| 1 | Mon Nov 4 | vs TBD | W86-59 | 1-0 | 1.000 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 2 | Fri Nov 8 | at #19Texas | L59-90 | 1-1 | .500 | - | ESPN+ | Moody Center · Austin, TX |
| 3 | Wed Nov 13 | at #14Creighton | L43-78 | 1-2 | .333 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 4 | Sat Nov 16 | vsTBD | W84-64 | 2-2 | .500 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 5 | Fri Nov 22 | vs Rice | L58-61 | 2-3 | .400 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 6 | Mon Nov 25 | vs E Michigan | L73-74 | 2-4 | .333 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 7 | Wed Nov 27 | vs N Arizona | L71-74 | 2-5 | .286 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 8 | Sat Nov 30 | at UTSA | L71-78 | 2-6 | .250 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 9 | Thu Dec 5 | vs E Texas A&M | W83-79 | 3-6 | .333 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 10 | Sat Dec 7 | vs N'Western St | L57-64 | 3-7 | .300 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 11 | Tue Dec 17 | at UL Monroe | W74-68 | 4-7 | .364 | - | ESPN+ | Fant-Ewing Coliseum · Monroe, LA |
| 12 | Fri Dec 20 | at #12Texas A&M | L45-77 | 4-8 | .333 | - | ESPN+ | Reed Arena · College Station, TX |
| 13 | Sun Dec 22 | at North Texas | L46-62 | 4-9 | .308 | - | ESPN+ | The Super Pit · Denton, TX |
| 14 | Sat Jan 4 | at Lamar | L61-63 | 4-10 | .286 | - | ESPN+ | Montagne Center · Beaumont, TX |
| 15 | Mon Jan 6 | at SF Austin | W83-73 | 5-10 | .333 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 16 | Sat Jan 11 | vs Incarnate Word | W81-76 | 6-10 | .375 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 17 | Mon Jan 13 | vs McNeese | L59-75 | 6-11 | .353 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 18 | Sat Jan 18 | vs UT Rio Grande | W66-57 | 7-11 | .389 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 19 | Mon Jan 20 | vs Texas A&M-CC | W76-72 | 8-11 | .421 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 20 | Sat Jan 25 | at New Orleans | W86-76 | 9-11 | .450 | - | ESPN+ | Lakefront Arena · New Orleans, LA |
| 21 | Mon Jan 27 | at SE Louisiana | W70-62 | 10-11 | .476 | - | ESPN+ | University Center (LA) · Hammond, LA |
| 22 | Sat Feb 1 | atIncarnate Word | L64-74 | 10-12 | .455 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 23 | Mon Feb 3 | at Nicholls | L67-75 | 10-13 | .435 | - | ESPN+ | David R. Stopher Gymnasium · Thibodaux, LA |
| 24 | Sat Feb 8 | vsNew Orleans | W81-68 | 11-13 | .458 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 25 | Mon Feb 10 | vsSE Louisiana | L60-69 | 11-14 | .440 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 26 | Sat Feb 15 | atUT Rio Grande | L52-76 | 11-15 | .423 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 27 | Mon Feb 17 | atTexas A&M-CC | L62-68 | 11-16 | .407 | - | ESPN+ | American Bank Center · Corpus Christi, TX |
