| 1 | Thu Mar 29 | at Mets | L4-9 | 0-1 | .000 | Citi Field · Queens, NY |
| 2 | Sat Mar 31 | at Mets | L2-6 | 0-2 | .000 | Citi Field · Queens, NY |
| 3 | Sun Apr 1 | at Mets | W5-1 | 1-2 | .333 | Citi Field · Queens, NY |
| 4 | Mon Apr 2 | at Brewers | W8-4 | 2-2 | .500 | American Family Field · Milwaukee, WI |
| 5 | Tue Apr 3 | at Brewers | L4-5 | 2-3 | .400 | American Family Field · Milwaukee, WI |
| 6 | Wed Apr 4 | at Brewers | W6-0 | 3-3 | .500 | American Family Field · Milwaukee, WI |
| 7 | Thu Apr 5 | vs D-backs | L1-3 | 3-4 | .429 | Busch Stadium · St. Louis, MO |
| 8 | Sat Apr 7 | vs D-backs | W5-3 | 4-4 | .500 | Busch Stadium · St. Louis, MO |
| 9 | Sun Apr 8 | vs D-backs | L1-4 | 4-5 | .444 | Busch Stadium · St. Louis, MO |
| 10 | Mon Apr 9 | vs Brewers | L4-5 (10) | 4-6 | .400 | Busch Stadium · St. Louis, MO |
| 11 | Tue Apr 10 | vs Brewers | W5-3 (11) | 5-6 | .455 | Busch Stadium · St. Louis, MO |
| 12 | Wed Apr 11 | vs Brewers | L2-3 | 5-7 | .417 | Busch Stadium · St. Louis, MO |
| 13 | Thu Apr 12 | at Reds | W13-4 | 6-7 | .462 | Great American Ball Park · Cincinnati, OH |
| 14 | Fri Apr 13 | at Reds | W5-3 | 7-7 | .500 | Great American Ball Park · Cincinnati, OH |
| 15 | Sat Apr 14 | at Reds | W6-1 | 8-7 | .533 | Great American Ball Park · Cincinnati, OH |
| 16 | Sun Apr 15 | at Reds | W3-2 | 9-7 | .563 | Great American Ball Park · Cincinnati, OH |
| 17 | Tue Apr 17 | at Cubs | W5-3 | 10-7 | .588 | Wrigley Field · Chicago, IL |
| 18 | Thu Apr 19 | at Cubs | L5-8 | 10-8 | .556 | Wrigley Field · Chicago, IL |
| 19 | Fri Apr 20 | vs Reds | W4-2 | 11-8 | .579 | Busch Stadium · St. Louis, MO |
| 20 | Sat Apr 21 | vs Reds | W4-3 | 12-8 | .600 | Busch Stadium · St. Louis, MO |
| 21 | Sun Apr 22 | vs Reds | W9-2 | 13-8 | .619 | Busch Stadium · St. Louis, MO |
| 22 | Tue Apr 24 | vs Mets | L5-6 (10) | 13-9 | .591 | Busch Stadium · St. Louis, MO |
| 23 | Wed Apr 25 | vs Mets | W9-1 | 14-9 | .609 | Busch Stadium · St. Louis, MO |
| 24 | Thu Apr 26 | vs Mets | W4-3 (13) | 15-9 | .625 | Busch Stadium · St. Louis, MO |
| 25 | Fri Apr 27 | at Pirates | L5-6 (11) | 15-10 | .600 | PNC Park · Pittsburgh, PA |
| 26 | Sat Apr 28 | at Pirates | L2-6 | 15-11 | .577 | PNC Park · Pittsburgh, PA |
| 27 | Sun Apr 29 | at Pirates | L0-5 | 15-12 | .556 | PNC Park · Pittsburgh, PA |
| 28 | Tue May 1 | vs White Sox | W3-2 | 16-12 | .571 | Busch Stadium · St. Louis, MO |
| 29 | Wed May 2 | vs White Sox | W3-2 | 17-12 | .586 | Busch Stadium · St. Louis, MO |
| 30 | Fri May 4 | vs Cubs | W3-2 | 18-12 | .600 | Busch Stadium · St. Louis, MO |
| 31 | Sat May 5 | vs Cubs | W8-6 (10) | 19-12 | .613 | Busch Stadium · St. Louis, MO |
| 32 | Sun May 6 | vs Cubs | W4-3 (14) | 20-12 | .625 | Busch Stadium · St. Louis, MO |
| 33 | Mon May 7 | vs Twins | L0-6 | 20-13 | .606 | Busch Stadium · St. Louis, MO |
