| 1 | Mon Nov 3 | vs TBD | W74-70 | - | 1-0 | 1.000 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 2 | Sat Nov 8 | atUC San Diego | L60-78 | - | 1-1 | .500 | - | ESPN+ | University Credit Union Center · Davis, CA |
| 3 | Thu Nov 13 | vsUL Monroe | W72-61 | - | 2-1 | .667 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 4 | Thu Nov 20 | vsTBD | W85-67 | - | 3-1 | .750 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 5 | Tue Nov 25 | atBellarmine | L69-74 | -2½ | 3-2 | .600 | - | | Knights Hall · Louisville, KY |
| 6 | Wed Nov 26 | atThe Citadel | W72-65 | -1½ | 4-2 | .667 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 7 | Sat Nov 29 | atGeorgia So | L62-80 | +7½ | 4-3 | .571 | - | ESPN+ | W.S. Hanner Fieldhouse · Statesboro, GA |
| 8 | Tue Dec 2 | atNorth Texas | L75-77 | +11½ | 4-4 | .500 | - | ESPN+ | The Super Pit · Denton, TX |
| 9 | Sat Dec 6 | atNew Orleans | W85-76 | +4½ | 5-4 | .556 | - | ESPN+ | Lakefront Arena · New Orleans, LA |
| 10 | Sat Dec 13 | vsSE Louisiana | L71-74 (OT) | -2½ | 5-5 | .500 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 11 | Mon Dec 15 | vsMcNeese | L68-78 | +14½ | 5-6 | .455 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 12 | Wed Dec 17 | atNicholls | L64-79 | +3½ | 5-7 | .417 | - | ESPN+ | David R. Stopher Gymnasium · Thibodaux, LA |
| 13 | Mon Dec 29 | at3Iowa State | L61-89 | +35½ | 5-8 | .385 | - | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 14 | Sat Jan 3 | atIncarnate Word | L56-73 | +6½ | 5-9 | .357 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 15 | Mon Jan 5 | vsTexas A&M-CC | L65-81 | +3½ | 5-10 | .333 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 16 | Sat Jan 10 | atSF Austin | L67-85 | +12½ | 5-11 | .313 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 17 | Mon Jan 12 | atLamar | L56-64 | +8½ | 5-12 | .294 | - | ESPN+ | Montagne Center · Beaumont, TX |
| 18 | Sat Jan 17 | vsE Texas A&M | W81-70 | -2½ | 6-12 | .333 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 19 | Mon Jan 19 | vsN'Western St | W82-80 | -2½ | 7-12 | .368 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 20 | Sat Jan 24 | vsUT Rio Grande | L51-68 | +2½ | 7-13 | .350 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 21 | Tue Jan 27 | vsIncarnate Word | W81-75 | +1½ | 8-13 | .381 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 22 | Sat Jan 31 | atTexas A&M-CC | L71-73 | +7½ | 8-14 | .364 | - | ESPN+ | American Bank Center · Corpus Christi, TX |
| 23 | Mon Feb 2 | atUT Rio Grande | L57-74 | +9½ | 8-15 | .348 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 24 | Sat Feb 7 | atSE Louisiana | L47-55 | +4½ | 8-16 | .333 | - | ESPN+ | University Center (LA) · Hammond, LA |
| 25 | Mon Feb 9 | atMcNeese | L69-73 | +21½ | 8-17 | .320 | - | ESPN+ | Legacy Center · Lake Charles, LA |
| 26 | Sat Feb 14 | vsNew Orleans | W61-60 | -1½ | 9-17 | .346 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 27 | Mon Feb 16 | vsNicholls | W72-68 | -1½ | 10-17 | .370 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 28 | Sat Feb 21 | atN'Western St | L53-71 | +2½ | 10-18 | .357 | - | ESPN+ | Prather Coliseum · Natchitoches, LA |
| 29 | Mon Feb 23 | atE Texas A&M | W69-68 | +2½ | 11-18 | .379 | - | ESPN+ | The Field House · Commerce, TX |
| 30 | Sat Feb 28 | vsSF Austin | L56-77 | +8½ | 11-19 | .367 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 31 | Mon Mar 2 | vsLamar | W75-53 | +2½ | 12-19 | .387 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 32 | Sun Mar 8 | atNew Orleans | L60-73 | +5½ | 12-20 | .375 | - | ESPN+ | Lakefront Arena · New Orleans, LA |
