| 1 | Mon Mar 31 | at Reds | W1-0 | 1-0 | 1.000 | Great American Ball Park · Cincinnati, OH |
| 2 | Wed Apr 2 | at Reds | L0-1 | 1-1 | .500 | Great American Ball Park · Cincinnati, OH |
| 3 | Thu Apr 3 | at Reds | W7-6 | 2-1 | .667 | Great American Ball Park · Cincinnati, OH |
| 4 | Fri Apr 4 | at Pirates | L2-12 | 2-2 | .500 | PNC Park · Pittsburgh, PA |
| 5 | Sat Apr 5 | at Pirates | W6-1 | 3-2 | .600 | PNC Park · Pittsburgh, PA |
| 6 | Sun Apr 6 | at Pirates | L1-2 | 3-3 | .500 | PNC Park · Pittsburgh, PA |
| 7 | Mon Apr 7 | vs Reds | W5-3 | 4-3 | .571 | Busch Stadium · St. Louis, MO |
| 8 | Tue Apr 8 | vs Reds | W7-5 | 5-3 | .625 | Busch Stadium · St. Louis, MO |
| 9 | Wed Apr 9 | vs Reds | L0-4 | 5-4 | .556 | Busch Stadium · St. Louis, MO |
| 10 | Fri Apr 11 | vs Cubs | L3-6 (11) | 5-5 | .500 | Busch Stadium · St. Louis, MO |
| 11 | Sat Apr 12 | vs Cubs | W10-4 | 6-5 | .545 | Busch Stadium · St. Louis, MO |
| 12 | Sun Apr 13 | vs Cubs | W6-4 | 7-5 | .583 | Busch Stadium · St. Louis, MO |
| 13 | Mon Apr 14 | at Brewers | W4-0 | 8-5 | .615 | American Family Field · Milwaukee, WI |
| 14 | Tue Apr 15 | at Brewers | W6-1 | 9-5 | .643 | American Family Field · Milwaukee, WI |
| 15 | Wed Apr 16 | at Brewers | L1-5 | 9-6 | .600 | American Family Field · Milwaukee, WI |
| 16 | Thu Apr 17 | at Nationals | W8-0 | 10-6 | .625 | Nationals Park · Washington, D.C. |
| 17 | Fri Apr 18 | at Nationals | L1-3 | 10-7 | .588 | Nationals Park · Washington, D.C. |
| 18 | Sat Apr 19 | at Nationals | W4-3 | 11-7 | .611 | Nationals Park · Washington, D.C. |
| 19 | Sun Apr 20 | at Nationals | L2-3 | 11-8 | .579 | Nationals Park · Washington, D.C. |
| 20 | Mon Apr 21 | at Mets | L0-2 | 11-9 | .550 | Citi Field · Queens, NY |
| 21 | Tue Apr 22 | at Mets | W3-0 | 12-9 | .571 | Citi Field · Queens, NY |
| 22 | Wed Apr 23 | at Mets | L2-3 | 12-10 | .545 | Citi Field · Queens, NY |
| 23 | Thu Apr 24 | at Mets | L1-4 | 12-11 | .522 | Citi Field · Queens, NY |
| 24 | Fri Apr 25 | vs Pirates | W1-0 | 13-11 | .542 | Busch Stadium · St. Louis, MO |
| 25 | Sat Apr 26 | vs Pirates | L1-6 | 13-12 | .520 | Busch Stadium · St. Louis, MO |
| 26 | Sun Apr 27 | vs Pirates | W7-0 | 14-12 | .538 | Busch Stadium · St. Louis, MO |
| 27 | Mon Apr 28 | vs Brewers | L3-5 (12) | 14-13 | .519 | Busch Stadium · St. Louis, MO |
| 28 | Tue Apr 29 | vs Brewers | L4-5 (11) | 14-14 | .500 | Busch Stadium · St. Louis, MO |
| 29 | Wed Apr 30 | vs Brewers | W9-3 | 15-14 | .517 | Busch Stadium · St. Louis, MO |