| 34 | Tue May 8 | vs Twins | L1-7 | 20-14 | .588 | Busch Stadium · St. Louis, MO |
| 35 | Thu May 10 | at Padres | W2-1 | 21-14 | .600 | Petco Park · San Diego, CA |
| 36 | Fri May 11 | at Padres | W9-5 | 22-14 | .611 | Petco Park · San Diego, CA |
| 37 | Sat May 12 | at Padres | L1-2 (13) | 22-15 | .595 | Petco Park · San Diego, CA |
| 38 | Sun May 13 | at Padres | L3-5 | 22-16 | .579 | Petco Park · San Diego, CA |
| 39 | Tue May 15 | at Twins | L1-4 | 22-17 | .564 | Target Field · Minneapolis, MN |
| 40 | Wed May 16 | at Twins | W7-5 | 23-17 | .575 | Target Field · Minneapolis, MN |
| 41 | Thu May 17 | vs Phillies | L2-6 | 23-18 | .561 | Busch Stadium · St. Louis, MO |
| 42 | Fri May 18 | vs Phillies | W12-4 | 24-18 | .571 | Busch Stadium · St. Louis, MO |
| 43 | Sat May 19 | vs Phillies | L6-7 | 24-19 | .558 | Busch Stadium · St. Louis, MO |
| 44 | Sun May 20 | vs Phillies | W5-1 | 25-19 | .568 | Busch Stadium · St. Louis, MO |
| 45 | Mon May 21 | vs Royals | W6-0 | 26-19 | .578 | Busch Stadium · St. Louis, MO |
| 46 | Tue May 22 | vs Royals | L1-5 | 26-20 | .565 | Busch Stadium · St. Louis, MO |
| 47 | Wed May 23 | vs Royals | L2-5 (10) | 26-21 | .553 | Busch Stadium · St. Louis, MO |
| 48 | Fri May 25 | at Pirates | L1-8 | 26-22 | .542 | PNC Park · Pittsburgh, PA |
| 49 | Sat May 26 | at Pirates | W4-1 | 27-22 | .551 | PNC Park · Pittsburgh, PA |
| 50 | Sun May 27 | at Pirates | W6-4 | 28-22 | .560 | PNC Park · Pittsburgh, PA |
| 51 | Mon May 28 | at Brewers | L3-8 | 28-23 | .549 | American Family Field · Milwaukee, WI |
| 52 | Tue May 29 | at Brewers | W6-1 | 29-23 | .558 | American Family Field · Milwaukee, WI |
| 53 | Wed May 30 | at Brewers | L2-3 | 29-24 | .547 | American Family Field · Milwaukee, WI |
| 54 | Thu May 31 | vs Pirates | W10-8 | 30-24 | .556 | Busch Stadium · St. Louis, MO |
| 55 | Fri Jun 1 | vs Pirates | L0-4 | 30-25 | .545 | Busch Stadium · St. Louis, MO |
| 56 | Sat Jun 2 | vs Pirates | W3-2 | 31-25 | .554 | Busch Stadium · St. Louis, MO |
| 57 | Sun Jun 3 | vs Pirates | W5-0 | 32-25 | .561 | Busch Stadium · St. Louis, MO |
| 58 | Tue Jun 5 | vs Marlins | L4-7 | 32-26 | .552 | Busch Stadium · St. Louis, MO |
| 59 | Wed Jun 6 | vs Marlins | L3-11 | 32-27 | .542 | Busch Stadium · St. Louis, MO |
| 60 | Thu Jun 7 | vs Marlins | W4-1 | 33-27 | .550 | Busch Stadium · St. Louis, MO |
| 61 | Fri Jun 8 | at Reds | W7-6 (10) | 34-27 | .557 | Great American Ball Park · Cincinnati, OH |
| 62 | Sat Jun 9 | at Reds | W6-4 | 35-27 | .565 | Great American Ball Park · Cincinnati, OH |
| 63 | Sun Jun 10 | at Reds | L3-6 | 35-28 | .556 | Great American Ball Park · Cincinnati, OH |
| 64 | Mon Jun 11 | vs Padres | W5-2 | 36-28 | .563 | Busch Stadium · St. Louis, MO |
| 65 | Tue Jun 12 | vs Padres | L2-4 | 36-29 | .554 | Busch Stadium · St. Louis, MO |
