| 1 | Fri Apr 6 | vs White Sox | W3-2 | 1-0 | 1.000 | Globe Life Field · Arlington, TX |
| 2 | Sat Apr 7 | vs White Sox | L3-4 | 1-1 | .500 | Globe Life Field · Arlington, TX |
| 3 | Sun Apr 8 | vs White Sox | W5-0 | 2-1 | .667 | Globe Life Field · Arlington, TX |
| 4 | Mon Apr 9 | vs Mariners | W11-5 | 3-1 | .750 | Globe Life Field · Arlington, TX |
| 5 | Tue Apr 10 | vs Mariners | W1-0 | 4-1 | .800 | Globe Life Field · Arlington, TX |
| 6 | Wed Apr 11 | vs Mariners | L3-4 | 4-2 | .667 | Globe Life Field · Arlington, TX |
| 7 | Thu Apr 12 | vs Mariners | W5-3 | 5-2 | .714 | Globe Life Field · Arlington, TX |
| 8 | Fri Apr 13 | at Twins | W4-1 | 6-2 | .750 | Target Field · Minneapolis, MN |
| 9 | Sat Apr 14 | at Twins | W6-2 | 7-2 | .778 | Target Field · Minneapolis, MN |
| 10 | Sun Apr 15 | at Twins | W4-3 | 8-2 | .800 | Target Field · Minneapolis, MN |
| 11 | Tue Apr 17 | at Red Sox | W18-3 | 9-2 | .818 | Fenway Park · Boston, MA |
| 12 | Wed Apr 18 | at Red Sox | W6-3 | 10-2 | .833 | Fenway Park · Boston, MA |
| 13 | Thu Apr 19 | at Tigers | W10-3 | 11-2 | .846 | Comerica Park · Detroit, MI |
| 14 | Sat Apr 21 | at Tigers | W10-4 | 12-2 | .857 | Comerica Park · Detroit, MI |
| 15 | Sat Apr 21 | at Tigers | L2-3 | 12-3 | .800 | Comerica Park · Detroit, MI |
| 16 | Sun Apr 22 | at Tigers | W3-2 (11) | 13-3 | .813 | Comerica Park · Detroit, MI |
| 17 | Mon Apr 23 | vs Yankees | L4-7 | 13-4 | .765 | Globe Life Field · Arlington, TX |
| 18 | Tue Apr 24 | vs Yankees | W2-0 | 14-4 | .778 | Globe Life Field · Arlington, TX |
| 19 | Wed Apr 25 | vs Yankees | W7-3 | 15-4 | .789 | Globe Life Field · Arlington, TX |
| 20 | Fri Apr 27 | vs Rays | L4-8 | 15-5 | .750 | Globe Life Field · Arlington, TX |
| 21 | Sat Apr 28 | vs Rays | W7-2 | 16-5 | .762 | Globe Life Field · Arlington, TX |
| 22 | Sun Apr 29 | vs Rays | L2-5 | 16-6 | .727 | Globe Life Field · Arlington, TX |
| 23 | Mon Apr 30 | at Blue Jays | W4-1 | 17-6 | .739 | Rogers Centre · Toronto, ON |
| 24 | Tue May 1 | at Blue Jays | L7-8 | 17-7 | .708 | Rogers Centre · Toronto, ON |
| 25 | Wed May 2 | at Blue Jays | L5-11 | 17-8 | .680 | Rogers Centre · Toronto, ON |
| 26 | Fri May 4 | at Guardians | L3-6 | 17-9 | .654 | Progressive Field · Cleveland, OH |
| 27 | Sat May 5 | at Guardians | W5-2 (11) | 18-9 | .667 | Progressive Field · Cleveland, OH |
| 28 | Sun May 6 | at Guardians | L2-4 | 18-10 | .643 | Progressive Field · Cleveland, OH |
| 29 | Mon May 7 | at Orioles | W14-3 | 19-10 | .655 | Camden Yards · Baltimore, MD |
| 30 | Tue May 8 | at Orioles | W10-3 | 20-10 | .667 | Camden Yards · Baltimore, MD |
| 31 | Thu May 10 | at Orioles | L5-6 | 20-11 | .645 | Camden Yards · Baltimore, MD |
| 32 | Thu May 10 | at Orioles | W7-3 | 21-11 | .656 | Camden Yards · Baltimore, MD |
| 33 | Fri May 11 | vs Angels | W10-3 | 22-11 | .667 | Globe Life Field · Arlington, TX |
| 34 | Sat May 12 | vs Angels | L2-4 | 22-12 | .647 | Globe Life Field · Arlington, TX |
