MO |
| 143 | Wed Sep 14 | vs Brewers | W4-1 | 84-59 | .587 | Busch Stadium · St. Louis, MO |
| 144 | Thu Sep 15 | vs Reds | L2-3 | 84-60 | .583 | Busch Stadium · St. Louis, MO |
| 145 | Fri Sep 16 | vs Reds | W6-5 | 85-60 | .586 | Busch Stadium · St. Louis, MO |
| 146 | Sat Sep 17 | vs Reds | W5-1 | 86-60 | .589 | Busch Stadium · St. Louis, MO |
| 147 | Sat Sep 17 | vs Reds | W1-0 (11) | 87-60 | .592 | Busch Stadium · St. Louis, MO |
| 148 | Sun Sep 18 | vs Reds | L0-3 | 87-61 | .588 | Busch Stadium · St. Louis, MO |
| 149 | Tue Sep 20 | at Padres | L0-5 | 87-62 | .584 | Petco Park · San Diego, CA |
| 150 | Wed Sep 21 | at Padres | L0-1 | 87-63 | .580 | Petco Park · San Diego, CA |
| 151 | Thu Sep 22 | at Padres | W5-4 | 88-63 | .583 | Petco Park · San Diego, CA |
| 152 | Fri Sep 23 | at Dodgers | W11-0 | 89-63 | .586 | Dodger Stadium · Los Angeles, CA |
| 153 | Sat Sep 24 | at Dodgers | L2-6 | 89-64 | .582 | Dodger Stadium · Los Angeles, CA |
| 154 | Sun Sep 25 | at Dodgers | L1-4 | 89-65 | .578 | Dodger Stadium · Los Angeles, CA |
| 155 | Tue Sep 27 | at Brewers | W6-2 | 90-65 | .581 | American Family Field · Milwaukee, WI |
| 156 | Wed Sep 28 | at Brewers | L1-5 | 90-66 | .577 | American Family Field · Milwaukee, WI |
| 157 | Fri Sep 30 | vs Pirates | W2-1 | 91-66 | .580 | Busch Stadium · St. Louis, MO |
| 158 | Sat Oct 1 | vs Pirates | W13-3 | 92-66 | .582 | Busch Stadium · St. Louis, MO |
| 159 | Sun Oct 2 | vs Pirates | L5-7 | 92-67 | .579 | Busch Stadium · St. Louis, MO |
| 160 | Mon Oct 3 | at Pirates | L2-3 | 92-68 | .575 | PNC Park · Pittsburgh, PA |
| 161 | Tue Oct 4 | at Pirates | W8-7 (10) | 93-68 | .578 | PNC Park · Pittsburgh, PA |
| 162 | Wed Oct 5 | at Pirates | L3-5 | 93-69 | .574 | PNC Park · Pittsburgh, PA |
| 163 | Fri Oct 7 | vs Phillies | L3-6 | 0-1 | .000 | Busch Stadium · St. Louis, MO |
| 164 | Sat Oct 8 | vs Phillies | L0-2 | 0-2 | .000 | Busch Stadium · St. Louis, MO |