| 1 | Fri Apr 6 | at Rangers | L2-3 | 0-1 | .000 | Globe Life Field · Arlington, TX |
| 2 | Sat Apr 7 | at Rangers | W4-3 | 1-1 | .500 | Globe Life Field · Arlington, TX |
| 3 | Sun Apr 8 | at Rangers | L0-5 | 1-2 | .333 | Globe Life Field · Arlington, TX |
| 4 | Mon Apr 9 | at Guardians | W4-2 | 2-2 | .500 | Progressive Field · Cleveland, OH |
| 5 | Wed Apr 11 | at Guardians | W10-6 | 3-2 | .600 | Progressive Field · Cleveland, OH |
| 6 | Fri Apr 13 | vs Tigers | W5-2 | 4-2 | .667 | Guaranteed Rate Field · Chicago, IL |
| 7 | Sat Apr 14 | vs Tigers | W5-1 | 5-2 | .714 | Guaranteed Rate Field · Chicago, IL |
| 8 | Sun Apr 15 | vs Tigers | L2-5 | 5-3 | .625 | Guaranteed Rate Field · Chicago, IL |
| 9 | Mon Apr 16 | vs Orioles | L4-10 (10) | 5-4 | .556 | Guaranteed Rate Field · Chicago, IL |
| 10 | Tue Apr 17 | vs Orioles | L2-3 | 5-5 | .500 | Guaranteed Rate Field · Chicago, IL |
| 11 | Wed Apr 18 | vs Orioles | W8-1 | 6-5 | .545 | Guaranteed Rate Field · Chicago, IL |
| 12 | Thu Apr 19 | vs Orioles | L3-5 | 6-6 | .500 | Guaranteed Rate Field · Chicago, IL |
| 13 | Fri Apr 20 | at Mariners | W7-3 | 7-6 | .538 | T-Mobile Park · Seattle, WA |
| 14 | Sat Apr 21 | at Mariners | W4-0 | 8-6 | .571 | T-Mobile Park · Seattle, WA |
| 15 | Sun Apr 22 | at Mariners | W7-4 | 9-6 | .600 | T-Mobile Park · Seattle, WA |
| 16 | Mon Apr 23 | at Athletics | W4-0 | 10-6 | .625 | RingCentral Coliseum · Oakland, CA |
| 17 | Tue Apr 24 | at Athletics | L0-2 | 10-7 | .588 | RingCentral Coliseum · Oakland, CA |
| 18 | Wed Apr 25 | at Athletics | L4-5 (14) | 10-8 | .556 | RingCentral Coliseum · Oakland, CA |
| 19 | Thu Apr 26 | vs Red Sox | L3-10 | 10-9 | .526 | Guaranteed Rate Field · Chicago, IL |
| 20 | Fri Apr 27 | vs Red Sox | L3-10 | 10-10 | .500 | Guaranteed Rate Field · Chicago, IL |
| 21 | Sat Apr 28 | vs Red Sox | L0-1 | 10-11 | .476 | Guaranteed Rate Field · Chicago, IL |
| 22 | Sun Apr 29 | vs Red Sox | W4-1 | 11-11 | .500 | Guaranteed Rate Field · Chicago, IL |
| 23 | Tue May 1 | vs Guardians | W7-2 | 12-11 | .522 | Guaranteed Rate Field · Chicago, IL |
| 24 | Wed May 2 | vs Guardians | L3-6 | 12-12 | .500 | Guaranteed Rate Field · Chicago, IL |
| 25 | Thu May 3 | vs Guardians | L5-7 | 12-13 | .480 | Guaranteed Rate Field · Chicago, IL |
| 26 | Fri May 4 | at Tigers | L4-5 | 12-14 | .462 | Comerica Park · Detroit, MI |
| 27 | Sat May 5 | at Tigers | W3-2 | 13-14 | .481 | Comerica Park · Detroit, MI |
| 28 | Sun May 6 | at Tigers | L1-3 | 13-15 | .464 | Comerica Park · Detroit, MI |
| 29 | Mon May 7 | at Guardians | L6-8 | 13-16 | .448 | Progressive Field · Cleveland, OH |
| 30 | Mon May 7 | at Guardians | L2-3 | 13-17 | .433 | Progressive Field · Cleveland, OH |
| 31 | Tue May 8 | at Guardians | W5-3 (10) | 14-17 | .452 | Progressive Field · Cleveland, OH |
| 32 | Wed May 9 | at Guardians | W8-1 | 15-17 | .469 | Progressive Field · Cleveland, OH |
| 33 | Fri May 11 | vs Royals | W5-0 | 16-17 | .485 | Guaranteed Rate Field · Chicago, IL |
