| 1 | Mon Mar 31 | vs Twins | W5-3 | 1-0 | 1.000 | Guaranteed Rate Field · Chicago, IL |
| 2 | Wed Apr 2 | vs Twins | W7-6 (11) | 2-0 | 1.000 | Guaranteed Rate Field · Chicago, IL |
| 3 | Thu Apr 3 | vs Twins | L9-10 | 2-1 | .667 | Guaranteed Rate Field · Chicago, IL |
| 4 | Fri Apr 4 | at Royals | L5-7 | 2-2 | .500 | Kauffman Stadium · Kansas City, MO |
| 5 | Sat Apr 5 | at Royals | L3-4 | 2-3 | .400 | Kauffman Stadium · Kansas City, MO |
| 6 | Sun Apr 6 | at Royals | W5-1 | 3-3 | .500 | Kauffman Stadium · Kansas City, MO |
| 7 | Mon Apr 7 | at Rockies | L1-8 | 3-4 | .429 | Coors Field · Denver, CO |
| 8 | Tue Apr 8 | at Rockies | W15-3 | 4-4 | .500 | Coors Field · Denver, CO |
| 9 | Wed Apr 9 | at Rockies | L4-10 | 4-5 | .444 | Coors Field · Denver, CO |
| 10 | Thu Apr 10 | vs Guardians | W7-3 | 5-5 | .500 | Guaranteed Rate Field · Chicago, IL |
| 11 | Fri Apr 11 | vs Guardians | W9-6 | 6-5 | .545 | Guaranteed Rate Field · Chicago, IL |
| 12 | Sat Apr 12 | vs Guardians | L6-12 | 6-6 | .500 | Guaranteed Rate Field · Chicago, IL |
| 13 | Sun Apr 13 | vs Guardians | W4-3 | 7-6 | .538 | Guaranteed Rate Field · Chicago, IL |
| 14 | Tue Apr 15 | vs Red Sox | W2-1 | 8-6 | .571 | Guaranteed Rate Field · Chicago, IL |
| 15 | Wed Apr 16 | vs Red Sox | L4-6 (14) | 8-7 | .533 | Guaranteed Rate Field · Chicago, IL |
| 16 | Thu Apr 17 | vs Red Sox | L1-3 | 8-8 | .500 | Guaranteed Rate Field · Chicago, IL |
| 17 | Fri Apr 18 | at Rangers | L0-12 | 8-9 | .471 | Globe Life Field · Arlington, TX |
| 18 | Sat Apr 19 | at Rangers | L3-6 | 8-10 | .444 | Globe Life Field · Arlington, TX |
| 19 | Sun Apr 20 | at Rangers | W16-2 | 9-10 | .474 | Globe Life Field · Arlington, TX |
| 20 | Mon Apr 21 | at Tigers | W3-1 | 10-10 | .500 | Comerica Park · Detroit, MI |
| 21 | Tue Apr 22 | at Tigers | L6-8 | 10-11 | .476 | Comerica Park · Detroit, MI |
| 22 | Wed Apr 23 | at Tigers | W6-4 | 11-11 | .500 | Comerica Park · Detroit, MI |
| 23 | Thu Apr 24 | at Tigers | L4-7 | 11-12 | .478 | Comerica Park · Detroit, MI |
| 24 | Fri Apr 25 | vs Rays | W9-6 | 12-12 | .500 | Guaranteed Rate Field · Chicago, IL |
| 25 | Sat Apr 26 | vs Rays | L0-4 | 12-13 | .480 | Guaranteed Rate Field · Chicago, IL |
| 26 | Sun Apr 27 | vs Rays | W9-2 | 13-13 | .500 | Guaranteed Rate Field · Chicago, IL |
| 27 | Mon Apr 28 | vs Rays | W7-3 | 14-13 | .519 | Guaranteed Rate Field · Chicago, IL |
| 28 | Tue Apr 29 | vs Tigers | L3-4 | 14-14 | .500 | Guaranteed Rate Field · Chicago, IL |
| 29 | Wed Apr 30 | vs Tigers | L1-5 | 14-15 | .483 | Guaranteed Rate Field · Chicago, IL |
| 30 | Fri May 2 | at Guardians | L5-12 | 14-16 | .467 | Progressive Field · Cleveland, OH |
| 31 | Sat May 3 | at Guardians | L0-2 | 14-17 | .452 | Progressive Field · Cleveland, OH |
| 32 | Sun May 4 | at Guardians | W4-3 | 15-17 | .469 | Progressive Field · Cleveland, OH |
| 33 | Mon May 5 | at Cubs | W3-1 (12) | 16-17 | .485 | Wrigley Field · Chicago, IL |
