| 1 | Wed Nov 5 | at Mississippi St | L62-86 | 0-1 | .000 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 2 | Fri Nov 7 | vsTBD | W90-84 | 1-1 | .500 | - | ESPN+ | Flowers Hall · Florence, AL |
| 3 | Tue Nov 11 | vsN'Western St | W87-83 (OT) | 2-1 | .667 | - | ESPN+ | Flowers Hall · Florence, AL |
| 4 | Sat Nov 15 | vsETSU | L74-78 | 2-2 | .500 | - | ESPN+ | Flowers Hall · Florence, AL |
| 5 | Mon Nov 17 | atClemson | L61-81 | 2-3 | .400 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 6 | Sat Nov 22 | atChattanooga | L57-71 | 2-4 | .333 | - | ESPN+ | McKenzie Arena · Chattanooga, TN |
| 7 | Tue Nov 25 | vsTBD | W92-60 | 3-4 | .429 | - | ESPN+ | Flowers Hall · Florence, AL |
| 8 | Mon Dec 1 | atJ'Ville St | W73-66 | 4-4 | .500 | - | ESPN+ | Pete Mathews Coliseum · Jacksonville, AL |
| 9 | Wed Dec 3 | atSan Francisco | W65-63 | 5-4 | .556 | - | ESPN+ | War Memorial at the Sobrato Center · San Francisco, CA |
| 10 | Mon Dec 15 | atAlabama A&M | L60-68 | 5-5 | .500 | - | | T.M. Elmore Gymnasium · Normal, AL |
| 11 | Fri Dec 19 | atLMU | L57-91 | 5-6 | .455 | - | ESPN+ | Gersten Pavilion · Los Angeles, CA |
| 12 | Thu Jan 1 | vsStetson | L67-70 | 5-7 | .417 | - | ESPN+ | Flowers Hall · Florence, AL |
| 13 | Sat Jan 3 | vsFGCU | L55-72 | 5-8 | .385 | - | ESPN+ | Flowers Hall · Florence, AL |
| 14 | Thu Jan 8 | atE Kentucky | L80-88 | 5-9 | .357 | - | ESPN+ | McBrayer Arena · Richmond, KY |
| 15 | Sat Jan 10 | atBellarmine | W82-73 | 6-9 | .400 | - | ESPN+ | Knights Hall · Louisville, KY |
| 16 | Thu Jan 15 | vsNorth Florida | L91-105 | 6-10 | .375 | - | ESPN+ | Flowers Hall · Florence, AL |
| 17 | Sat Jan 17 | vsJacksonville | L68-90 | 6-11 | .353 | - | ESPN+ | Flowers Hall · Florence, AL |
| 18 | Wed Jan 21 | atQueens | L62-87 | 6-12 | .333 | - | ESPN+ | Curry Arena · Charlotte, NC |
| 19 | Thu Jan 29 | atFGCU | L64-72 | 6-13 | .316 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 20 | Sat Jan 31 | atStetson | W68-66 | 7-13 | .350 | - | ESPN+ | Edmunds Center · Deland, FL |
| 21 | Wed Feb 4 | atC Arkansas | L60-81 | 7-14 | .333 | - | ESPN+ | Farris Center · Conway, AR |
| 22 | Sat Feb 7 | atAustin Peay | L62-91 | 7-15 | .318 | - | ESPN+ | Winfield Dunn Center · Clarksville, TN |
| 23 | Mon Feb 9 | vsC Arkansas | L65-72 | 7-16 | .304 | - | ESPN+ | Flowers Hall · Florence, AL |
| 24 | Wed Feb 11 | vsW Georgia | L73-82 | 7-17 | .292 | - | ESPN+ | Flowers Hall · Florence, AL |
| 25 | Sun Feb 15 | vsE Kentucky | W84-78 (OT) | 8-17 | .320 | - | ESPNU | Flowers Hall · Florence, AL |
| 26 | Wed Feb 18 | vsQueens | L78-85 | 8-18 | .308 | - | ESPN+ | Flowers Hall · Florence, AL |
| 27 | Sat Feb 21 | atLipscomb | L51-73 | 8-19 | .296 | - | ESPN+ | Allen Arena · Nashville, TN |
| 28 | Wed Feb 25 | vsBellarmine | W73-68 | 9-19 | .321 | - | ESPN+ | Flowers Hall · Florence, AL |
| 29 | Sat Feb 28 | atW Georgia | L63-75 | 9-20 | .310 | - | ESPN+ | The Coliseum · Carrollton, GA |
