| 1 | Mon Nov 7 | at FIU | L66-77 | +13½ | 0-1 | .000 | - | | Ocean Bank Convocation Center · Miami, FL |
| 2 | Thu Nov 10 | atTexas | L31-82 | +37 | 0-2 | .000 | - | | Moody Center · Austin, TX |
| 3 | Mon Nov 14 | vsTBD | W119-97 | - | 1-2 | .333 | - | | Sharp Gymnasium · Houston, TX |
| 4 | Fri Nov 18 | vsW Michigan | L84-90 | +7½ | 1-3 | .250 | - | | Sharp Gymnasium · Houston, TX |
| 5 | Sat Nov 19 | vsGeorgia So | L77-84 | +4 | 1-4 | .200 | - | | Sharp Gymnasium · Houston, TX |
| 6 | Mon Nov 21 | atRice | L67-76 | +12½ | 1-5 | .167 | - | | Tudor Fieldhouse · Houston, TX |
| 7 | Sat Nov 26 | atMissouri | L69-105 | +29½ | 1-6 | .143 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 8 | Thu Dec 1 | vsDenver | L83-93 | +5½ | 1-7 | .125 | - | | Sharp Gymnasium · Houston, TX |
| 9 | Sun Dec 4 | vsTBD | W94-62 | - | 2-7 | .222 | - | | Sharp Gymnasium · Houston, TX |
| 10 | Tue Dec 6 | vsTBD | W100-33 | - | 3-7 | .300 | - | | Sharp Gymnasium · Houston, TX |
| 11 | Sat Dec 10 | vsUT Rio Grande | L82-95 | +3 | 3-8 | .273 | - | | Sharp Gymnasium · Houston, TX |
| 12 | Sun Dec 18 | atUT Rio Grande | L90-100 | +7½ | 3-9 | .250 | - | | UTRGV Fieldhouse · Edinburg, TX |
| 13 | Wed Dec 21 | atTexas Tech | L67-111 | +33½ | 3-10 | .231 | - | | United Supermarkets Arena · Lubbock, TX |
| 14 | Fri Dec 30 | vsNew Orleans | W101-96 (OT) | +1½ | 4-10 | .286 | - | | Sharp Gymnasium · Houston, TX |
| 15 | Thu Jan 5 | atSE Louisiana | L59-71 | +9½ | 4-11 | .267 | - | | University Center (LA) · Hammond, LA |
| 16 | Sat Jan 7 | atNew Orleans | L59-82 | +5½ | 4-12 | .250 | - | | Lakefront Arena · New Orleans, LA |
| 17 | Thu Jan 12 | vsE Texas A&M | W68-59 | +4½ | 5-12 | .294 | - | | Sharp Gymnasium · Houston, TX |
| 18 | Sat Jan 14 | atMcNeese | W90-81 | +8½ | 6-12 | .333 | - | | Legacy Center · Lake Charles, LA |
| 19 | Thu Jan 19 | vsIncarnate Word | L78-89 | -3½ | 6-13 | .316 | - | | Sharp Gymnasium · Houston, TX |
| 20 | Sat Jan 21 | vsTexas A&M-CC | W90-78 | +8½ | 7-13 | .350 | - | | Sharp Gymnasium · Houston, TX |
| 21 | Thu Jan 26 | atN'Western St | L63-82 | +12 | 7-14 | .333 | - | | Prather Coliseum · Natchitoches, LA |
| 22 | Sat Jan 28 | atE Texas A&M | L76-77 | +7½ | 7-15 | .318 | - | | The Field House · Commerce, TX |
| 23 | Thu Feb 2 | vsN'Western St | L76-94 | +6½ | 7-16 | .304 | - | | Sharp Gymnasium · Houston, TX |
| 24 | Sat Feb 4 | vsNicholls | L91-92 | +6 | 7-17 | .292 | - | | Sharp Gymnasium · Houston, TX |
| 25 | Thu Feb 9 | atTexas A&M-CC | L68-91 | +14½ | 7-18 | .280 | - | | American Bank Center · Corpus Christi, TX |
| 26 | Sat Feb 11 | atIncarnate Word | W84-78 | +3½ | 8-18 | .308 | - | | Alice P. McDermott Convocation Center · San Antonio, TX |
| 27 | Thu Feb 16 | atLamar | L75-91 | +1 | 8-19 | .296 | - | | Montagne Center · Beaumont, TX |
| 28 | Sat Feb 18 | vsLamar | W93-74 | -4½ | 9-19 | .321 | - | | Sharp Gymnasium · Houston, TX |
| 29 | Thu Feb 23 | vsMcNeese | W85-80 | -1½ | 10-19 | .345 | - | | Sharp Gymnasium · Houston, TX |
| 30 | Sat Feb 25 | atNicholls | L64-68 | +11½ | 10-20 | .333 | - | | David R. Stopher Gymnasium · Thibodaux, LA |
| 31 | Wed Mar 1 | vsSE Louisiana | L64-80 | +3 | 10-21 | .323 | - | | Sharp Gymnasium · Houston, TX |
| 32 | Sun Mar 5 | vsNew Orleans | L69-90 | +4 | 10-22 | .313 | - | | Sharp Gymnasium · Houston, TX |
