| 1 | Thu Mar 30 | at Astros | W3-2 | 1-0 | 1.000 | Minute Maid Park · Houston, TX |
| 2 | Fri Mar 31 | at Astros | L3-6 | 1-1 | .500 | Minute Maid Park · Houston, TX |
| 3 | Sat Apr 1 | at Astros | L4-6 | 1-2 | .333 | Minute Maid Park · Houston, TX |
| 4 | Sun Apr 2 | at Astros | W6-3 | 2-2 | .500 | Minute Maid Park · Houston, TX |
| 5 | Mon Apr 3 | vs Giants | L3-12 | 2-3 | .400 | Guaranteed Rate Field · Chicago, IL |
| 6 | Wed Apr 5 | vs Giants | W7-3 | 3-3 | .500 | Guaranteed Rate Field · Chicago, IL |
| 7 | Thu Apr 6 | vs Giants | L6-16 | 3-4 | .429 | Guaranteed Rate Field · Chicago, IL |
| 8 | Fri Apr 7 | at Pirates | L9-13 | 3-5 | .375 | PNC Park · Pittsburgh, PA |
| 9 | Sat Apr 8 | at Pirates | W11-5 | 4-5 | .444 | PNC Park · Pittsburgh, PA |
| 10 | Sun Apr 9 | at Pirates | L0-1 | 4-6 | .400 | PNC Park · Pittsburgh, PA |
| 11 | Mon Apr 10 | at Twins | W4-3 | 5-6 | .455 | Target Field · Minneapolis, MN |
| 12 | Tue Apr 11 | at Twins | L3-4 (10) | 5-7 | .417 | Target Field · Minneapolis, MN |
| 13 | Wed Apr 12 | at Twins | L1-3 | 5-8 | .385 | Target Field · Minneapolis, MN |
| 14 | Fri Apr 14 | vs Orioles | L3-6 | 5-9 | .357 | Guaranteed Rate Field · Chicago, IL |
| 15 | Sat Apr 15 | vs Orioles | W7-6 (10) | 6-9 | .400 | Guaranteed Rate Field · Chicago, IL |
| 16 | Sun Apr 16 | vs Orioles | L4-8 | 6-10 | .375 | Guaranteed Rate Field · Chicago, IL |
| 17 | Tue Apr 18 | vs Phillies | L4-7 | 6-11 | .353 | Guaranteed Rate Field · Chicago, IL |
| 18 | Tue Apr 18 | vs Phillies | W3-0 | 7-11 | .389 | Guaranteed Rate Field · Chicago, IL |
| 19 | Wed Apr 19 | vs Phillies | L2-5 | 7-12 | .368 | Guaranteed Rate Field · Chicago, IL |
| 20 | Fri Apr 21 | at Rays | L7-8 | 7-13 | .350 | Tropicana Field · St. Petersburg, FL |
| 21 | Sat Apr 22 | at Rays | L3-4 (10) | 7-14 | .333 | Tropicana Field · St. Petersburg, FL |
| 22 | Sun Apr 23 | at Rays | L1-4 | 7-15 | .318 | Tropicana Field · St. Petersburg, FL |
| 23 | Mon Apr 24 | at Blue Jays | L2-5 | 7-16 | .304 | Rogers Centre · Toronto, ON |
| 24 | Tue Apr 25 | at Blue Jays | L0-7 | 7-17 | .292 | Rogers Centre · Toronto, ON |
| 25 | Wed Apr 26 | at Blue Jays | L0-8 | 7-18 | .280 | Rogers Centre · Toronto, ON |
| 26 | Thu Apr 27 | vs Rays | L5-14 | 7-19 | .269 | Guaranteed Rate Field · Chicago, IL |
| 27 | Fri Apr 28 | vs Rays | L2-3 | 7-20 | .259 | Guaranteed Rate Field · Chicago, IL |
| 28 | Sat Apr 29 | vs Rays | L3-12 | 7-21 | .250 | Guaranteed Rate Field · Chicago, IL |
| 29 | Sun Apr 30 | vs Rays | W12-9 | 8-21 | .276 | Guaranteed Rate Field · Chicago, IL |
| 30 | Tue May 2 | vs Twins | W3-2 (10) | 9-21 | .300 | Guaranteed Rate Field · Chicago, IL |
| 31 | Wed May 3 | vs Twins | W6-4 | 10-21 | .323 | Guaranteed Rate Field · Chicago, IL |
| 32 | Thu May 4 | vs Twins | L3-7 (12) | 10-22 | .313 | Guaranteed Rate Field · Chicago, IL |
| 33 | Fri May 5 | at Reds | W5-4 | 11-22 | .333 | Great American Ball Park · Cincinnati, OH |
