| 1 | Mon Apr 3 | vs Guardians | L5-8 | 0-1 | .000 | Globe Life Field · Arlington, TX |
| 2 | Tue Apr 4 | vs Guardians | L3-4 | 0-2 | .000 | Globe Life Field · Arlington, TX |
| 3 | Wed Apr 5 | vs Guardians | L6-9 | 0-3 | .000 | Globe Life Field · Arlington, TX |
| 4 | Fri Apr 7 | vs Athletics | W10-5 | 1-3 | .250 | Globe Life Field · Arlington, TX |
| 5 | Sat Apr 8 | vs Athletics | L1-6 | 1-4 | .200 | Globe Life Field · Arlington, TX |
| 6 | Sun Apr 9 | vs Athletics | W8-1 | 2-4 | .333 | Globe Life Field · Arlington, TX |
| 7 | Tue Apr 11 | at Angels | L5-6 (10) | 2-5 | .286 | Angel Stadium · Anaheim, CA |
| 8 | Wed Apr 12 | at Angels | W8-3 | 3-5 | .375 | Angel Stadium · Anaheim, CA |
| 9 | Thu Apr 13 | at Angels | W8-3 | 4-5 | .444 | Angel Stadium · Anaheim, CA |
| 10 | Fri Apr 14 | at Mariners | L1-2 | 4-6 | .400 | T-Mobile Park · Seattle, WA |
| 11 | Sat Apr 15 | at Mariners | L0-5 | 4-7 | .364 | T-Mobile Park · Seattle, WA |
| 12 | Sun Apr 16 | at Mariners | L7-8 | 4-8 | .333 | T-Mobile Park · Seattle, WA |
| 13 | Mon Apr 17 | at Athletics | W7-0 | 5-8 | .385 | RingCentral Coliseum · Oakland, CA |
| 14 | Tue Apr 18 | at Athletics | L2-4 | 5-9 | .357 | RingCentral Coliseum · Oakland, CA |
| 15 | Wed Apr 19 | at Athletics | L1-9 | 5-10 | .333 | RingCentral Coliseum · Oakland, CA |
| 16 | Thu Apr 20 | vs Royals | W1-0 (13) | 6-10 | .375 | Globe Life Field · Arlington, TX |
| 17 | Fri Apr 21 | vs Royals | W6-2 | 7-10 | .412 | Globe Life Field · Arlington, TX |
| 18 | Sat Apr 22 | vs Royals | W2-1 | 8-10 | .444 | Globe Life Field · Arlington, TX |
| 19 | Sun Apr 23 | vs Royals | W5-2 | 9-10 | .474 | Globe Life Field · Arlington, TX |
| 20 | Mon Apr 24 | vs Twins | L2-3 | 9-11 | .450 | Globe Life Field · Arlington, TX |
| 21 | Tue Apr 25 | vs Twins | L1-8 | 9-12 | .429 | Globe Life Field · Arlington, TX |
| 22 | Wed Apr 26 | vs Twins | W14-3 | 10-12 | .455 | Globe Life Field · Arlington, TX |
| 23 | Fri Apr 28 | vs Angels | L3-6 | 10-13 | .435 | Globe Life Field · Arlington, TX |
| 24 | Sat Apr 29 | vs Angels | W6-3 | 11-13 | .458 | Globe Life Field · Arlington, TX |
| 25 | Sun Apr 30 | vs Angels | L2-5 | 11-14 | .440 | Globe Life Field · Arlington, TX |
| 26 | Mon May 1 | at Astros | L2-6 | 11-15 | .423 | Minute Maid Park · Houston, TX |
| 27 | Tue May 2 | at Astros | L7-8 | 11-16 | .407 | Minute Maid Park · Houston, TX |
| 28 | Wed May 3 | at Astros | L1-10 | 11-17 | .393 | Minute Maid Park · Houston, TX |
| 29 | Thu May 4 | at Astros | W10-4 | 12-17 | .414 | Minute Maid Park · Houston, TX |
| 30 | Fri May 5 | at Mariners | W3-1 (13) | 13-17 | .433 | T-Mobile Park · Seattle, WA |
| 31 | Sat May 6 | at Mariners | L2-8 | 13-18 | .419 | T-Mobile Park · Seattle, WA |
| 32 | Sun May 7 | at Mariners | L3-4 | 13-19 | .406 | T-Mobile Park · Seattle, WA |
| 33 | Mon May 8 | at Padres | L1-5 | 13-20 | .394 | Petco Park · San Diego, CA |
