| 1 | Thu Mar 29 | at Royals | W14-7 | 1-0 | 1.000 | Kauffman Stadium · Kansas City, MO |
| 2 | Sat Mar 31 | at Royals | W4-3 | 2-0 | 1.000 | Kauffman Stadium · Kansas City, MO |
| 3 | Mon Apr 2 | at Blue Jays | L2-4 | 2-1 | .667 | Rogers Centre · Toronto, ON |
| 4 | Tue Apr 3 | at Blue Jays | L5-14 | 2-2 | .500 | Rogers Centre · Toronto, ON |
| 5 | Wed Apr 4 | at Blue Jays | W4-3 | 3-2 | .600 | Rogers Centre · Toronto, ON |
| 6 | Thu Apr 5 | vs Tigers | L7-9 (10) | 3-3 | .500 | Guaranteed Rate Field · Chicago, IL |
| 7 | Sat Apr 7 | vs Tigers | L1-6 | 3-4 | .429 | Guaranteed Rate Field · Chicago, IL |
| 8 | Sun Apr 8 | vs Tigers | L0-1 | 3-5 | .375 | Guaranteed Rate Field · Chicago, IL |
| 9 | Mon Apr 9 | vs Rays | L4-5 | 3-6 | .333 | Guaranteed Rate Field · Chicago, IL |
| 10 | Tue Apr 10 | vs Rays | L5-6 | 3-7 | .300 | Guaranteed Rate Field · Chicago, IL |
| 11 | Wed Apr 11 | vs Rays | W2-1 | 4-7 | .364 | Guaranteed Rate Field · Chicago, IL |
| 12 | Thu Apr 12 | at Twins | L0-4 | 4-8 | .333 | Target Field · Minneapolis, MN |
| 13 | Mon Apr 16 | at Athletics | L1-8 | 4-9 | .308 | RingCentral Coliseum · Oakland, CA |
| 14 | Tue Apr 17 | at Athletics | L2-10 | 4-10 | .286 | RingCentral Coliseum · Oakland, CA |
| 15 | Wed Apr 18 | at Athletics | L11-12 (14) | 4-11 | .267 | RingCentral Coliseum · Oakland, CA |
| 16 | Fri Apr 20 | vs Astros | L0-10 | 4-12 | .250 | Guaranteed Rate Field · Chicago, IL |
| 17 | Sat Apr 21 | vs Astros | L1-10 | 4-13 | .235 | Guaranteed Rate Field · Chicago, IL |
| 18 | Sun Apr 22 | vs Astros | L1-7 | 4-14 | .222 | Guaranteed Rate Field · Chicago, IL |
| 19 | Mon Apr 23 | vs Mariners | W10-4 | 5-14 | .263 | Guaranteed Rate Field · Chicago, IL |
| 20 | Tue Apr 24 | vs Mariners | L0-1 | 5-15 | .250 | Guaranteed Rate Field · Chicago, IL |
| 21 | Wed Apr 25 | vs Mariners | L3-4 | 5-16 | .238 | Guaranteed Rate Field · Chicago, IL |
| 22 | Thu Apr 26 | at Royals | W6-3 | 6-16 | .273 | Kauffman Stadium · Kansas City, MO |
| 23 | Fri Apr 27 | at Royals | W7-4 (11) | 7-16 | .304 | Kauffman Stadium · Kansas City, MO |
| 24 | Sat Apr 28 | at Royals | W8-0 | 8-16 | .333 | Kauffman Stadium · Kansas City, MO |
| 25 | Sat Apr 28 | at Royals | L2-5 | 8-17 | .320 | Kauffman Stadium · Kansas City, MO |
| 26 | Sun Apr 29 | at Royals | L4-5 | 8-18 | .308 | Kauffman Stadium · Kansas City, MO |
| 27 | Tue May 1 | at Cardinals | L2-3 | 8-19 | .296 | Busch Stadium · St. Louis, MO |
| 28 | Wed May 2 | at Cardinals | L2-3 | 8-20 | .286 | Busch Stadium · St. Louis, MO |
| 29 | Thu May 3 | vs Twins | W6-5 | 9-20 | .310 | Guaranteed Rate Field · Chicago, IL |
| 30 | Fri May 4 | vs Twins | L4-6 | 9-21 | .300 | Guaranteed Rate Field · Chicago, IL |
| 31 | Sat May 5 | vs Twins | L4-8 | 9-22 | .290 | Guaranteed Rate Field · Chicago, IL |
| 32 | Sun May 6 | vs Twins | L3-5 | 9-23 | .281 | Guaranteed Rate Field · Chicago, IL |
| 33 | Tue May 8 | vs Pirates | L6-10 | 9-24 | .273 | Guaranteed Rate Field · Chicago, IL |