| 34 | Tue May 6 | at Cubs | W5-1 | 17-17 | .500 | Wrigley Field · Chicago, IL |
| 35 | Wed May 7 | vs Cubs | W8-3 | 18-17 | .514 | Guaranteed Rate Field · Chicago, IL |
| 36 | Thu May 8 | vs Cubs | L5-12 | 18-18 | .500 | Guaranteed Rate Field · Chicago, IL |
| 37 | Fri May 9 | vs D-backs | W9-3 | 19-18 | .514 | Guaranteed Rate Field · Chicago, IL |
| 38 | Sat May 10 | vs D-backs | L3-4 | 19-19 | .500 | Guaranteed Rate Field · Chicago, IL |
| 39 | Sun May 11 | vs D-backs | L1-5 | 19-20 | .487 | Guaranteed Rate Field · Chicago, IL |
| 40 | Mon May 12 | at Athletics | L4-5 | 19-21 | .475 | RingCentral Coliseum · Oakland, CA |
| 41 | Tue May 13 | at Athletics | L0-11 | 19-22 | .463 | RingCentral Coliseum · Oakland, CA |
| 42 | Wed May 14 | at Athletics | W4-2 | 20-22 | .476 | RingCentral Coliseum · Oakland, CA |
| 43 | Fri May 16 | at Astros | W7-2 | 21-22 | .488 | Minute Maid Park · Houston, TX |
| 44 | Sat May 17 | at Astros | L5-6 | 21-23 | .477 | Minute Maid Park · Houston, TX |
| 45 | Sun May 18 | at Astros | L2-8 | 21-24 | .467 | Minute Maid Park · Houston, TX |
| 46 | Mon May 19 | at Royals | W7-6 | 22-24 | .478 | Kauffman Stadium · Kansas City, MO |
| 47 | Tue May 20 | at Royals | W7-6 | 23-24 | .489 | Kauffman Stadium · Kansas City, MO |
| 48 | Wed May 21 | at Royals | L1-3 | 23-25 | .479 | Kauffman Stadium · Kansas City, MO |
| 49 | Thu May 22 | vs Yankees | W3-2 | 24-25 | .490 | Guaranteed Rate Field · Chicago, IL |
| 50 | Fri May 23 | vs Yankees | W6-5 | 25-25 | .500 | Guaranteed Rate Field · Chicago, IL |
| 51 | Sat May 24 | vs Yankees | L3-4 (10) | 25-26 | .490 | Guaranteed Rate Field · Chicago, IL |
| 52 | Sun May 25 | vs Yankees | L1-7 | 25-27 | .481 | Guaranteed Rate Field · Chicago, IL |
| 53 | Mon May 26 | vs Guardians | W6-2 | 26-27 | .491 | Guaranteed Rate Field · Chicago, IL |
| 54 | Tue May 27 | vs Guardians | W2-1 | 27-27 | .500 | Guaranteed Rate Field · Chicago, IL |
| 55 | Wed May 28 | vs Guardians | W3-2 | 28-27 | .509 | Guaranteed Rate Field · Chicago, IL |
| 56 | Fri May 30 | vs Padres | L1-4 | 28-28 | .500 | Guaranteed Rate Field · Chicago, IL |
| 57 | Sat May 31 | vs Padres | L2-4 | 28-29 | .491 | Guaranteed Rate Field · Chicago, IL |
| 58 | Sun Jun 1 | vs Padres | W4-1 | 29-29 | .500 | Guaranteed Rate Field · Chicago, IL |
| 59 | Mon Jun 2 | at Dodgers | L2-5 | 29-30 | .492 | Dodger Stadium · Los Angeles, CA |
| 60 | Tue Jun 3 | at Dodgers | W4-1 | 30-30 | .500 | Dodger Stadium · Los Angeles, CA |
| 61 | Wed Jun 4 | at Dodgers | W2-1 | 31-30 | .508 | Dodger Stadium · Los Angeles, CA |
| 62 | Fri Jun 6 | at Angels | L4-8 | 31-31 | .500 | Angel Stadium · Anaheim, CA |
| 63 | Sat Jun 7 | at Angels | L5-6 | 31-32 | .492 | Angel Stadium · Anaheim, CA |
| 64 | Sun Jun 8 | at Angels | L2-4 | 31-33 | .484 | Angel Stadium · Anaheim, CA |
| 65 | Mon Jun 9 | vs Tigers | W6-5 | 32-33 | .492 | Guaranteed Rate Field · Chicago, IL |