| 66 | Wed Jun 13 | vs Padres | L2-4 | 36-30 | .545 | Busch Stadium · St. Louis, MO |
| 67 | Fri Jun 15 | vs Cubs | L5-13 | 36-31 | .537 | Busch Stadium · St. Louis, MO |
| 68 | Sat Jun 16 | vs Cubs | L3-6 | 36-32 | .529 | Busch Stadium · St. Louis, MO |
| 69 | Sun Jun 17 | vs Cubs | W5-0 | 37-32 | .536 | Busch Stadium · St. Louis, MO |
| 70 | Mon Jun 18 | at Phillies | L5-6 (10) | 37-33 | .529 | Citizens Bank Park · Philadelphi, PA |
| 71 | Tue Jun 19 | at Phillies | W7-6 | 38-33 | .535 | Citizens Bank Park · Philadelphi, PA |
| 72 | Wed Jun 20 | at Phillies | L3-4 | 38-34 | .528 | Citizens Bank Park · Philadelphi, PA |
| 73 | Thu Jun 21 | at Brewers | L3-11 | 38-35 | .521 | American Family Field · Milwaukee, WI |
| 74 | Fri Jun 22 | at Brewers | L1-2 | 38-36 | .514 | American Family Field · Milwaukee, WI |
| 75 | Sat Jun 23 | at Brewers | W3-2 | 39-36 | .520 | American Family Field · Milwaukee, WI |
| 76 | Sun Jun 24 | at Brewers | W8-2 | 40-36 | .526 | American Family Field · Milwaukee, WI |
| 77 | Mon Jun 25 | vs Guardians | W4-0 | 41-36 | .532 | Busch Stadium · St. Louis, MO |
| 78 | Tue Jun 26 | vs Guardians | W11-2 | 42-36 | .538 | Busch Stadium · St. Louis, MO |
| 79 | Wed Jun 27 | vs Guardians | L1-5 | 42-37 | .532 | Busch Stadium · St. Louis, MO |
| 80 | Fri Jun 29 | vs Braves | L1-5 | 42-38 | .525 | Busch Stadium · St. Louis, MO |
| 81 | Sat Jun 30 | vs Braves | L4-11 | 42-39 | .519 | Busch Stadium · St. Louis, MO |
| 82 | Sun Jul 1 | vs Braves | L5-6 | 42-40 | .512 | Busch Stadium · St. Louis, MO |
| 83 | Mon Jul 2 | at D-backs | W6-3 | 43-40 | .518 | Chase Field · Phoenix, AZ |
| 84 | Tue Jul 3 | at D-backs | L2-4 | 43-41 | .512 | Chase Field · Phoenix, AZ |
| 85 | Wed Jul 4 | at D-backs | W8-4 | 44-41 | .518 | Chase Field · Phoenix, AZ |
| 86 | Thu Jul 5 | at Giants | W11-2 | 45-41 | .523 | Oracle Park · San Francisco, CA |
| 87 | Fri Jul 6 | at Giants | L2-3 | 45-42 | .517 | Oracle Park · San Francisco, CA |
| 88 | Sat Jul 7 | at Giants | W3-2 | 46-42 | .523 | Oracle Park · San Francisco, CA |
| 89 | Sun Jul 8 | at Giants | L8-13 | 46-43 | .517 | Oracle Park · San Francisco, CA |
| 90 | Tue Jul 10 | at White Sox | W14-2 | 47-43 | .522 | Guaranteed Rate Field · Chicago, IL |
| 91 | Wed Jul 11 | at White Sox | L0-4 | 47-44 | .516 | Guaranteed Rate Field · Chicago, IL |
| 92 | Fri Jul 13 | vs Reds | L1-9 | 47-45 | .511 | Busch Stadium · St. Louis, MO |
| 93 | Sat Jul 14 | vs Reds | L2-8 | 47-46 | .505 | Busch Stadium · St. Louis, MO |
| 94 | Sun Jul 15 | vs Reds | W6-4 | 48-46 | .511 | Busch Stadium · St. Louis, MO |
| 95 | Thu Jul 19 | at Cubs | L6-9 | 48-47 | .505 | Wrigley Field · Chicago, IL |
| 96 | Fri Jul 20 | at Cubs | W18-5 | 49-47 | .510 | Wrigley Field · Chicago, IL |
| 97 | Sat Jul 21 | at Cubs | L2-7 | 49-48 | .505 | Wrigley Field · Chicago, IL |
| 98 | Sat Jul 21 | at Cubs | W6-3 | 50-48 | .510 | Wrigley Field · Chicago, IL |