| 34 | Wed May 9 | vs Pirates | L5-6 | 9-25 | .265 | Guaranteed Rate Field · Chicago, IL |
| 35 | Fri May 11 | at Cubs | L2-11 | 9-26 | .257 | Wrigley Field · Chicago, IL |
| 36 | Sat May 12 | at Cubs | L4-8 | 9-27 | .250 | Wrigley Field · Chicago, IL |
| 37 | Sun May 13 | at Cubs | W5-3 | 10-27 | .270 | Wrigley Field · Chicago, IL |
| 38 | Tue May 15 | at Pirates | L0-7 | 10-28 | .263 | PNC Park · Pittsburgh, PA |
| 39 | Wed May 16 | at Pirates | L2-3 | 10-29 | .256 | PNC Park · Pittsburgh, PA |
| 40 | Thu May 17 | vs Rangers | W4-2 | 11-29 | .275 | Guaranteed Rate Field · Chicago, IL |
| 41 | Fri May 18 | vs Rangers | L5-12 | 11-30 | .268 | Guaranteed Rate Field · Chicago, IL |
| 42 | Sat May 19 | vs Rangers | W5-3 | 12-30 | .286 | Guaranteed Rate Field · Chicago, IL |
| 43 | Sun May 20 | vs Rangers | W3-0 | 13-30 | .302 | Guaranteed Rate Field · Chicago, IL |
| 44 | Mon May 21 | vs Orioles | L2-3 | 13-31 | .295 | Guaranteed Rate Field · Chicago, IL |
| 45 | Tue May 22 | vs Orioles | W3-2 | 14-31 | .311 | Guaranteed Rate Field · Chicago, IL |
| 46 | Wed May 23 | vs Orioles | W11-1 | 15-31 | .326 | Guaranteed Rate Field · Chicago, IL |
| 47 | Thu May 24 | vs Orioles | L3-9 | 15-32 | .319 | Guaranteed Rate Field · Chicago, IL |
| 48 | Fri May 25 | at Tigers | L4-5 | 15-33 | .313 | Comerica Park · Detroit, MI |
| 49 | Sat May 26 | at Tigers | W8-4 | 16-33 | .327 | Comerica Park · Detroit, MI |
| 50 | Sun May 27 | at Tigers | L2-3 | 16-34 | .320 | Comerica Park · Detroit, MI |
| 51 | Mon May 28 | at Guardians | L6-9 | 16-35 | .314 | Progressive Field · Cleveland, OH |
| 52 | Tue May 29 | at Guardians | L3-7 | 16-36 | .308 | Progressive Field · Cleveland, OH |
| 53 | Wed May 30 | at Guardians | L1-9 | 16-37 | .302 | Progressive Field · Cleveland, OH |
| 54 | Fri Jun 1 | vs Brewers | W8-3 | 17-37 | .315 | Guaranteed Rate Field · Chicago, IL |
| 55 | Sat Jun 2 | vs Brewers | L0-5 | 17-38 | .309 | Guaranteed Rate Field · Chicago, IL |
| 56 | Sun Jun 3 | vs Brewers | W6-1 | 18-38 | .321 | Guaranteed Rate Field · Chicago, IL |
| 57 | Tue Jun 5 | at Twins | L2-4 | 18-39 | .316 | Target Field · Minneapolis, MN |
| 58 | Tue Jun 5 | at Twins | W6-3 | 19-39 | .328 | Target Field · Minneapolis, MN |
| 59 | Wed Jun 6 | at Twins | W5-2 | 20-39 | .339 | Target Field · Minneapolis, MN |
| 60 | Thu Jun 7 | at Twins | L2-7 | 20-40 | .333 | Target Field · Minneapolis, MN |
| 61 | Fri Jun 8 | at Red Sox | W1-0 | 21-40 | .344 | Fenway Park · Boston, MA |
| 62 | Sat Jun 9 | at Red Sox | L2-4 | 21-41 | .339 | Fenway Park · Boston, MA |
| 63 | Sun Jun 10 | at Red Sox | W5-2 | 22-41 | .349 | Fenway Park · Boston, MA |
| 64 | Mon Jun 11 | vs Guardians | L0-4 | 22-42 | .344 | Guaranteed Rate Field · Chicago, IL |
| 65 | Tue Jun 12 | vs Guardians | W5-1 | 23-42 | .354 | Guaranteed Rate Field · Chicago, IL |
| 66 | Wed Jun 13 | vs Guardians | W3-2 | 24-42 | .364 | Guaranteed Rate Field · Chicago, IL |