| 35 | Sun May 13 | vs Angels | W13-6 | 23-12 | .657 | Globe Life Field · Arlington, TX |
| 36 | Mon May 14 | vs Royals | L1-3 | 23-13 | .639 | Globe Life Field · Arlington, TX |
| 37 | Tue May 15 | vs Royals | L4-7 | 23-14 | .622 | Globe Life Field · Arlington, TX |
| 38 | Wed May 16 | vs Athletics | W4-1 | 24-14 | .632 | Globe Life Field · Arlington, TX |
| 39 | Thu May 17 | vs Athletics | L4-5 (10) | 24-15 | .615 | Globe Life Field · Arlington, TX |
| 40 | Fri May 18 | at Astros | W4-1 | 25-15 | .625 | Minute Maid Park · Houston, TX |
| 41 | Sat May 19 | at Astros | L5-6 | 25-16 | .610 | Minute Maid Park · Houston, TX |
| 42 | Sun May 20 | at Astros | W6-1 | 26-16 | .619 | Minute Maid Park · Houston, TX |
| 43 | Mon May 21 | at Mariners | L1-6 | 26-17 | .605 | T-Mobile Park · Seattle, WA |
| 44 | Tue May 22 | at Mariners | W3-1 | 27-17 | .614 | T-Mobile Park · Seattle, WA |
| 45 | Wed May 23 | at Mariners | L3-5 | 27-18 | .600 | T-Mobile Park · Seattle, WA |
| 46 | Fri May 25 | vs Blue Jays | W14-3 | 28-18 | .609 | Globe Life Field · Arlington, TX |
| 47 | Sat May 26 | vs Blue Jays | W8-7 (13) | 29-18 | .617 | Globe Life Field · Arlington, TX |
| 48 | Sun May 27 | vs Blue Jays | W12-6 | 30-18 | .625 | Globe Life Field · Arlington, TX |
| 49 | Mon May 28 | vs Mariners | W4-2 | 31-18 | .633 | Globe Life Field · Arlington, TX |
| 50 | Tue May 29 | vs Mariners | L3-10 | 31-19 | .620 | Globe Life Field · Arlington, TX |
| 51 | Wed May 30 | vs Mariners | L8-21 | 31-20 | .608 | Globe Life Field · Arlington, TX |
| 52 | Fri Jun 1 | at Angels | L2-4 | 31-21 | .596 | Angel Stadium · Anaheim, CA |
| 53 | Sat Jun 2 | at Angels | L2-3 | 31-22 | .585 | Angel Stadium · Anaheim, CA |
| 54 | Sun Jun 3 | at Angels | W7-3 | 32-22 | .593 | Angel Stadium · Anaheim, CA |
| 55 | Mon Jun 4 | at Athletics | L1-12 | 32-23 | .582 | RingCentral Coliseum · Oakland, CA |
| 56 | Tue Jun 5 | at Athletics | W6-3 | 33-23 | .589 | RingCentral Coliseum · Oakland, CA |
| 57 | Wed Jun 6 | at Athletics | L0-2 | 33-24 | .579 | RingCentral Coliseum · Oakland, CA |
| 58 | Thu Jun 7 | at Athletics | L1-7 | 33-25 | .569 | RingCentral Coliseum · Oakland, CA |
| 59 | Fri Jun 8 | at Giants | W5-0 | 34-25 | .576 | Oracle Park · San Francisco, CA |
| 60 | Sat Jun 9 | at Giants | L2-5 | 34-26 | .567 | Oracle Park · San Francisco, CA |
| 61 | Sun Jun 10 | at Giants | W5-0 | 35-26 | .574 | Oracle Park · San Francisco, CA |
| 62 | Tue Jun 12 | vs D-backs | W9-1 | 36-26 | .581 | Globe Life Field · Arlington, TX |
| 63 | Wed Jun 13 | vs D-backs | W1-0 | 37-26 | .587 | Globe Life Field · Arlington, TX |
| 64 | Thu Jun 14 | vs D-backs | L3-11 | 37-27 | .578 | Globe Life Field · Arlington, TX |
| 65 | Fri Jun 15 | vs Astros | W6-2 | 38-27 | .585 | Globe Life Field · Arlington, TX |
| 66 | Sat Jun 16 | vs Astros | W8-3 | 39-27 | .591 | Globe Life Field · Arlington, TX |