| 34 | Tue May 9 | at Padres | W11-0 | 14-20 | .412 | Petco Park · San Diego, CA |
| 35 | Wed May 10 | vs Padres | W4-3 | 15-20 | .429 | Globe Life Field · Arlington, TX |
| 36 | Thu May 11 | vs Padres | W5-2 | 16-20 | .444 | Globe Life Field · Arlington, TX |
| 37 | Fri May 12 | vs Athletics | W5-2 | 17-20 | .459 | Globe Life Field · Arlington, TX |
| 38 | Sat May 13 | vs Athletics | W6-5 | 18-20 | .474 | Globe Life Field · Arlington, TX |
| 39 | Sun May 14 | vs Athletics | W6-4 | 19-20 | .487 | Globe Life Field · Arlington, TX |
| 40 | Tue May 16 | vs Phillies | W5-1 | 20-20 | .500 | Globe Life Field · Arlington, TX |
| 41 | Wed May 17 | vs Phillies | W9-3 | 21-20 | .512 | Globe Life Field · Arlington, TX |
| 42 | Thu May 18 | vs Phillies | W8-4 | 22-20 | .524 | Globe Life Field · Arlington, TX |
| 43 | Fri May 19 | at Tigers | W5-3 | 23-20 | .535 | Comerica Park · Detroit, MI |
| 44 | Sat May 20 | at Tigers | L3-9 | 23-21 | .523 | Comerica Park · Detroit, MI |
| 45 | Sun May 21 | at Tigers | W5-2 | 24-21 | .533 | Comerica Park · Detroit, MI |
| 46 | Tue May 23 | at Red Sox | L6-11 | 24-22 | .522 | Fenway Park · Boston, MA |
| 47 | Wed May 24 | at Red Sox | L4-9 | 24-23 | .511 | Fenway Park · Boston, MA |
| 48 | Thu May 25 | at Red Sox | L2-6 | 24-24 | .500 | Fenway Park · Boston, MA |
| 49 | Fri May 26 | at Blue Jays | L6-7 | 24-25 | .490 | Rogers Centre · Toronto, ON |
| 50 | Sat May 27 | at Blue Jays | L1-3 | 24-26 | .480 | Rogers Centre · Toronto, ON |
| 51 | Sun May 28 | at Blue Jays | W3-1 | 25-26 | .490 | Rogers Centre · Toronto, ON |
| 52 | Mon May 29 | vs Rays | L8-10 | 25-27 | .481 | Globe Life Field · Arlington, TX |
| 53 | Tue May 30 | vs Rays | W9-5 | 26-27 | .491 | Globe Life Field · Arlington, TX |
| 54 | Wed May 31 | vs Rays | L5-7 (10) | 26-28 | .481 | Globe Life Field · Arlington, TX |
| 55 | Fri Jun 2 | vs Astros | L1-7 | 26-29 | .473 | Globe Life Field · Arlington, TX |
| 56 | Sat Jun 3 | vs Astros | L5-6 | 26-30 | .464 | Globe Life Field · Arlington, TX |
| 57 | Sun Jun 4 | vs Astros | L2-7 | 26-31 | .456 | Globe Life Field · Arlington, TX |
| 58 | Tue Jun 6 | vs Mets | W10-8 | 27-31 | .466 | Globe Life Field · Arlington, TX |
| 59 | Wed Jun 7 | vs Mets | L3-4 | 27-32 | .458 | Globe Life Field · Arlington, TX |
| 60 | Fri Jun 9 | at Nationals | W5-2 | 28-32 | .467 | Nationals Park · Washington, D.C. |
| 61 | Sat Jun 10 | at Nationals | W6-3 (11) | 29-32 | .475 | Nationals Park · Washington, D.C. |
| 62 | Sun Jun 11 | at Nationals | W5-1 | 30-32 | .484 | Nationals Park · Washington, D.C. |
| 63 | Mon Jun 12 | at Astros | W6-1 | 31-32 | .492 | Minute Maid Park · Houston, TX |
| 64 | Tue Jun 13 | at Astros | W4-2 | 32-32 | .500 | Minute Maid Park · Houston, TX |
| 65 | Wed Jun 14 | at Astros | L2-13 | 32-33 | .492 | Minute Maid Park · Houston, TX |
| 66 | Fri Jun 16 | vs Mariners | W10-4 | 33-33 | .500 | Globe Life Field · Arlington, TX |
