| 1 | Mon Nov 7 | vs TBD | W94-79 | 1-0 | 1.000 | - | | William Nicks Building · Prairie View, TX |
| 2 | Wed Nov 9 | vsTBD | W95-68 | 2-0 | 1.000 | - | | William Nicks Building · Prairie View, TX |
| 3 | Tue Nov 15 | vs Washington St | W70-59 | 3-0 | 1.000 | - | | William Nicks Building · Prairie View, TX |
| 4 | Sun Nov 20 | at UT Martin | L79-80 | 3-1 | .750 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 5 | Tue Nov 22 | at UTSA | L75-82 | 3-2 | .600 | - | | UTSA Convocation Center · San Antonio, TX |
| 6 | Fri Nov 25 | at Arkansas St | W67-59 | 4-2 | .667 | - | | First National Bank Arena · Jonesboro, AR |
| 7 | Sun Nov 27 | at Oklahoma St | L53-78 | 4-3 | .571 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 8 | Wed Nov 30 | at Rice | L62-70 | 4-4 | .500 | - | | Tudor Fieldhouse · Houston, TX |
| 9 | Sun Dec 11 | at Northwestern | L51-61 | 4-5 | .444 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 10 | Tue Dec 13 | at UIC | L61-70 | 4-6 | .400 | - | | Credit Union 1 Arena · Chicago, IL |
| 11 | Sat Dec 17 | vs Montana | L76-81 | 4-7 | .364 | - | | William Nicks Building · Prairie View, TX |
| 12 | Tue Dec 20 | at New Mexico | L63-94 | 4-8 | .333 | - | | The Pit · Albuquerque, NM |
| 13 | Fri Dec 30 | at Texas A&M | L66-86 | 4-9 | .308 | - | | Reed Arena · College Station, TX |
| 14 | Mon Jan 2 | vs Grambling | W61-60 | 5-9 | .357 | - | | William Nicks Building · Prairie View, TX |
| 15 | Wed Jan 4 | vs Southern | L62-66 | 5-10 | .333 | - | | William Nicks Building · Prairie View, TX |
| 16 | Sat Jan 7 | at Miss Valley St | W67-60 | 6-10 | .375 | - | | Robert W. Harrison HPER Complex · Itta Bena, MS |
| 17 | Mon Jan 9 | at AR-Pine Bluff | L55-63 | 6-11 | .353 | - | | H. O. Clemmons Arena · Pine Bluff, AR |
| 18 | Sat Jan 14 | vs Jackson St | W59-50 | 7-11 | .389 | - | | William Nicks Building · Prairie View, TX |
| 19 | Mon Jan 16 | vs Alcorn St | L68-77 (OT) | 7-12 | .368 | - | ESPNU | William Nicks Building · Prairie View, TX |
| 20 | Sat Jan 21 | at Alabama St | L55-56 (OT) | 7-13 | .350 | - | | Dunn-Oliver Acadome · Montgomery, AL |
| 21 | Mon Jan 23 | at Alabama A&M | L59-67 | 7-14 | .333 | - | | T.M. Elmore Gymnasium · Normal, AL |
| 22 | Sat Jan 28 | at Texas So | W89-74 (2OT) | 8-14 | .364 | - | | H&PE Arena · Houston, TX |
| 23 | Sat Feb 4 | vs Bethune | L58-60 | 8-15 | .348 | - | | William Nicks Building · Prairie View, TX |
| 24 | Mon Feb 6 | vs FAMU | W75-45 | 9-15 | .375 | - | | William Nicks Building · Prairie View, TX |
| 25 | Sat Feb 11 | atSouthern | L65-79 | 9-16 | .360 | - | | F. G. Clark Activity Center · Baton Rouge, LA |
| 26 | Mon Feb 13 | atGrambling | L64-68 | 9-17 | .346 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 27 | Sat Feb 18 | vsAR-Pine Bluff | W82-71 | 10-17 | .370 | - | | William Nicks Building · Prairie View, TX |
| 28 | Mon Feb 20 | vsMiss Valley St | W67-65 | 11-17 | .393 | - | | William Nicks Building · Prairie View, TX |
| 29 | Sat Feb 25 | atAlcorn St | W75-71 | 12-17 | .414 | - | | Davey L. Whitney Complex · Lorman, MS |
| 30 | Mon Feb 27 | atJackson St | L57-61 | 12-18 | .400 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 31 | Sat Mar 4 | vsTexas So | W78-74 | 13-18 | .419 | - | | William Nicks Building · Prairie View, TX |
| 32 | Thu Mar 9 | atJackson St | L60-62 (OT) | 13-19 | .406 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