| 34 | Sat May 6 | at Reds | L3-5 | 11-23 | .324 | Great American Ball Park · Cincinnati, OH |
| 35 | Sun May 7 | at Reds | W17-4 | 12-23 | .343 | Great American Ball Park · Cincinnati, OH |
| 36 | Mon May 8 | at Royals | L5-12 | 12-24 | .333 | Kauffman Stadium · Kansas City, MO |
| 37 | Tue May 9 | at Royals | W4-2 | 13-24 | .351 | Kauffman Stadium · Kansas City, MO |
| 38 | Wed May 10 | at Royals | L1-9 | 13-25 | .342 | Kauffman Stadium · Kansas City, MO |
| 39 | Thu May 11 | at Royals | L3-4 | 13-26 | .333 | Kauffman Stadium · Kansas City, MO |
| 40 | Fri May 12 | vs Astros | L1-5 | 13-27 | .325 | Guaranteed Rate Field · Chicago, IL |
| 41 | Sat May 13 | vs Astros | W3-1 | 14-27 | .341 | Guaranteed Rate Field · Chicago, IL |
| 42 | Sun May 14 | vs Astros | L3-4 | 14-28 | .333 | Guaranteed Rate Field · Chicago, IL |
| 43 | Tue May 16 | vs Guardians | W8-3 | 15-28 | .349 | Guaranteed Rate Field · Chicago, IL |
| 44 | Wed May 17 | vs Guardians | W7-2 | 16-28 | .364 | Guaranteed Rate Field · Chicago, IL |
| 45 | Thu May 18 | vs Guardians | L1-3 | 16-29 | .356 | Guaranteed Rate Field · Chicago, IL |
| 46 | Fri May 19 | vs Royals | W2-0 | 17-29 | .370 | Guaranteed Rate Field · Chicago, IL |
| 47 | Sat May 20 | vs Royals | W5-1 | 18-29 | .383 | Guaranteed Rate Field · Chicago, IL |
| 48 | Sun May 21 | vs Royals | W5-2 | 19-29 | .396 | Guaranteed Rate Field · Chicago, IL |
| 49 | Mon May 22 | at Guardians | L0-3 | 19-30 | .388 | Progressive Field · Cleveland, OH |
| 50 | Tue May 23 | at Guardians | W4-2 | 20-30 | .400 | Progressive Field · Cleveland, OH |
| 51 | Wed May 24 | at Guardians | W6-0 | 21-30 | .412 | Progressive Field · Cleveland, OH |
| 52 | Thu May 25 | at Tigers | L2-7 | 21-31 | .404 | Comerica Park · Detroit, MI |
| 53 | Fri May 26 | at Tigers | W12-3 | 22-31 | .415 | Comerica Park · Detroit, MI |
| 54 | Sat May 27 | at Tigers | L3-7 | 22-32 | .407 | Comerica Park · Detroit, MI |
| 55 | Sun May 28 | at Tigers | L5-6 (10) | 22-33 | .400 | Comerica Park · Detroit, MI |
| 56 | Mon May 29 | vs Angels | L4-6 | 22-34 | .393 | Guaranteed Rate Field · Chicago, IL |
| 57 | Tue May 30 | vs Angels | W7-3 | 23-34 | .404 | Guaranteed Rate Field · Chicago, IL |
| 58 | Wed May 31 | vs Angels | L5-12 | 23-35 | .397 | Guaranteed Rate Field · Chicago, IL |
| 59 | Fri Jun 2 | vs Tigers | W3-0 | 24-35 | .407 | Guaranteed Rate Field · Chicago, IL |
| 60 | Sat Jun 3 | vs Tigers | W2-1 (10) | 25-35 | .417 | Guaranteed Rate Field · Chicago, IL |
| 61 | Sun Jun 4 | vs Tigers | W6-2 | 26-35 | .426 | Guaranteed Rate Field · Chicago, IL |
| 62 | Tue Jun 6 | at Yankees | W3-2 | 27-35 | .435 | Yankee Stadium · The Bronx, NY |
| 63 | Thu Jun 8 | at Yankees | W6-5 | 28-35 | .444 | Yankee Stadium · The Bronx, NY |
| 64 | Thu Jun 8 | at Yankees | L0-3 | 28-36 | .438 | Yankee Stadium · The Bronx, NY |
| 65 | Fri Jun 9 | vs Marlins | W2-1 | 29-36 | .446 | Guaranteed Rate Field · Chicago, IL |