| 67 | Sat Jun 17 | vs Mariners | W10-4 | 34-33 | .507 | Globe Life Field · Arlington, TX |
| 68 | Sun Jun 18 | vs Mariners | L3-7 | 34-34 | .500 | Globe Life Field · Arlington, TX |
| 69 | Mon Jun 19 | vs Blue Jays | L6-7 | 34-35 | .493 | Globe Life Field · Arlington, TX |
| 70 | Tue Jun 20 | vs Blue Jays | W6-1 | 35-35 | .500 | Globe Life Field · Arlington, TX |
| 71 | Wed Jun 21 | vs Blue Jays | L5-7 | 35-36 | .493 | Globe Life Field · Arlington, TX |
| 72 | Thu Jun 22 | vs Blue Jays | W11-4 | 36-36 | .500 | Globe Life Field · Arlington, TX |
| 73 | Fri Jun 23 | at Yankees | L1-2 (10) | 36-37 | .493 | Yankee Stadium · The Bronx, NY |
| 74 | Sat Jun 24 | at Yankees | W8-1 | 37-37 | .500 | Yankee Stadium · The Bronx, NY |
| 75 | Sun Jun 25 | at Yankees | W7-6 | 38-37 | .507 | Yankee Stadium · The Bronx, NY |
| 76 | Mon Jun 26 | at Guardians | L9-15 | 38-38 | .500 | Progressive Field · Cleveland, OH |
| 77 | Tue Jun 27 | at Guardians | W2-1 | 39-38 | .506 | Progressive Field · Cleveland, OH |
| 78 | Wed Jun 28 | at Guardians | L3-5 | 39-39 | .500 | Progressive Field · Cleveland, OH |
| 79 | Thu Jun 29 | at Guardians | L1-5 | 39-40 | .494 | Progressive Field · Cleveland, OH |
| 80 | Fri Jun 30 | at White Sox | L7-8 | 39-41 | .487 | Guaranteed Rate Field · Chicago, IL |
| 81 | Sat Jul 1 | at White Sox | W10-4 | 40-41 | .494 | Guaranteed Rate Field · Chicago, IL |
| 82 | Sun Jul 2 | at White Sox | L5-6 | 40-42 | .488 | Guaranteed Rate Field · Chicago, IL |
| 83 | Mon Jul 3 | vs Red Sox | L5-7 (11) | 40-43 | .482 | Globe Life Field · Arlington, TX |
| 84 | Tue Jul 4 | vs Red Sox | L4-11 | 40-44 | .476 | Globe Life Field · Arlington, TX |
| 85 | Wed Jul 5 | vs Red Sox | W8-2 | 41-44 | .482 | Globe Life Field · Arlington, TX |
| 86 | Fri Jul 7 | vs Angels | W10-0 | 42-44 | .488 | Globe Life Field · Arlington, TX |
| 87 | Sat Jul 8 | vs Angels | W5-2 | 43-44 | .494 | Globe Life Field · Arlington, TX |
| 88 | Sun Jul 9 | vs Angels | L0-3 | 43-45 | .489 | Globe Life Field · Arlington, TX |
| 89 | Fri Jul 14 | at Royals | W5-3 | 44-45 | .494 | Kauffman Stadium · Kansas City, MO |
| 90 | Sat Jul 15 | at Royals | W1-0 | 45-45 | .500 | Kauffman Stadium · Kansas City, MO |
| 91 | Sun Jul 16 | at Royals | L3-4 | 45-46 | .495 | Kauffman Stadium · Kansas City, MO |
| 92 | Mon Jul 17 | at Orioles | L1-3 | 45-47 | .489 | Camden Yards · Baltimore, MD |
| 93 | Tue Jul 18 | at Orioles | L1-12 | 45-48 | .484 | Camden Yards · Baltimore, MD |
| 94 | Wed Jul 19 | at Orioles | L2-10 | 45-49 | .479 | Camden Yards · Baltimore, MD |
| 95 | Thu Jul 20 | at Orioles | L7-9 | 45-50 | .474 | Camden Yards · Baltimore, MD |
| 96 | Fri Jul 21 | at Rays | W4-3 (10) | 46-50 | .479 | Tropicana Field · St. Petersburg, FL |
| 97 | Sat Jul 22 | at Rays | W4-3 | 47-50 | .485 | Tropicana Field · St. Petersburg, FL |
| 98 | Sun Jul 23 | at Rays | W6-5 | 48-50 | .490 | Tropicana Field · St. Petersburg, FL |
