| 1 | Thu Mar 28 | at Brewers | L4-5 | 0-1 | .000 | American Family Field · Milwaukee, WI |
| 2 | Fri Mar 29 | at Brewers | W9-5 | 1-1 | .500 | American Family Field · Milwaukee, WI |
| 3 | Sat Mar 30 | at Brewers | L2-4 | 1-2 | .333 | American Family Field · Milwaukee, WI |
| 4 | Sun Mar 31 | at Brewers | L4-5 | 1-3 | .250 | American Family Field · Milwaukee, WI |
| 5 | Mon Apr 1 | at Pirates | W6-5 (11) | 2-3 | .400 | PNC Park · Pittsburgh, PA |
| 6 | Wed Apr 3 | at Pirates | W5-4 (10) | 3-3 | .500 | PNC Park · Pittsburgh, PA |
| 7 | Fri Apr 5 | vs Padres | L3-5 | 3-4 | .429 | Busch Stadium · St. Louis, MO |
| 8 | Sat Apr 6 | vs Padres | L4-6 | 3-5 | .375 | Busch Stadium · St. Louis, MO |
| 9 | Sun Apr 7 | vs Padres | W4-1 | 4-5 | .444 | Busch Stadium · St. Louis, MO |
| 10 | Mon Apr 8 | vs Dodgers | W4-3 | 5-5 | .500 | Busch Stadium · St. Louis, MO |
| 11 | Tue Apr 9 | vs Dodgers | W4-0 | 6-5 | .545 | Busch Stadium · St. Louis, MO |
| 12 | Wed Apr 10 | vs Dodgers | W7-2 | 7-5 | .583 | Busch Stadium · St. Louis, MO |
| 13 | Thu Apr 11 | vs Dodgers | W11-7 | 8-5 | .615 | Busch Stadium · St. Louis, MO |
| 14 | Sat Apr 13 | at Reds | L2-5 | 8-6 | .571 | Great American Ball Park · Cincinnati, OH |
| 15 | Sun Apr 14 | at Reds | W9-5 | 9-6 | .600 | Great American Ball Park · Cincinnati, OH |
| 16 | Mon Apr 15 | at Brewers | L7-10 | 9-7 | .563 | American Family Field · Milwaukee, WI |
| 17 | Tue Apr 16 | at Brewers | L4-8 | 9-8 | .529 | American Family Field · Milwaukee, WI |
| 18 | Wed Apr 17 | at Brewers | W6-3 | 10-8 | .556 | American Family Field · Milwaukee, WI |
| 19 | Fri Apr 19 | vs Mets | L4-5 | 10-9 | .526 | Busch Stadium · St. Louis, MO |
| 20 | Sat Apr 20 | vs Mets | W10-2 | 11-9 | .550 | Busch Stadium · St. Louis, MO |
| 21 | Sun Apr 21 | vs Mets | W6-4 | 12-9 | .571 | Busch Stadium · St. Louis, MO |
| 22 | Mon Apr 22 | vs Brewers | W13-5 | 13-9 | .591 | Busch Stadium · St. Louis, MO |
| 23 | Tue Apr 23 | vs Brewers | W4-3 | 14-9 | .609 | Busch Stadium · St. Louis, MO |
| 24 | Wed Apr 24 | vs Brewers | W5-2 | 15-9 | .625 | Busch Stadium · St. Louis, MO |
| 25 | Fri Apr 26 | vs Reds | L1-12 | 15-10 | .600 | Busch Stadium · St. Louis, MO |
| 26 | Sat Apr 27 | vs Reds | W6-3 | 16-10 | .615 | Busch Stadium · St. Louis, MO |
| 27 | Sun Apr 28 | vs Reds | W5-2 | 17-10 | .630 | Busch Stadium · St. Louis, MO |
| 28 | Mon Apr 29 | at Nationals | W6-3 | 18-10 | .643 | Nationals Park · Washington, D.C. |