| 66 | Sat Jun 10 | vs Marlins | L1-5 | 29-37 | .439 | Guaranteed Rate Field · Chicago, IL |
| 67 | Sun Jun 11 | vs Marlins | L5-6 | 29-38 | .433 | Guaranteed Rate Field · Chicago, IL |
| 68 | Tue Jun 13 | at Dodgers | L1-5 | 29-39 | .426 | Dodger Stadium · Los Angeles, CA |
| 69 | Wed Jun 14 | at Dodgers | W8-4 | 30-39 | .435 | Dodger Stadium · Los Angeles, CA |
| 70 | Thu Jun 15 | at Dodgers | L4-5 (11) | 30-40 | .429 | Dodger Stadium · Los Angeles, CA |
| 71 | Fri Jun 16 | at Mariners | L2-3 | 30-41 | .423 | T-Mobile Park · Seattle, WA |
| 72 | Sat Jun 17 | at Mariners | W4-3 (11) | 31-41 | .431 | T-Mobile Park · Seattle, WA |
| 73 | Sun Jun 18 | at Mariners | L1-5 | 31-42 | .425 | T-Mobile Park · Seattle, WA |
| 74 | Mon Jun 19 | vs Rangers | L2-5 | 31-43 | .419 | Guaranteed Rate Field · Chicago, IL |
| 75 | Tue Jun 20 | vs Rangers | W7-6 | 32-43 | .427 | Guaranteed Rate Field · Chicago, IL |
| 76 | Wed Jun 21 | vs Rangers | L3-6 | 32-44 | .421 | Guaranteed Rate Field · Chicago, IL |
| 77 | Fri Jun 23 | vs Red Sox | L1-3 | 32-45 | .416 | Guaranteed Rate Field · Chicago, IL |
| 78 | Sat Jun 24 | vs Red Sox | W5-4 | 33-45 | .423 | Guaranteed Rate Field · Chicago, IL |
| 79 | Sun Jun 25 | vs Red Sox | W4-1 | 34-45 | .430 | Guaranteed Rate Field · Chicago, IL |
| 80 | Mon Jun 26 | at Angels | L1-2 | 34-46 | .425 | Angel Stadium · Anaheim, CA |
| 81 | Tue Jun 27 | at Angels | L2-4 | 34-47 | .420 | Angel Stadium · Anaheim, CA |
| 82 | Wed Jun 28 | at Angels | W11-5 | 35-47 | .427 | Angel Stadium · Anaheim, CA |
| 83 | Thu Jun 29 | at Angels | W9-7 | 36-47 | .434 | Angel Stadium · Anaheim, CA |
| 84 | Fri Jun 30 | at Athletics | L4-7 | 36-48 | .429 | RingCentral Coliseum · Oakland, CA |
| 85 | Sat Jul 1 | at Athletics | L6-7 (10) | 36-49 | .424 | RingCentral Coliseum · Oakland, CA |
| 86 | Sun Jul 2 | at Athletics | W8-7 | 37-49 | .430 | RingCentral Coliseum · Oakland, CA |
| 87 | Tue Jul 4 | vs Blue Jays | L3-4 | 37-50 | .425 | Guaranteed Rate Field · Chicago, IL |
| 88 | Thu Jul 6 | vs Blue Jays | L2-6 (11) | 37-51 | .420 | Guaranteed Rate Field · Chicago, IL |
| 89 | Thu Jul 6 | vs Blue Jays | L4-5 | 37-52 | .416 | Guaranteed Rate Field · Chicago, IL |
| 90 | Fri Jul 7 | vs Cardinals | W8-7 | 38-52 | .422 | Guaranteed Rate Field · Chicago, IL |
| 91 | Sat Jul 8 | vs Cardinals | L0-3 | 38-53 | .418 | Guaranteed Rate Field · Chicago, IL |
| 92 | Sun Jul 9 | vs Cardinals | L3-4 (10) | 38-54 | .413 | Guaranteed Rate Field · Chicago, IL |
| 93 | Fri Jul 14 | at Braves | L0-9 | 38-55 | .409 | Truist Park · Cumberland, GA |
| 94 | Sat Jul 15 | at Braves | W6-5 | 39-55 | .415 | Truist Park · Cumberland, GA |
| 95 | Sun Jul 16 | at Braves | W8-1 | 40-55 | .421 | Truist Park · Cumberland, GA |
| 96 | Tue Jul 18 | at Mets | L10-11 | 40-56 | .417 | Citi Field · Queens, NY |
| 97 | Wed Jul 19 | at Mets | L1-5 | 40-57 | .412 | Citi Field · Queens, NY |
| 98 | Thu Jul 20 | at Mets | W6-2 | 41-57 | .418 | Citi Field · Queens, NY |
