| 1 | Fri Apr 1 | vs Red Sox | W9-5 | 1-0 | 1.000 | Globe Life Field · Arlington, TX |
| 2 | Sat Apr 2 | vs Red Sox | W12-5 | 2-0 | 1.000 | Globe Life Field · Arlington, TX |
| 3 | Sun Apr 3 | vs Red Sox | W5-1 | 3-0 | 1.000 | Globe Life Field · Arlington, TX |
| 4 | Mon Apr 4 | vs Mariners | W6-4 | 4-0 | 1.000 | Globe Life Field · Arlington, TX |
| 5 | Tue Apr 5 | vs Mariners | W3-2 | 5-0 | 1.000 | Globe Life Field · Arlington, TX |
| 6 | Wed Apr 6 | vs Mariners | W7-3 | 6-0 | 1.000 | Globe Life Field · Arlington, TX |
| 7 | Sat Apr 9 | at Orioles | L0-5 | 6-1 | .857 | Camden Yards · Baltimore, MD |
| 8 | Sat Apr 9 | at Orioles | W13-1 | 7-1 | .875 | Camden Yards · Baltimore, MD |
| 9 | Sun Apr 10 | at Orioles | W3-0 | 8-1 | .889 | Camden Yards · Baltimore, MD |
| 10 | Mon Apr 11 | at Tigers | W2-0 | 9-1 | .900 | Comerica Park · Detroit, MI |
| 11 | Tue Apr 12 | at Tigers | L4-5 | 9-2 | .818 | Comerica Park · Detroit, MI |
| 12 | Wed Apr 13 | at Tigers | L2-3 | 9-3 | .750 | Comerica Park · Detroit, MI |
| 13 | Fri Apr 15 | at Yankees | W5-3 | 10-3 | .769 | Yankee Stadium · The Bronx, NY |
| 14 | Sat Apr 16 | at Yankees | L2-5 | 10-4 | .714 | Yankee Stadium · The Bronx, NY |
| 15 | Sun Apr 17 | at Yankees | L5-6 | 10-5 | .667 | Yankee Stadium · The Bronx, NY |
| 16 | Mon Apr 18 | vs Angels | W7-1 | 11-5 | .688 | Globe Life Field · Arlington, TX |
| 17 | Tue Apr 19 | vs Angels | L4-15 | 11-6 | .647 | Globe Life Field · Arlington, TX |
| 18 | Wed Apr 20 | vs Angels | L1-4 | 11-7 | .611 | Globe Life Field · Arlington, TX |
| 19 | Fri Apr 22 | vs Royals | W11-6 | 12-7 | .632 | Globe Life Field · Arlington, TX |
| 20 | Sat Apr 23 | vs Royals | W3-1 | 13-7 | .650 | Globe Life Field · Arlington, TX |
| 21 | Sun Apr 24 | vs Royals | W8-7 | 14-7 | .667 | Globe Life Field · Arlington, TX |
| 22 | Mon Apr 25 | vs Blue Jays | L4-6 | 14-8 | .636 | Globe Life Field · Arlington, TX |
| 23 | Tue Apr 26 | vs Blue Jays | L3-10 | 14-9 | .609 | Globe Life Field · Arlington, TX |
| 24 | Wed Apr 27 | vs Blue Jays | W7-6 | 15-9 | .625 | Globe Life Field · Arlington, TX |
| 25 | Thu Apr 28 | vs Blue Jays | L2-5 | 15-10 | .600 | Globe Life Field · Arlington, TX |
| 26 | Fri Apr 29 | at Athletics | L1-3 | 15-11 | .577 | RingCentral Coliseum · Oakland, CA |
| 27 | Sat Apr 30 | at Athletics | W11-2 | 16-11 | .593 | RingCentral Coliseum · Oakland, CA |
| 28 | Sun May 1 | at Athletics | L2-7 | 16-12 | .571 | RingCentral Coliseum · Oakland, CA |
| 29 | Mon May 2 | at Athletics | L4-5 (10) | 16-13 | .552 | RingCentral Coliseum · Oakland, CA |
| 30 | Tue May 3 | at Mariners | L3-4 | 16-14 | .533 | T-Mobile Park · Seattle, WA |
