| 1 | Wed Nov 9 | at Louisville | W67-66 | 1-0 | 1.000 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 2 | Sat Nov 12 | at Morehead St | L55-62 | 1-1 | .500 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 3 | Mon Nov 14 | vs TBD | W86-46 | 2-1 | .667 | - | | Knights Hall · Louisville, KY |
| 4 | Fri Nov 18 | at Clemson | L66-76 | 2-2 | .500 | - | | Littlejohn Coliseum · Clemson, SC |
| 5 | Mon Nov 21 | at #8Duke | L57-74 | 2-3 | .400 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 6 | Fri Nov 25 | at LMU | L59-80 | 2-4 | .333 | - | | Gersten Pavilion · Los Angeles, CA |
| 7 | Sun Nov 27 | at #19UCLA | L60-81 | 2-5 | .286 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 8 | Tue Nov 29 | at #19Kentucky | L41-60 | 2-6 | .250 | - | | Rupp Arena · Lexington, KY |
| 9 | Sun Dec 4 | vsTBD | W110-38 | 3-6 | .333 | - | | Knights Hall · Louisville, KY |
| 10 | Tue Dec 6 | vsTBD | W86-45 | 4-6 | .400 | - | | Knights Hall · Louisville, KY |
| 11 | Sat Dec 10 | vs Murray St | W69-58 | 5-6 | .455 | - | | Knights Hall · Louisville, KY |
| 12 | Sat Dec 17 | vs Miami OH | L67-71 | 5-7 | .417 | - | | Knights Hall · Louisville, KY |
| 13 | Wed Dec 21 | at Evansville | L61-73 | 5-8 | .385 | - | | Ford Center · Evansville, IN |
| 14 | Thu Dec 29 | vs Liberty | L53-70 | 5-9 | .357 | - | | Knights Hall · Louisville, KY |
| 15 | Mon Jan 2 | at North Alabama | W69-65 | 6-9 | .400 | - | | Flowers Hall · Florence, AL |
| 16 | Thu Jan 5 | vs Queens | L74-75 | 6-10 | .375 | - | | Knights Hall · Louisville, KY |
| 17 | Sat Jan 7 | at J'Ville St | W75-62 | 7-10 | .412 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 18 | Thu Jan 12 | vs Stetson | L51-80 | 7-11 | .389 | - | | Knights Hall · Louisville, KY |
| 19 | Sat Jan 14 | vs FGCU | W61-41 | 8-11 | .421 | - | | Knights Hall · Louisville, KY |
| 20 | Thu Jan 19 | at Austin Peay | W56-45 | 9-11 | .450 | - | | Winfield Dunn Center · Clarksville, TN |
| 21 | Sat Jan 21 | at Lipscomb | L49-69 | 9-12 | .429 | - | | Allen Arena · Nashville, TN |
| 22 | Thu Jan 26 | vs E Kentucky | W72-71 | 10-12 | .455 | - | | Knights Hall · Louisville, KY |
| 23 | Sat Jan 28 | atE Kentucky | L63-73 | 10-13 | .435 | - | | McBrayer Arena · Richmond, KY |
| 24 | Thu Feb 2 | vs Kennesaw St | L84-90 (2OT) | 10-14 | .417 | - | | Knights Hall · Louisville, KY |
| 25 | Sat Feb 4 | vsJ'Ville St | W71-64 | 11-14 | .440 | - | | Knights Hall · Louisville, KY |
| 26 | Thu Feb 9 | atLiberty | L50-70 | 11-15 | .423 | - | | Liberty Arena · Lynchburg, VA |
| 27 | Sat Feb 11 | atQueens | W88-84 | 12-15 | .444 | - | | Curry Arena · Charlotte, NC |
| 28 | Thu Feb 16 | vsNorth Alabama | L57-70 | 12-16 | .429 | - | | Knights Hall · Louisville, KY |
| 29 | Sun Feb 19 | vs C Arkansas | W68-67 | 13-16 | .448 | - | | Knights Hall · Louisville, KY |
| 30 | Wed Feb 22 | at Jacksonville | W63-61 | 14-16 | .467 | - | ESPNU | Swisher Gymnasium · Jacksonville, FL |
| 31 | Fri Feb 24 | at North Florida | L67-79 | 14-17 | .452 | - | | UNF Arena · Jacksonville, FL |
| 32 | Mon Feb 27 | atNorth Florida | W76-74 | 15-17 | .469 | - | | UNF Arena · Jacksonville, FL |
| 33 | Tue Feb 28 | atLiberty | L56-76 | 15-18 | .455 | - | | Liberty Arena · Lynchburg, VA |