| 99 | Fri Jul 21 | at Twins | L4-9 | 41-58 | .414 | Target Field · Minneapolis, MN |
| 100 | Sat Jul 22 | at Twins | L2-3 | 41-59 | .410 | Target Field · Minneapolis, MN |
| 101 | Sun Jul 23 | at Twins | L4-5 (12) | 41-60 | .406 | Target Field · Minneapolis, MN |
| 102 | Tue Jul 25 | vs Cubs | L3-7 | 41-61 | .402 | Guaranteed Rate Field · Chicago, IL |
| 103 | Wed Jul 26 | vs Cubs | L7-10 | 41-62 | .398 | Guaranteed Rate Field · Chicago, IL |
| 104 | Thu Jul 27 | vs Guardians | L3-6 | 41-63 | .394 | Guaranteed Rate Field · Chicago, IL |
| 105 | Fri Jul 28 | vs Guardians | W3-0 | 42-63 | .400 | Guaranteed Rate Field · Chicago, IL |
| 106 | Sat Jul 29 | vs Guardians | W7-2 | 43-63 | .406 | Guaranteed Rate Field · Chicago, IL |
| 107 | Sun Jul 30 | vs Guardians | L0-5 | 43-64 | .402 | Guaranteed Rate Field · Chicago, IL |
| 108 | Tue Aug 1 | at Rangers | L0-2 | 43-65 | .398 | Globe Life Field · Arlington, TX |
| 109 | Wed Aug 2 | at Rangers | L1-11 | 43-66 | .394 | Globe Life Field · Arlington, TX |
| 110 | Thu Aug 3 | at Rangers | L3-5 | 43-67 | .391 | Globe Life Field · Arlington, TX |
| 111 | Fri Aug 4 | at Guardians | L2-4 | 43-68 | .387 | Progressive Field · Cleveland, OH |
| 112 | Sat Aug 5 | at Guardians | W7-4 | 44-68 | .393 | Progressive Field · Cleveland, OH |
| 113 | Sun Aug 6 | at Guardians | W5-3 | 45-68 | .398 | Progressive Field · Cleveland, OH |
| 114 | Mon Aug 7 | vs Yankees | W5-1 | 46-68 | .404 | Guaranteed Rate Field · Chicago, IL |
| 115 | Tue Aug 8 | vs Yankees | L1-7 | 46-69 | .400 | Guaranteed Rate Field · Chicago, IL |
| 116 | Wed Aug 9 | vs Yankees | W9-2 | 47-69 | .405 | Guaranteed Rate Field · Chicago, IL |
| 117 | Fri Aug 11 | vs Brewers | L6-7 (10) | 47-70 | .402 | Guaranteed Rate Field · Chicago, IL |
| 118 | Sat Aug 12 | vs Brewers | L2-3 | 47-71 | .398 | Guaranteed Rate Field · Chicago, IL |
| 119 | Sun Aug 13 | vs Brewers | L3-7 | 47-72 | .395 | Guaranteed Rate Field · Chicago, IL |
| 120 | Tue Aug 15 | at Cubs | W5-3 | 48-72 | .400 | Wrigley Field · Chicago, IL |
| 121 | Wed Aug 16 | at Cubs | L3-4 | 48-73 | .397 | Wrigley Field · Chicago, IL |
| 122 | Fri Aug 18 | at Rockies | L1-14 | 48-74 | .393 | Coors Field · Denver, CO |
| 123 | Sat Aug 19 | at Rockies | L5-11 | 48-75 | .390 | Coors Field · Denver, CO |
| 124 | Sun Aug 20 | at Rockies | W10-5 | 49-75 | .395 | Coors Field · Denver, CO |
| 125 | Mon Aug 21 | vs Mariners | L2-14 | 49-76 | .392 | Guaranteed Rate Field · Chicago, IL |
| 126 | Tue Aug 22 | vs Mariners | L3-6 | 49-77 | .389 | Guaranteed Rate Field · Chicago, IL |
| 127 | Wed Aug 23 | vs Mariners | W5-4 (10) | 50-77 | .394 | Guaranteed Rate Field · Chicago, IL |
| 128 | Thu Aug 24 | vs Athletics | L5-8 | 50-78 | .391 | Guaranteed Rate Field · Chicago, IL |
| 129 | Fri Aug 25 | vs Athletics | L4-12 | 50-79 | .388 | Guaranteed Rate Field · Chicago, IL |
| 130 | Sat Aug 26 | vs Athletics | W6-2 | 51-79 | .392 | Guaranteed Rate Field · Chicago, IL |