| 31 | Wed May 4 | at Mariners | W5-2 | 17-14 | .548 | T-Mobile Park · Seattle, WA |
| 32 | Thu May 5 | at Mariners | L1-3 | 17-15 | .531 | T-Mobile Park · Seattle, WA |
| 33 | Fri May 6 | vs Yankees | L1-4 | 17-16 | .515 | Globe Life Field · Arlington, TX |
| 34 | Sat May 7 | vs Yankees | W7-5 | 18-16 | .529 | Globe Life Field · Arlington, TX |
| 35 | Sun May 8 | vs Yankees | L5-12 | 18-17 | .514 | Globe Life Field · Arlington, TX |
| 36 | Mon May 9 | vs Athletics | L2-7 | 18-18 | .500 | Globe Life Field · Arlington, TX |
| 37 | Tue May 10 | vs Athletics | W7-2 | 19-18 | .514 | Globe Life Field · Arlington, TX |
| 38 | Fri May 13 | vs Angels | W4-1 | 20-18 | .526 | Globe Life Field · Arlington, TX |
| 39 | Sat May 14 | vs Angels | L2-3 | 20-19 | .513 | Globe Life Field · Arlington, TX |
| 40 | Sun May 15 | vs Angels | W5-4 | 21-19 | .525 | Globe Life Field · Arlington, TX |
| 41 | Mon May 16 | at White Sox | W4-0 | 22-19 | .537 | Guaranteed Rate Field · Chicago, IL |
| 42 | Tue May 17 | at White Sox | L3-4 | 22-20 | .524 | Guaranteed Rate Field · Chicago, IL |
| 43 | Wed May 18 | at Royals | W5-4 (11) | 23-20 | .535 | Kauffman Stadium · Kansas City, MO |
| 44 | Thu May 19 | at Royals | L1-2 (10) | 23-21 | .523 | Kauffman Stadium · Kansas City, MO |
| 45 | Fri May 20 | at Phillies | L2-3 | 23-22 | .511 | Citizens Bank Park · Philadelphi, PA |
| 46 | Sat May 21 | at Phillies | L0-2 | 23-23 | .500 | Citizens Bank Park · Philadelphi, PA |
| 47 | Sun May 22 | at Phillies | W2-0 | 24-23 | .511 | Citizens Bank Park · Philadelphi, PA |
| 48 | Mon May 23 | vs White Sox | W4-0 | 25-23 | .521 | Globe Life Field · Arlington, TX |
| 49 | Tue May 24 | vs White Sox | L6-8 | 25-24 | .510 | Globe Life Field · Arlington, TX |
| 50 | Wed May 25 | vs White Sox | W2-1 | 26-24 | .520 | Globe Life Field · Arlington, TX |
| 51 | Fri May 27 | vs Royals | L7-12 (14) | 26-25 | .510 | Globe Life Field · Arlington, TX |
| 52 | Sat May 28 | vs Royals | W10-1 | 27-25 | .519 | Globe Life Field · Arlington, TX |
| 53 | Sun May 29 | vs Royals | W7-6 | 28-25 | .528 | Globe Life Field · Arlington, TX |
| 54 | Mon May 30 | at Rays | W11-5 | 29-25 | .537 | Tropicana Field · St. Petersburg, FL |
| 55 | Tue May 31 | at Rays | L4-5 | 29-26 | .527 | Tropicana Field · St. Petersburg, FL |
| 56 | Wed Jun 1 | at Rays | W3-0 | 30-26 | .536 | Tropicana Field · St. Petersburg, FL |
| 57 | Thu Jun 2 | at Guardians | W7-4 | 31-26 | .544 | Progressive Field · Cleveland, OH |
| 58 | Fri Jun 3 | at Guardians | W11-2 | 32-26 | .552 | Progressive Field · Cleveland, OH |
| 59 | Sat Jun 4 | at Guardians | W4-0 | 33-26 | .559 | Progressive Field · Cleveland, OH |