| 30 | Fri May 2 | at Cubs | L5-6 | 15-15 | .500 | Wrigley Field · Chicago, IL |
| 31 | Sat May 3 | at Cubs | L0-3 | 15-16 | .484 | Wrigley Field · Chicago, IL |
| 32 | Sun May 4 | at Cubs | W5-4 | 16-16 | .500 | Wrigley Field · Chicago, IL |
| 33 | Mon May 5 | at Braves | W4-3 | 17-16 | .515 | Truist Park · Cumberland, GA |
| 34 | Tue May 6 | at Braves | L1-2 | 17-17 | .500 | Truist Park · Cumberland, GA |
| 35 | Wed May 7 | at Braves | W7-1 | 18-17 | .514 | Truist Park · Cumberland, GA |
| 36 | Fri May 9 | at Pirates | L4-6 | 18-18 | .500 | PNC Park · Pittsburgh, PA |
| 37 | Sat May 10 | at Pirates | L3-4 | 18-19 | .486 | PNC Park · Pittsburgh, PA |
| 38 | Sun May 11 | at Pirates | W6-5 | 19-19 | .500 | PNC Park · Pittsburgh, PA |
| 39 | Mon May 12 | vs Cubs | L5-17 | 19-20 | .487 | Busch Stadium · St. Louis, MO |
| 40 | Tue May 13 | vs Cubs | W4-3 (12) | 20-20 | .500 | Busch Stadium · St. Louis, MO |
| 41 | Thu May 15 | vs Cubs | W5-3 | 21-20 | .512 | Busch Stadium · St. Louis, MO |
| 42 | Fri May 16 | vs Braves | W5-2 | 22-20 | .524 | Busch Stadium · St. Louis, MO |
| 43 | Sat May 17 | vs Braves | W4-1 | 23-20 | .535 | Busch Stadium · St. Louis, MO |
| 44 | Sun May 18 | vs Braves | L5-6 | 23-21 | .523 | Busch Stadium · St. Louis, MO |
| 45 | Tue May 20 | vs D-backs | W5-0 | 24-21 | .533 | Busch Stadium · St. Louis, MO |
| 46 | Wed May 21 | vs D-backs | W3-2 (12) | 25-21 | .543 | Busch Stadium · St. Louis, MO |
| 47 | Thu May 22 | vs D-backs | W4-2 | 26-21 | .553 | Busch Stadium · St. Louis, MO |
| 48 | Fri May 23 | at Reds | L3-5 | 26-22 | .542 | Great American Ball Park · Cincinnati, OH |
| 49 | Sat May 24 | at Reds | W6-3 | 27-22 | .551 | Great American Ball Park · Cincinnati, OH |
| 50 | Sun May 25 | at Reds | W4-0 | 28-22 | .560 | Great American Ball Park · Cincinnati, OH |
| 51 | Mon May 26 | vs Yankees | L4-6 (12) | 28-23 | .549 | Busch Stadium · St. Louis, MO |
| 52 | Tue May 27 | vs Yankees | W6-0 | 29-23 | .558 | Busch Stadium · St. Louis, MO |
| 53 | Wed May 28 | vs Yankees | L4-7 | 29-24 | .547 | Busch Stadium · St. Louis, MO |
| 54 | Thu May 29 | vs Giants | L5-6 | 29-25 | .537 | Busch Stadium · St. Louis, MO |
| 55 | Fri May 30 | vs Giants | L4-9 | 29-26 | .527 | Busch Stadium · St. Louis, MO |
| 56 | Sat May 31 | vs Giants | W2-0 | 30-26 | .536 | Busch Stadium · St. Louis, MO |
| 57 | Sun Jun 1 | vs Giants | L0-8 | 30-27 | .526 | Busch Stadium · St. Louis, MO |
| 58 | Mon Jun 2 | vs Royals | L0-6 | 30-28 | .517 | Busch Stadium · St. Louis, MO |