| 99 | Mon Jul 24 | vs Marlins | L0-4 | 48-51 | .485 | Globe Life Field · Arlington, TX |
| 100 | Tue Jul 25 | vs Marlins | W10-4 | 49-51 | .490 | Globe Life Field · Arlington, TX |
| 101 | Wed Jul 26 | vs Marlins | L10-22 | 49-52 | .485 | Globe Life Field · Arlington, TX |
| 102 | Fri Jul 28 | vs Orioles | W8-2 | 50-52 | .490 | Globe Life Field · Arlington, TX |
| 103 | Sat Jul 29 | vs Orioles | L0-4 | 50-53 | .485 | Globe Life Field · Arlington, TX |
| 104 | Sun Jul 30 | vs Orioles | L6-10 | 50-54 | .481 | Globe Life Field · Arlington, TX |
| 105 | Mon Jul 31 | vs Mariners | L4-6 | 50-55 | .476 | Globe Life Field · Arlington, TX |
| 106 | Tue Aug 1 | vs Mariners | L7-8 | 50-56 | .472 | Globe Life Field · Arlington, TX |
| 107 | Wed Aug 2 | vs Mariners | W5-1 | 51-56 | .477 | Globe Life Field · Arlington, TX |
| 108 | Thu Aug 3 | at Twins | W4-1 | 52-56 | .481 | Target Field · Minneapolis, MN |
| 109 | Fri Aug 4 | at Twins | L4-8 | 52-57 | .477 | Target Field · Minneapolis, MN |
| 110 | Sat Aug 5 | at Twins | W4-1 | 53-57 | .482 | Target Field · Minneapolis, MN |
| 111 | Sun Aug 6 | at Twins | L5-6 | 53-58 | .477 | Target Field · Minneapolis, MN |
| 112 | Tue Aug 8 | at Mets | L4-5 | 53-59 | .473 | Citi Field · Queens, NY |
| 113 | Wed Aug 9 | at Mets | W5-1 | 54-59 | .478 | Citi Field · Queens, NY |
| 114 | Fri Aug 11 | vs Astros | W6-4 | 55-59 | .482 | Globe Life Field · Arlington, TX |
| 115 | Sat Aug 12 | vs Astros | W8-3 | 56-59 | .487 | Globe Life Field · Arlington, TX |
| 116 | Sun Aug 13 | vs Astros | L1-2 | 56-60 | .483 | Globe Life Field · Arlington, TX |
| 117 | Mon Aug 14 | vs Tigers | W6-2 | 57-60 | .487 | Globe Life Field · Arlington, TX |
| 118 | Tue Aug 15 | vs Tigers | W10-4 | 58-60 | .492 | Globe Life Field · Arlington, TX |
| 119 | Wed Aug 16 | vs Tigers | W12-6 | 59-60 | .496 | Globe Life Field · Arlington, TX |
| 120 | Thu Aug 17 | vs White Sox | W9-8 | 60-60 | .500 | Globe Life Field · Arlington, TX |
| 121 | Fri Aug 18 | vs White Sox | L3-4 | 60-61 | .496 | Globe Life Field · Arlington, TX |
| 122 | Sat Aug 19 | vs White Sox | W17-7 | 61-61 | .500 | Globe Life Field · Arlington, TX |
| 123 | Sun Aug 20 | vs White Sox | L2-3 | 61-62 | .496 | Globe Life Field · Arlington, TX |
| 124 | Mon Aug 21 | at Angels | W5-3 | 62-62 | .500 | Angel Stadium · Anaheim, CA |
| 125 | Tue Aug 22 | at Angels | L1-10 | 62-63 | .496 | Angel Stadium · Anaheim, CA |
| 126 | Wed Aug 23 | at Angels | W7-5 (10) | 63-63 | .500 | Angel Stadium · Anaheim, CA |
| 127 | Thu Aug 24 | at Angels | W3-0 | 64-63 | .504 | Angel Stadium · Anaheim, CA |
| 128 | Fri Aug 25 | at Athletics | L1-3 | 64-64 | .500 | RingCentral Coliseum · Oakland, CA |
| 129 | Sat Aug 26 | at Athletics | L3-8 | 64-65 | .496 | RingCentral Coliseum · Oakland, CA |
| 130 | Sun Aug 27 | at Athletics | L3-8 | 64-66 | .492 | RingCentral Coliseum · Oakland, CA |
