| 1 | Mon Nov 6 | at Washington | L57-91 | 0-1 | .000 | - | | Alaska Airlines Arena · Seattle, WA |
| 2 | Fri Nov 10 | atKansas St | L75-83 | 0-2 | .000 | - | | Bramlage Coliseum · Manhattan, KS |
| 3 | Tue Nov 14 | atChattanooga | L64-72 | 0-3 | .000 | - | | McKenzie Arena · Chattanooga, TN |
| 4 | Fri Nov 17 | atBowling Green | W85-67 | 1-3 | .250 | - | | Stroh Center · Bowling Green, OH |
| 5 | Mon Nov 20 | vsMorehead St | L51-64 | 1-4 | .200 | - | | Knights Hall · Louisville, KY |
| 6 | Tue Nov 21 | vsTBD | W77-56 | 2-4 | .333 | - | | Knights Hall · Louisville, KY |
| 7 | Sun Nov 26 | atWest Virginia | L58-62 | 2-5 | .286 | - | | WVU Coliseum · Morgantown, WV |
| 8 | Wed Nov 29 | atLouisville | L68-73 | 2-6 | .250 | - | | KFC Yum! Center · Louisville, KY |
| 9 | Sat Dec 2 | atBall State | L58-67 | 2-7 | .222 | - | | Worthen Arena · Muncie, IN |
| 10 | Mon Dec 4 | vsTBD | W88-54 | 3-7 | .300 | - | | Knights Hall · Louisville, KY |
| 11 | Thu Dec 7 | vsTBD | W98-59 | 4-7 | .364 | - | | Knights Hall · Louisville, KY |
| 12 | Sat Dec 16 | vsEvansville | L61-70 | 4-8 | .333 | - | | Knights Hall · Louisville, KY |
| 13 | Wed Dec 20 | atUtah | L43-85 | 4-9 | .308 | - | PACN | Jon M. Huntsman Center · Salt Lake City, UT |
| 14 | Fri Dec 22 | at17BYU | L59-101 | 4-10 | .286 | - | | Marriott Center · Provo, UT |
| 15 | Sat Dec 30 | atHigh Point | L85-90 | 4-11 | .267 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 16 | Thu Jan 4 | vsAustin Peay | L68-84 | 4-12 | .250 | - | | Knights Hall · Louisville, KY |
| 17 | Sat Jan 6 | vsLipscomb | L70-81 | 4-13 | .235 | - | | Knights Hall · Louisville, KY |
| 18 | Thu Jan 11 | atNorth Alabama | L53-69 | 4-14 | .222 | - | | Flowers Hall · Florence, AL |
| 19 | Sat Jan 13 | atC Arkansas | L57-59 | 4-15 | .211 | - | | Farris Center · Conway, AR |
| 20 | Sat Jan 20 | atE Kentucky | L70-82 | 4-16 | .200 | - | | McBrayer Arena · Richmond, KY |
| 21 | Thu Jan 25 | vsNorth Florida | L63-71 | 4-17 | .190 | - | | Knights Hall · Louisville, KY |
| 22 | Sat Jan 27 | vsJacksonville | W69-63 | 5-17 | .227 | - | | Knights Hall · Louisville, KY |
| 23 | Thu Feb 1 | atKennesaw St | W96-95 (OT) | 6-17 | .261 | - | | KSU Convocation Center · Kennesaw, GA |
| 24 | Sat Feb 3 | atQueens | L75-85 | 6-18 | .250 | - | | Curry Arena · Charlotte, NC |
| 25 | Wed Feb 7 | vsStetson | L77-84 | 6-19 | .240 | - | | Knights Hall · Louisville, KY |
| 26 | Sat Feb 10 | atFGCU | L52-63 | 6-20 | .231 | - | | Alico Arena · Fort Myers, FL |
| 27 | Sat Feb 17 | vsE Kentucky | L65-75 | 6-21 | .222 | - | | Knights Hall · Louisville, KY |
| 28 | Thu Feb 22 | vsC Arkansas | W68-65 | 7-21 | .250 | - | | Knights Hall · Louisville, KY |
| 29 | Sat Feb 24 | vsNorth Alabama | W82-70 | 8-21 | .276 | - | | Knights Hall · Louisville, KY |
| 30 | Wed Feb 28 | atLipscomb | L74-90 | 8-22 | .267 | - | | Allen Arena · Nashville, TN |
| 31 | Fri Mar 1 | atAustin Peay | L87-90 (OT) | 8-23 | .258 | - | | Winfield Dunn Center · Clarksville, TN |
