| 1 | Mon Nov 3 | at Georgia | 7:30 PM | 20-13 | .606 | - | | Stegeman Coliseum · Athens, GA |
| 2 | Sat Nov 8 | atKansas St | 8:00 PM | 16-17 | .485 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 3 | Wed Nov 12 | vsTBD | TBD | 0-0 | .000 | - | ESPN+ | Knights Hall · Louisville, KY |
| 4 | Sat Nov 15 | vsWofford | TBD | 19-16 | .543 | - | ESPN+ | Knights Hall · Louisville, KY |
| 5 | Wed Nov 19 | atNotre Dame | TBD | 15-18 | .455 | - | | Purcell Pavilion · South Bend, IN |
| 6 | Mon Nov 24 | atThe Citadel | 7:00 PM | 5-25 | .167 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 7 | Tue Nov 25 | vsHou Christian | TBD | 12-20 | .375 | - | | Knights Hall · Louisville, KY |
| 8 | Sat Nov 29 | atN Illinois | TBD | 6-25 | .194 | - | | NIU Convocation Center · Dekalb, IL |
| 9 | Wed Dec 3 | vsTBD | TBD | 0-0 | .000 | - | | Knights Hall · Louisville, KY |
| 10 | Sat Dec 6 | atMurray St | 3:00 PM | 16-17 | .485 | - | | CFSB Center · Murray, KY |
| 11 | Sat Dec 13 | vsN Kentucky | TBD | 17-16 | .515 | - | | Knights Hall · Louisville, KY |
| 12 | Wed Dec 17 | vsChattanooga | TBD | 29-9 | .763 | - | | Knights Hall · Louisville, KY |
| 13 | Tue Dec 23 | at#9Kentucky | 1:00 PM | 24-12 | .667 | - | SECN+ | Rupp Arena · Lexington, KY |
| 14 | Thu Jan 1 | atW Georgia | TBD | 6-25 | .194 | - | | The Coliseum · Carrollton, GA |
| 15 | Sat Jan 3 | atQueens | TBD | 20-15 | .571 | - | | Curry Arena · Charlotte, NC |
| 16 | Thu Jan 8 | vsC Arkansas | TBD | 9-24 | .273 | - | | Knights Hall · Louisville, KY |
| 17 | Sat Jan 10 | vsNorth Alabama | TBD | 24-11 | .686 | - | | Knights Hall · Louisville, KY |
| 18 | Thu Jan 15 | atLipscomb | TBD | 25-10 | .714 | - | | Allen Arena · Nashville, TN |
| 19 | Sat Jan 17 | atE Kentucky | TBD | 18-14 | .563 | - | | McBrayer Arena · Richmond, KY |
| 20 | Thu Jan 22 | atJacksonville | 7:00 PM | 19-14 | .576 | - | | Swisher Gymnasium · Jacksonville, FL |
| 21 | Sat Jan 24 | atNorth Florida | TBD | 15-17 | .469 | - | | UNF Arena · Jacksonville, FL |
| 22 | Wed Jan 28 | vsW Georgia | TBD | 6-25 | .194 | - | | Knights Hall · Louisville, KY |
| 23 | Sat Jan 31 | vsQueens | TBD | 20-15 | .571 | - | | Knights Hall · Louisville, KY |
| 24 | Thu Feb 5 | vsStetson | TBD | 8-24 | .250 | - | | Knights Hall · Louisville, KY |
| 25 | Sat Feb 7 | vsFGCU | TBD | 19-15 | .559 | - | | Knights Hall · Louisville, KY |
| 26 | Thu Feb 12 | atC Arkansas | TBD | 9-24 | .273 | - | | Farris Center · Conway, AR |
| 27 | Sat Feb 14 | atAustin Peay | TBD | 14-19 | .424 | - | | Winfield Dunn Center · Clarksville, TN |
| 28 | Thu Feb 19 | vsLipscomb | TBD | 25-10 | .714 | - | | Knights Hall · Louisville, KY |
| 29 | Sat Feb 21 | vsE Kentucky | TBD | 18-14 | .563 | - | | Knights Hall · Louisville, KY |
| 30 | Wed Feb 25 | atNorth Alabama | TBD | 24-11 | .686 | - | | Flowers Hall · Florence, AL |
| 31 | Sat Feb 28 | vsAustin Peay | TBD | 14-19 | .424 | - | | Knights Hall · Louisville, KY |