| 67 | Sun Jun 17 | vs Astros | W9-3 | 40-27 | .597 | Globe Life Field · Arlington, TX |
| 68 | Mon Jun 18 | at Padres | W2-1 | 41-27 | .603 | Petco Park · San Diego, CA |
| 69 | Tue Jun 19 | at Padres | W7-3 | 42-27 | .609 | Petco Park · San Diego, CA |
| 70 | Wed Jun 20 | at Padres | W4-2 | 43-27 | .614 | Petco Park · San Diego, CA |
| 71 | Fri Jun 22 | vs Rockies | W4-1 | 44-27 | .620 | Globe Life Field · Arlington, TX |
| 72 | Sat Jun 23 | vs Rockies | L7-11 | 44-28 | .611 | Globe Life Field · Arlington, TX |
| 73 | Sun Jun 24 | vs Rockies | W4-2 | 45-28 | .616 | Globe Life Field · Arlington, TX |
| 74 | Mon Jun 25 | vs Tigers | L2-8 | 45-29 | .608 | Globe Life Field · Arlington, TX |
| 75 | Tue Jun 26 | vs Tigers | W7-5 | 46-29 | .613 | Globe Life Field · Arlington, TX |
| 76 | Wed Jun 27 | vs Tigers | W13-9 | 47-29 | .618 | Globe Life Field · Arlington, TX |
| 77 | Thu Jun 28 | vs Athletics | W7-6 | 48-29 | .623 | Globe Life Field · Arlington, TX |
| 78 | Fri Jun 29 | vs Athletics | W4-3 | 49-29 | .628 | Globe Life Field · Arlington, TX |
| 79 | Sat Jun 30 | vs Athletics | W7-2 | 50-29 | .633 | Globe Life Field · Arlington, TX |
| 80 | Sun Jul 1 | vs Athletics | L1-3 | 50-30 | .625 | Globe Life Field · Arlington, TX |
| 81 | Tue Jul 3 | at White Sox | L2-19 | 50-31 | .617 | Guaranteed Rate Field · Chicago, IL |
| 82 | Wed Jul 4 | at White Sox | L4-5 (10) | 50-32 | .610 | Guaranteed Rate Field · Chicago, IL |
| 83 | Thu Jul 5 | at White Sox | L1-2 | 50-33 | .602 | Guaranteed Rate Field · Chicago, IL |
| 84 | Fri Jul 6 | vs Twins | L1-5 | 50-34 | .595 | Globe Life Field · Arlington, TX |
| 85 | Sat Jul 7 | vs Twins | W4-3 (10) | 51-34 | .600 | Globe Life Field · Arlington, TX |
| 86 | Sun Jul 8 | vs Twins | W4-3 (13) | 52-34 | .605 | Globe Life Field · Arlington, TX |
| 87 | Fri Jul 13 | at Mariners | W3-2 | 53-34 | .609 | T-Mobile Park · Seattle, WA |
| 88 | Sat Jul 14 | at Mariners | L0-7 | 53-35 | .602 | T-Mobile Park · Seattle, WA |
| 89 | Sun Jul 15 | at Mariners | W4-0 | 54-35 | .607 | T-Mobile Park · Seattle, WA |
| 90 | Tue Jul 17 | at Athletics | W6-1 | 55-35 | .611 | RingCentral Coliseum · Oakland, CA |
| 91 | Wed Jul 18 | at Athletics | L3-4 | 55-36 | .604 | RingCentral Coliseum · Oakland, CA |
| 92 | Fri Jul 20 | at Angels | L1-6 | 55-37 | .598 | Angel Stadium · Anaheim, CA |
| 93 | Sat Jul 21 | at Angels | W9-2 | 56-37 | .602 | Angel Stadium · Anaheim, CA |
| 94 | Sun Jul 22 | at Angels | L4-7 | 56-38 | .596 | Angel Stadium · Anaheim, CA |
| 95 | Mon Jul 23 | vs Red Sox | W9-1 | 57-38 | .600 | Globe Life Field · Arlington, TX |
| 96 | Tue Jul 24 | vs Red Sox | L1-2 | 57-39 | .594 | Globe Life Field · Arlington, TX |
| 97 | Wed Jul 25 | vs Red Sox | W5-3 | 58-39 | .598 | Globe Life Field · Arlington, TX |
| 98 | Fri Jul 27 | vs White Sox | L5-9 | 58-40 | .592 | Globe Life Field · Arlington, TX |
| 99 | Sat Jul 28 | vs White Sox | L2-5 | 58-41 | .586 | Globe Life Field · Arlington, TX |
