| 1 | Mon Nov 4 | at TCU | L59-105 | 0-1 | .000 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 2 | Thu Nov 7 | at SMU | L73-102 | 0-2 | .000 | - | ESPN+ | Moody Coliseum · Dallas, TX |
| 3 | Mon Nov 11 | at Maryland | L53-84 | 0-3 | .000 | - | B1G+ | XFINITY Center · College Park, MD |
| 4 | Tue Nov 19 | at #21Florida | L60-84 | 0-4 | .000 | - | ESPN+ | O'Connell Center · Gainesville, FL |
| 5 | Fri Nov 22 | vs TBD | W110-68 | 1-4 | .200 | - | | Al Lawson Center · Tallahassee, FL |
| 6 | Fri Nov 29 | at Clemson | L58-86 | 1-5 | .167 | - | ESPN+ | Littlejohn Coliseum · Clemson, SC |
| 7 | Tue Dec 3 | vs Presbyterian | W66-63 | 2-5 | .286 | - | | Al Lawson Center · Tallahassee, FL |
| 8 | Fri Dec 6 | vsTBD | W130-58 | 3-5 | .375 | - | | Al Lawson Center · Tallahassee, FL |
| 9 | Tue Dec 17 | at Utah | L59-89 | 3-6 | .333 | - | ESPN+ | Jon M. Huntsman Center · Salt Lake City, UT |
| 10 | Fri Dec 20 | at BYU | L57-103 | 3-7 | .300 | - | ESPN+ | Marriott Center · Provo, UT |
| 11 | Sun Dec 29 | at Tarleton | L60-70 | 3-8 | .273 | - | ESPN+ | placeholder · sf, ca |
| 12 | Sat Jan 4 | vs Bethune | L55-62 | 3-9 | .250 | - | | Al Lawson Center · Tallahassee, FL |
| 13 | Sat Jan 11 | at Southern | L57-91 | 3-10 | .231 | - | | F. G. Clark Activity Center · Baton Rouge, LA |
| 14 | Mon Jan 13 | at Grambling | L72-79 | 3-11 | .214 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 15 | Sat Jan 18 | vs AR-Pine Bluff | W86-76 | 4-11 | .267 | - | | Al Lawson Center · Tallahassee, FL |
| 16 | Mon Jan 20 | vs Miss Valley St | W83-53 | 5-11 | .313 | - | | Al Lawson Center · Tallahassee, FL |
| 17 | Sat Jan 25 | at Alcorn St | W65-64 | 6-11 | .353 | - | | Davey L. Whitney Complex · Lorman, MS |
| 18 | Mon Jan 27 | at Jackson St | W72-62 | 7-11 | .389 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 19 | Sat Feb 1 | vs Alabama A&M | W95-79 | 8-11 | .421 | - | | Al Lawson Center · Tallahassee, FL |
| 20 | Mon Feb 3 | vs Alabama St | L66-67 | 8-12 | .400 | - | | Al Lawson Center · Tallahassee, FL |
| 21 | Sat Feb 8 | at Texas So | W66-64 | 9-12 | .429 | - | | H&PE Arena · Houston, TX |
| 22 | Mon Feb 10 | at Prairie View | W78-67 | 10-12 | .455 | - | | William Nicks Building · Prairie View, TX |
| 23 | Sat Feb 15 | vsJackson St | W76-71 | 11-12 | .478 | - | | Al Lawson Center · Tallahassee, FL |
| 24 | Mon Feb 17 | vsAlcorn St | W85-76 | 12-12 | .500 | - | | Al Lawson Center · Tallahassee, FL |
| 25 | Sat Feb 22 | atAlabama St | L59-60 | 12-13 | .480 | - | | Dunn-Oliver Acadome · Montgomery, AL |
| 26 | Mon Feb 24 | atAlabama A&M | L66-77 | 12-14 | .462 | - | | T.M. Elmore Gymnasium · Normal, AL |
| 27 | Sat Mar 1 | vsGrambling | W73-68 | 13-14 | .481 | - | | Al Lawson Center · Tallahassee, FL |
| 28 | Mon Mar 3 | vsSouthern | L70-73 | 13-15 | .464 | - | | Al Lawson Center · Tallahassee, FL |
| 29 | Sat Mar 8 | atBethune | L75-76 | 13-16 | .448 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
| 30 | Tue Mar 11 | vsPrairie View | W75-66 | 14-16 | .467 | - | ESPN+ | Al Lawson Center · Tallahassee, FL |
| 31 | Wed Mar 12 | atJackson St | L76-91 | 14-17 | .452 | - | ESPN+ | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