| 67 | Thu Jun 14 | vs Guardians | L2-5 | 24-43 | .358 | Guaranteed Rate Field · Chicago, IL |
| 68 | Fri Jun 15 | vs Tigers | L3-4 | 24-44 | .353 | Guaranteed Rate Field · Chicago, IL |
| 69 | Sat Jun 16 | vs Tigers | L5-7 | 24-45 | .348 | Guaranteed Rate Field · Chicago, IL |
| 70 | Sun Jun 17 | vs Tigers | L1-3 | 24-46 | .343 | Guaranteed Rate Field · Chicago, IL |
| 71 | Mon Jun 18 | at Guardians | L2-6 | 24-47 | .338 | Progressive Field · Cleveland, OH |
| 72 | Tue Jun 19 | at Guardians | L3-6 | 24-48 | .333 | Progressive Field · Cleveland, OH |
| 73 | Wed Jun 20 | at Guardians | L0-12 | 24-49 | .329 | Progressive Field · Cleveland, OH |
| 74 | Fri Jun 22 | vs Athletics | L2-11 | 24-50 | .324 | Guaranteed Rate Field · Chicago, IL |
| 75 | Fri Jun 22 | vs Athletics | W6-4 | 25-50 | .333 | Guaranteed Rate Field · Chicago, IL |
| 76 | Sat Jun 23 | vs Athletics | L6-7 | 25-51 | .329 | Guaranteed Rate Field · Chicago, IL |
| 77 | Sun Jun 24 | vs Athletics | W10-3 | 26-51 | .338 | Guaranteed Rate Field · Chicago, IL |
| 78 | Tue Jun 26 | vs Twins | W8-4 | 27-51 | .346 | Guaranteed Rate Field · Chicago, IL |
| 79 | Wed Jun 27 | vs Twins | W6-1 | 28-51 | .354 | Guaranteed Rate Field · Chicago, IL |
| 80 | Thu Jun 28 | vs Twins | L1-2 (13) | 28-52 | .350 | Guaranteed Rate Field · Chicago, IL |
| 81 | Fri Jun 29 | at Rangers | L3-11 | 28-53 | .346 | Globe Life Field · Arlington, TX |
| 82 | Sat Jun 30 | at Rangers | L4-13 | 28-54 | .341 | Globe Life Field · Arlington, TX |
| 83 | Sun Jul 1 | at Rangers | W10-5 | 29-54 | .349 | Globe Life Field · Arlington, TX |
| 84 | Mon Jul 2 | at Reds | L3-5 | 29-55 | .345 | Great American Ball Park · Cincinnati, OH |
| 85 | Tue Jul 3 | at Reds | W12-8 (12) | 30-55 | .353 | Great American Ball Park · Cincinnati, OH |
| 86 | Wed Jul 4 | at Reds | L4-7 | 30-56 | .349 | Great American Ball Park · Cincinnati, OH |
| 87 | Thu Jul 5 | at Astros | L3-4 | 30-57 | .345 | Minute Maid Park · Houston, TX |
| 88 | Fri Jul 6 | at Astros | L4-11 | 30-58 | .341 | Minute Maid Park · Houston, TX |
| 89 | Sat Jul 7 | at Astros | L6-12 | 30-59 | .337 | Minute Maid Park · Houston, TX |
| 90 | Sun Jul 8 | at Astros | L1-2 | 30-60 | .333 | Minute Maid Park · Houston, TX |
| 91 | Tue Jul 10 | vs Cardinals | L2-14 | 30-61 | .330 | Guaranteed Rate Field · Chicago, IL |
| 92 | Wed Jul 11 | vs Cardinals | W4-0 | 31-61 | .337 | Guaranteed Rate Field · Chicago, IL |
| 93 | Fri Jul 13 | vs Royals | W9-6 | 32-61 | .344 | Guaranteed Rate Field · Chicago, IL |
| 94 | Sat Jul 14 | vs Royals | L0-5 | 32-62 | .340 | Guaranteed Rate Field · Chicago, IL |
| 95 | Sun Jul 15 | vs Royals | W10-1 | 33-62 | .347 | Guaranteed Rate Field · Chicago, IL |
| 96 | Fri Jul 20 | at Mariners | L1-3 | 33-63 | .344 | T-Mobile Park · Seattle, WA |
| 97 | Sat Jul 21 | at Mariners | W5-0 | 34-63 | .351 | T-Mobile Park · Seattle, WA |
| 98 | Sun Jul 22 | at Mariners | L2-8 | 34-64 | .347 | T-Mobile Park · Seattle, WA |
