| 1 | Mon Nov 4 | at Penn State | L66-108 | 0-1 | .000 | - | B1G+ | Bryce Jordan Center · University Park, PA |
| 2 | Thu Nov 7 | vsTBD | W82-63 | 1-1 | .500 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 3 | Sun Nov 10 | atMiami | L64-88 | 1-2 | .333 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 4 | Tue Nov 12 | atFordham | L63-78 | 1-3 | .250 | - | ESPN+ | Rose Hill Gymnasium · Bronx, NY |
| 5 | Sat Nov 16 | vsTBD | W77-48 | 2-3 | .400 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 6 | Tue Nov 19 | vsLongwood | L60-66 | 2-4 | .333 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 7 | Sun Nov 24 | atC Connecticut | L56-64 | 2-5 | .286 | - | | William H. Detrick Gymnasium · New Britain, CT |
| 8 | Fri Nov 29 | vsNiagara | L62-65 | 2-6 | .250 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 9 | Sat Nov 30 | atLong Island | W75-70 (OT) | 3-6 | .333 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 10 | Sun Dec 1 | atLafayette | W82-81 (OT) | 4-6 | .400 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 11 | Sat Dec 7 | atLe Moyne | W72-62 | 5-6 | .455 | - | | Ted Grant Court · Syracuse, NY |
| 12 | Sun Dec 15 | vsTBD | W85-60 | 6-6 | .500 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 13 | Wed Dec 18 | vsMercyhurst | W62-60 | 7-6 | .538 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 14 | Sun Dec 22 | atArmy | W78-68 | 8-6 | .571 | - | ESPN+ | Christl Arena · West Point, NY |
| 15 | Sun Dec 29 | atMarist | L51-69 | 8-7 | .533 | - | ESPN+ | McCann Arena · Poughkeepsie, NY |
| 16 | Sat Jan 4 | vsUMBC | W87-82 | 9-7 | .563 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 17 | Thu Jan 9 | atMaine | L71-82 | 9-8 | .529 | - | ESPN+ | Cross Insurance Center · Bangor, ME |
| 18 | Sat Jan 11 | atNew Hampshire | L72-79 | 9-9 | .500 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 19 | Thu Jan 16 | atVermont | L64-72 | 9-10 | .474 | - | ESPN+ | Patrick Gymnasium · Burlington, VT |
| 20 | Sat Jan 18 | vsAlbany | L65-70 | 9-11 | .450 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 21 | Sat Jan 25 | atBryant | L69-83 | 9-12 | .429 | - | ESPN+ | Chace Athletic Center · Smithfield, RI |
| 22 | Thu Jan 30 | vsVermont | W75-72 | 10-12 | .455 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 23 | Sat Feb 1 | atAlbany | W65-61 | 11-12 | .478 | - | ESPN+ | SEFCU Arena · Albany, NY |
| 24 | Thu Feb 6 | vsUMass Lowell | W66-54 | 12-12 | .500 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 25 | Sat Feb 8 | vsBryant | L71-78 | 12-13 | .480 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 26 | Thu Feb 13 | atUMBC | L77-81 | 12-14 | .462 | - | ESPN+ | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 27 | Sat Feb 15 | atNJIT | W75-71 (OT) | 13-14 | .481 | - | ESPN+ | NJIT Wellness and Events Center · Newark, NJ |
| 28 | Thu Feb 20 | vsNew Hampshire | W79-60 | 14-14 | .500 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 29 | Sat Feb 22 | vsMaine | W71-69 | 15-14 | .517 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 30 | Sat Mar 1 | atUMass Lowell | L53-79 | 15-15 | .500 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 31 | Tue Mar 4 | vsNJIT | L72-75 | 15-16 | .484 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 32 | Sat Mar 8 | atAlbany | L66-69 | 15-17 | .469 | - | ESPN+ | SEFCU Arena · Albany, NY |
