| 2 | Fri Dec 4 | at Duke | L54-76 | 0-1 | .000 | - | | Cameron Indoor Stadium · Durham, NC |
| 3 | Sun Dec 6 | atHoward | W84-63 | 1-1 | .500 | - | | Burr Gymnasium · Washington, D.C. |
| 4 | Wed Dec 9 | vsChattanooga | L68-77 | 1-2 | .333 | - | | Knights Hall · Louisville, KY |
| 8 | Wed Dec 23 | atNotre Dame | L70-81 | 1-3 | .250 | - | | Purcell Pavilion · South Bend, IN |
| 9 | Fri Jan 1 | vsTBD | W90-40 | 2-3 | .400 | - | | Knights Hall · Louisville, KY |
| 10 | Sat Jan 2 | vsTBD | W90-38 | 3-3 | .500 | - | | Knights Hall · Louisville, KY |
| 11 | Fri Jan 8 | vsLipscomb | L72-77 | 3-4 | .429 | - | | Knights Hall · Louisville, KY |
| 12 | Sat Jan 9 | vsLipscomb | L58-65 | 3-5 | .375 | - | | Knights Hall · Louisville, KY |
| 13 | Fri Jan 15 | atFGCU | W74-60 | 4-5 | .444 | - | | Alico Arena · Fort Myers, FL |
| 14 | Sat Jan 16 | atFGCU | W80-63 | 5-5 | .500 | - | | Alico Arena · Fort Myers, FL |
| 15 | Fri Jan 22 | vsStetson | W67-62 | 6-5 | .545 | - | | Knights Hall · Louisville, KY |
| 16 | Sat Jan 23 | vsStetson | W76-65 | 7-5 | .583 | - | | Knights Hall · Louisville, KY |
| 17 | Fri Jan 29 | atKennesaw St | W84-67 | 8-5 | .615 | - | | KSU Convocation Center · Kennesaw, GA |
| 18 | Sat Jan 30 | atKennesaw St | W84-79 | 9-5 | .643 | - | | KSU Convocation Center · Kennesaw, GA |
| 19 | Fri Feb 5 | vsJacksonville | W71-56 | 10-5 | .667 | - | | Knights Hall · Louisville, KY |
| 20 | Sat Feb 6 | vsJacksonville | W63-44 | 11-5 | .688 | - | | Knights Hall · Louisville, KY |
| 21 | Fri Feb 12 | atNorth Alabama | W66-64 | 12-5 | .706 | - | | Flowers Hall · Florence, AL |
| 22 | Sat Feb 13 | atNorth Alabama | W87-63 | 13-5 | .722 | - | | Flowers Hall · Florence, AL |
| 26 | Sat Feb 27 | vsLiberty | L78-94 | 13-6 | .684 | - | ESPNU | Knights Hall · Louisville, KY |
| 27 | Thu Mar 4 | vsStetson | L70-73 | 13-7 | .650 | - | | UNF Arena · Jacksonville, FL |
| 21 | Mon Mar 22 | atArmy | W77-67 | 14-7 | .667 | - | | Christl Arena · West Point, NY |
| 22 | Tue Mar 23 | atPepperdine | L71-82 | 14-8 | .636 | - | | Firestone Fieldhouse · Malibu, CA |