| 59 | Tue Jun 3 | vs Royals | L7-8 | 30-29 | .508 | Busch Stadium · St. Louis, MO |
| 60 | Wed Jun 4 | at Royals | W5-2 (11) | 31-29 | .517 | Kauffman Stadium · Kansas City, MO |
| 61 | Thu Jun 5 | at Royals | L2-3 | 31-30 | .508 | Kauffman Stadium · Kansas City, MO |
| 62 | Fri Jun 6 | at Blue Jays | L1-3 | 31-31 | .500 | Rogers Centre · Toronto, ON |
| 63 | Sat Jun 7 | at Blue Jays | W5-0 | 32-31 | .508 | Rogers Centre · Toronto, ON |
| 64 | Sun Jun 8 | at Blue Jays | W5-0 | 33-31 | .516 | Rogers Centre · Toronto, ON |
| 65 | Tue Jun 10 | at Rays | W1-0 | 34-31 | .523 | Tropicana Field · St. Petersburg, FL |
| 66 | Wed Jun 11 | at Rays | L3-6 | 34-32 | .515 | Tropicana Field · St. Petersburg, FL |
| 67 | Fri Jun 13 | vs Nationals | W1-0 | 35-32 | .522 | Busch Stadium · St. Louis, MO |
| 68 | Sat Jun 14 | vs Nationals | W4-1 | 36-32 | .529 | Busch Stadium · St. Louis, MO |
| 69 | Sun Jun 15 | vs Nationals | W5-2 | 37-32 | .536 | Busch Stadium · St. Louis, MO |
| 70 | Mon Jun 16 | vs Mets | W6-2 | 38-32 | .543 | Busch Stadium · St. Louis, MO |
| 71 | Tue Jun 17 | vs Mets | W5-2 | 39-32 | .549 | Busch Stadium · St. Louis, MO |
| 72 | Wed Jun 18 | vs Mets | L2-3 | 39-33 | .542 | Busch Stadium · St. Louis, MO |
| 73 | Thu Jun 19 | vs Phillies | L1-4 | 39-34 | .534 | Busch Stadium · St. Louis, MO |
| 74 | Fri Jun 20 | vs Phillies | L1-5 | 39-35 | .527 | Busch Stadium · St. Louis, MO |
| 75 | Sat Jun 21 | vs Phillies | W4-1 | 40-35 | .533 | Busch Stadium · St. Louis, MO |
| 76 | Sun Jun 22 | vs Phillies | W5-3 | 41-35 | .539 | Busch Stadium · St. Louis, MO |
| 77 | Mon Jun 23 | at Rockies | W8-0 | 42-35 | .545 | Coors Field · Denver, CO |
| 78 | Tue Jun 24 | at Rockies | L5-10 | 42-36 | .538 | Coors Field · Denver, CO |
| 79 | Wed Jun 25 | at Rockies | W9-6 | 43-36 | .544 | Coors Field · Denver, CO |
| 80 | Thu Jun 26 | at Dodgers | L0-1 | 43-37 | .537 | Dodger Stadium · Los Angeles, CA |
| 81 | Fri Jun 27 | at Dodgers | W3-1 | 44-37 | .543 | Dodger Stadium · Los Angeles, CA |
| 82 | Sat Jun 28 | at Dodgers | L1-9 | 44-38 | .537 | Dodger Stadium · Los Angeles, CA |
| 83 | Sun Jun 29 | at Dodgers | L0-6 | 44-39 | .530 | Dodger Stadium · Los Angeles, CA |
| 84 | Tue Jul 1 | at Giants | L0-5 | 44-40 | .524 | Oracle Park · San Francisco, CA |
| 85 | Wed Jul 2 | at Giants | W2-0 | 45-40 | .529 | Oracle Park · San Francisco, CA |
| 86 | Thu Jul 3 | at Giants | W7-2 | 46-40 | .535 | Oracle Park · San Francisco, CA |
