| 1 | Mon Apr 1 | vs Royals | W1-0 | 1-0 | 1.000 | Guaranteed Rate Field · Chicago, IL |
| 2 | Wed Apr 3 | vs Royals | W5-2 | 2-0 | 1.000 | Guaranteed Rate Field · Chicago, IL |
| 3 | Thu Apr 4 | vs Royals | L1-3 | 2-1 | .667 | Guaranteed Rate Field · Chicago, IL |
| 4 | Fri Apr 5 | vs Mariners | L7-8 (10) | 2-2 | .500 | Guaranteed Rate Field · Chicago, IL |
| 5 | Sat Apr 6 | vs Mariners | W4-3 | 3-2 | .600 | Guaranteed Rate Field · Chicago, IL |
| 6 | Sun Apr 7 | vs Mariners | W4-3 (10) | 4-2 | .667 | Guaranteed Rate Field · Chicago, IL |
| 7 | Tue Apr 9 | at Nationals | L7-8 | 4-3 | .571 | Nationals Park · Washington, D.C. |
| 8 | Wed Apr 10 | at Nationals | L2-5 | 4-4 | .500 | Nationals Park · Washington, D.C. |
| 9 | Thu Apr 11 | at Nationals | L4-7 | 4-5 | .444 | Nationals Park · Washington, D.C. |
| 10 | Fri Apr 12 | at Guardians | L0-1 | 4-6 | .400 | Progressive Field · Cleveland, OH |
| 11 | Sat Apr 13 | at Guardians | L4-9 | 4-7 | .364 | Progressive Field · Cleveland, OH |
| 12 | Sun Apr 14 | at Guardians | W3-1 | 5-7 | .417 | Progressive Field · Cleveland, OH |
| 13 | Mon Apr 15 | at Blue Jays | L3-4 | 5-8 | .385 | Rogers Centre · Toronto, ON |
| 14 | Tue Apr 16 | at Blue Jays | W4-3 | 6-8 | .429 | Rogers Centre · Toronto, ON |
| 15 | Wed Apr 17 | at Blue Jays | W7-0 | 7-8 | .467 | Rogers Centre · Toronto, ON |
| 16 | Thu Apr 18 | at Blue Jays | L1-3 | 7-9 | .438 | Rogers Centre · Toronto, ON |
| 17 | Sat Apr 20 | vs Twins | L1-2 (10) | 7-10 | .412 | Guaranteed Rate Field · Chicago, IL |
| 18 | Sun Apr 21 | vs Twins | L3-5 | 7-11 | .389 | Guaranteed Rate Field · Chicago, IL |
| 19 | Mon Apr 22 | vs Guardians | L2-3 | 7-12 | .368 | Guaranteed Rate Field · Chicago, IL |
| 20 | Wed Apr 24 | vs Guardians | W3-2 | 8-12 | .400 | Guaranteed Rate Field · Chicago, IL |
| 21 | Thu Apr 25 | vs Rays | W5-2 | 9-12 | .429 | Guaranteed Rate Field · Chicago, IL |
| 22 | Fri Apr 26 | vs Rays | W5-4 | 10-12 | .455 | Guaranteed Rate Field · Chicago, IL |
| 23 | Sat Apr 27 | vs Rays | L4-10 | 10-13 | .435 | Guaranteed Rate Field · Chicago, IL |
| 24 | Sun Apr 28 | vs Rays | L3-8 | 10-14 | .417 | Guaranteed Rate Field · Chicago, IL |
| 25 | Tue Apr 30 | at Rangers | L6-10 | 10-15 | .400 | Globe Life Field · Arlington, TX |
| 26 | Wed May 1 | at Rangers | W5-2 | 11-15 | .423 | Globe Life Field · Arlington, TX |
| 27 | Thu May 2 | at Rangers | W3-1 | 12-15 | .444 | Globe Life Field · Arlington, TX |
| 28 | Sat May 4 | at Royals | L0-2 | 12-16 | .429 | Kauffman Stadium · Kansas City, MO |
| 29 | Sun May 5 | at Royals | L5-6 (10) | 12-17 | .414 | Kauffman Stadium · Kansas City, MO |
| 30 | Mon May 6 | at Royals | W2-1 (11) | 13-17 | .433 | Kauffman Stadium · Kansas City, MO |
| 31 | Tue May 7 | at Mets | L0-1 (10) | 13-18 | .419 | Citi Field · Queens, NY |
| 32 | Wed May 8 | at Mets | W6-3 | 14-18 | .438 | Citi Field · Queens, NY |
| 33 | Fri May 10 | vs Angels | L5-7 | 14-19 | .424 | Guaranteed Rate Field · Chicago, IL |