| 60 | Sun Jun 5 | at Guardians | W2-0 | 34-26 | .567 | Progressive Field · Cleveland, OH |
| 61 | Mon Jun 6 | vs Tigers | L7-13 | 34-27 | .557 | Globe Life Field · Arlington, TX |
| 62 | Tue Jun 7 | vs Tigers | L1-8 | 34-28 | .548 | Globe Life Field · Arlington, TX |
| 63 | Wed Jun 8 | vs Tigers | W7-3 | 35-28 | .556 | Globe Life Field · Arlington, TX |
| 64 | Thu Jun 9 | at Twins | L4-5 | 35-29 | .547 | Target Field · Minneapolis, MN |
| 65 | Fri Jun 10 | at Twins | W9-3 | 36-29 | .554 | Target Field · Minneapolis, MN |
| 66 | Sat Jun 11 | at Twins | L1-8 | 36-30 | .545 | Target Field · Minneapolis, MN |
| 67 | Sun Jun 12 | at Twins | L1-6 | 36-31 | .537 | Target Field · Minneapolis, MN |
| 68 | Tue Jun 14 | at Yankees | L4-12 | 36-32 | .529 | Yankee Stadium · The Bronx, NY |
| 69 | Wed Jun 15 | at Yankees | L4-12 | 36-33 | .522 | Yankee Stadium · The Bronx, NY |
| 70 | Thu Jun 16 | at Yankees | L2-3 (12) | 36-34 | .514 | Yankee Stadium · The Bronx, NY |
| 71 | Fri Jun 17 | at Braves | W6-2 | 37-34 | .521 | Truist Park · Cumberland, GA |
| 72 | Sat Jun 18 | at Braves | W5-4 (10) | 38-34 | .528 | Truist Park · Cumberland, GA |
| 73 | Sun Jun 19 | at Braves | L2-4 | 38-35 | .521 | Truist Park · Cumberland, GA |
| 74 | Mon Jun 20 | vs Astros | W8-3 | 39-35 | .527 | Globe Life Field · Arlington, TX |
| 75 | Tue Jun 21 | vs Astros | W5-4 (11) | 40-35 | .533 | Globe Life Field · Arlington, TX |
| 76 | Wed Jun 22 | vs Astros | L3-5 | 40-36 | .526 | Globe Life Field · Arlington, TX |
| 77 | Fri Jun 24 | vs Mets | W8-1 | 41-36 | .532 | Globe Life Field · Arlington, TX |
| 78 | Sat Jun 25 | vs Mets | L5-14 | 41-37 | .526 | Globe Life Field · Arlington, TX |
| 79 | Sun Jun 26 | vs Mets | L5-8 | 41-38 | .519 | Globe Life Field · Arlington, TX |
| 80 | Tue Jun 28 | at Astros | W7-3 | 42-38 | .525 | Minute Maid Park · Houston, TX |
| 81 | Wed Jun 29 | at Astros | W3-2 | 43-38 | .531 | Minute Maid Park · Houston, TX |
| 82 | Thu Jun 30 | at Astros | L0-7 | 43-39 | .524 | Minute Maid Park · Houston, TX |
| 83 | Fri Jul 1 | vs Marlins | W15-5 | 44-39 | .530 | Globe Life Field · Arlington, TX |
| 84 | Sat Jul 2 | vs Marlins | L5-9 | 44-40 | .524 | Globe Life Field · Arlington, TX |
| 85 | Sun Jul 3 | vs Marlins | L4-6 | 44-41 | .518 | Globe Life Field · Arlington, TX |
| 86 | Mon Jul 4 | vs Orioles | W13-4 | 45-41 | .523 | Globe Life Field · Arlington, TX |
| 87 | Tue Jul 5 | vs Orioles | W4-2 | 46-41 | .529 | Globe Life Field · Arlington, TX |
| 88 | Wed Jul 6 | vs Orioles | W13-5 | 47-41 | .534 | Globe Life Field · Arlington, TX |
| 89 | Thu Jul 7 | vs Athletics | W6-0 | 48-41 | .539 | Globe Life Field · Arlington, TX |
| 90 | Fri Jul 8 | vs Athletics | W8-5 | 49-41 | .544 | Globe Life Field · Arlington, TX |