| 87 | Fri Jul 4 | vs Marlins | W3-2 | 47-40 | .540 | Busch Stadium · St. Louis, MO |
| 88 | Sat Jul 5 | vs Marlins | L5-6 | 47-41 | .534 | Busch Stadium · St. Louis, MO |
| 89 | Sun Jul 6 | vs Marlins | L4-8 | 47-42 | .528 | Busch Stadium · St. Louis, MO |
| 90 | Mon Jul 7 | vs Pirates | W2-0 | 48-42 | .533 | Busch Stadium · St. Louis, MO |
| 91 | Tue Jul 8 | vs Pirates | W5-4 | 49-42 | .538 | Busch Stadium · St. Louis, MO |
| 92 | Wed Jul 9 | vs Pirates | W5-2 | 50-42 | .543 | Busch Stadium · St. Louis, MO |
| 93 | Thu Jul 10 | vs Pirates | L1-9 | 50-43 | .538 | Busch Stadium · St. Louis, MO |
| 94 | Fri Jul 11 | at Brewers | W7-6 | 51-43 | .543 | American Family Field · Milwaukee, WI |
| 95 | Sat Jul 12 | at Brewers | W10-2 | 52-43 | .547 | American Family Field · Milwaukee, WI |
| 96 | Sun Jul 13 | at Brewers | L2-11 | 52-44 | .542 | American Family Field · Milwaukee, WI |
| 97 | Fri Jul 18 | vs Dodgers | W3-2 | 53-44 | .546 | Busch Stadium · St. Louis, MO |
| 98 | Sat Jul 19 | vs Dodgers | W4-2 | 54-44 | .551 | Busch Stadium · St. Louis, MO |
| 99 | Sun Jul 20 | vs Dodgers | L3-4 | 54-45 | .545 | Busch Stadium · St. Louis, MO |
| 100 | Tue Jul 22 | vs Rays | L2-7 | 54-46 | .540 | Busch Stadium · St. Louis, MO |
| 101 | Wed Jul 23 | vs Rays | L0-3 | 54-47 | .535 | Busch Stadium · St. Louis, MO |
| 102 | Fri Jul 25 | at Cubs | L6-7 | 54-48 | .529 | Wrigley Field · Chicago, IL |
| 103 | Sat Jul 26 | at Cubs | W6-3 | 55-48 | .534 | Wrigley Field · Chicago, IL |
| 104 | Sun Jul 27 | at Cubs | W1-0 | 56-48 | .538 | Wrigley Field · Chicago, IL |
| 105 | Tue Jul 29 | at Padres | L1-3 | 56-49 | .533 | Petco Park · San Diego, CA |
| 106 | Wed Jul 30 | at Padres | L1-12 | 56-50 | .528 | Petco Park · San Diego, CA |
| 107 | Thu Jul 31 | at Padres | W6-2 | 57-50 | .533 | Petco Park · San Diego, CA |
| 108 | Fri Aug 1 | vs Brewers | L4-7 | 57-51 | .528 | Busch Stadium · St. Louis, MO |
| 109 | Sat Aug 2 | vs Brewers | W9-7 | 58-51 | .532 | Busch Stadium · St. Louis, MO |
| 110 | Sun Aug 3 | vs Brewers | W3-2 | 59-51 | .536 | Busch Stadium · St. Louis, MO |
| 111 | Tue Aug 5 | vs Red Sox | W3-2 | 60-51 | .541 | Busch Stadium · St. Louis, MO |
| 112 | Wed Aug 6 | vs Red Sox | L1-2 | 60-52 | .536 | Busch Stadium · St. Louis, MO |
| 113 | Thu Aug 7 | vs Red Sox | W5-2 | 61-52 | .540 | Busch Stadium · St. Louis, MO |
| 114 | Fri Aug 8 | at Orioles | L2-12 | 61-53 | .535 | Camden Yards · Baltimore, MD |
| 115 | Sat Aug 9 | at Orioles | L3-10 | 61-54 | .530 | Camden Yards · Baltimore, MD |
