| 1 | Wed Nov 25 | at Alabama | L57-81 | 0-1 | .000 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 2 | Fri Nov 27 | atFAU | W60-50 | 1-1 | .500 | - | | FAU Arena · Boca Raton, FL |
| 3 | Sun Nov 29 | atSouth Alabama | W77-73 | 2-1 | .667 | - | | Mitchell Center · Mobile, AL |
| 4 | Mon Nov 30 | vsTBD | W85-66 | 3-1 | .750 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 5 | Fri Dec 4 | atFIU | L70-74 | 3-2 | .600 | - | | Ocean Bank Convocation Center · Miami, FL |
| 7 | Sun Dec 13 | atTennessee Tech | W73-67 | 4-2 | .667 | - | | Hooper Eblen Center · Cookeville, TN |
| 8 | Wed Dec 16 | vsTennessee Tech | W74-50 | 5-2 | .714 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 10 | Sun Dec 27 | vsTBD | W104-45 | 6-2 | .750 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 11 | Wed Dec 30 | vsUT Martin | W80-70 | 7-2 | .778 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 13 | Thu Jan 7 | atE Kentucky | L66-69 (OT) | 7-3 | .700 | - | | McBrayer Arena · Richmond, KY |
| 14 | Sat Jan 9 | atMorehead St | L55-56 | 7-4 | .636 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 15 | Thu Jan 14 | vsTennessee St | W65-64 | 8-4 | .667 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 16 | Sat Jan 16 | vsBelmont | L91-98 | 8-5 | .615 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 18 | Thu Jan 21 | atMurray St | W85-82 | 9-5 | .643 | - | | CFSB Center · Murray, KY |
| 19 | Sat Jan 23 | atAustin Peay | W76-70 | 10-5 | .667 | - | | Winfield Dunn Center · Clarksville, TN |
| 20 | Thu Jan 28 | vsMorehead St | L66-85 | 10-6 | .625 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 21 | Sat Jan 30 | vsE Kentucky | PPD | 18-9 | .667 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 22 | Tue Feb 2 | vsE Kentucky | L82-86 (OT) | 10-7 | .588 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 23 | Thu Feb 4 | atUT Martin | W82-70 | 11-7 | .611 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 24 | Sat Feb 6 | atSE Missouri St | W66-54 | 12-7 | .632 | - | | Show Me Center · Cape Girardeau, MO |
| 25 | Thu Feb 11 | vsE Illinois | W76-64 | 13-7 | .650 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 26 | Sat Feb 13 | vsSIUE | W80-60 | 14-7 | .667 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 27 | Thu Feb 18 | atBelmont | L59-63 | 14-8 | .636 | - | | Curb Event Center Arena · Nashville, TN |
| 28 | Sat Feb 20 | atTennessee St | W77-76 | 15-8 | .652 | - | | Gentry Center · Nashville, TN |
| 29 | Thu Feb 25 | vsMurray St | W87-74 | 16-8 | .667 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 30 | Sat Feb 27 | vsAustin Peay | W75-67 | 17-8 | .680 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 31 | Thu Mar 4 | vsMurray St | W68-65 (OT) | 18-8 | .692 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 32 | Fri Mar 5 | atBelmont | L69-72 | 18-9 | .667 | - | ESPNU | Curb Event Center Arena · Nashville, TN |
