| 1 | Fri Jul 24 | vs Twins | L5-10 | 0-1 | .000 | Guaranteed Rate Field · Chicago, IL |
| 2 | Sat Jul 25 | vsTwins | W10-3 | 1-1 | .500 | Guaranteed Rate Field · Chicago, IL |
| 3 | Sun Jul 26 | vsTwins | L2-14 | 1-2 | .333 | Guaranteed Rate Field · Chicago, IL |
| 4 | Tue Jul 28 | at Guardians | L3-4 | 1-3 | .250 | Progressive Field · Cleveland, OH |
| 5 | Tue Jul 28 | atGuardians | L3-5 | 1-4 | .200 | Progressive Field · Cleveland, OH |
| 6 | Wed Jul 29 | atGuardians | W4-0 | 2-4 | .333 | Progressive Field · Cleveland, OH |
| 7 | Fri Jul 31 | at Royals | W3-2 | 3-4 | .429 | Kauffman Stadium · Kansas City, MO |
| 8 | Sat Aug 1 | atRoyals | W11-5 | 4-4 | .500 | Kauffman Stadium · Kansas City, MO |
| 9 | Sun Aug 2 | atRoyals | W9-2 | 5-4 | .556 | Kauffman Stadium · Kansas City, MO |
| 10 | Mon Aug 3 | at Brewers | W6-4 | 6-4 | .600 | American Family Field · Milwaukee, WI |
| 11 | Tue Aug 4 | atBrewers | W3-2 | 7-4 | .636 | American Family Field · Milwaukee, WI |
| 12 | Wed Aug 5 | vsBrewers | L0-1 | 7-5 | .583 | Guaranteed Rate Field · Chicago, IL |
| 13 | Thu Aug 6 | vsBrewers | L3-8 | 7-6 | .538 | Guaranteed Rate Field · Chicago, IL |
| 14 | Fri Aug 7 | vsGuardians | W2-0 | 8-6 | .571 | Guaranteed Rate Field · Chicago, IL |
| 15 | Sat Aug 8 | vsGuardians | L1-7 | 8-7 | .533 | Guaranteed Rate Field · Chicago, IL |
| 16 | Sun Aug 9 | vsGuardians | L4-5 (10) | 8-8 | .500 | Guaranteed Rate Field · Chicago, IL |
| 17 | Mon Aug 10 | at Tigers | L1-5 | 8-9 | .471 | Comerica Park · Detroit, MI |
| 18 | Tue Aug 11 | atTigers | W8-4 | 9-9 | .500 | Comerica Park · Detroit, MI |
| 19 | Wed Aug 12 | atTigers | W7-5 | 10-9 | .526 | Comerica Park · Detroit, MI |
| 20 | Sat Aug 15 | vs Cardinals | L1-5 | 10-10 | .500 | Guaranteed Rate Field · Chicago, IL |
| 21 | Sat Aug 15 | vsCardinals | L3-6 | 10-11 | .476 | Guaranteed Rate Field · Chicago, IL |
| 22 | Sun Aug 16 | vsCardinals | W7-2 | 11-11 | .500 | Guaranteed Rate Field · Chicago, IL |
| 23 | Mon Aug 17 | vsTigers | W7-2 | 12-11 | .522 | Guaranteed Rate Field · Chicago, IL |
| 24 | Tue Aug 18 | vsTigers | W10-4 | 13-11 | .542 | Guaranteed Rate Field · Chicago, IL |
| 25 | Wed Aug 19 | vsTigers | W5-3 | 14-11 | .560 | Guaranteed Rate Field · Chicago, IL |
| 26 | Thu Aug 20 | vsTigers | W9-0 | 15-11 | .577 | Guaranteed Rate Field · Chicago, IL |
| 27 | Fri Aug 21 | at Cubs | W10-1 | 16-11 | .593 | Wrigley Field · Chicago, IL |
| 28 | Sat Aug 22 | atCubs | W7-4 | 17-11 | .607 | Wrigley Field · Chicago, IL |
| 29 | Sun Aug 23 | atCubs | L1-2 | 17-12 | .586 | Wrigley Field · Chicago, IL |
| 30 | Tue Aug 25 | vs Pirates | W4-0 | 18-12 | .600 | Guaranteed Rate Field · Chicago, IL |
| 31 | Wed Aug 26 | vsPirates | W10-3 | 19-12 | .613 | Guaranteed Rate Field · Chicago, IL |
| 32 | Fri Aug 28 | vsRoyals | W6-5 | 20-12 | .625 | Guaranteed Rate Field · Chicago, IL |