| 99 | Sun Jul 22 | at Cubs | L2-7 | 50-49 | .505 | Wrigley Field · Chicago, IL |
| 100 | Mon Jul 23 | at Reds | L1-2 | 50-50 | .500 | Great American Ball Park · Cincinnati, OH |
| 101 | Tue Jul 24 | at Reds | W4-2 (11) | 51-50 | .505 | Great American Ball Park · Cincinnati, OH |
| 102 | Wed Jul 25 | at Reds | L3-7 | 51-51 | .500 | Great American Ball Park · Cincinnati, OH |
| 103 | Fri Jul 27 | vs Cubs | W5-2 | 52-51 | .505 | Busch Stadium · St. Louis, MO |
| 104 | Sat Jul 28 | vs Cubs | W6-2 | 53-51 | .510 | Busch Stadium · St. Louis, MO |
| 105 | Sun Jul 29 | vs Cubs | L2-5 | 53-52 | .505 | Busch Stadium · St. Louis, MO |
| 106 | Mon Jul 30 | vs Rockies | W5-4 (10) | 54-52 | .509 | Busch Stadium · St. Louis, MO |
| 107 | Tue Jul 31 | vs Rockies | L3-6 | 54-53 | .505 | Busch Stadium · St. Louis, MO |
| 108 | Wed Aug 1 | vs Rockies | W6-3 | 55-53 | .509 | Busch Stadium · St. Louis, MO |
| 109 | Thu Aug 2 | vs Rockies | W3-2 | 56-53 | .514 | Busch Stadium · St. Louis, MO |
| 110 | Fri Aug 3 | at Pirates | L6-7 | 56-54 | .509 | PNC Park · Pittsburgh, PA |
| 111 | Sat Aug 4 | at Pirates | W8-4 | 57-54 | .514 | PNC Park · Pittsburgh, PA |
| 112 | Sun Aug 5 | at Pirates | W2-1 | 58-54 | .518 | PNC Park · Pittsburgh, PA |
| 113 | Mon Aug 6 | at Marlins | L1-2 | 58-55 | .513 | LoanDepot Park · Miami, FL |
| 114 | Tue Aug 7 | at Marlins | W3-2 | 59-55 | .518 | LoanDepot Park · Miami, FL |
| 115 | Wed Aug 8 | at Marlins | W7-1 | 60-55 | .522 | LoanDepot Park · Miami, FL |
| 116 | Fri Aug 10 | at Royals | W7-0 | 61-55 | .526 | Kauffman Stadium · Kansas City, MO |
| 117 | Sat Aug 11 | at Royals | W8-3 | 62-55 | .530 | Kauffman Stadium · Kansas City, MO |
| 118 | Sun Aug 12 | at Royals | W8-2 | 63-55 | .534 | Kauffman Stadium · Kansas City, MO |
| 119 | Mon Aug 13 | vs Nationals | W7-6 | 64-55 | .538 | Busch Stadium · St. Louis, MO |
| 120 | Tue Aug 14 | vs Nationals | W6-4 | 65-55 | .542 | Busch Stadium · St. Louis, MO |
| 121 | Wed Aug 15 | vs Nationals | W4-2 | 66-55 | .545 | Busch Stadium · St. Louis, MO |
| 122 | Thu Aug 16 | vs Nationals | L4-5 | 66-56 | .541 | Busch Stadium · St. Louis, MO |
| 123 | Fri Aug 17 | vs Brewers | W5-2 | 67-56 | .545 | Busch Stadium · St. Louis, MO |
| 124 | Sat Aug 18 | vs Brewers | W7-2 | 68-56 | .548 | Busch Stadium · St. Louis, MO |
| 125 | Sun Aug 19 | vs Brewers | L1-2 | 68-57 | .544 | Busch Stadium · St. Louis, MO |
| 126 | Mon Aug 20 | at Dodgers | W5-3 | 69-57 | .548 | Dodger Stadium · Los Angeles, CA |
| 127 | Tue Aug 21 | at Dodgers | W5-2 | 70-57 | .551 | Dodger Stadium · Los Angeles, CA |
| 128 | Wed Aug 22 | at Dodgers | W3-1 | 71-57 | .555 | Dodger Stadium · Los Angeles, CA |
| 129 | Fri Aug 24 | at Rockies | W7-5 | 72-57 | .558 | Coors Field · Denver, CO |
| 130 | Sat Aug 25 | at Rockies | L1-9 | 72-58 | .554 | Coors Field · Denver, CO |
