| 1 | Mon Nov 6 | at BYU | L63-110 | 0-1 | .000 | - | | Marriott Center · Provo, UT |
| 2 | Wed Nov 15 | vs FIU | L74-83 | 0-2 | .000 | - | | Sharp Gymnasium · Houston, TX |
| 3 | Mon Nov 20 | vs UTSA | L87-89 | 0-3 | .000 | - | | Sharp Gymnasium · Houston, TX |
| 4 | Fri Nov 24 | at Oklahoma St | L65-92 | 0-4 | .000 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 5 | Mon Nov 27 | at TCU | L64-101 | 0-5 | .000 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 6 | Sat Dec 2 | at Rice | L56-65 | 0-6 | .000 | - | | Tudor Fieldhouse · Houston, TX |
| 7 | Wed Dec 6 | vs TBD | W95-58 | 1-6 | .143 | - | | Sharp Gymnasium · Houston, TX |
| 8 | Sat Dec 9 | at #12Texas | L50-77 | 1-7 | .125 | - | LHN | Moody Center · Austin, TX |
| 9 | Sat Dec 16 | vsTBD | W107-72 | 2-7 | .222 | - | | Sharp Gymnasium · Houston, TX |
| 10 | Tue Dec 19 | at SMU | L53-89 | 2-8 | .200 | - | | Moody Coliseum · Dallas, TX |
| 11 | Fri Dec 22 | at Texas A&M | L52-79 | 2-9 | .182 | - | SEC Network | Reed Arena · College Station, TX |
| 12 | Sat Jan 6 | vs Nicholls | L94-98 (OT) | 2-10 | .167 | - | | Sharp Gymnasium · Houston, TX |
| 13 | Mon Jan 8 | at Texas A&M-CC | L59-81 | 2-11 | .154 | - | | American Bank Center · Corpus Christi, TX |
| 14 | Sat Jan 13 | at E Texas A&M | W69-65 | 3-11 | .214 | - | | The Field House · Commerce, TX |
| 15 | Mon Jan 15 | at N'Western St | L64-69 | 3-12 | .200 | - | | Prather Coliseum · Natchitoches, LA |
| 16 | Sat Jan 20 | vs Lamar | W78-77 | 4-12 | .250 | - | | Sharp Gymnasium · Houston, TX |
| 17 | Mon Jan 22 | vs New Orleans | W88-80 | 5-12 | .294 | - | | Sharp Gymnasium · Houston, TX |
| 18 | Sat Jan 27 | at Incarnate Word | L75-79 | 5-13 | .278 | - | | Alice P. McDermott Convocation Center · San Antonio, TX |
| 19 | Mon Jan 29 | vs SE Louisiana | L58-80 | 5-14 | .263 | - | | Sharp Gymnasium · Houston, TX |
| 20 | Sat Feb 3 | atNicholls | L73-83 | 5-15 | .250 | - | | David R. Stopher Gymnasium · Thibodaux, LA |
| 21 | Mon Feb 5 | atNew Orleans | L58-84 | 5-16 | .238 | - | | Lakefront Arena · New Orleans, LA |
| 22 | Sat Feb 10 | vsIncarnate Word | W86-83 | 6-16 | .273 | - | | Sharp Gymnasium · Houston, TX |
| 23 | Mon Feb 12 | vs McNeese | L54-105 | 6-17 | .261 | - | | Sharp Gymnasium · Houston, TX |
| 24 | Sat Feb 17 | atSE Louisiana | L78-81 | 6-18 | .250 | - | | University Center (LA) · Hammond, LA |
| 25 | Sat Feb 24 | vsN'Western St | L73-86 | 6-19 | .240 | - | | Sharp Gymnasium · Houston, TX |
| 26 | Mon Feb 26 | vsTexas A&M-CC | L79-91 | 6-20 | .231 | - | | Sharp Gymnasium · Houston, TX |
| 27 | Sat Mar 2 | vsE Texas A&M | L85-98 | 6-21 | .222 | - | | Sharp Gymnasium · Houston, TX |
| 28 | Mon Mar 4 | atMcNeese | L69-87 | 6-22 | .214 | - | | Legacy Center · Lake Charles, LA |
| 29 | Wed Mar 6 | atLamar | L68-78 | 6-23 | .207 | - | | Montagne Center · Beaumont, TX |
