| 1 | Mon Nov 3 | vs TBD | 1:00 PM | 0-0 | .000 | - | | William Nicks Building · Prairie View, TX |
| 2 | Wed Nov 5 | vsTBD | 7:00 PM | 0-0 | .000 | - | | William Nicks Building · Prairie View, TX |
| 3 | Sat Nov 8 | atWichita St | 7:00 PM | 19-15 | .559 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 4 | Wed Nov 12 | atOklahoma St | 8:00 PM | 17-18 | .486 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 5 | Mon Nov 17 | atMissouri | 8:00 PM | 22-12 | .647 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 6 | Sat Nov 22 | vsUT Martin | 5:00 PM | 14-19 | .424 | - | | William Nicks Building · Prairie View, TX |
| 7 | Sun Nov 30 | atNorth Texas | 4:00 PM | 27-9 | .750 | - | ESPN+ | The Super Pit · Denton, TX |
| 8 | Sat Dec 6 | vsTBD | 4:00 PM | 0-0 | .000 | - | | William Nicks Building · Prairie View, TX |
| 9 | Sat Dec 13 | atSouth Dakota | 2:00 PM | 19-14 | .576 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 10 | Sat Dec 20 | vsTBD | 2:00 PM | 0-0 | .000 | - | | William Nicks Building · Prairie View, TX |
| 11 | Mon Dec 22 | atLSU | 7:00 PM | 14-18 | .438 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 12 | Mon Dec 29 | atTexas A&M | TBD | 23-11 | .676 | - | | Reed Arena · College Station, TX |
| 13 | Sat Jan 3 | atGrambling | TBD | 12-22 | .353 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 14 | Mon Jan 5 | atSouthern | 7:30 PM | 20-12 | .625 | - | | F. G. Clark Activity Center · Baton Rouge, LA |
| 15 | Sat Jan 10 | vsMiss Valley St | 5:30 PM | 3-28 | .097 | - | | William Nicks Building · Prairie View, TX |
| 16 | Mon Jan 12 | vsAR-Pine Bluff | 7:00 PM | 6-25 | .194 | - | | William Nicks Building · Prairie View, TX |
| 17 | Sat Jan 17 | atJackson St | 4:00 PM | 16-18 | .471 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 18 | Mon Jan 19 | atAlcorn St | TBD | 11-21 | .344 | - | | Davey L. Whitney Complex · Lorman, MS |
| 19 | Sat Jan 24 | vsAlabama St | 5:30 PM | 20-16 | .556 | - | | William Nicks Building · Prairie View, TX |
| 20 | Mon Jan 26 | vsAlabama A&M | 7:00 PM | 10-22 | .313 | - | | William Nicks Building · Prairie View, TX |
| 21 | Sat Jan 31 | vsTexas So | 5:30 PM | 15-17 | .469 | - | | William Nicks Building · Prairie View, TX |
| 22 | Sat Feb 7 | atBethune | TBD | 17-16 | .515 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
| 23 | Mon Feb 9 | atFAMU | TBD | 14-17 | .452 | - | | Al Lawson Center · Tallahassee, FL |
| 24 | Sat Feb 14 | vsSouthern | 5:30 PM | 20-12 | .625 | - | | William Nicks Building · Prairie View, TX |
| 25 | Mon Feb 16 | vsGrambling | 7:00 PM | 12-22 | .353 | - | | William Nicks Building · Prairie View, TX |
| 26 | Thu Feb 19 | atMiss Valley St | 8:30 PM | 3-28 | .097 | - | | Robert W. Harrison HPER Complex · Itta Bena, MS |
| 27 | Sat Feb 21 | atAR-Pine Bluff | TBD | 6-25 | .194 | - | | H. O. Clemmons Arena · Pine Bluff, AR |
| 28 | Thu Feb 26 | vsJackson St | 9:30 PM | 16-18 | .471 | - | | William Nicks Building · Prairie View, TX |
| 29 | Sat Feb 28 | vsAlcorn St | 5:30 PM | 11-21 | .344 | - | | William Nicks Building · Prairie View, TX |
| 30 | Thu Mar 5 | atTexas So | TBD | 15-17 | .469 | - | | H&PE Arena · Houston, TX |