| 91 | Sat Jul 9 | vs Athletics | W7-6 | 50-41 | .549 | Globe Life Field · Arlington, TX |
| 92 | Sun Jul 10 | vs Athletics | W2-0 | 51-41 | .554 | Globe Life Field · Arlington, TX |
| 93 | Thu Jul 14 | at Mariners | W5-0 | 52-41 | .559 | T-Mobile Park · Seattle, WA |
| 94 | Fri Jul 15 | at Mariners | W4-0 | 53-41 | .564 | T-Mobile Park · Seattle, WA |
| 95 | Sat Jul 16 | at Mariners | W5-1 | 54-41 | .568 | T-Mobile Park · Seattle, WA |
| 96 | Sun Jul 17 | at Mariners | W3-1 | 55-41 | .573 | T-Mobile Park · Seattle, WA |
| 97 | Tue Jul 19 | at Angels | W7-0 | 56-41 | .577 | Angel Stadium · Anaheim, CA |
| 98 | Wed Jul 20 | at Angels | L8-9 | 56-42 | .571 | Angel Stadium · Anaheim, CA |
| 99 | Thu Jul 21 | at Angels | L0-1 | 56-43 | .566 | Angel Stadium · Anaheim, CA |
| 100 | Fri Jul 22 | vs Blue Jays | W12-2 | 57-43 | .570 | Globe Life Field · Arlington, TX |
| 101 | Sat Jul 23 | vs Blue Jays | W5-4 | 58-43 | .574 | Globe Life Field · Arlington, TX |
| 102 | Sun Jul 24 | vs Blue Jays | L0-3 | 58-44 | .569 | Globe Life Field · Arlington, TX |
| 103 | Mon Jul 25 | vs Twins | W20-6 | 59-44 | .573 | Globe Life Field · Arlington, TX |
| 104 | Tue Jul 26 | vs Twins | L8-9 | 59-45 | .567 | Globe Life Field · Arlington, TX |
| 105 | Wed Jul 27 | vs Twins | L2-7 | 59-46 | .562 | Globe Life Field · Arlington, TX |
| 106 | Thu Jul 28 | vs Twins | W4-1 | 60-46 | .566 | Globe Life Field · Arlington, TX |
| 107 | Fri Jul 29 | at Blue Jays | L2-3 | 60-47 | .561 | Rogers Centre · Toronto, ON |
| 108 | Sat Jul 30 | at Blue Jays | W3-0 | 61-47 | .565 | Rogers Centre · Toronto, ON |
| 109 | Sun Jul 31 | at Blue Jays | L3-7 | 61-48 | .560 | Rogers Centre · Toronto, ON |
| 110 | Tue Aug 2 | at Tigers | L5-6 | 61-49 | .555 | Comerica Park · Detroit, MI |
| 111 | Wed Aug 3 | at Tigers | L4-5 | 61-50 | .550 | Comerica Park · Detroit, MI |
| 112 | Thu Aug 4 | at Tigers | W5-2 | 62-50 | .554 | Comerica Park · Detroit, MI |
| 113 | Fri Aug 5 | vs Guardians | W8-7 (11) | 63-50 | .558 | Globe Life Field · Arlington, TX |
| 114 | Sat Aug 6 | vs Guardians | L5-7 | 63-51 | .553 | Globe Life Field · Arlington, TX |
| 115 | Sun Aug 7 | vs Guardians | W5-3 | 64-51 | .557 | Globe Life Field · Arlington, TX |
| 116 | Mon Aug 8 | vs Mariners | W9-2 | 65-51 | .560 | Globe Life Field · Arlington, TX |
| 117 | Tue Aug 9 | vs Mariners | W7-6 | 66-51 | .564 | Globe Life Field · Arlington, TX |
| 118 | Wed Aug 10 | vs Mariners | L3-4 | 66-52 | .559 | Globe Life Field · Arlington, TX |
| 119 | Fri Aug 12 | at Athletics | W9-1 | 67-52 | .563 | RingCentral Coliseum · Oakland, CA |
| 120 | Sat Aug 13 | at Athletics | W7-1 | 68-52 | .567 | RingCentral Coliseum · Oakland, CA |