| 29 | Tue Apr 30 | at Nationals | W3-2 | 19-10 | .655 | Nationals Park · Washington, D.C. |
| 30 | Wed May 1 | at Nationals | W5-1 | 20-10 | .667 | Nationals Park · Washington, D.C. |
| 31 | Thu May 2 | at Nationals | L1-2 | 20-11 | .645 | Nationals Park · Washington, D.C. |
| 32 | Fri May 3 | at Cubs | L0-4 | 20-12 | .625 | Wrigley Field · Chicago, IL |
| 33 | Sat May 4 | at Cubs | L5-6 | 20-13 | .606 | Wrigley Field · Chicago, IL |
| 34 | Sun May 5 | at Cubs | L5-13 | 20-14 | .588 | Wrigley Field · Chicago, IL |
| 35 | Mon May 6 | vs Phillies | W6-0 | 21-14 | .600 | Busch Stadium · St. Louis, MO |
| 36 | Tue May 7 | vs Phillies | L1-11 | 21-15 | .583 | Busch Stadium · St. Louis, MO |
| 37 | Wed May 8 | vs Phillies | L0-5 | 21-16 | .568 | Busch Stadium · St. Louis, MO |
| 38 | Thu May 9 | vs Pirates | W17-4 | 22-16 | .579 | Busch Stadium · St. Louis, MO |
| 39 | Fri May 10 | vs Pirates | L1-2 | 22-17 | .564 | Busch Stadium · St. Louis, MO |
| 40 | Sat May 11 | vs Pirates | L1-2 | 22-18 | .550 | Busch Stadium · St. Louis, MO |
| 41 | Sun May 12 | vs Pirates | L6-10 | 22-19 | .537 | Busch Stadium · St. Louis, MO |
| 42 | Tue May 14 | at Braves | W14-3 | 23-19 | .548 | Truist Park · Cumberland, GA |
| 43 | Wed May 15 | at Braves | L0-4 | 23-20 | .535 | Truist Park · Cumberland, GA |
| 44 | Thu May 16 | at Braves | L2-10 | 23-21 | .523 | Truist Park · Cumberland, GA |
| 45 | Fri May 17 | at Rangers | L3-7 | 23-22 | .511 | Globe Life Field · Arlington, TX |
| 46 | Sat May 18 | at Rangers | W8-2 | 24-22 | .522 | Globe Life Field · Arlington, TX |
| 47 | Sun May 19 | at Rangers | L4-5 (10) | 24-23 | .511 | Globe Life Field · Arlington, TX |
| 48 | Wed May 22 | vs Royals | L2-8 | 24-24 | .500 | Busch Stadium · St. Louis, MO |
| 49 | Wed May 22 | vs Royals | W10-3 | 25-24 | .510 | Busch Stadium · St. Louis, MO |
| 50 | Fri May 24 | vs Braves | L2-5 | 25-25 | .500 | Busch Stadium · St. Louis, MO |
| 51 | Sat May 25 | vs Braves | W6-3 | 26-25 | .510 | Busch Stadium · St. Louis, MO |
| 52 | Sun May 26 | vs Braves | L3-4 (10) | 26-26 | .500 | Busch Stadium · St. Louis, MO |
| 53 | Tue May 28 | at Phillies | L3-4 | 26-27 | .491 | Citizens Bank Park · Philadelphi, PA |
| 54 | Wed May 29 | at Phillies | L4-11 | 26-28 | .481 | Citizens Bank Park · Philadelphi, PA |
| 55 | Thu May 30 | at Phillies | W5-3 | 27-28 | .491 | Citizens Bank Park · Philadelphi, PA |
| 56 | Fri May 31 | vs Cubs | W2-1 (10) | 28-28 | .500 | Busch Stadium · St. Louis, MO |
| 57 | Sat Jun 1 | vs Cubs | W7-4 | 29-28 | .509 | Busch Stadium · St. Louis, MO |