| 34 | Sat May 11 | vs Angels | L2-3 | 14-20 | .412 | Guaranteed Rate Field · Chicago, IL |
| 35 | Sun May 12 | vs Angels | W3-0 | 15-20 | .429 | Guaranteed Rate Field · Chicago, IL |
| 36 | Mon May 13 | at Twins | L3-10 | 15-21 | .417 | Target Field · Minneapolis, MN |
| 37 | Tue May 14 | at Twins | W4-2 | 16-21 | .432 | Target Field · Minneapolis, MN |
| 38 | Wed May 15 | at Twins | W9-4 | 17-21 | .447 | Target Field · Minneapolis, MN |
| 39 | Thu May 16 | at Angels | W5-4 | 18-21 | .462 | Angel Stadium · Anaheim, CA |
| 40 | Fri May 17 | at Angels | W3-0 | 19-21 | .475 | Angel Stadium · Anaheim, CA |
| 41 | Sat May 18 | at Angels | L9-12 | 19-22 | .463 | Angel Stadium · Anaheim, CA |
| 42 | Sun May 19 | at Angels | L2-6 | 19-23 | .452 | Angel Stadium · Anaheim, CA |
| 43 | Mon May 20 | vs Red Sox | W6-4 | 20-23 | .465 | Guaranteed Rate Field · Chicago, IL |
| 44 | Tue May 21 | vs Red Sox | W3-1 | 21-23 | .477 | Guaranteed Rate Field · Chicago, IL |
| 45 | Wed May 22 | vs Red Sox | L2-6 | 21-24 | .467 | Guaranteed Rate Field · Chicago, IL |
| 46 | Fri May 24 | vs Marlins | W4-3 (11) | 22-24 | .478 | Guaranteed Rate Field · Chicago, IL |
| 47 | Sat May 25 | vs Marlins | W2-1 | 23-24 | .489 | Guaranteed Rate Field · Chicago, IL |
| 48 | Sun May 26 | vs Marlins | W5-3 | 24-24 | .500 | Guaranteed Rate Field · Chicago, IL |
| 49 | Mon May 27 | vs Cubs | L0-7 | 24-25 | .490 | Guaranteed Rate Field · Chicago, IL |
| 50 | Wed May 29 | at Cubs | L3-9 | 24-26 | .480 | Wrigley Field · Chicago, IL |
| 51 | Thu May 30 | at Cubs | L3-8 | 24-27 | .471 | Wrigley Field · Chicago, IL |
| 52 | Fri May 31 | at Athletics | L0-3 | 24-28 | .462 | RingCentral Coliseum · Oakland, CA |
| 53 | Sat Jun 1 | at Athletics | L3-4 (10) | 24-29 | .453 | RingCentral Coliseum · Oakland, CA |
| 54 | Sun Jun 2 | at Athletics | L0-2 | 24-30 | .444 | RingCentral Coliseum · Oakland, CA |
| 55 | Mon Jun 3 | at Mariners | L2-4 | 24-31 | .436 | T-Mobile Park · Seattle, WA |
| 56 | Tue Jun 4 | at Mariners | L4-7 | 24-32 | .429 | T-Mobile Park · Seattle, WA |
| 57 | Wed Jun 5 | at Mariners | W7-5 (16) | 25-32 | .439 | T-Mobile Park · Seattle, WA |
| 58 | Thu Jun 6 | vs Athletics | L4-5 (10) | 25-33 | .431 | Guaranteed Rate Field · Chicago, IL |
| 59 | Fri Jun 7 | vs Athletics | L3-4 | 25-34 | .424 | Guaranteed Rate Field · Chicago, IL |
| 60 | Sat Jun 8 | vs Athletics | W4-1 | 26-34 | .433 | Guaranteed Rate Field · Chicago, IL |
| 61 | Sun Jun 9 | vs Athletics | W4-2 | 27-34 | .443 | Guaranteed Rate Field · Chicago, IL |
| 62 | Mon Jun 10 | vs Blue Jays | W10-6 | 28-34 | .452 | Guaranteed Rate Field · Chicago, IL |
| 63 | Tue Jun 11 | vs Blue Jays | L5-7 (10) | 28-35 | .444 | Guaranteed Rate Field · Chicago, IL |
| 64 | Fri Jun 14 | at Astros | L1-2 | 28-36 | .438 | Minute Maid Park · Houston, TX |
| 65 | Sat Jun 15 | at Astros | L3-4 | 28-37 | .431 | Minute Maid Park · Houston, TX |