| 121 | Sun Aug 14 | at Athletics | W7-6 | 69-52 | .570 | RingCentral Coliseum · Oakland, CA |
| 122 | Mon Aug 15 | at Angels | W8-4 | 70-52 | .574 | Angel Stadium · Anaheim, CA |
| 123 | Tue Aug 16 | at Angels | W7-3 | 71-52 | .577 | Angel Stadium · Anaheim, CA |
| 124 | Wed Aug 17 | at Angels | W4-3 | 72-52 | .581 | Angel Stadium · Anaheim, CA |
| 125 | Thu Aug 18 | at Angels | L1-2 | 72-53 | .576 | Angel Stadium · Anaheim, CA |
| 126 | Fri Aug 19 | at White Sox | W7-4 | 73-53 | .579 | Guaranteed Rate Field · Chicago, IL |
| 127 | Sat Aug 20 | at White Sox | L2-3 | 73-54 | .575 | Guaranteed Rate Field · Chicago, IL |
| 128 | Sun Aug 21 | at White Sox | L0-10 | 73-55 | .570 | Guaranteed Rate Field · Chicago, IL |
| 129 | Mon Aug 22 | vs Red Sox | W4-0 | 74-55 | .574 | Globe Life Field · Arlington, TX |
| 130 | Tue Aug 23 | vs Red Sox | L5-11 | 74-56 | .569 | Globe Life Field · Arlington, TX |
| 131 | Wed Aug 24 | vs Red Sox | L2-13 | 74-57 | .565 | Globe Life Field · Arlington, TX |
| 132 | Thu Aug 25 | vs Red Sox | L0-6 | 74-58 | .561 | Globe Life Field · Arlington, TX |
| 133 | Fri Aug 26 | vs Angels | W11-7 | 75-58 | .564 | Globe Life Field · Arlington, TX |
| 134 | Sat Aug 27 | vs Angels | L4-8 | 75-59 | .560 | Globe Life Field · Arlington, TX |
| 135 | Sun Aug 28 | vs Angels | W9-5 | 76-59 | .563 | Globe Life Field · Arlington, TX |
| 136 | Tue Aug 30 | vs Rays | W2-0 | 77-59 | .566 | Globe Life Field · Arlington, TX |
| 137 | Wed Aug 31 | vs Rays | L1-4 | 77-60 | .562 | Globe Life Field · Arlington, TX |
| 138 | Thu Sep 1 | vs Rays | W7-2 | 78-60 | .565 | Globe Life Field · Arlington, TX |
| 139 | Fri Sep 2 | at Red Sox | W10-0 | 79-60 | .568 | Fenway Park · Boston, MA |
| 140 | Sat Sep 3 | at Red Sox | L7-12 | 79-61 | .564 | Fenway Park · Boston, MA |
| 141 | Sun Sep 4 | at Red Sox | W11-4 | 80-61 | .567 | Fenway Park · Boston, MA |
| 142 | Mon Sep 5 | at Rays | L1-5 | 80-62 | .563 | Tropicana Field · St. Petersburg, FL |
| 143 | Tue Sep 6 | at Rays | W8-0 | 81-62 | .566 | Tropicana Field · St. Petersburg, FL |
| 144 | Wed Sep 7 | at Rays | L4-5 (10) | 81-63 | .563 | Tropicana Field · St. Petersburg, FL |
| 145 | Fri Sep 9 | vs Athletics | W13-4 | 82-63 | .566 | Globe Life Field · Arlington, TX |
| 146 | Sat Sep 10 | vs Athletics | L7-8 | 82-64 | .562 | Globe Life Field · Arlington, TX |
| 147 | Sun Sep 11 | vs Athletics | W8-1 | 83-64 | .565 | Globe Life Field · Arlington, TX |
| 148 | Tue Sep 13 | vs Guardians | W10-4 | 84-64 | .568 | Globe Life Field · Arlington, TX |
| 149 | Wed Sep 14 | vs Guardians | W9-1 | 85-64 | .570 | Globe Life Field · Arlington, TX |