| 58 | Sun Jun 2 | vs Cubs | W2-1 | 30-28 | .517 | Busch Stadium · St. Louis, MO |
| 59 | Tue Jun 4 | vs Reds | L1-4 | 30-29 | .508 | Busch Stadium · St. Louis, MO |
| 60 | Thu Jun 6 | vs Reds | W3-1 | 31-29 | .517 | Busch Stadium · St. Louis, MO |
| 61 | Fri Jun 7 | at Cubs | L1-3 | 31-30 | .508 | Wrigley Field · Chicago, IL |
| 62 | Sat Jun 8 | at Cubs | L4-9 | 31-31 | .500 | Wrigley Field · Chicago, IL |
| 63 | Sun Jun 9 | at Cubs | L1-5 | 31-32 | .492 | Wrigley Field · Chicago, IL |
| 64 | Mon Jun 10 | at Marlins | W4-1 | 32-32 | .500 | LoanDepot Park · Miami, FL |
| 65 | Tue Jun 11 | at Marlins | W7-1 | 33-32 | .508 | LoanDepot Park · Miami, FL |
| 66 | Wed Jun 12 | at Marlins | L0-9 | 33-33 | .500 | LoanDepot Park · Miami, FL |
| 67 | Fri Jun 14 | at Mets | W5-4 (10) | 34-33 | .507 | Citi Field · Queens, NY |
| 68 | Fri Jun 14 | at Mets | W9-5 | 35-33 | .515 | Citi Field · Queens, NY |
| 69 | Sat Jun 15 | at Mets | L7-8 | 35-34 | .507 | Citi Field · Queens, NY |
| 70 | Sun Jun 16 | at Mets | W4-3 | 36-34 | .514 | Citi Field · Queens, NY |
| 71 | Mon Jun 17 | vs Marlins | W5-0 | 37-34 | .521 | Busch Stadium · St. Louis, MO |
| 72 | Tue Jun 18 | vs Marlins | L0-6 | 37-35 | .514 | Busch Stadium · St. Louis, MO |
| 73 | Wed Jun 19 | vs Marlins | W2-1 (11) | 38-35 | .521 | Busch Stadium · St. Louis, MO |
| 74 | Thu Jun 20 | vs Marlins | L6-7 (11) | 38-36 | .514 | Busch Stadium · St. Louis, MO |
| 75 | Fri Jun 21 | vs Angels | W5-1 | 39-36 | .520 | Busch Stadium · St. Louis, MO |
| 76 | Sat Jun 22 | vs Angels | W4-2 | 40-36 | .526 | Busch Stadium · St. Louis, MO |
| 77 | Sun Jun 23 | vs Angels | L4-6 | 40-37 | .519 | Busch Stadium · St. Louis, MO |
| 78 | Tue Jun 25 | vs Athletics | L3-7 | 40-38 | .513 | Busch Stadium · St. Louis, MO |
| 79 | Wed Jun 26 | vs Athletics | L0-2 | 40-39 | .506 | Busch Stadium · St. Louis, MO |
| 80 | Fri Jun 28 | at Padres | L1-3 | 40-40 | .500 | Petco Park · San Diego, CA |
| 81 | Sat Jun 29 | at Padres | L2-12 | 40-41 | .494 | Petco Park · San Diego, CA |
| 82 | Sun Jun 30 | at Padres | W5-3 (11) | 41-41 | .500 | Petco Park · San Diego, CA |
| 83 | Tue Jul 2 | at Mariners | L4-5 | 41-42 | .494 | T-Mobile Park · Seattle, WA |
| 84 | Wed Jul 3 | at Mariners | W5-2 | 42-42 | .500 | T-Mobile Park · Seattle, WA |
| 85 | Thu Jul 4 | at Mariners | W5-4 | 43-42 | .506 | T-Mobile Park · Seattle, WA |
| 86 | Fri Jul 5 | at Giants | W9-4 | 44-42 | .512 | Oracle Park · San Francisco, CA |