| 34 | Sat May 12 | vs Royals | L0-5 | 16-18 | .471 | Guaranteed Rate Field · Chicago, IL |
| 35 | Sun May 13 | vs Royals | L1-9 | 16-19 | .457 | Guaranteed Rate Field · Chicago, IL |
| 36 | Mon May 14 | vs Tigers | W7-5 | 17-19 | .472 | Guaranteed Rate Field · Chicago, IL |
| 37 | Tue May 15 | vs Tigers | L8-10 | 17-20 | .459 | Guaranteed Rate Field · Chicago, IL |
| 38 | Wed May 16 | at Angels | L2-7 | 17-21 | .447 | Angel Stadium · Anaheim, CA |
| 39 | Thu May 17 | at Angels | W6-1 | 18-21 | .462 | Angel Stadium · Anaheim, CA |
| 40 | Fri May 18 | at Cubs | W3-2 | 19-21 | .475 | Wrigley Field · Chicago, IL |
| 41 | Sat May 19 | at Cubs | W7-4 | 20-21 | .488 | Wrigley Field · Chicago, IL |
| 42 | Sun May 20 | at Cubs | W6-0 | 21-21 | .500 | Wrigley Field · Chicago, IL |
| 43 | Tue May 22 | vs Twins | L2-9 | 21-22 | .488 | Guaranteed Rate Field · Chicago, IL |
| 44 | Wed May 23 | vs Twins | W6-0 | 22-22 | .500 | Guaranteed Rate Field · Chicago, IL |
| 45 | Thu May 24 | vs Twins | W11-8 | 23-22 | .511 | Guaranteed Rate Field · Chicago, IL |
| 46 | Fri May 25 | vs Guardians | W9-3 | 24-22 | .522 | Guaranteed Rate Field · Chicago, IL |
| 47 | Sat May 26 | vs Guardians | W14-7 | 25-22 | .532 | Guaranteed Rate Field · Chicago, IL |
| 48 | Sun May 27 | vs Guardians | W12-6 | 26-22 | .542 | Guaranteed Rate Field · Chicago, IL |
| 49 | Mon May 28 | at Rays | W2-1 | 27-22 | .551 | Tropicana Field · St. Petersburg, FL |
| 50 | Tue May 29 | at Rays | W7-2 | 28-22 | .560 | Tropicana Field · St. Petersburg, FL |
| 51 | Wed May 30 | at Rays | W4-3 | 29-22 | .569 | Tropicana Field · St. Petersburg, FL |
| 52 | Fri Jun 1 | vs Mariners | W7-4 | 30-22 | .577 | Guaranteed Rate Field · Chicago, IL |
| 53 | Sat Jun 2 | vs Mariners | L8-10 (12) | 30-23 | .566 | Guaranteed Rate Field · Chicago, IL |
| 54 | Sun Jun 3 | vs Mariners | W4-2 | 31-23 | .574 | Guaranteed Rate Field · Chicago, IL |
| 55 | Tue Jun 5 | vs Blue Jays | L5-9 | 31-24 | .564 | Guaranteed Rate Field · Chicago, IL |
| 56 | Wed Jun 6 | vs Blue Jays | L0-4 | 31-25 | .554 | Guaranteed Rate Field · Chicago, IL |
| 57 | Thu Jun 7 | vs Blue Jays | W4-3 | 32-25 | .561 | Guaranteed Rate Field · Chicago, IL |
| 58 | Fri Jun 8 | vs Astros | L3-8 | 32-26 | .552 | Guaranteed Rate Field · Chicago, IL |
| 59 | Sat Jun 9 | vs Astros | W10-1 | 33-26 | .559 | Guaranteed Rate Field · Chicago, IL |
| 60 | Sun Jun 10 | vs Astros | L9-11 | 33-27 | .550 | Guaranteed Rate Field · Chicago, IL |
| 61 | Tue Jun 12 | at Cardinals | W6-1 | 34-27 | .557 | Busch Stadium · St. Louis, MO |
| 62 | Wed Jun 13 | at Cardinals | L0-1 | 34-28 | .548 | Busch Stadium · St. Louis, MO |
| 63 | Thu Jun 14 | at Cardinals | L3-5 | 34-29 | .540 | Busch Stadium · St. Louis, MO |
| 64 | Fri Jun 15 | at Dodgers | L6-7 | 34-30 | .531 | Dodger Stadium · Los Angeles, CA |
| 65 | Sat Jun 16 | at Dodgers | W5-4 | 35-30 | .538 | Dodger Stadium · Los Angeles, CA |
