| 3 | Wed Nov 12 | vs TBD | 7:00 PM | 0-0 | .000 | - | ESPN+ | Knights Hall · Louisville, KY |
| 4 | Sat Nov 15 | vsWofford | 2:00 PM | 1-1 | .500 | - | ESPN+ | Knights Hall · Louisville, KY |
| 5 | Wed Nov 19 | atNotre Dame | 7:00 PM | 2-0 | 1.000 | - | ACC Extra | Purcell Pavilion · South Bend, IN |
| 6 | Mon Nov 24 | atThe Citadel | 7:00 PM | 1-1 | .500 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 7 | Tue Nov 25 | vsHou Christian | 7:00 PM | 1-1 | .500 | - | | Knights Hall · Louisville, KY |
| 8 | Sat Nov 29 | atN Illinois | 3:00 PM | 1-1 | .500 | - | ESPN+ | NIU Convocation Center · Dekalb, IL |
| 9 | Wed Dec 3 | vsTBD | 7:00 PM | 0-0 | .000 | - | ESPN+ | Knights Hall · Louisville, KY |
| 10 | Sat Dec 6 | atMurray St | 3:00 PM | 2-0 | 1.000 | - | ESPN+ | CFSB Center · Murray, KY |
| 11 | Sat Dec 13 | vsN Kentucky | 2:00 PM | 1-1 | .500 | - | ESPN+ | Knights Hall · Louisville, KY |
| 12 | Wed Dec 17 | vsChattanooga | 7:00 PM | 1-2 | .333 | - | ESPN+ | Knights Hall · Louisville, KY |
| 13 | Tue Dec 23 | at#9Kentucky | 1:00 PM | 2-0 | 1.000 | - | SECN+ | Rupp Arena · Lexington, KY |
| 14 | Thu Jan 1 | atW Georgia | 7:00 PM | 1-1 | .500 | - | ESPN+ | The Coliseum · Carrollton, GA |
| 15 | Sat Jan 3 | atQueens | 3:00 PM | 1-2 | .333 | - | ESPN+ | Curry Arena · Charlotte, NC |
| 16 | Thu Jan 8 | vsC Arkansas | 7:00 PM | 1-1 | .500 | - | ESPN+ | Knights Hall · Louisville, KY |
| 17 | Sat Jan 10 | vsNorth Alabama | 2:00 PM | 1-1 | .500 | - | ESPN+ | Knights Hall · Louisville, KY |
| 18 | Thu Jan 15 | atLipscomb | 8:00 PM | 0-1 | .000 | - | ESPN+ | Allen Arena · Nashville, TN |
| 19 | Sat Jan 17 | atE Kentucky | 7:00 PM | 1-0 | 1.000 | - | ESPN+ | McBrayer Arena · Richmond, KY |
| 20 | Thu Jan 22 | atJacksonville | 7:00 PM | 1-1 | .500 | - | ESPN+ | Swisher Gymnasium · Jacksonville, FL |
| 21 | Sat Jan 24 | atNorth Florida | 2:00 PM | 0-1 | .000 | - | ESPN+ | UNF Arena · Jacksonville, FL |
| 22 | Wed Jan 28 | vsW Georgia | 7:00 PM | 1-1 | .500 | - | ESPN+ | Knights Hall · Louisville, KY |
| 23 | Sat Jan 31 | vsQueens | 2:00 PM | 1-2 | .333 | - | ESPN+ | Knights Hall · Louisville, KY |
| 24 | Thu Feb 5 | vsStetson | 7:00 PM | 1-1 | .500 | - | ESPN+ | Knights Hall · Louisville, KY |
| 25 | Sat Feb 7 | vsFGCU | 2:00 PM | 1-1 | .500 | - | ESPN+ | Knights Hall · Louisville, KY |
| 26 | Wed Feb 11 | atC Arkansas | 7:30 PM | 1-1 | .500 | - | ESPN+ | Farris Center · Conway, AR |
| 27 | Sat Feb 14 | atAustin Peay | 5:30 PM | 2-0 | 1.000 | - | ESPN+ | Winfield Dunn Center · Clarksville, TN |
| 28 | Wed Feb 18 | vsLipscomb | TBD | 0-1 | .000 | - | ESPN+ | Knights Hall · Louisville, KY |
| 29 | Sat Feb 21 | vsE Kentucky | 7:00 PM | 1-0 | 1.000 | - | ESPN+ | Knights Hall · Louisville, KY |
| 30 | Wed Feb 25 | atNorth Alabama | 8:45 PM | 1-1 | .500 | - | ESPN+ | Flowers Hall · Florence, AL |
| 31 | Sat Feb 28 | vsAustin Peay | 2:00 PM | 2-0 | 1.000 | - | ESPN+ | Knights Hall · Louisville, KY |