| 87 | Sat Jul 6 | at Giants | L4-8 | 44-43 | .506 | Oracle Park · San Francisco, CA |
| 88 | Sun Jul 7 | at Giants | L0-1 | 44-44 | .500 | Oracle Park · San Francisco, CA |
| 89 | Fri Jul 12 | vs D-backs | L2-4 | 44-45 | .494 | Busch Stadium · St. Louis, MO |
| 90 | Sat Jul 13 | vs D-backs | W4-2 | 45-45 | .500 | Busch Stadium · St. Louis, MO |
| 91 | Sun Jul 14 | vs D-backs | W5-2 | 46-45 | .505 | Busch Stadium · St. Louis, MO |
| 92 | Mon Jul 15 | vs Pirates | W7-0 | 47-45 | .511 | Busch Stadium · St. Louis, MO |
| 93 | Tue Jul 16 | vs Pirates | L1-3 | 47-46 | .505 | Busch Stadium · St. Louis, MO |
| 94 | Wed Jul 17 | vs Pirates | W6-5 | 48-46 | .511 | Busch Stadium · St. Louis, MO |
| 95 | Thu Jul 18 | at Reds | W7-4 | 49-46 | .516 | Great American Ball Park · Cincinnati, OH |
| 96 | Fri Jul 19 | at Reds | W12-11 | 50-46 | .521 | Great American Ball Park · Cincinnati, OH |
| 97 | Sat Jul 20 | at Reds | L2-3 | 50-47 | .515 | Great American Ball Park · Cincinnati, OH |
| 98 | Sun Jul 21 | at Reds | W3-1 | 51-47 | .520 | Great American Ball Park · Cincinnati, OH |
| 99 | Mon Jul 22 | at Pirates | W6-5 (10) | 52-47 | .525 | PNC Park · Pittsburgh, PA |
| 100 | Tue Jul 23 | at Pirates | W4-3 | 53-47 | .530 | PNC Park · Pittsburgh, PA |
| 101 | Wed Jul 24 | at Pirates | W14-8 | 54-47 | .535 | PNC Park · Pittsburgh, PA |
| 102 | Thu Jul 25 | at Pirates | W6-3 | 55-47 | .539 | PNC Park · Pittsburgh, PA |
| 103 | Fri Jul 26 | vs Astros | W5-3 | 56-47 | .544 | Busch Stadium · St. Louis, MO |
| 104 | Sat Jul 27 | vs Astros | L2-8 | 56-48 | .538 | Busch Stadium · St. Louis, MO |
| 105 | Sun Jul 28 | vs Astros | L2-6 | 56-49 | .533 | Busch Stadium · St. Louis, MO |
| 106 | Tue Jul 30 | vs Cubs | W2-1 | 57-49 | .538 | Busch Stadium · St. Louis, MO |
| 107 | Wed Jul 31 | vs Cubs | L0-2 | 57-50 | .533 | Busch Stadium · St. Louis, MO |
| 108 | Thu Aug 1 | vs Cubs | W8-0 | 58-50 | .537 | Busch Stadium · St. Louis, MO |
| 109 | Sat Aug 3 | at Athletics | L3-8 | 58-51 | .532 | RingCentral Coliseum · Oakland, CA |
| 110 | Sun Aug 4 | at Athletics | L2-4 | 58-52 | .527 | RingCentral Coliseum · Oakland, CA |
| 111 | Mon Aug 5 | at Dodgers | L0-8 | 58-53 | .523 | Dodger Stadium · Los Angeles, CA |
| 112 | Tue Aug 6 | at Dodgers | L1-3 | 58-54 | .518 | Dodger Stadium · Los Angeles, CA |
| 113 | Wed Aug 7 | at Dodgers | L1-2 | 58-55 | .513 | Dodger Stadium · Los Angeles, CA |
| 114 | Fri Aug 9 | vs Pirates | W6-2 | 59-55 | .518 | Busch Stadium · St. Louis, MO |