| 66 | Wed Jun 11 | vs Tigers | W8-2 | 33-33 | .500 | Guaranteed Rate Field · Chicago, IL |
| 67 | Thu Jun 12 | vs Tigers | L0-4 | 33-34 | .493 | Guaranteed Rate Field · Chicago, IL |
| 68 | Fri Jun 13 | vs Royals | L2-7 | 33-35 | .485 | Guaranteed Rate Field · Chicago, IL |
| 69 | Sat Jun 14 | vs Royals | L1-9 | 33-36 | .478 | Guaranteed Rate Field · Chicago, IL |
| 70 | Sun Jun 15 | vs Royals | L3-6 | 33-37 | .471 | Guaranteed Rate Field · Chicago, IL |
| 71 | Tue Jun 17 | vs Giants | W8-2 | 34-37 | .479 | Guaranteed Rate Field · Chicago, IL |
| 72 | Wed Jun 18 | vs Giants | W7-6 | 35-37 | .486 | Guaranteed Rate Field · Chicago, IL |
| 73 | Thu Jun 19 | at Twins | L2-4 | 35-38 | .479 | Target Field · Minneapolis, MN |
| 74 | Fri Jun 20 | at Twins | L4-5 | 35-39 | .473 | Target Field · Minneapolis, MN |
| 75 | Sat Jun 21 | at Twins | L3-4 | 35-40 | .467 | Target Field · Minneapolis, MN |
| 76 | Sun Jun 22 | at Twins | L5-6 | 35-41 | .461 | Target Field · Minneapolis, MN |
| 77 | Mon Jun 23 | at Orioles | L4-6 | 35-42 | .455 | Camden Yards · Baltimore, MD |
| 78 | Tue Jun 24 | at Orioles | W4-2 | 36-42 | .462 | Camden Yards · Baltimore, MD |
| 79 | Wed Jun 25 | at Orioles | L4-5 (12) | 36-43 | .456 | Camden Yards · Baltimore, MD |
| 80 | Thu Jun 26 | at Blue Jays | L0-7 | 36-44 | .450 | Rogers Centre · Toronto, ON |
| 81 | Fri Jun 27 | at Blue Jays | W5-4 | 37-44 | .457 | Rogers Centre · Toronto, ON |
| 82 | Sat Jun 28 | at Blue Jays | W4-3 | 38-44 | .463 | Rogers Centre · Toronto, ON |
| 83 | Sun Jun 29 | at Blue Jays | W4-0 | 39-44 | .470 | Rogers Centre · Toronto, ON |
| 84 | Tue Jul 1 | vs Angels | L4-8 | 39-45 | .464 | Guaranteed Rate Field · Chicago, IL |
| 85 | Tue Jul 1 | vs Angels | L5-7 | 39-46 | .459 | Guaranteed Rate Field · Chicago, IL |
| 86 | Wed Jul 2 | vs Angels | W3-2 | 40-46 | .465 | Guaranteed Rate Field · Chicago, IL |
| 87 | Fri Jul 4 | vs Mariners | W7-1 | 41-46 | .471 | Guaranteed Rate Field · Chicago, IL |
| 88 | Sat Jul 5 | vs Mariners | L2-3 (14) | 41-47 | .466 | Guaranteed Rate Field · Chicago, IL |
| 89 | Sun Jul 6 | vs Mariners | W1-0 | 42-47 | .472 | Guaranteed Rate Field · Chicago, IL |
| 90 | Mon Jul 7 | at Red Sox | W4-0 | 43-47 | .478 | Fenway Park · Boston, MA |
| 91 | Tue Jul 8 | at Red Sox | W8-3 | 44-47 | .484 | Fenway Park · Boston, MA |
| 92 | Wed Jul 9 | at Red Sox | L4-5 | 44-48 | .478 | Fenway Park · Boston, MA |
| 93 | Thu Jul 10 | at Red Sox | L3-4 (10) | 44-49 | .473 | Fenway Park · Boston, MA |
| 94 | Fri Jul 11 | at Guardians | L4-7 | 44-50 | .468 | Progressive Field · Cleveland, OH |
| 95 | Sat Jul 12 | at Guardians | W6-2 | 45-50 | .474 | Progressive Field · Cleveland, OH |
| 96 | Sun Jul 13 | at Guardians | L2-3 | 45-51 | .469 | Progressive Field · Cleveland, OH |
| 97 | Fri Jul 18 | vs Astros | W3-2 | 46-51 | .474 | Guaranteed Rate Field · Chicago, IL |
| 98 | Sat Jul 19 | vs Astros | W4-3 | 47-51 | .480 | Guaranteed Rate Field · Chicago, IL |