| 99 | Mon Jul 23 | at Angels | W5-3 | 35-64 | .354 | Angel Stadium · Anaheim, CA |
| 100 | Tue Jul 24 | at Angels | W4-2 | 36-64 | .360 | Angel Stadium · Anaheim, CA |
| 101 | Wed Jul 25 | at Angels | L3-11 | 36-65 | .356 | Angel Stadium · Anaheim, CA |
| 102 | Thu Jul 26 | at Angels | L8-12 | 36-66 | .353 | Angel Stadium · Anaheim, CA |
| 103 | Fri Jul 27 | vs Blue Jays | L5-10 | 36-67 | .350 | Guaranteed Rate Field · Chicago, IL |
| 104 | Sat Jul 28 | vs Blue Jays | W9-5 | 37-67 | .356 | Guaranteed Rate Field · Chicago, IL |
| 105 | Sun Jul 29 | vs Blue Jays | L4-7 | 37-68 | .352 | Guaranteed Rate Field · Chicago, IL |
| 106 | Tue Jul 31 | vs Royals | L2-4 | 37-69 | .349 | Guaranteed Rate Field · Chicago, IL |
| 107 | Wed Aug 1 | vs Royals | L5-10 | 37-70 | .346 | Guaranteed Rate Field · Chicago, IL |
| 108 | Thu Aug 2 | vs Royals | W6-4 | 38-70 | .352 | Guaranteed Rate Field · Chicago, IL |
| 109 | Fri Aug 3 | at Rays | W3-2 (10) | 39-70 | .358 | Tropicana Field · St. Petersburg, FL |
| 110 | Sat Aug 4 | at Rays | W2-1 | 40-70 | .364 | Tropicana Field · St. Petersburg, FL |
| 111 | Sun Aug 5 | at Rays | W8-7 | 41-70 | .369 | Tropicana Field · St. Petersburg, FL |
| 112 | Mon Aug 6 | vs Yankees | L0-7 | 41-71 | .366 | Guaranteed Rate Field · Chicago, IL |
| 113 | Tue Aug 7 | vs Yankees | L3-4 (13) | 41-72 | .363 | Guaranteed Rate Field · Chicago, IL |
| 114 | Wed Aug 8 | vs Yankees | L3-7 | 41-73 | .360 | Guaranteed Rate Field · Chicago, IL |
| 115 | Fri Aug 10 | vs Guardians | W1-0 | 42-73 | .365 | Guaranteed Rate Field · Chicago, IL |
| 116 | Sat Aug 11 | vs Guardians | L1-3 | 42-74 | .362 | Guaranteed Rate Field · Chicago, IL |
| 117 | Sun Aug 12 | vs Guardians | L7-9 | 42-75 | .359 | Guaranteed Rate Field · Chicago, IL |
| 118 | Mon Aug 13 | at Tigers | L5-9 | 42-76 | .356 | Comerica Park · Detroit, MI |
| 119 | Tue Aug 14 | at Tigers | W6-3 | 43-76 | .361 | Comerica Park · Detroit, MI |
| 120 | Wed Aug 15 | at Tigers | W6-5 | 44-76 | .367 | Comerica Park · Detroit, MI |
| 121 | Fri Aug 17 | vs Royals | W9-3 | 45-76 | .372 | Guaranteed Rate Field · Chicago, IL |
| 122 | Sat Aug 18 | vs Royals | L1-3 | 45-77 | .369 | Guaranteed Rate Field · Chicago, IL |
| 123 | Sun Aug 19 | vs Royals | W7-6 | 46-77 | .374 | Guaranteed Rate Field · Chicago, IL |
| 124 | Mon Aug 20 | at Twins | W8-5 | 47-77 | .379 | Target Field · Minneapolis, MN |
| 125 | Tue Aug 21 | vs Twins | L2-5 | 47-78 | .376 | Guaranteed Rate Field · Chicago, IL |
| 126 | Wed Aug 22 | vs Twins | W7-3 | 48-78 | .381 | Guaranteed Rate Field · Chicago, IL |
| 127 | Thu Aug 23 | at Tigers | L2-7 | 48-79 | .378 | Comerica Park · Detroit, MI |
| 128 | Fri Aug 24 | at Tigers | W6-3 | 49-79 | .383 | Comerica Park · Detroit, MI |
| 129 | Sat Aug 25 | at Tigers | W6-1 | 50-79 | .388 | Comerica Park · Detroit, MI |
| 130 | Sun Aug 26 | at Tigers | W7-2 | 51-79 | .392 | Comerica Park · Detroit, MI |