| 66 | Sun Jun 17 | at Dodgers | L1-2 (10) | 35-31 | .530 | Dodger Stadium · Los Angeles, CA |
| 67 | Mon Jun 18 | vs Cubs | L3-12 | 35-32 | .522 | Guaranteed Rate Field · Chicago, IL |
| 68 | Tue Jun 19 | vs Cubs | L1-2 | 35-33 | .515 | Guaranteed Rate Field · Chicago, IL |
| 69 | Wed Jun 20 | vs Cubs | W7-0 | 36-33 | .522 | Guaranteed Rate Field · Chicago, IL |
| 70 | Fri Jun 22 | vs Brewers | L0-1 (10) | 36-34 | .514 | Guaranteed Rate Field · Chicago, IL |
| 71 | Sat Jun 23 | vs Brewers | W8-6 | 37-34 | .521 | Guaranteed Rate Field · Chicago, IL |
| 72 | Sun Jun 24 | vs Brewers | W1-0 (10) | 38-34 | .528 | Guaranteed Rate Field · Chicago, IL |
| 73 | Mon Jun 25 | at Twins | L1-4 | 38-35 | .521 | Target Field · Minneapolis, MN |
| 74 | Tue Jun 26 | at Twins | W3-2 | 39-35 | .527 | Target Field · Minneapolis, MN |
| 75 | Wed Jun 27 | at Twins | W12-5 | 40-35 | .533 | Target Field · Minneapolis, MN |
| 76 | Thu Jun 28 | at Yankees | W4-3 | 41-35 | .539 | Yankee Stadium · The Bronx, NY |
| 77 | Fri Jun 29 | at Yankees | W14-7 | 42-35 | .545 | Yankee Stadium · The Bronx, NY |
| 78 | Sat Jun 30 | at Yankees | L0-4 | 42-36 | .538 | Yankee Stadium · The Bronx, NY |
| 79 | Sun Jul 1 | at Yankees | L2-4 | 42-37 | .532 | Yankee Stadium · The Bronx, NY |
| 80 | Tue Jul 3 | vs Rangers | W19-2 | 43-37 | .537 | Guaranteed Rate Field · Chicago, IL |
| 81 | Wed Jul 4 | vs Rangers | W5-4 (10) | 44-37 | .543 | Guaranteed Rate Field · Chicago, IL |
| 82 | Thu Jul 5 | vs Rangers | W2-1 | 45-37 | .549 | Guaranteed Rate Field · Chicago, IL |
| 83 | Fri Jul 6 | vs Blue Jays | W4-2 | 46-37 | .554 | Guaranteed Rate Field · Chicago, IL |
| 84 | Sat Jul 7 | vs Blue Jays | W2-0 | 47-37 | .560 | Guaranteed Rate Field · Chicago, IL |
| 85 | Sun Jul 8 | vs Blue Jays | L9-11 | 47-38 | .553 | Guaranteed Rate Field · Chicago, IL |
| 86 | Fri Jul 13 | at Royals | W9-8 (14) | 48-38 | .558 | Kauffman Stadium · Kansas City, MO |
| 87 | Sat Jul 14 | at Royals | L3-6 | 48-39 | .552 | Kauffman Stadium · Kansas City, MO |
| 88 | Sun Jul 15 | at Royals | W2-1 | 49-39 | .557 | Kauffman Stadium · Kansas City, MO |
| 89 | Mon Jul 16 | at Red Sox | L1-5 | 49-40 | .551 | Fenway Park · Boston, MA |
| 90 | Tue Jul 17 | at Red Sox | W7-5 | 50-40 | .556 | Fenway Park · Boston, MA |
| 91 | Wed Jul 18 | at Red Sox | L1-10 | 50-41 | .549 | Fenway Park · Boston, MA |
| 92 | Thu Jul 19 | at Red Sox | L1-3 | 50-42 | .543 | Fenway Park · Boston, MA |
| 93 | Fri Jul 20 | at Tigers | L2-4 | 50-43 | .538 | Comerica Park · Detroit, MI |
| 94 | Sat Jul 21 | at Tigers | L1-7 | 50-44 | .532 | Comerica Park · Detroit, MI |
| 95 | Sun Jul 22 | at Tigers | L4-6 | 50-45 | .526 | Comerica Park · Detroit, MI |
| 96 | Mon Jul 23 | vs Twins | W7-4 | 51-45 | .531 | Guaranteed Rate Field · Chicago, IL |
| 97 | Tue Jul 24 | vs Twins | W11-4 | 52-45 | .536 | Guaranteed Rate Field · Chicago, IL |
| 98 | Wed Jul 25 | vs Twins | W8-2 | 53-45 | .541 | Guaranteed Rate Field · Chicago, IL |
