| 1 | Mon Nov 4 | at VCU | L65-84 | 0-1 | .000 | - | ESPN+ | Stuart C. Siegel Center · Richmond, VA |
| 2 | Sat Nov 9 | vsVMI | L71-76 | 0-2 | .000 | - | ESPN+ | Knights Hall · Louisville, KY |
| 3 | Wed Nov 13 | vsSo Indiana | L69-71 | 0-3 | .000 | - | ESPN+ | Knights Hall · Louisville, KY |
| 4 | Sat Nov 16 | atMarshall | L62-83 | 0-4 | .000 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 5 | Tue Nov 19 | atLouisville | L68-100 | 0-5 | .000 | - | ESPN+ | KFC Yum! Center · Louisville, KY |
| 6 | Sat Nov 23 | vsBowling Green | W80-68 | 1-5 | .167 | - | ESPN+ | Knights Hall · Louisville, KY |
| 7 | Tue Nov 26 | vsTBD | W101-60 | 2-5 | .286 | - | ESPN+ | Knights Hall · Louisville, KY |
| 8 | Sat Nov 30 | atN Kentucky | L70-86 | 2-6 | .250 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 9 | Wed Dec 4 | atW Carolina | L74-86 | 2-7 | .222 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 10 | Sat Dec 7 | vsTBD | W94-66 | 3-7 | .300 | - | ESPN+ | Knights Hall · Louisville, KY |
| 11 | Sat Dec 14 | vsBall State | L82-86 | 3-8 | .273 | - | ESPN+ | Knights Hall · Louisville, KY |
| 12 | Thu Dec 19 | atWyoming | L55-92 | 3-9 | .250 | - | | Arena Auditorium · Laramie, WY |
| 13 | Sat Dec 21 | atColorado | L55-79 | 3-10 | .231 | - | ESPN+ | CU Events Center · Boulder, CO |
| 14 | Thu Jan 2 | atNorth Alabama | L66-82 | 3-11 | .214 | - | ESPN+ | Flowers Hall · Florence, AL |
| 15 | Sat Jan 4 | atC Arkansas | L65-71 | 3-12 | .200 | - | ESPN+ | Farris Center · Conway, AR |
| 16 | Thu Jan 9 | vsJacksonville | L59-74 | 3-13 | .188 | - | ESPN+ | Knights Hall · Louisville, KY |
| 17 | Sat Jan 11 | vsNorth Florida | L83-98 | 3-14 | .176 | - | ESPN+ | Knights Hall · Louisville, KY |
| 18 | Thu Jan 16 | vsLipscomb | L53-87 | 3-15 | .167 | - | ESPN+ | Knights Hall · Louisville, KY |
| 19 | Sat Jan 18 | atE Kentucky | L69-72 | 3-16 | .158 | - | ESPN+ | McBrayer Arena · Richmond, KY |
| 20 | Thu Jan 23 | vsFGCU | L61-77 | 3-17 | .150 | - | ESPN+ | Knights Hall · Louisville, KY |
| 21 | Sat Jan 25 | vsStetson | L76-81 | 3-18 | .143 | - | ESPN+ | Knights Hall · Louisville, KY |
| 22 | Thu Jan 30 | atAustin Peay | L77-86 (OT) | 3-19 | .136 | - | ESPN+ | Winfield Dunn Center · Clarksville, TN |
| 23 | Sat Feb 1 | atLipscomb | L80-87 | 3-20 | .130 | - | ESPN+ | Allen Arena · Nashville, TN |
| 24 | Thu Feb 6 | atNorth Florida | L88-95 | 3-21 | .125 | - | ESPN+ | UNF Arena · Jacksonville, FL |
| 25 | Sat Feb 8 | atJacksonville | L64-73 | 3-22 | .120 | - | ESPN+ | Swisher Gymnasium · Jacksonville, FL |
| 26 | Thu Feb 13 | vsQueens | L87-92 (OT) | 3-23 | .115 | - | ESPN+ | Knights Hall · Louisville, KY |
| 27 | Sat Feb 15 | vsW Georgia | L76-81 | 3-24 | .111 | - | ESPN+ | Knights Hall · Louisville, KY |
| 28 | Tue Feb 18 | vsAustin Peay | W94-68 | 4-24 | .143 | - | ESPN+ | Knights Hall · Louisville, KY |
| 29 | Thu Feb 20 | vsE Kentucky | W80-74 | 5-24 | .172 | - | ESPN+ | Knights Hall · Louisville, KY |
| 30 | Mon Feb 24 | atStetson | L67-69 | 5-25 | .167 | - | ESPN+ | Edmunds Center · Deland, FL |
| 31 | Wed Feb 26 | atFGCU | L61-80 | 5-26 | .161 | - | ESPN+ | Alico Arena · Fort Myers, FL |