| 131 | Sun Aug 26 | at Rockies | W12-3 | 73-58 | .557 | Coors Field · Denver, CO |
| 132 | Tue Aug 28 | vs Pirates | W5-2 | 74-58 | .561 | Busch Stadium · St. Louis, MO |
| 133 | Wed Aug 29 | vs Pirates | L0-2 | 74-59 | .556 | Busch Stadium · St. Louis, MO |
| 134 | Thu Aug 30 | vs Pirates | W5-0 | 75-59 | .560 | Busch Stadium · St. Louis, MO |
| 135 | Fri Aug 31 | vs Reds | W12-5 | 76-59 | .563 | Busch Stadium · St. Louis, MO |
| 136 | Sat Sep 1 | vs Reds | L0-4 | 76-60 | .559 | Busch Stadium · St. Louis, MO |
| 137 | Sun Sep 2 | vs Reds | L4-6 (10) | 76-61 | .555 | Busch Stadium · St. Louis, MO |
| 138 | Mon Sep 3 | at Nationals | L3-4 (10) | 76-62 | .551 | Nationals Park · Washington, D.C. |
| 139 | Tue Sep 4 | at Nationals | W11-8 | 77-62 | .554 | Nationals Park · Washington, D.C. |
| 140 | Wed Sep 5 | at Nationals | W7-6 | 78-62 | .557 | Nationals Park · Washington, D.C. |
| 141 | Fri Sep 7 | at Tigers | L3-5 | 78-63 | .553 | Comerica Park · Detroit, MI |
| 142 | Sat Sep 8 | at Tigers | L3-4 | 78-64 | .549 | Comerica Park · Detroit, MI |
| 143 | Sun Sep 9 | at Tigers | W5-2 | 79-64 | .552 | Comerica Park · Detroit, MI |
| 144 | Mon Sep 10 | vs Pirates | W8-7 | 80-64 | .556 | Busch Stadium · St. Louis, MO |
| 145 | Tue Sep 11 | vs Pirates | W11-5 | 81-64 | .559 | Busch Stadium · St. Louis, MO |
| 146 | Wed Sep 12 | vs Pirates | L3-4 | 81-65 | .555 | Busch Stadium · St. Louis, MO |
| 147 | Thu Sep 13 | vs Dodgers | L7-9 | 81-66 | .551 | Busch Stadium · St. Louis, MO |
| 148 | Fri Sep 14 | vs Dodgers | L0-3 | 81-67 | .547 | Busch Stadium · St. Louis, MO |
| 149 | Sat Sep 15 | vs Dodgers | L4-17 | 81-68 | .544 | Busch Stadium · St. Louis, MO |
| 150 | Sun Sep 16 | vs Dodgers | W5-0 | 82-68 | .547 | Busch Stadium · St. Louis, MO |
| 151 | Mon Sep 17 | at Braves | W11-6 | 83-68 | .550 | Truist Park · Cumberland, GA |
| 152 | Tue Sep 18 | at Braves | W8-1 | 84-68 | .553 | Truist Park · Cumberland, GA |
| 153 | Wed Sep 19 | at Braves | L3-7 | 84-69 | .549 | Truist Park · Cumberland, GA |
| 154 | Fri Sep 21 | vs Giants | W5-3 | 85-69 | .552 | Busch Stadium · St. Louis, MO |
| 155 | Sat Sep 22 | vs Giants | W5-4 (10) | 86-69 | .555 | Busch Stadium · St. Louis, MO |
| 156 | Sun Sep 23 | vs Giants | W9-2 | 87-69 | .558 | Busch Stadium · St. Louis, MO |
| 157 | Mon Sep 24 | vs Brewers | L4-6 | 87-70 | .554 | Busch Stadium · St. Louis, MO |
| 158 | Tue Sep 25 | vs Brewers | L4-12 | 87-71 | .551 | Busch Stadium · St. Louis, MO |
| 159 | Wed Sep 26 | vs Brewers | L1-2 | 87-72 | .547 | Busch Stadium · St. Louis, MO |
| 160 | Fri Sep 28 | at Cubs | L4-8 | 87-73 | .544 | Wrigley Field · Chicago, IL |
| 161 | Sat Sep 29 | at Cubs | W2-1 | 88-73 | .547 | Wrigley Field · Chicago, IL |
| 162 | Sun Sep 30 | at Cubs | L5-10 | 88-74 | .543 | Wrigley Field · Chicago, IL |