| 1 | Tue Nov 9 | at #7Purdue | L67-96 | 0-1 | .000 | - | | Mackey Arena · West Lafayette, IN |
| 2 | Sat Nov 13 | at Murray St | L59-78 | 0-2 | .000 | - | | CFSB Center · Murray, KY |
| 3 | Wed Nov 17 | at Saint Mary's | L64-73 | 0-3 | .000 | - | | University Credit Union Pavilion · Moraga, CA |
| 4 | Fri Nov 19 | at #1Gonzaga | L50-92 | 0-4 | .000 | - | | McCarthey Athletic Center · Spokane, WA |
| 5 | Mon Nov 22 | vs UCLA | L62-75 | 0-5 | .000 | - | | Knights Hall · Louisville, KY |
| 6 | Tue Nov 23 | vs C Michigan | W76-69 | 1-5 | .167 | - | | Knights Hall · Louisville, KY |
| 7 | Sun Nov 28 | vs TBD | W75-37 | 2-5 | .286 | - | | Knights Hall · Louisville, KY |
| 8 | Tue Nov 30 | at West Virginia | L55-74 | 2-6 | .250 | - | | WVU Coliseum · Morgantown, WV |
| 9 | Sun Dec 5 | vsTBD | W92-43 | 3-6 | .333 | - | | Knights Hall · Louisville, KY |
| 10 | Thu Dec 9 | vsTBD | W87-55 | 4-6 | .400 | - | | Knights Hall · Louisville, KY |
| 11 | Fri Dec 10 | vsTBD | W89-39 | 5-6 | .455 | - | | Knights Hall · Louisville, KY |
| 12 | Wed Dec 15 | at South Dakota | L64-78 | 5-7 | .417 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 13 | Sat Dec 18 | at Miami OH | W77-68 | 6-7 | .462 | - | | Millett Hall · Oxford, OH |
| 14 | Tue Dec 21 | vs LMU | L57-71 | 6-8 | .429 | - | | Knights Hall · Louisville, KY |
| 16 | Tue Jan 4 | at J'Ville St | PPD | 20-13 | .606 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 17 | Sat Jan 8 | vs E Kentucky | W66-61 | 7-8 | .467 | - | | Knights Hall · Louisville, KY |
| 18 | Tue Jan 11 | vs C Arkansas | W85-63 | 8-8 | .500 | - | | Knights Hall · Louisville, KY |
| 19 | Sat Jan 15 | at Lipscomb | W77-71 | 9-8 | .529 | - | | Allen Arena · Nashville, TN |
| 20 | Tue Jan 18 | vs North Alabama | W68-60 | 10-8 | .556 | - | | Knights Hall · Louisville, KY |
| 21 | Sat Jan 22 | vs Jacksonville | W76-73 (OT) | 11-8 | .579 | - | | Knights Hall · Louisville, KY |
| 22 | Mon Jan 24 | atJ'Ville St | L60-65 | 11-9 | .550 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 23 | Thu Jan 27 | at Stetson | W72-47 | 12-9 | .571 | - | | Edmunds Center · Deland, FL |
| 24 | Sat Jan 29 | at FGCU | W74-63 | 13-9 | .591 | - | | Alico Arena · Fort Myers, FL |
| 25 | Thu Feb 3 | vs Liberty | L53-66 | 13-10 | .565 | - | | Knights Hall · Louisville, KY |
| 26 | Sat Feb 5 | vs Kennesaw St | L70-75 | 13-11 | .542 | - | | Knights Hall · Louisville, KY |
| 27 | Wed Feb 9 | at North Florida | W73-70 | 14-11 | .560 | - | | UNF Arena · Jacksonville, FL |
| 28 | Sat Feb 12 | atNorth Alabama | W75-69 | 15-11 | .577 | - | | Flowers Hall · Florence, AL |
| 29 | Wed Feb 16 | atC Arkansas | W79-69 | 16-11 | .593 | - | | Farris Center · Conway, AR |
| 30 | Sun Feb 20 | vsJ'Ville St | L67-82 | 16-12 | .571 | - | | Knights Hall · Louisville, KY |
| 31 | Wed Feb 23 | vsLipscomb | W76-73 | 17-12 | .586 | - | | Knights Hall · Louisville, KY |
| 32 | Sat Feb 26 | atE Kentucky | L58-72 | 17-13 | .567 | - | | McBrayer Arena · Richmond, KY |
| 33 | Thu Mar 3 | vsFGCU | W81-68 | 18-13 | .581 | - | | Knights Hall · Louisville, KY |
| 34 | Sat Mar 5 | atLiberty | W53-50 | 19-13 | .594 | - | | Liberty Arena · Lynchburg, VA |
| 35 | Tue Mar 8 | vsJacksonville | W77-72 | 20-13 | .606 | - | ESPN2 | Knights Hall · Louisville, KY |