| 33 | Sat Aug 29 | vsRoyals | L6-9 | 20-13 | .606 | Guaranteed Rate Field · Chicago, IL |
| 34 | Sun Aug 30 | vsRoyals | W5-2 (10) | 21-13 | .618 | Guaranteed Rate Field · Chicago, IL |
| 35 | Mon Aug 31 | atTwins | W8-5 | 22-13 | .629 | Target Field · Minneapolis, MN |
| 36 | Tue Sep 1 | atTwins | L2-3 | 22-14 | .611 | Target Field · Minneapolis, MN |
| 37 | Wed Sep 2 | atTwins | L1-8 | 22-15 | .595 | Target Field · Minneapolis, MN |
| 38 | Thu Sep 3 | atRoyals | W11-6 | 23-15 | .605 | Kauffman Stadium · Kansas City, MO |
| 39 | Fri Sep 4 | atRoyals | W7-4 | 24-15 | .615 | Kauffman Stadium · Kansas City, MO |
| 40 | Sat Sep 5 | atRoyals | W5-3 | 25-15 | .625 | Kauffman Stadium · Kansas City, MO |
| 41 | Sun Sep 6 | atRoyals | W8-2 | 26-15 | .634 | Kauffman Stadium · Kansas City, MO |
| 42 | Tue Sep 8 | atPirates | L4-5 | 26-16 | .619 | PNC Park · Pittsburgh, PA |
| 43 | Wed Sep 9 | atPirates | W8-1 | 27-16 | .628 | PNC Park · Pittsburgh, PA |
| 44 | Fri Sep 11 | vsTigers | W4-3 | 28-16 | .636 | Guaranteed Rate Field · Chicago, IL |
| 45 | Sat Sep 12 | vsTigers | W14-0 | 29-16 | .644 | Guaranteed Rate Field · Chicago, IL |
| 46 | Sun Sep 13 | vsTigers | W5-2 | 30-16 | .652 | Guaranteed Rate Field · Chicago, IL |
| 47 | Mon Sep 14 | vsTwins | W3-1 | 31-16 | .660 | Guaranteed Rate Field · Chicago, IL |
| 48 | Tue Sep 15 | vsTwins | W6-2 | 32-16 | .667 | Guaranteed Rate Field · Chicago, IL |
| 49 | Wed Sep 16 | vsTwins | L1-5 | 32-17 | .653 | Guaranteed Rate Field · Chicago, IL |
| 50 | Thu Sep 17 | vsTwins | W4-3 | 33-17 | .660 | Guaranteed Rate Field · Chicago, IL |
| 51 | Fri Sep 18 | at Reds | L1-7 | 33-18 | .647 | Great American Ball Park · Cincinnati, OH |
| 52 | Sat Sep 19 | atReds | W5-0 | 34-18 | .654 | Great American Ball Park · Cincinnati, OH |
| 53 | Sun Sep 20 | atReds | L3-7 | 34-19 | .642 | Great American Ball Park · Cincinnati, OH |
| 54 | Mon Sep 21 | atGuardians | L4-7 | 34-20 | .630 | Progressive Field · Cleveland, OH |
| 55 | Tue Sep 22 | atGuardians | L3-5 (10) | 34-21 | .618 | Progressive Field · Cleveland, OH |
| 56 | Wed Sep 23 | atGuardians | L2-3 | 34-22 | .607 | Progressive Field · Cleveland, OH |
| 57 | Thu Sep 24 | atGuardians | L4-5 | 34-23 | .596 | Progressive Field · Cleveland, OH |
| 58 | Fri Sep 25 | vsCubs | L0-10 | 34-24 | .586 | Guaranteed Rate Field · Chicago, IL |
| 59 | Sat Sep 26 | vsCubs | W9-5 | 35-24 | .593 | Guaranteed Rate Field · Chicago, IL |
| 60 | Sun Sep 27 | vsCubs | L8-10 | 35-25 | .583 | Guaranteed Rate Field · Chicago, IL |
| 61 | Tue Sep 29 | at Athletics | W4-1 | 1-0 | 1.000 | RingCentral Coliseum · Oakland, CA |
| 62 | Wed Sep 30 | atAthletics | L3-5 | 1-1 | .500 | RingCentral Coliseum · Oakland, CA |
| 63 | Thu Oct 1 | atAthletics | L4-6 | 1-2 | .333 | RingCentral Coliseum · Oakland, CA |
