| 1 | Mon Nov 4 | vs TBD | W111-90 | 1-0 | 1.000 | - | | William Nicks Building · Prairie View, TX |
| 2 | Thu Nov 7 | at DePaul | L59-92 | 1-1 | .500 | - | FS1 | Wintrust Arena · Chicago, IL |
| 3 | Tue Nov 12 | at Incarnate Word | L81-84 | 1-2 | .333 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 4 | Mon Nov 18 | at SMU | L69-110 | 1-3 | .250 | - | ESPN+ | Moody Coliseum · Dallas, TX |
| 5 | Wed Nov 20 | at Fresno St | L83-94 | 1-4 | .200 | - | | Save Mart Center · Fresno, CA |
| 6 | Sat Nov 23 | at N Colorado | L98-114 | 1-5 | .167 | - | ESPN+ | Bank of Colorado Arena · Greeley, CO |
| 7 | Sat Nov 30 | at Texas A&M-CC | L74-109 | 1-6 | .143 | - | ESPN+ | American Bank Center · Corpus Christi, TX |
| 8 | Fri Dec 6 | at UAB | L66-95 | 1-7 | .125 | - | ESPN+ | Bartow Arena · Birmingham, AL |
| 9 | Sun Dec 8 | at Mississippi St | L84-91 | 1-8 | .111 | - | ESPN+ | Humphrey Coliseum · Starkville, MS |
| 10 | Sat Dec 14 | at LMU | L75-76 | 1-9 | .100 | - | ESPN+ | Gersten Pavilion · Los Angeles, CA |
| 11 | Tue Dec 17 | at #18UCLA | L75-111 | 1-10 | .091 | - | BTN | Pauley Pavilion · Los Angeles, CA |
| 12 | Sun Dec 22 | at Rice | L46-64 | 1-11 | .083 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 13 | Sun Dec 29 | at #12Oklahoma | L67-89 | 1-12 | .077 | - | ESPN+ | Lloyd Noble Center · Norman, OK |
| 14 | Sat Jan 4 | vs Grambling | W73-55 | 2-12 | .143 | - | | William Nicks Building · Prairie View, TX |
| 15 | Mon Jan 6 | vs Southern | L80-84 | 2-13 | .133 | - | | William Nicks Building · Prairie View, TX |
| 16 | Sat Jan 11 | at Miss Valley St | W74-65 | 3-13 | .188 | - | | Robert W. Harrison HPER Complex · Itta Bena, MS |
| 17 | Mon Jan 13 | at AR-Pine Bluff | W75-64 | 4-13 | .235 | - | | H. O. Clemmons Arena · Pine Bluff, AR |
| 18 | Sat Jan 18 | vs Jackson St | L70-79 | 4-14 | .222 | - | | William Nicks Building · Prairie View, TX |
| 19 | Mon Jan 20 | vs Alcorn St | L70-78 | 4-15 | .211 | - | | William Nicks Building · Prairie View, TX |
| 20 | Sat Jan 25 | at Alabama St | L63-66 | 4-16 | .200 | - | | Dunn-Oliver Acadome · Montgomery, AL |
| 21 | Mon Jan 27 | at Alabama A&M | L82-98 | 4-17 | .190 | - | | T.M. Elmore Gymnasium · Normal, AL |
| 22 | Sat Feb 1 | at Texas So | L63-79 | 4-18 | .182 | - | | H&PE Arena · Houston, TX |
| 23 | Sat Feb 8 | vs Bethune | L82-85 | 4-19 | .174 | - | | William Nicks Building · Prairie View, TX |
| 24 | Mon Feb 10 | vs FAMU | L67-78 | 4-20 | .167 | - | | William Nicks Building · Prairie View, TX |
| 25 | Sat Feb 15 | atSouthern | L60-72 | 4-21 | .160 | - | | F. G. Clark Activity Center · Baton Rouge, LA |
| 26 | Mon Feb 17 | atGrambling | L48-70 | 4-22 | .154 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