| 99 | Sun Jul 20 | vs Astros | L7-11 | 47-52 | .475 | Guaranteed Rate Field · Chicago, IL |
| 100 | Mon Jul 21 | vs Royals | W3-1 | 48-52 | .480 | Guaranteed Rate Field · Chicago, IL |
| 101 | Tue Jul 22 | vs Royals | L1-7 | 48-53 | .475 | Guaranteed Rate Field · Chicago, IL |
| 102 | Wed Jul 23 | vs Royals | L1-2 | 48-54 | .471 | Guaranteed Rate Field · Chicago, IL |
| 103 | Thu Jul 24 | at Twins | W5-2 | 49-54 | .476 | Target Field · Minneapolis, MN |
| 104 | Fri Jul 25 | at Twins | W9-5 | 50-54 | .481 | Target Field · Minneapolis, MN |
| 105 | Sat Jul 26 | at Twins | W7-0 | 51-54 | .486 | Target Field · Minneapolis, MN |
| 106 | Sun Jul 27 | at Twins | L3-4 | 51-55 | .481 | Target Field · Minneapolis, MN |
| 107 | Tue Jul 29 | at Tigers | W11-4 | 52-55 | .486 | Comerica Park · Detroit, MI |
| 108 | Wed Jul 30 | at Tigers | L2-7 | 52-56 | .481 | Comerica Park · Detroit, MI |
| 109 | Thu Jul 31 | at Tigers | W7-4 | 53-56 | .486 | Comerica Park · Detroit, MI |
| 110 | Fri Aug 1 | vs Twins | W10-8 | 54-56 | .491 | Guaranteed Rate Field · Chicago, IL |
| 111 | Sat Aug 2 | vs Twins | L6-8 | 54-57 | .486 | Guaranteed Rate Field · Chicago, IL |
| 112 | Sun Aug 3 | vs Twins | L3-16 | 54-58 | .482 | Guaranteed Rate Field · Chicago, IL |
| 113 | Mon Aug 4 | vs Rangers | W5-3 | 55-58 | .487 | Guaranteed Rate Field · Chicago, IL |
| 114 | Tue Aug 5 | vs Rangers | L0-16 | 55-59 | .482 | Guaranteed Rate Field · Chicago, IL |
| 115 | Wed Aug 6 | vs Rangers | L1-3 | 55-60 | .478 | Guaranteed Rate Field · Chicago, IL |
| 116 | Thu Aug 7 | at Mariners | L3-13 | 55-61 | .474 | T-Mobile Park · Seattle, WA |
| 117 | Fri Aug 8 | at Mariners | L1-4 | 55-62 | .470 | T-Mobile Park · Seattle, WA |
| 118 | Sat Aug 9 | at Mariners | W2-1 (10) | 56-62 | .475 | T-Mobile Park · Seattle, WA |
| 119 | Sun Aug 10 | at Mariners | L2-4 | 56-63 | .471 | T-Mobile Park · Seattle, WA |
| 120 | Tue Aug 12 | at Giants | W3-2 (10) | 57-63 | .475 | Oracle Park · San Francisco, CA |
| 121 | Wed Aug 13 | at Giants | L1-7 | 57-64 | .471 | Oracle Park · San Francisco, CA |
| 122 | Fri Aug 15 | vs Blue Jays | W11-5 | 58-64 | .475 | Guaranteed Rate Field · Chicago, IL |
| 123 | Sat Aug 16 | vs Blue Jays | L3-6 | 58-65 | .472 | Guaranteed Rate Field · Chicago, IL |
| 124 | Sun Aug 17 | vs Blue Jays | W7-5 | 59-65 | .476 | Guaranteed Rate Field · Chicago, IL |
| 125 | Mon Aug 18 | vs Orioles | L2-8 | 59-66 | .472 | Guaranteed Rate Field · Chicago, IL |
| 126 | Tue Aug 19 | vs Orioles | L1-5 | 59-67 | .468 | Guaranteed Rate Field · Chicago, IL |
| 127 | Wed Aug 20 | vs Orioles | L3-4 | 59-68 | .465 | Guaranteed Rate Field · Chicago, IL |
| 128 | Fri Aug 22 | at Yankees | L3-4 | 59-69 | .461 | Yankee Stadium · The Bronx, NY |
| 129 | Sat Aug 23 | at Yankees | L3-5 | 59-70 | .457 | Yankee Stadium · The Bronx, NY |
| 130 | Sun Aug 24 | at Yankees | L4-7 (10) | 59-71 | .454 | Yankee Stadium · The Bronx, NY |