| 66 | Sun Jun 16 | at Astros | L4-5 | 28-38 | .424 | Minute Maid Park · Houston, TX |
| 67 | Mon Jun 17 | at Astros | W4-2 | 29-38 | .433 | Minute Maid Park · Houston, TX |
| 68 | Tue Jun 18 | at Twins | L5-7 | 29-39 | .426 | Target Field · Minneapolis, MN |
| 69 | Wed Jun 19 | at Twins | L4-7 | 29-40 | .420 | Target Field · Minneapolis, MN |
| 70 | Thu Jun 20 | at Twins | L4-8 | 29-41 | .414 | Target Field · Minneapolis, MN |
| 71 | Fri Jun 21 | at Royals | W9-1 | 30-41 | .423 | Kauffman Stadium · Kansas City, MO |
| 72 | Sat Jun 22 | at Royals | W3-2 | 31-41 | .431 | Kauffman Stadium · Kansas City, MO |
| 73 | Sun Jun 23 | at Royals | L6-7 | 31-42 | .425 | Kauffman Stadium · Kansas City, MO |
| 74 | Tue Jun 25 | vs Mets | W5-4 | 32-42 | .432 | Guaranteed Rate Field · Chicago, IL |
| 75 | Wed Jun 26 | vs Mets | L0-3 | 32-43 | .427 | Guaranteed Rate Field · Chicago, IL |
| 76 | Fri Jun 28 | vs Guardians | L10-19 | 32-44 | .421 | Guaranteed Rate Field · Chicago, IL |
| 77 | Fri Jun 28 | vs Guardians | L8-9 | 32-45 | .416 | Guaranteed Rate Field · Chicago, IL |
| 78 | Sat Jun 29 | vs Guardians | L3-4 | 32-46 | .410 | Guaranteed Rate Field · Chicago, IL |
| 79 | Sun Jun 30 | vs Guardians | L0-4 | 32-47 | .405 | Guaranteed Rate Field · Chicago, IL |
| 80 | Tue Jul 2 | vs Orioles | W5-2 | 33-47 | .412 | Guaranteed Rate Field · Chicago, IL |
| 81 | Wed Jul 3 | vs Orioles | L2-4 | 33-48 | .407 | Guaranteed Rate Field · Chicago, IL |
| 82 | Thu Jul 4 | vs Orioles | W3-2 | 34-48 | .415 | Guaranteed Rate Field · Chicago, IL |
| 83 | Fri Jul 5 | at Rays | L3-8 | 34-49 | .410 | Tropicana Field · St. Petersburg, FL |
| 84 | Sat Jul 6 | at Rays | L0-3 | 34-50 | .405 | Tropicana Field · St. Petersburg, FL |
| 85 | Sun Jul 7 | at Rays | L1-3 | 34-51 | .400 | Tropicana Field · St. Petersburg, FL |
| 86 | Mon Jul 8 | vs Cubs | L2-8 | 34-52 | .395 | Guaranteed Rate Field · Chicago, IL |
| 87 | Tue Jul 9 | at Tigers | W11-4 | 35-52 | .402 | Comerica Park · Detroit, MI |
| 88 | Wed Jul 10 | at Tigers | L5-8 | 35-53 | .398 | Comerica Park · Detroit, MI |
| 89 | Thu Jul 11 | at Tigers | W6-3 | 36-53 | .404 | Comerica Park · Detroit, MI |
| 90 | Sat Jul 13 | at Phillies | W5-4 (11) | 37-53 | .411 | Citizens Bank Park · Philadelphi, PA |
| 91 | Sat Jul 13 | at Phillies | L1-2 (13) | 37-54 | .407 | Citizens Bank Park · Philadelphi, PA |
| 92 | Sun Jul 14 | at Phillies | L3-4 (10) | 37-55 | .402 | Citizens Bank Park · Philadelphi, PA |
| 93 | Fri Jul 19 | vs Braves | L4-6 | 37-56 | .398 | Guaranteed Rate Field · Chicago, IL |
| 94 | Sat Jul 20 | vs Braves | W10-6 | 38-56 | .404 | Guaranteed Rate Field · Chicago, IL |
| 95 | Sun Jul 21 | vs Braves | W3-1 | 39-56 | .411 | Guaranteed Rate Field · Chicago, IL |
| 96 | Mon Jul 22 | vs Tigers | L3-7 | 39-57 | .406 | Guaranteed Rate Field · Chicago, IL |
| 97 | Tue Jul 23 | vs Tigers | L2-6 | 39-58 | .402 | Guaranteed Rate Field · Chicago, IL |
| 98 | Wed Jul 24 | vs Tigers | L2-6 | 39-59 | .398 | Guaranteed Rate Field · Chicago, IL |