| 99 | Fri Jul 27 | at Rangers | W9-5 | 54-45 | .545 | Globe Life Field · Arlington, TX |
| 100 | Sat Jul 28 | at Rangers | W5-2 | 55-45 | .550 | Globe Life Field · Arlington, TX |
| 101 | Sun Jul 29 | at Rangers | L0-2 | 55-46 | .545 | Globe Life Field · Arlington, TX |
| 102 | Mon Jul 30 | at Twins | L6-7 | 55-47 | .539 | Target Field · Minneapolis, MN |
| 103 | Tue Jul 31 | at Twins | W4-3 | 56-47 | .544 | Target Field · Minneapolis, MN |
| 104 | Wed Aug 1 | at Twins | W3-2 | 57-47 | .548 | Target Field · Minneapolis, MN |
| 105 | Fri Aug 3 | vs Angels | W8-6 (10) | 58-47 | .552 | Guaranteed Rate Field · Chicago, IL |
| 106 | Sat Aug 4 | vs Angels | L5-6 (10) | 58-48 | .547 | Guaranteed Rate Field · Chicago, IL |
| 107 | Sun Aug 5 | vs Angels | W4-2 | 59-48 | .551 | Guaranteed Rate Field · Chicago, IL |
| 108 | Mon Aug 6 | vs Royals | W4-2 | 60-48 | .556 | Guaranteed Rate Field · Chicago, IL |
| 109 | Tue Aug 7 | vs Royals | L2-5 | 60-49 | .550 | Guaranteed Rate Field · Chicago, IL |
| 110 | Wed Aug 8 | vs Royals | L1-2 | 60-50 | .545 | Guaranteed Rate Field · Chicago, IL |
| 111 | Fri Aug 10 | vs Athletics | W4-3 | 61-50 | .550 | Guaranteed Rate Field · Chicago, IL |
| 112 | Sat Aug 11 | vs Athletics | L7-9 | 61-51 | .545 | Guaranteed Rate Field · Chicago, IL |
| 113 | Sun Aug 12 | vs Athletics | W7-3 | 62-51 | .549 | Guaranteed Rate Field · Chicago, IL |
| 114 | Mon Aug 13 | at Blue Jays | L2-3 (11) | 62-52 | .544 | Rogers Centre · Toronto, ON |
| 115 | Tue Aug 14 | at Blue Jays | W3-2 | 63-52 | .548 | Rogers Centre · Toronto, ON |
| 116 | Wed Aug 15 | at Blue Jays | W9-5 | 64-52 | .552 | Rogers Centre · Toronto, ON |
| 117 | Thu Aug 16 | at Blue Jays | W7-2 | 65-52 | .556 | Rogers Centre · Toronto, ON |
| 118 | Fri Aug 17 | at Royals | L2-4 | 65-53 | .551 | Kauffman Stadium · Kansas City, MO |
| 119 | Sat Aug 18 | at Royals | L4-9 | 65-54 | .546 | Kauffman Stadium · Kansas City, MO |
| 120 | Sun Aug 19 | at Royals | L2-5 | 65-55 | .542 | Kauffman Stadium · Kansas City, MO |
| 121 | Mon Aug 20 | vs Yankees | W9-6 | 66-55 | .545 | Guaranteed Rate Field · Chicago, IL |
| 122 | Tue Aug 21 | vs Yankees | W7-3 | 67-55 | .549 | Guaranteed Rate Field · Chicago, IL |
| 123 | Wed Aug 22 | vs Yankees | W2-1 | 68-55 | .553 | Guaranteed Rate Field · Chicago, IL |
| 124 | Fri Aug 24 | vs Mariners | W9-8 | 69-55 | .556 | Guaranteed Rate Field · Chicago, IL |
| 125 | Sat Aug 25 | vs Mariners | W5-4 | 70-55 | .560 | Guaranteed Rate Field · Chicago, IL |
| 126 | Sun Aug 26 | vs Mariners | W4-3 | 71-55 | .563 | Guaranteed Rate Field · Chicago, IL |
| 127 | Mon Aug 27 | at Orioles | L3-4 | 71-56 | .559 | Camden Yards · Baltimore, MD |
| 128 | Tue Aug 28 | at Orioles | L0-6 | 71-57 | .555 | Camden Yards · Baltimore, MD |
| 129 | Wed Aug 29 | at Orioles | W8-1 | 72-57 | .558 | Camden Yards · Baltimore, MD |
| 130 | Thu Aug 30 | at Orioles | L3-5 | 72-58 | .554 | Camden Yards · Baltimore, MD |