| 131 | Mon Aug 27 | at Yankees | W6-2 | 52-79 | .397 | Yankee Stadium · The Bronx, NY |
| 132 | Tue Aug 28 | at Yankees | L4-5 | 52-80 | .394 | Yankee Stadium · The Bronx, NY |
| 133 | Wed Aug 29 | at Yankees | W4-1 | 53-80 | .398 | Yankee Stadium · The Bronx, NY |
| 134 | Thu Aug 30 | vs Red Sox | L4-9 | 53-81 | .396 | Guaranteed Rate Field · Chicago, IL |
| 135 | Fri Aug 31 | vs Red Sox | W6-1 | 54-81 | .400 | Guaranteed Rate Field · Chicago, IL |
| 136 | Sat Sep 1 | vs Red Sox | L1-6 | 54-82 | .397 | Guaranteed Rate Field · Chicago, IL |
| 137 | Sun Sep 2 | vs Red Sox | W8-0 | 55-82 | .401 | Guaranteed Rate Field · Chicago, IL |
| 138 | Mon Sep 3 | vs Tigers | W4-2 | 56-82 | .406 | Guaranteed Rate Field · Chicago, IL |
| 139 | Tue Sep 4 | vs Tigers | L3-8 | 56-83 | .403 | Guaranteed Rate Field · Chicago, IL |
| 140 | Wed Sep 5 | vs Tigers | L2-10 | 56-84 | .400 | Guaranteed Rate Field · Chicago, IL |
| 141 | Fri Sep 7 | vs Angels | L2-5 | 56-85 | .397 | Guaranteed Rate Field · Chicago, IL |
| 142 | Sat Sep 8 | vs Angels | L3-12 | 56-86 | .394 | Guaranteed Rate Field · Chicago, IL |
| 143 | Sun Sep 9 | vs Angels | L0-1 | 56-87 | .392 | Guaranteed Rate Field · Chicago, IL |
| 144 | Mon Sep 10 | at Royals | L3-4 (10) | 56-88 | .389 | Kauffman Stadium · Kansas City, MO |
| 145 | Tue Sep 11 | at Royals | L3-6 | 56-89 | .386 | Kauffman Stadium · Kansas City, MO |
| 146 | Wed Sep 12 | at Royals | W4-2 (12) | 57-89 | .390 | Kauffman Stadium · Kansas City, MO |
| 147 | Fri Sep 14 | at Orioles | W8-6 | 58-89 | .395 | Camden Yards · Baltimore, MD |
| 148 | Sat Sep 15 | at Orioles | W2-0 | 59-89 | .399 | Camden Yards · Baltimore, MD |
| 149 | Sun Sep 16 | at Orioles | L4-8 | 59-90 | .396 | Camden Yards · Baltimore, MD |
| 150 | Tue Sep 18 | at Guardians | L3-5 | 59-91 | .393 | Progressive Field · Cleveland, OH |
| 151 | Wed Sep 19 | at Guardians | L1-4 | 59-92 | .391 | Progressive Field · Cleveland, OH |
| 152 | Thu Sep 20 | at Guardians | W5-4 (11) | 60-92 | .395 | Progressive Field · Cleveland, OH |
| 153 | Fri Sep 21 | vs Cubs | W10-4 | 61-92 | .399 | Guaranteed Rate Field · Chicago, IL |
| 154 | Sat Sep 22 | vs Cubs | L3-8 | 61-93 | .396 | Guaranteed Rate Field · Chicago, IL |
| 155 | Sun Sep 23 | vs Cubs | L1-6 | 61-94 | .394 | Guaranteed Rate Field · Chicago, IL |
| 156 | Mon Sep 24 | vs Guardians | L0-4 | 61-95 | .391 | Guaranteed Rate Field · Chicago, IL |
| 157 | Tue Sep 25 | vs Guardians | W5-4 | 62-95 | .395 | Guaranteed Rate Field · Chicago, IL |
| 158 | Wed Sep 26 | vs Guardians | L2-10 | 62-96 | .392 | Guaranteed Rate Field · Chicago, IL |
| 159 | Fri Sep 28 | at Twins | L1-2 | 62-97 | .390 | Target Field · Minneapolis, MN |
| 160 | Fri Sep 28 | at Twins | L4-12 | 62-98 | .388 | Target Field · Minneapolis, MN |
| 161 | Sat Sep 29 | at Twins | L3-8 | 62-99 | .385 | Target Field · Minneapolis, MN |
| 162 | Sun Sep 30 | at Twins | L4-5 | 62-100 | .383 | Target Field · Minneapolis, MN |