| 131 | Tue Aug 29 | at Astros | W12-2 | 65-66 | .496 | Tropicana Field · St. Petersburg, FL |
| 132 | Wed Aug 30 | at Astros | W8-1 | 66-66 | .500 | Tropicana Field · St. Petersburg, FL |
| 133 | Thu Aug 31 | at Astros | L1-5 | 66-67 | .496 | Tropicana Field · St. Petersburg, FL |
| 134 | Fri Sep 1 | vs Angels | W10-9 | 67-67 | .500 | Globe Life Field · Arlington, TX |
| 135 | Sat Sep 2 | vs Angels | L4-7 (10) | 67-68 | .496 | Globe Life Field · Arlington, TX |
| 136 | Sun Sep 3 | vs Angels | W7-6 | 68-68 | .500 | Globe Life Field · Arlington, TX |
| 137 | Mon Sep 4 | at Braves | W8-2 | 69-68 | .504 | Truist Park · Cumberland, GA |
| 138 | Wed Sep 6 | at Braves | W12-8 | 70-68 | .507 | Truist Park · Cumberland, GA |
| 139 | Wed Sep 6 | at Braves | L4-5 | 70-69 | .504 | Truist Park · Cumberland, GA |
| 140 | Fri Sep 8 | vs Yankees | W11-5 | 71-69 | .507 | Globe Life Field · Arlington, TX |
| 141 | Sat Sep 9 | vs Yankees | L1-3 | 71-70 | .504 | Globe Life Field · Arlington, TX |
| 142 | Sun Sep 10 | vs Yankees | L7-16 | 71-71 | .500 | Globe Life Field · Arlington, TX |
| 143 | Mon Sep 11 | vs Mariners | W5-3 | 72-71 | .503 | Globe Life Field · Arlington, TX |
| 144 | Tue Sep 12 | vs Mariners | L3-10 | 72-72 | .500 | Globe Life Field · Arlington, TX |
| 145 | Wed Sep 13 | vs Mariners | L1-8 | 72-73 | .497 | Globe Life Field · Arlington, TX |
| 146 | Thu Sep 14 | vs Mariners | L4-10 | 72-74 | .493 | Globe Life Field · Arlington, TX |
| 147 | Fri Sep 15 | at Angels | L6-7 | 72-75 | .490 | Angel Stadium · Anaheim, CA |
| 148 | Sat Sep 16 | at Angels | L0-2 | 72-76 | .486 | Angel Stadium · Anaheim, CA |
| 149 | Sun Sep 17 | at Angels | W4-2 | 73-76 | .490 | Angel Stadium · Anaheim, CA |
| 150 | Tue Sep 19 | at Mariners | W3-1 | 74-76 | .493 | T-Mobile Park · Seattle, WA |
| 151 | Wed Sep 20 | at Mariners | W8-6 | 75-76 | .497 | T-Mobile Park · Seattle, WA |
| 152 | Thu Sep 21 | at Mariners | W4-2 | 76-76 | .500 | T-Mobile Park · Seattle, WA |
| 153 | Fri Sep 22 | at Athletics | L1-4 | 76-77 | .497 | RingCentral Coliseum · Oakland, CA |
| 154 | Sat Sep 23 | at Athletics | L0-1 | 76-78 | .494 | RingCentral Coliseum · Oakland, CA |
| 155 | Sun Sep 24 | at Athletics | L1-8 | 76-79 | .490 | RingCentral Coliseum · Oakland, CA |
| 156 | Mon Sep 25 | vs Astros | L2-11 | 76-80 | .487 | Globe Life Field · Arlington, TX |
| 157 | Tue Sep 26 | vs Astros | L3-14 | 76-81 | .484 | Globe Life Field · Arlington, TX |
| 158 | Wed Sep 27 | vs Astros | L2-12 | 76-82 | .481 | Globe Life Field · Arlington, TX |
| 159 | Thu Sep 28 | vs Athletics | L1-4 | 76-83 | .478 | Globe Life Field · Arlington, TX |
| 160 | Fri Sep 29 | vs Athletics | W5-3 | 77-83 | .481 | Globe Life Field · Arlington, TX |
| 161 | Sat Sep 30 | vs Athletics | W8-4 | 78-83 | .484 | Globe Life Field · Arlington, TX |
| 162 | Sun Oct 1 | vs Athletics | L2-5 | 78-84 | .481 | Globe Life Field · Arlington, TX |