| 131 | Fri Aug 31 | at Tigers | L4-7 | 72-59 | .550 | Comerica Park · Detroit, MI |
| 132 | Sat Sep 1 | at Tigers | L1-5 | 72-60 | .545 | Comerica Park · Detroit, MI |
| 133 | Sun Sep 2 | at Tigers | L2-4 | 72-61 | .541 | Comerica Park · Detroit, MI |
| 134 | Mon Sep 3 | vs Twins | W4-2 | 73-61 | .545 | Guaranteed Rate Field · Chicago, IL |
| 135 | Tue Sep 4 | vs Twins | L9-18 | 73-62 | .541 | Guaranteed Rate Field · Chicago, IL |
| 136 | Wed Sep 5 | vs Twins | W6-2 | 74-62 | .544 | Guaranteed Rate Field · Chicago, IL |
| 137 | Fri Sep 7 | vs Royals | L5-7 | 74-63 | .540 | Guaranteed Rate Field · Chicago, IL |
| 138 | Sat Sep 8 | vs Royals | W5-4 | 75-63 | .543 | Guaranteed Rate Field · Chicago, IL |
| 139 | Sun Sep 9 | vs Royals | L1-2 (10) | 75-64 | .540 | Guaranteed Rate Field · Chicago, IL |
| 140 | Mon Sep 10 | vs Tigers | W6-1 | 76-64 | .543 | Guaranteed Rate Field · Chicago, IL |
| 141 | Tue Sep 11 | vs Tigers | L3-5 | 76-65 | .539 | Guaranteed Rate Field · Chicago, IL |
| 142 | Wed Sep 12 | vs Tigers | L6-8 | 76-66 | .535 | Guaranteed Rate Field · Chicago, IL |
| 143 | Fri Sep 14 | at Twins | W6-0 | 77-66 | .538 | Target Field · Minneapolis, MN |
| 144 | Sat Sep 15 | at Twins | W5-3 | 78-66 | .542 | Target Field · Minneapolis, MN |
| 145 | Sun Sep 16 | at Twins | W9-2 | 79-66 | .545 | Target Field · Minneapolis, MN |
| 146 | Mon Sep 17 | vs Tigers | W5-4 | 80-66 | .548 | Guaranteed Rate Field · Chicago, IL |
| 147 | Tue Sep 18 | at Royals | W3-2 | 81-66 | .551 | Kauffman Stadium · Kansas City, MO |
| 148 | Wed Sep 19 | at Royals | L0-3 | 81-67 | .547 | Kauffman Stadium · Kansas City, MO |
| 149 | Thu Sep 20 | at Royals | L3-4 | 81-68 | .544 | Kauffman Stadium · Kansas City, MO |
| 150 | Fri Sep 21 | at Angels | L2-6 | 81-69 | .540 | Angel Stadium · Anaheim, CA |
| 151 | Sat Sep 22 | at Angels | L2-4 | 81-70 | .536 | Angel Stadium · Anaheim, CA |
| 152 | Sun Sep 23 | at Angels | L1-4 | 81-71 | .533 | Angel Stadium · Anaheim, CA |
| 153 | Mon Sep 24 | vs Guardians | W5-4 | 82-71 | .536 | Guaranteed Rate Field · Chicago, IL |
| 154 | Tue Sep 25 | vs Guardians | L3-4 | 82-72 | .532 | Guaranteed Rate Field · Chicago, IL |
| 155 | Wed Sep 26 | vs Guardians | L4-6 | 82-73 | .529 | Guaranteed Rate Field · Chicago, IL |
| 156 | Thu Sep 27 | vs Rays | L2-3 | 82-74 | .526 | Guaranteed Rate Field · Chicago, IL |
| 157 | Fri Sep 28 | vs Rays | W3-1 | 83-74 | .529 | Guaranteed Rate Field · Chicago, IL |
| 158 | Sat Sep 29 | vs Rays | L4-10 | 83-75 | .525 | Guaranteed Rate Field · Chicago, IL |
| 159 | Sun Sep 30 | vs Rays | L2-6 | 83-76 | .522 | Guaranteed Rate Field · Chicago, IL |
| 160 | Mon Oct 1 | at Guardians | W11-0 | 84-76 | .525 | Progressive Field · Cleveland, OH |
| 161 | Tue Oct 2 | at Guardians | L3-4 (12) | 84-77 | .522 | Progressive Field · Cleveland, OH |
| 162 | Wed Oct 3 | at Guardians | W9-0 | 85-77 | .525 | Progressive Field · Cleveland, OH |