| 116 | Sun Aug 10 | at Orioles | W8-3 | 62-54 | .534 | Camden Yards · Baltimore, MD |
| 117 | Mon Aug 11 | at Marlins | L5-6 | 62-55 | .530 | LoanDepot Park · Miami, FL |
| 118 | Tue Aug 12 | at Marlins | L0-3 | 62-56 | .525 | LoanDepot Park · Miami, FL |
| 119 | Wed Aug 13 | at Marlins | W5-2 | 63-56 | .529 | LoanDepot Park · Miami, FL |
| 120 | Thu Aug 14 | vs Padres | W4-3 | 64-56 | .533 | Busch Stadium · St. Louis, MO |
| 121 | Fri Aug 15 | vs Padres | W4-2 | 65-56 | .537 | Busch Stadium · St. Louis, MO |
| 122 | Sat Aug 16 | vs Padres | L5-9 | 65-57 | .533 | Busch Stadium · St. Louis, MO |
| 123 | Sun Aug 17 | vs Padres | W7-6 | 66-57 | .537 | Busch Stadium · St. Louis, MO |
| 124 | Mon Aug 18 | vs Reds | W6-5 (10) | 67-57 | .540 | Busch Stadium · St. Louis, MO |
| 125 | Tue Aug 19 | vs Reds | W5-4 | 68-57 | .544 | Busch Stadium · St. Louis, MO |
| 126 | Wed Aug 20 | vs Reds | W7-3 | 69-57 | .548 | Busch Stadium · St. Louis, MO |
| 127 | Fri Aug 22 | at Phillies | L4-5 | 69-58 | .543 | Citizens Bank Park · Philadelphi, PA |
| 128 | Sat Aug 23 | at Phillies | W6-5 (12) | 70-58 | .547 | Citizens Bank Park · Philadelphi, PA |
| 129 | Sun Aug 24 | at Phillies | L1-7 | 70-59 | .543 | Citizens Bank Park · Philadelphi, PA |
| 130 | Mon Aug 25 | at Pirates | W3-2 | 71-59 | .546 | PNC Park · Pittsburgh, PA |
| 131 | Tue Aug 26 | at Pirates | L2-5 | 71-60 | .542 | PNC Park · Pittsburgh, PA |
| 132 | Wed Aug 27 | at Pirates | L1-3 | 71-61 | .538 | PNC Park · Pittsburgh, PA |
| 133 | Fri Aug 29 | vs Cubs | L2-7 | 71-62 | .534 | Busch Stadium · St. Louis, MO |
| 134 | Sat Aug 30 | vs Cubs | L1-5 | 71-63 | .530 | Busch Stadium · St. Louis, MO |
| 135 | Sat Aug 30 | vs Cubs | W13-2 | 72-63 | .533 | Busch Stadium · St. Louis, MO |
| 136 | Sun Aug 31 | vs Cubs | W9-6 | 73-63 | .537 | Busch Stadium · St. Louis, MO |
| 137 | Mon Sep 1 | vs Pirates | W5-4 | 74-63 | .540 | Busch Stadium · St. Louis, MO |
| 138 | Tue Sep 2 | vs Pirates | W6-4 | 75-63 | .543 | Busch Stadium · St. Louis, MO |
| 139 | Wed Sep 3 | vs Pirates | W1-0 | 76-63 | .547 | Busch Stadium · St. Louis, MO |
| 140 | Thu Sep 4 | at Brewers | W3-2 | 77-63 | .550 | American Family Field · Milwaukee, WI |
| 141 | Fri Sep 5 | at Brewers | L2-6 | 77-64 | .546 | American Family Field · Milwaukee, WI |
| 142 | Sat Sep 6 | at Brewers | W5-3 | 78-64 | .549 | American Family Field · Milwaukee, WI |
| 143 | Sun Sep 7 | at Brewers | W9-1 | 79-64 | .552 | American Family Field · Milwaukee, WI |