| 99 | Thu Jul 25 | vs Tigers | W7-4 | 40-59 | .404 | Guaranteed Rate Field · Chicago, IL |
| 100 | Fri Jul 26 | vs Royals | L1-5 | 40-60 | .400 | Guaranteed Rate Field · Chicago, IL |
| 101 | Sat Jul 27 | vs Royals | L0-1 | 40-61 | .396 | Guaranteed Rate Field · Chicago, IL |
| 102 | Sun Jul 28 | vs Royals | L2-4 (12) | 40-62 | .392 | Guaranteed Rate Field · Chicago, IL |
| 103 | Mon Jul 29 | at Guardians | L2-3 | 40-63 | .388 | Progressive Field · Cleveland, OH |
| 104 | Tue Jul 30 | at Guardians | L4-7 | 40-64 | .385 | Progressive Field · Cleveland, OH |
| 105 | Wed Jul 31 | at Guardians | L5-6 (10) | 40-65 | .381 | Progressive Field · Cleveland, OH |
| 106 | Thu Aug 1 | at Guardians | L1-6 | 40-66 | .377 | Progressive Field · Cleveland, OH |
| 107 | Fri Aug 2 | at Tigers | L1-2 | 40-67 | .374 | Comerica Park · Detroit, MI |
| 108 | Sat Aug 3 | at Tigers | L0-3 | 40-68 | .370 | Comerica Park · Detroit, MI |
| 109 | Sun Aug 4 | at Tigers | L2-3 (12) | 40-69 | .367 | Comerica Park · Detroit, MI |
| 110 | Mon Aug 5 | vs Yankees | W8-1 | 41-69 | .373 | Guaranteed Rate Field · Chicago, IL |
| 111 | Tue Aug 6 | vs Yankees | W3-2 | 42-69 | .378 | Guaranteed Rate Field · Chicago, IL |
| 112 | Wed Aug 7 | vs Yankees | W6-5 (12) | 43-69 | .384 | Guaranteed Rate Field · Chicago, IL |
| 113 | Fri Aug 9 | vs Twins | L5-7 | 43-70 | .381 | Guaranteed Rate Field · Chicago, IL |
| 114 | Fri Aug 9 | vs Twins | L2-3 (10) | 43-71 | .377 | Guaranteed Rate Field · Chicago, IL |
| 115 | Sat Aug 10 | vs Twins | W5-4 | 44-71 | .383 | Guaranteed Rate Field · Chicago, IL |
| 116 | Sun Aug 11 | vs Twins | L2-5 | 44-72 | .379 | Guaranteed Rate Field · Chicago, IL |
| 117 | Mon Aug 12 | vs Tigers | W6-2 | 45-72 | .385 | Guaranteed Rate Field · Chicago, IL |
| 118 | Tue Aug 13 | vs Tigers | W4-3 (11) | 46-72 | .390 | Guaranteed Rate Field · Chicago, IL |
| 119 | Wed Aug 14 | vs Tigers | L4-6 | 46-73 | .387 | Guaranteed Rate Field · Chicago, IL |
| 120 | Thu Aug 15 | at Twins | L3-4 | 46-74 | .383 | Target Field · Minneapolis, MN |
| 121 | Fri Aug 16 | at Twins | W5-2 | 47-74 | .388 | Target Field · Minneapolis, MN |
| 122 | Sat Aug 17 | at Twins | W8-5 | 48-74 | .393 | Target Field · Minneapolis, MN |
| 123 | Sun Aug 18 | at Twins | W5-2 | 49-74 | .398 | Target Field · Minneapolis, MN |
| 124 | Tue Aug 20 | at Royals | W2-0 | 50-74 | .403 | Kauffman Stadium · Kansas City, MO |
| 125 | Wed Aug 21 | at Royals | W5-2 | 51-74 | .408 | Kauffman Stadium · Kansas City, MO |
| 126 | Thu Aug 22 | at Royals | W4-3 (12) | 52-74 | .413 | Kauffman Stadium · Kansas City, MO |
| 127 | Fri Aug 23 | vs Rangers | L5-11 | 52-75 | .409 | Guaranteed Rate Field · Chicago, IL |
| 128 | Sat Aug 24 | vs Rangers | W3-2 | 53-75 | .414 | Guaranteed Rate Field · Chicago, IL |
| 129 | Sun Aug 25 | vs Rangers | W5-2 | 54-75 | .419 | Guaranteed Rate Field · Chicago, IL |
| 130 | Mon Aug 26 | vs Astros | L8-10 | 54-76 | .415 | Guaranteed Rate Field · Chicago, IL |