| 131 | Sun Aug 27 | vs Athletics | W6-1 | 52-79 | .397 | Guaranteed Rate Field · Chicago, IL |
| 132 | Mon Aug 28 | at Orioles | L0-9 | 52-80 | .394 | Camden Yards · Baltimore, MD |
| 133 | Tue Aug 29 | at Orioles | L3-9 | 52-81 | .391 | Camden Yards · Baltimore, MD |
| 134 | Wed Aug 30 | at Orioles | W10-5 | 53-81 | .396 | Camden Yards · Baltimore, MD |
| 135 | Fri Sep 1 | vs Tigers | L2-4 | 53-82 | .393 | Guaranteed Rate Field · Chicago, IL |
| 136 | Sat Sep 2 | vs Tigers | L0-10 | 53-83 | .390 | Guaranteed Rate Field · Chicago, IL |
| 137 | Sun Sep 3 | vs Tigers | L2-3 | 53-84 | .387 | Guaranteed Rate Field · Chicago, IL |
| 138 | Mon Sep 4 | at Royals | L1-12 | 53-85 | .384 | Kauffman Stadium · Kansas City, MO |
| 139 | Tue Sep 5 | at Royals | L6-7 | 53-86 | .381 | Kauffman Stadium · Kansas City, MO |
| 140 | Wed Sep 6 | at Royals | W6-4 | 54-86 | .386 | Kauffman Stadium · Kansas City, MO |
| 141 | Fri Sep 8 | at Tigers | W6-0 | 55-86 | .390 | Comerica Park · Detroit, MI |
| 142 | Sat Sep 9 | at Tigers | L1-3 | 55-87 | .387 | Comerica Park · Detroit, MI |
| 143 | Sun Sep 10 | at Tigers | L2-3 | 55-88 | .385 | Comerica Park · Detroit, MI |
| 144 | Tue Sep 12 | vs Royals | W6-2 | 56-88 | .389 | Guaranteed Rate Field · Chicago, IL |
| 145 | Tue Sep 12 | vs Royals | L10-11 | 56-89 | .386 | Guaranteed Rate Field · Chicago, IL |
| 146 | Wed Sep 13 | vs Royals | L1-7 | 56-90 | .384 | Guaranteed Rate Field · Chicago, IL |
| 147 | Thu Sep 14 | vs Twins | L2-10 | 56-91 | .381 | Guaranteed Rate Field · Chicago, IL |
| 148 | Fri Sep 15 | vs Twins | L2-10 | 56-92 | .378 | Guaranteed Rate Field · Chicago, IL |
| 149 | Sat Sep 16 | vs Twins | W7-6 | 57-92 | .383 | Guaranteed Rate Field · Chicago, IL |
| 150 | Sun Sep 17 | vs Twins | L0-4 | 57-93 | .380 | Guaranteed Rate Field · Chicago, IL |
| 151 | Mon Sep 18 | at Nationals | W6-1 | 58-93 | .384 | Nationals Park · Washington, D.C. |
| 152 | Tue Sep 19 | at Nationals | L3-4 | 58-94 | .382 | Nationals Park · Washington, D.C. |
| 153 | Wed Sep 20 | at Nationals | L3-13 | 58-95 | .379 | Nationals Park · Washington, D.C. |
| 154 | Fri Sep 22 | at Red Sox | L2-3 | 58-96 | .377 | Fenway Park · Boston, MA |
| 155 | Sat Sep 23 | at Red Sox | W1-0 | 59-96 | .381 | Fenway Park · Boston, MA |
| 156 | Sun Sep 24 | at Red Sox | W3-2 | 60-96 | .385 | Fenway Park · Boston, MA |
| 157 | Tue Sep 26 | vs D-backs | L4-15 | 60-97 | .382 | Guaranteed Rate Field · Chicago, IL |
| 158 | Wed Sep 27 | vs D-backs | L0-3 | 60-98 | .380 | Guaranteed Rate Field · Chicago, IL |
| 159 | Thu Sep 28 | vs D-backs | W3-1 | 61-98 | .384 | Guaranteed Rate Field · Chicago, IL |
| 160 | Fri Sep 29 | vs Padres | L2-3 | 61-99 | .381 | Guaranteed Rate Field · Chicago, IL |
| 161 | Sat Sep 30 | vs Padres | L1-6 | 61-100 | .379 | Guaranteed Rate Field · Chicago, IL |
| 162 | Sun Oct 1 | vs Padres | L1-2 (11) | 61-101 | .377 | Guaranteed Rate Field · Chicago, IL |