| 100 | Sun Jul 29 | vs White Sox | W2-0 | 59-41 | .590 | Globe Life Field · Arlington, TX |
| 101 | Mon Jul 30 | vs Angels | L8-15 | 59-42 | .584 | Globe Life Field · Arlington, TX |
| 102 | Tue Jul 31 | vs Angels | L2-6 | 59-43 | .578 | Globe Life Field · Arlington, TX |
| 103 | Wed Aug 1 | vs Angels | W11-10 (10) | 60-43 | .583 | Globe Life Field · Arlington, TX |
| 104 | Thu Aug 2 | vs Angels | W15-9 | 61-43 | .587 | Globe Life Field · Arlington, TX |
| 105 | Fri Aug 3 | at Royals | W5-3 | 62-43 | .590 | Kauffman Stadium · Kansas City, MO |
| 106 | Sat Aug 4 | at Royals | W4-2 | 63-43 | .594 | Kauffman Stadium · Kansas City, MO |
| 107 | Sun Aug 5 | at Royals | L6-7 (10) | 63-44 | .589 | Kauffman Stadium · Kansas City, MO |
| 108 | Mon Aug 6 | at Red Sox | L2-9 | 63-45 | .583 | Fenway Park · Boston, MA |
| 109 | Tue Aug 7 | at Red Sox | W6-3 | 64-45 | .587 | Fenway Park · Boston, MA |
| 110 | Wed Aug 8 | at Red Sox | W10-9 | 65-45 | .591 | Fenway Park · Boston, MA |
| 111 | Fri Aug 10 | vs Tigers | L2-6 | 65-46 | .586 | Globe Life Field · Arlington, TX |
| 112 | Sat Aug 11 | vs Tigers | W2-1 | 66-46 | .589 | Globe Life Field · Arlington, TX |
| 113 | Sun Aug 12 | vs Tigers | W8-3 | 67-46 | .593 | Globe Life Field · Arlington, TX |
| 114 | Mon Aug 13 | at Yankees | L2-8 | 67-47 | .588 | Yankee Stadium · The Bronx, NY |
| 115 | Tue Aug 14 | at Yankees | L0-3 | 67-48 | .583 | Yankee Stadium · The Bronx, NY |
| 116 | Wed Aug 15 | at Yankees | L2-3 | 67-49 | .578 | Yankee Stadium · The Bronx, NY |
| 117 | Thu Aug 16 | at Yankees | W10-6 | 68-49 | .581 | Yankee Stadium · The Bronx, NY |
| 118 | Fri Aug 17 | at Blue Jays | L2-3 | 68-50 | .576 | Rogers Centre · Toronto, ON |
| 119 | Sat Aug 18 | at Blue Jays | W2-1 | 69-50 | .580 | Rogers Centre · Toronto, ON |
| 120 | Sun Aug 19 | at Blue Jays | W11-2 | 70-50 | .583 | Rogers Centre · Toronto, ON |
| 121 | Mon Aug 20 | vs Orioles | W5-1 | 71-50 | .587 | Globe Life Field · Arlington, TX |
| 122 | Tue Aug 21 | vs Orioles | L3-5 | 71-51 | .582 | Globe Life Field · Arlington, TX |
| 123 | Wed Aug 22 | vs Orioles | W12-3 | 72-51 | .585 | Globe Life Field · Arlington, TX |
| 124 | Thu Aug 23 | vs Twins | W10-6 | 73-51 | .589 | Globe Life Field · Arlington, TX |
| 125 | Fri Aug 24 | vs Twins | W8-0 | 74-51 | .592 | Globe Life Field · Arlington, TX |
| 126 | Sat Aug 25 | vs Twins | W9-3 | 75-51 | .595 | Globe Life Field · Arlington, TX |
| 127 | Sun Aug 26 | vs Twins | L5-6 | 75-52 | .591 | Globe Life Field · Arlington, TX |
| 128 | Mon Aug 27 | vs Rays | W6-5 | 76-52 | .594 | Globe Life Field · Arlington, TX |
| 129 | Tue Aug 28 | vs Rays | W1-0 | 77-52 | .597 | Globe Life Field · Arlington, TX |
| 130 | Wed Aug 29 | vs Rays | L4-8 | 77-53 | .592 | Globe Life Field · Arlington, TX |
| 131 | Fri Aug 31 | at Guardians | W5-3 | 78-53 | .595 | Progressive Field · Cleveland, OH |