| 131 | Tue Aug 27 | vs Astros | W4-3 | 55-76 | .420 | Guaranteed Rate Field · Chicago, IL |
| 132 | Wed Aug 28 | vs Astros | W6-1 | 56-76 | .424 | Guaranteed Rate Field · Chicago, IL |
| 133 | Fri Aug 30 | at Red Sox | L3-4 | 56-77 | .421 | Fenway Park · Boston, MA |
| 134 | Sat Aug 31 | at Red Sox | L2-7 | 56-78 | .418 | Fenway Park · Boston, MA |
| 135 | Sun Sep 1 | at Red Sox | L6-7 | 56-79 | .415 | Fenway Park · Boston, MA |
| 136 | Mon Sep 2 | at Yankees | L1-9 | 56-80 | .412 | Yankee Stadium · The Bronx, NY |
| 137 | Tue Sep 3 | at Yankees | L4-6 | 56-81 | .409 | Yankee Stadium · The Bronx, NY |
| 138 | Wed Sep 4 | at Yankees | L5-6 | 56-82 | .406 | Yankee Stadium · The Bronx, NY |
| 139 | Thu Sep 5 | at Orioles | L1-3 | 56-83 | .403 | Camden Yards · Baltimore, MD |
| 140 | Fri Sep 6 | at Orioles | L0-4 | 56-84 | .400 | Camden Yards · Baltimore, MD |
| 141 | Sat Sep 7 | at Orioles | L3-4 (10) | 56-85 | .397 | Camden Yards · Baltimore, MD |
| 142 | Sun Sep 8 | at Orioles | W4-2 | 57-85 | .401 | Camden Yards · Baltimore, MD |
| 143 | Mon Sep 9 | vs Tigers | W5-1 | 58-85 | .406 | Guaranteed Rate Field · Chicago, IL |
| 144 | Tue Sep 10 | vs Tigers | L1-9 | 58-86 | .403 | Guaranteed Rate Field · Chicago, IL |
| 145 | Wed Sep 11 | vs Tigers | L0-1 | 58-87 | .400 | Guaranteed Rate Field · Chicago, IL |
| 146 | Thu Sep 12 | vs Guardians | L3-14 | 58-88 | .397 | Guaranteed Rate Field · Chicago, IL |
| 147 | Fri Sep 13 | vs Guardians | L1-3 | 58-89 | .395 | Guaranteed Rate Field · Chicago, IL |
| 148 | Sat Sep 14 | vs Guardians | L1-8 | 58-90 | .392 | Guaranteed Rate Field · Chicago, IL |
| 149 | Sun Sep 15 | vs Guardians | L1-7 | 58-91 | .389 | Guaranteed Rate Field · Chicago, IL |
| 150 | Mon Sep 16 | vs Twins | W12-1 | 59-91 | .393 | Guaranteed Rate Field · Chicago, IL |
| 151 | Tue Sep 17 | vs Twins | W4-3 | 60-91 | .397 | Guaranteed Rate Field · Chicago, IL |
| 152 | Wed Sep 18 | vs Twins | L3-4 | 60-92 | .395 | Guaranteed Rate Field · Chicago, IL |
| 153 | Fri Sep 20 | at Tigers | L5-12 | 60-93 | .392 | Comerica Park · Detroit, MI |
| 154 | Sat Sep 21 | at Tigers | L6-7 (12) | 60-94 | .390 | Comerica Park · Detroit, MI |
| 155 | Sun Sep 22 | at Tigers | W6-3 | 61-94 | .394 | Comerica Park · Detroit, MI |
| 156 | Mon Sep 23 | vs Blue Jays | W3-2 | 62-94 | .397 | Guaranteed Rate Field · Chicago, IL |
| 157 | Tue Sep 24 | at Guardians | L4-5 | 62-95 | .395 | Progressive Field · Cleveland, OH |
| 158 | Wed Sep 25 | at Guardians | L2-7 | 62-96 | .392 | Progressive Field · Cleveland, OH |
| 159 | Thu Sep 26 | vs Royals | L2-3 | 62-97 | .390 | Guaranteed Rate Field · Chicago, IL |
| 160 | Fri Sep 27 | vs Royals | L1-6 | 62-98 | .388 | Guaranteed Rate Field · Chicago, IL |
| 161 | Sat Sep 28 | vs Royals | W6-5 | 63-98 | .391 | Guaranteed Rate Field · Chicago, IL |
| 162 | Sun Sep 29 | vs Royals | L1-4 | 63-99 | .389 | Guaranteed Rate Field · Chicago, IL |