| 115 | Sat Aug 10 | vs Pirates | W3-1 | 60-55 | .522 | Busch Stadium · St. Louis, MO |
| 116 | Sun Aug 11 | vs Pirates | W11-9 | 61-55 | .526 | Busch Stadium · St. Louis, MO |
| 117 | Tue Aug 13 | at Royals | W2-0 | 62-55 | .530 | Kauffman Stadium · Kansas City, MO |
| 118 | Wed Aug 14 | at Royals | W6-0 | 63-55 | .534 | Kauffman Stadium · Kansas City, MO |
| 119 | Thu Aug 15 | at Reds | L1-2 | 63-56 | .529 | Great American Ball Park · Cincinnati, OH |
| 120 | Fri Aug 16 | at Reds | W13-4 | 64-56 | .533 | Great American Ball Park · Cincinnati, OH |
| 121 | Sat Aug 17 | at Reds | L1-6 | 64-57 | .529 | Great American Ball Park · Cincinnati, OH |
| 122 | Sun Aug 18 | at Reds | W5-4 | 65-57 | .533 | Great American Ball Park · Cincinnati, OH |
| 123 | Mon Aug 19 | vs Brewers | W3-0 | 66-57 | .537 | Busch Stadium · St. Louis, MO |
| 124 | Tue Aug 20 | vs Brewers | W9-4 | 67-57 | .540 | Busch Stadium · St. Louis, MO |
| 125 | Wed Aug 21 | vs Brewers | L3-5 | 67-58 | .536 | Busch Stadium · St. Louis, MO |
| 126 | Thu Aug 22 | vs Rockies | W6-5 | 68-58 | .540 | Busch Stadium · St. Louis, MO |
| 127 | Fri Aug 23 | vs Rockies | W8-3 | 69-58 | .543 | Busch Stadium · St. Louis, MO |
| 128 | Sat Aug 24 | vs Rockies | W6-0 | 70-58 | .547 | Busch Stadium · St. Louis, MO |
| 129 | Sun Aug 25 | vs Rockies | W11-4 | 71-58 | .550 | Busch Stadium · St. Louis, MO |
| 130 | Mon Aug 26 | at Brewers | W12-2 | 72-58 | .554 | American Family Field · Milwaukee, WI |
| 131 | Tue Aug 27 | at Brewers | W6-3 | 73-58 | .557 | American Family Field · Milwaukee, WI |
| 132 | Wed Aug 28 | at Brewers | L1-4 | 73-59 | .553 | American Family Field · Milwaukee, WI |
| 133 | Sat Aug 31 | vs Reds | W10-6 | 74-59 | .556 | Busch Stadium · St. Louis, MO |
| 134 | Sat Aug 31 | vs Reds | W3-2 | 75-59 | .560 | Busch Stadium · St. Louis, MO |
| 135 | Sun Sep 1 | vs Reds | W4-3 | 76-59 | .563 | Busch Stadium · St. Louis, MO |
| 136 | Sun Sep 1 | vs Reds | L3-5 | 76-60 | .559 | Busch Stadium · St. Louis, MO |
| 137 | Mon Sep 2 | vs Giants | W3-1 | 77-60 | .562 | Busch Stadium · St. Louis, MO |
| 138 | Tue Sep 3 | vs Giants | W1-0 | 78-60 | .565 | Busch Stadium · St. Louis, MO |
| 139 | Wed Sep 4 | vs Giants | L8-9 | 78-61 | .561 | Busch Stadium · St. Louis, MO |
| 140 | Thu Sep 5 | vs Giants | W10-0 | 79-61 | .564 | Busch Stadium · St. Louis, MO |
| 141 | Fri Sep 6 | at Pirates | L4-9 | 79-62 | .560 | PNC Park · Pittsburgh, PA |
| 142 | Sat Sep 7 | at Pirates | W10-1 | 80-62 | .563 | PNC Park · Pittsburgh, PA |