| 131 | Tue Aug 26 | vs Guardians | L6-8 (10) | 59-72 | .450 | Guaranteed Rate Field · Chicago, IL |
| 132 | Wed Aug 27 | vs Guardians | W3-2 | 60-72 | .455 | Guaranteed Rate Field · Chicago, IL |
| 133 | Thu Aug 28 | vs Guardians | L2-3 | 60-73 | .451 | Guaranteed Rate Field · Chicago, IL |
| 134 | Fri Aug 29 | vs Tigers | L1-7 | 60-74 | .448 | Guaranteed Rate Field · Chicago, IL |
| 135 | Sat Aug 30 | vs Tigers | W6-3 | 61-74 | .452 | Guaranteed Rate Field · Chicago, IL |
| 136 | Sat Aug 30 | vs Tigers | L4-8 | 61-75 | .449 | Guaranteed Rate Field · Chicago, IL |
| 137 | Sun Aug 31 | vs Tigers | W6-2 | 62-75 | .453 | Guaranteed Rate Field · Chicago, IL |
| 138 | Tue Sep 2 | at Twins | W6-3 (10) | 63-75 | .457 | Target Field · Minneapolis, MN |
| 139 | Wed Sep 3 | at Twins | L4-11 | 63-76 | .453 | Target Field · Minneapolis, MN |
| 140 | Fri Sep 5 | at Guardians | L1-2 (10) | 63-77 | .450 | Progressive Field · Cleveland, OH |
| 141 | Sat Sep 6 | at Guardians | L1-3 | 63-78 | .447 | Progressive Field · Cleveland, OH |
| 142 | Sun Sep 7 | at Guardians | L0-2 | 63-79 | .444 | Progressive Field · Cleveland, OH |
| 143 | Mon Sep 8 | vs Athletics | W5-4 (12) | 64-79 | .448 | Guaranteed Rate Field · Chicago, IL |
| 144 | Tue Sep 9 | vs Athletics | L2-11 | 64-80 | .444 | Guaranteed Rate Field · Chicago, IL |
| 145 | Wed Sep 10 | vs Athletics | W2-1 | 65-80 | .448 | Guaranteed Rate Field · Chicago, IL |
| 146 | Thu Sep 11 | vs Athletics | W1-0 | 66-80 | .452 | Guaranteed Rate Field · Chicago, IL |
| 147 | Sat Sep 13 | vs Twins | W5-1 | 67-80 | .456 | Guaranteed Rate Field · Chicago, IL |
| 148 | Sat Sep 13 | vs Twins | W7-6 | 68-80 | .459 | Guaranteed Rate Field · Chicago, IL |
| 149 | Sun Sep 14 | vs Twins | L4-6 | 68-81 | .456 | Guaranteed Rate Field · Chicago, IL |
| 150 | Mon Sep 15 | at Royals | L3-4 | 68-82 | .453 | Kauffman Stadium · Kansas City, MO |
| 151 | Tue Sep 16 | at Royals | W7-5 | 69-82 | .457 | Kauffman Stadium · Kansas City, MO |
| 152 | Wed Sep 17 | at Royals | L2-6 | 69-83 | .454 | Kauffman Stadium · Kansas City, MO |
| 153 | Fri Sep 19 | at Rays | W4-3 | 70-83 | .458 | Tropicana Field · St. Petersburg, FL |
| 154 | Sat Sep 20 | at Rays | L1-3 | 70-84 | .455 | Tropicana Field · St. Petersburg, FL |
| 155 | Sun Sep 21 | at Rays | W10-5 | 71-84 | .458 | Tropicana Field · St. Petersburg, FL |
| 156 | Mon Sep 22 | at Tigers | W2-0 | 72-84 | .462 | Comerica Park · Detroit, MI |
| 157 | Tue Sep 23 | at Tigers | L3-4 | 72-85 | .459 | Comerica Park · Detroit, MI |
| 158 | Wed Sep 24 | at Tigers | L1-6 | 72-86 | .456 | Comerica Park · Detroit, MI |
| 159 | Thu Sep 25 | vs Royals | L3-6 | 72-87 | .453 | Guaranteed Rate Field · Chicago, IL |
| 160 | Fri Sep 26 | vs Royals | L1-3 | 72-88 | .450 | Guaranteed Rate Field · Chicago, IL |
| 161 | Sat Sep 27 | vs Royals | W5-4 | 73-88 | .453 | Guaranteed Rate Field · Chicago, IL |
| 162 | Sun Sep 28 | vs Royals | L4-6 | 73-89 | .451 | Guaranteed Rate Field · Chicago, IL |