| 1 | Mon Nov 6 | at UTSA | L68-78 (OT) | - | 0-1 | .000 | - | | UTSA Convocation Center · San Antonio, TX |
| 2 | Wed Nov 8 | atSMU | L53-90 | - | 0-2 | .000 | - | | Moody Coliseum · Dallas, TX |
| 3 | Sun Nov 12 | vsTBD | W94-59 | - | 1-2 | .333 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 4 | Fri Nov 17 | vsSouthern | W88-80 (OT) | - | 2-2 | .500 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 5 | Tue Nov 21 | atValparaiso | L66-73 | - | 2-3 | .400 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 6 | Fri Nov 24 | atIllinois | L52-84 | - | 2-4 | .333 | - | Big Ten Network | State Farm Center · Champaign, IL |
| 7 | Mon Nov 27 | atWisconsin | L49-71 | - | 2-5 | .286 | - | Big Ten Network | Kohl Center · Madison, WI |
| 8 | Thu Nov 30 | vsTBD | W92-40 | - | 3-5 | .375 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 9 | Sun Dec 3 | vsSouth Dakota | L68-70 | - | 3-6 | .333 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 10 | Wed Dec 6 | vsTBD | W80-58 | - | 4-6 | .400 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 11 | Sat Dec 9 | atGreen Bay | W68-59 | - | 5-6 | .455 | - | | Resch Center · Ashwaubenon, WI |
| 12 | Mon Dec 18 | vsTBD | W92-56 | - | 6-6 | .500 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 13 | Wed Dec 20 | atC Arkansas | W65-54 | - | 7-6 | .538 | - | | Farris Center · Conway, AR |
| 14 | Sun Dec 31 | atSIUE | W78-70 | - | 8-6 | .571 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 15 | Thu Jan 4 | vsSE Missouri St | W68-61 | - | 9-6 | .600 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 16 | Sat Jan 6 | vsLindenwood | W68-57 | - | 10-6 | .625 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 17 | Thu Jan 11 | atUT Martin | W73-64 | - | 11-6 | .647 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 18 | Sat Jan 13 | atE Illinois | W63-60 | - | 12-6 | .667 | - | | Lantz Arena · Charleston, IL |
| 19 | Sat Jan 20 | vsTennessee St | L57-58 | - | 12-7 | .632 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 20 | Thu Jan 25 | atSo Indiana | W73-68 | - | 13-7 | .650 | - | ESPNU | Screaming Eagles Arena · Evansville, IN |
| 21 | Sat Jan 27 | atMorehead St | L50-64 | - | 13-8 | .619 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 22 | Thu Feb 1 | atLindenwood | W79-71 | - | 14-8 | .636 | - | | placeholder · sf, ca |
| 23 | Sat Feb 3 | atSE Missouri St | W76-55 | - | 15-8 | .652 | - | | Show Me Center · Cape Girardeau, MO |
| 24 | Thu Feb 8 | vsLittle Rock | L60-63 | - | 15-9 | .625 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 25 | Sat Feb 10 | vsUT Martin | L59-62 | - | 15-10 | .600 | - | ESPNU | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 26 | Thu Feb 15 | atTennessee Tech | W62-55 | - | 16-10 | .615 | - | | Hooper Eblen Center · Cookeville, TN |
| 27 | Sat Feb 17 | atTennessee St | W68-61 | - | 17-10 | .630 | - | | Gentry Center · Nashville, TN |
| 28 | Thu Feb 22 | vsMorehead St | L57-78 | - | 17-11 | .607 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 29 | Sat Feb 24 | vsSo Indiana | W82-76 | - | 18-11 | .621 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 30 | Thu Feb 29 | vsE Illinois | W70-66 | - | 19-11 | .633 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 31 | Sat Mar 2 | vsSIUE | W76-65 | - | 20-11 | .645 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 32 | Thu Mar 7 | vsTennessee St | W61-59 | - | 21-11 | .656 | - | | Ford Center · Evansville, IN |
| 33 | Fri Mar 8 | atLittle Rock | L57-82 | - | 21-12 | .636 | - | ESPNU | Ford Center · Evansville, IN |