| 143 | Sun Sep 8 | at Pirates | W2-0 | 81-62 | .566 | PNC Park · Pittsburgh, PA |
| 144 | Tue Sep 10 | at Rockies | L1-2 | 81-63 | .563 | Coors Field · Denver, CO |
| 145 | Wed Sep 11 | at Rockies | L1-2 | 81-64 | .559 | Coors Field · Denver, CO |
| 146 | Thu Sep 12 | at Rockies | W10-3 | 82-64 | .562 | Coors Field · Denver, CO |
| 147 | Fri Sep 13 | vs Brewers | W10-0 | 83-64 | .565 | Busch Stadium · St. Louis, MO |
| 148 | Sat Sep 14 | vs Brewers | L2-5 | 83-65 | .561 | Busch Stadium · St. Louis, MO |
| 149 | Sun Sep 15 | vs Brewers | L6-7 | 83-66 | .557 | Busch Stadium · St. Louis, MO |
| 150 | Mon Sep 16 | vs Nationals | W4-2 | 84-66 | .560 | Busch Stadium · St. Louis, MO |
| 151 | Tue Sep 17 | vs Nationals | L2-6 | 84-67 | .556 | Busch Stadium · St. Louis, MO |
| 152 | Wed Sep 18 | vs Nationals | W5-1 | 85-67 | .559 | Busch Stadium · St. Louis, MO |
| 153 | Thu Sep 19 | at Cubs | W5-4 (10) | 86-67 | .562 | Wrigley Field · Chicago, IL |
| 154 | Fri Sep 20 | at Cubs | W2-1 | 87-67 | .565 | Wrigley Field · Chicago, IL |
| 155 | Sat Sep 21 | at Cubs | W9-8 | 88-67 | .568 | Wrigley Field · Chicago, IL |
| 156 | Sun Sep 22 | at Cubs | W3-2 | 89-67 | .571 | Wrigley Field · Chicago, IL |
| 157 | Mon Sep 23 | at D-backs | W9-7 | 90-67 | .573 | Chase Field · Phoenix, AZ |
| 158 | Tue Sep 24 | at D-backs | L2-3 (19) | 90-68 | .570 | Chase Field · Phoenix, AZ |
| 159 | Wed Sep 25 | at D-backs | L7-9 | 90-69 | .566 | Chase Field · Phoenix, AZ |
| 160 | Fri Sep 27 | vs Cubs | L2-8 | 90-70 | .563 | Busch Stadium · St. Louis, MO |
| 161 | Sat Sep 28 | vs Cubs | L6-8 | 90-71 | .559 | Busch Stadium · St. Louis, MO |
| 162 | Sun Sep 29 | vs Cubs | W9-0 | 91-71 | .562 | Busch Stadium · St. Louis, MO |
| 163 | Thu Oct 3 | at Braves | W7-6 | 1-0 | 1.000 | Truist Park · Cumberland, GA |
| 164 | Fri Oct 4 | at Braves | L0-3 | 1-1 | .500 | Truist Park · Cumberland, GA |
| 165 | Sun Oct 6 | vs Braves | L1-3 | 1-2 | .333 | Busch Stadium · St. Louis, MO |
| 166 | Mon Oct 7 | vs Braves | W5-4 (10) | 2-2 | .500 | Busch Stadium · St. Louis, MO |
| 167 | Wed Oct 9 | at Braves | W13-1 | 3-2 | .600 | Truist Park · Cumberland, GA |
| 168 | Fri Oct 11 | vs Nationals | L0-2 | 0-1 | .000 | Busch Stadium · St. Louis, MO |
| 169 | Sat Oct 12 | vs Nationals | L1-3 | 0-2 | .000 | Busch Stadium · St. Louis, MO |
| 170 | Mon Oct 14 | at Nationals | L1-8 | 0-3 | .000 | Nationals Park · Washington, D.C. |
| 171 | Tue Oct 15 | at Nationals | L4-7 | 0-4 | .000 | Nationals Park · Washington, D.C. |