| 132 | Sat Sep 1 | at Guardians | L3-4 | 78-54 | .591 | Progressive Field · Cleveland, OH |
| 133 | Sun Sep 2 | at Guardians | W8-3 | 79-54 | .594 | Progressive Field · Cleveland, OH |
| 134 | Mon Sep 3 | at Royals | W8-4 | 80-54 | .597 | Kauffman Stadium · Kansas City, MO |
| 135 | Tue Sep 4 | at Royals | L3-6 | 80-55 | .593 | Kauffman Stadium · Kansas City, MO |
| 136 | Wed Sep 5 | at Royals | W7-6 | 81-55 | .596 | Kauffman Stadium · Kansas City, MO |
| 137 | Thu Sep 6 | at Royals | W5-4 (10) | 82-55 | .599 | Kauffman Stadium · Kansas City, MO |
| 138 | Fri Sep 7 | at Rays | L1-3 (11) | 82-56 | .594 | Tropicana Field · St. Petersburg, FL |
| 139 | Sat Sep 8 | at Rays | W4-2 (10) | 83-56 | .597 | Tropicana Field · St. Petersburg, FL |
| 140 | Sun Sep 9 | at Rays | L0-6 | 83-57 | .593 | Tropicana Field · St. Petersburg, FL |
| 141 | Tue Sep 11 | vs Guardians | W6-4 | 84-57 | .596 | Globe Life Field · Arlington, TX |
| 142 | Wed Sep 12 | vs Guardians | W5-2 | 85-57 | .599 | Globe Life Field · Arlington, TX |
| 143 | Thu Sep 13 | vs Guardians | L4-5 | 85-58 | .594 | Globe Life Field · Arlington, TX |
| 144 | Fri Sep 14 | vs Mariners | W9-3 | 86-58 | .597 | Globe Life Field · Arlington, TX |
| 145 | Sat Sep 15 | vs Mariners | L6-8 | 86-59 | .593 | Globe Life Field · Arlington, TX |
| 146 | Sun Sep 16 | vs Mariners | W2-1 | 87-59 | .596 | Globe Life Field · Arlington, TX |
| 147 | Tue Sep 18 | at Angels | L3-11 | 87-60 | .592 | Angel Stadium · Anaheim, CA |
| 148 | Wed Sep 19 | at Angels | W6-2 | 88-60 | .595 | Angel Stadium · Anaheim, CA |
| 149 | Thu Sep 20 | at Angels | W3-1 | 89-60 | .597 | Angel Stadium · Anaheim, CA |
| 150 | Fri Sep 21 | at Mariners | L3-6 | 89-61 | .593 | T-Mobile Park · Seattle, WA |
| 151 | Sat Sep 22 | at Mariners | L0-1 | 89-62 | .589 | T-Mobile Park · Seattle, WA |
| 152 | Sun Sep 23 | at Mariners | W3-2 | 90-62 | .592 | T-Mobile Park · Seattle, WA |
| 153 | Mon Sep 24 | vs Athletics | W5-4 | 91-62 | .595 | Globe Life Field · Arlington, TX |
| 154 | Tue Sep 25 | vs Athletics | L2-3 (10) | 91-63 | .591 | Globe Life Field · Arlington, TX |
| 155 | Wed Sep 26 | vs Athletics | L3-9 | 91-64 | .587 | Globe Life Field · Arlington, TX |
| 156 | Thu Sep 27 | vs Athletics | W9-7 | 92-64 | .590 | Globe Life Field · Arlington, TX |
| 157 | Fri Sep 28 | vs Angels | L4-7 | 92-65 | .586 | Globe Life Field · Arlington, TX |
| 158 | Sun Sep 30 | vs Angels | L4-5 | 92-66 | .582 | Globe Life Field · Arlington, TX |
| 159 | Sun Sep 30 | vs Angels | W8-7 | 93-66 | .585 | Globe Life Field · Arlington, TX |
| 160 | Mon Oct 1 | at Athletics | L3-4 | 93-67 | .581 | RingCentral Coliseum · Oakland, CA |
| 161 | Tue Oct 2 | at Athletics | L1-3 | 93-68 | .578 | RingCentral Coliseum · Oakland, CA |
| 162 | Wed Oct 3 | at Athletics | L5-12 | 93-69 | .574 | RingCentral Coliseum · Oakland, CA |
| 163 | Fri Oct 5 | vs Orioles | L1-5 | 0-1 | .000 | Globe Life Field · Arlington, TX |