| 144 | Mon Sep 8 | at Reds | W5-0 | 80-64 | .556 | Great American Ball Park · Cincinnati, OH |
| 145 | Tue Sep 9 | at Reds | L5-9 | 80-65 | .552 | Great American Ball Park · Cincinnati, OH |
| 146 | Wed Sep 10 | at Reds | L2-4 | 80-66 | .548 | Great American Ball Park · Cincinnati, OH |
| 147 | Thu Sep 11 | at Reds | L0-1 | 80-67 | .544 | Great American Ball Park · Cincinnati, OH |
| 148 | Fri Sep 12 | vs Rockies | W5-1 | 81-67 | .547 | Busch Stadium · St. Louis, MO |
| 149 | Sat Sep 13 | vs Rockies | W5-4 | 82-67 | .550 | Busch Stadium · St. Louis, MO |
| 150 | Sun Sep 14 | vs Rockies | W4-1 | 83-67 | .553 | Busch Stadium · St. Louis, MO |
| 151 | Tue Sep 16 | vs Brewers | L2-3 (12) | 83-68 | .550 | Busch Stadium · St. Louis, MO |
| 152 | Wed Sep 17 | vs Brewers | W2-0 | 84-68 | .553 | Busch Stadium · St. Louis, MO |
| 153 | Thu Sep 18 | vs Brewers | W3-2 (13) | 85-68 | .556 | Busch Stadium · St. Louis, MO |
| 154 | Fri Sep 19 | vs Reds | W2-1 | 86-68 | .558 | Busch Stadium · St. Louis, MO |
| 155 | Sat Sep 20 | vs Reds | W8-4 | 87-68 | .561 | Busch Stadium · St. Louis, MO |
| 156 | Sun Sep 21 | vs Reds | L2-7 | 87-69 | .558 | Busch Stadium · St. Louis, MO |
| 157 | Mon Sep 22 | at Cubs | W8-0 | 88-69 | .561 | Wrigley Field · Chicago, IL |
| 158 | Tue Sep 23 | at Cubs | L3-4 (10) | 88-70 | .557 | Wrigley Field · Chicago, IL |
| 159 | Wed Sep 24 | at Cubs | L1-3 | 88-71 | .553 | Wrigley Field · Chicago, IL |
| 160 | Fri Sep 26 | at D-backs | W7-6 (10) | 89-71 | .556 | Chase Field · Phoenix, AZ |
| 161 | Sat Sep 27 | at D-backs | L2-5 | 89-72 | .553 | Chase Field · Phoenix, AZ |
| 162 | Sun Sep 28 | at D-backs | W1-0 | 90-72 | .556 | Chase Field · Phoenix, AZ |
| 163 | Fri Oct 3 | at Dodgers | W10-9 | 1-0 | 1.000 | Dodger Stadium · Los Angeles, CA |
| 164 | Sat Oct 4 | at Dodgers | L2-3 | 1-1 | .500 | Dodger Stadium · Los Angeles, CA |
| 165 | Mon Oct 6 | vs Dodgers | W3-1 | 2-1 | .667 | Busch Stadium · St. Louis, MO |
| 166 | Tue Oct 7 | vs Dodgers | W3-2 | 3-1 | .750 | Busch Stadium · St. Louis, MO |
| 167 | Sat Oct 11 | vs Giants | L0-3 | 0-1 | .000 | Busch Stadium · St. Louis, MO |
| 168 | Sun Oct 12 | vs Giants | W5-4 | 1-1 | .500 | Busch Stadium · St. Louis, MO |
| 169 | Tue Oct 14 | at Giants | L4-5 (10) | 1-2 | .333 | Oracle Park · San Francisco, CA |
| 170 | Wed Oct 15 | at Giants | L4-6 | 1-3 | .250 | Oracle Park · San Francisco, CA |
| 171 | Thu Oct 16 | at Giants | L3-6 | 1-4 | .200 | Oracle Park · San Francisco, CA |