| 150 | Thu Sep 15 | vs Guardians | W7-4 | 86-64 | .573 | Globe Life Field · Arlington, TX |
| 151 | Fri Sep 16 | at Mariners | L0-4 | 86-65 | .570 | T-Mobile Park · Seattle, WA |
| 152 | Sat Sep 17 | at Mariners | W7-6 | 87-65 | .572 | T-Mobile Park · Seattle, WA |
| 153 | Sun Sep 18 | at Mariners | W3-0 | 88-65 | .575 | T-Mobile Park · Seattle, WA |
| 154 | Tue Sep 20 | at Athletics | W7-2 | 89-65 | .578 | RingCentral Coliseum · Oakland, CA |
| 155 | Wed Sep 21 | at Athletics | W3-2 | 90-65 | .581 | RingCentral Coliseum · Oakland, CA |
| 156 | Thu Sep 22 | at Athletics | L3-4 | 90-66 | .577 | RingCentral Coliseum · Oakland, CA |
| 157 | Fri Sep 23 | vs Mariners | W5-3 | 91-66 | .580 | Globe Life Field · Arlington, TX |
| 158 | Sat Sep 24 | vs Mariners | W7-3 | 92-66 | .582 | Globe Life Field · Arlington, TX |
| 159 | Sun Sep 25 | vs Mariners | W12-5 | 93-66 | .585 | Globe Life Field · Arlington, TX |
| 160 | Mon Sep 26 | at Angels | W4-3 | 94-66 | .588 | Angel Stadium · Anaheim, CA |
| 161 | Tue Sep 27 | at Angels | W10-3 | 95-66 | .590 | Angel Stadium · Anaheim, CA |
| 162 | Wed Sep 28 | at Angels | W3-1 | 96-66 | .593 | Angel Stadium · Anaheim, CA |
| 163 | Fri Sep 30 | vs Rays | L0-9 | 0-1 | .000 | Globe Life Field · Arlington, TX |
| 164 | Sat Oct 1 | vs Rays | W8-6 | 1-1 | .500 | Globe Life Field · Arlington, TX |
| 165 | Mon Oct 3 | at Rays | W4-3 | 2-1 | .667 | Tropicana Field · St. Petersburg, FL |
| 166 | Tue Oct 4 | at Rays | W4-3 | 3-1 | .750 | Tropicana Field · St. Petersburg, FL |
| 167 | Sat Oct 8 | vs Tigers | W3-2 | 1-0 | 1.000 | Globe Life Field · Arlington, TX |
| 168 | Mon Oct 10 | vs Tigers | W7-3 (11) | 2-0 | 1.000 | Globe Life Field · Arlington, TX |
| 169 | Tue Oct 11 | at Tigers | L2-5 | 2-1 | .667 | Comerica Park · Detroit, MI |
| 170 | Wed Oct 12 | at Tigers | W7-3 (11) | 3-1 | .750 | Comerica Park · Detroit, MI |
| 171 | Thu Oct 13 | at Tigers | L5-7 | 3-2 | .600 | Comerica Park · Detroit, MI |
| 172 | Sat Oct 15 | vs Tigers | W15-5 | 4-2 | .667 | Globe Life Field · Arlington, TX |
| 173 | Wed Oct 19 | at Cardinals | L2-3 | 0-1 | .000 | Busch Stadium · St. Louis, MO |
| 174 | Thu Oct 20 | at Cardinals | W2-1 | 1-1 | .500 | Busch Stadium · St. Louis, MO |
| 175 | Sat Oct 22 | vs Cardinals | L7-16 | 1-2 | .333 | Globe Life Field · Arlington, TX |
| 176 | Sun Oct 23 | vs Cardinals | W4-0 | 2-2 | .500 | Globe Life Field · Arlington, TX |
| 177 | Mon Oct 24 | vs Cardinals | W4-2 | 3-2 | .600 | Globe Life Field · Arlington, TX |
| 178 | Thu Oct 27 | at Cardinals | L9-10 (11) | 3-3 | .500 | Busch Stadium · St. Louis, MO |
| 179 | Fri Oct 28 | at Cardinals | L2-6 | 3-4 | .429 | Busch Stadium · St. Louis, MO |