| 1 | Tue Apr 4 | vs Tigers | L3-6 | 0-1 | .000 | Guaranteed Rate Field · Chicago, IL |
| 2 | Thu Apr 6 | vs Tigers | W11-2 | 1-1 | .500 | Guaranteed Rate Field · Chicago, IL |
| 3 | Fri Apr 7 | vs Twins | L1-3 | 1-2 | .333 | Guaranteed Rate Field · Chicago, IL |
| 4 | Sat Apr 8 | vs Twins | W6-2 | 2-2 | .500 | Guaranteed Rate Field · Chicago, IL |
| 5 | Sun Apr 9 | vs Twins | L1-4 | 2-3 | .400 | Guaranteed Rate Field · Chicago, IL |
| 6 | Tue Apr 11 | at Guardians | L1-2 (10) | 2-4 | .333 | Progressive Field · Cleveland, OH |
| 7 | Wed Apr 12 | at Guardians | W2-1 | 3-4 | .429 | Progressive Field · Cleveland, OH |
| 8 | Thu Apr 13 | at Guardians | W10-4 | 4-4 | .500 | Progressive Field · Cleveland, OH |
| 9 | Fri Apr 14 | at Twins | W2-1 | 5-4 | .556 | Target Field · Minneapolis, MN |
| 10 | Sat Apr 15 | at Twins | L0-6 | 5-5 | .500 | Target Field · Minneapolis, MN |
| 11 | Sun Apr 16 | at Twins | W3-1 (10) | 6-5 | .545 | Target Field · Minneapolis, MN |
| 12 | Mon Apr 17 | at Yankees | L4-7 | 6-6 | .500 | Yankee Stadium · The Bronx, NY |
| 13 | Tue Apr 18 | at Yankees | W4-1 | 7-6 | .538 | Yankee Stadium · The Bronx, NY |
| 14 | Wed Apr 19 | at Yankees | L1-9 | 7-7 | .500 | Yankee Stadium · The Bronx, NY |
| 15 | Fri Apr 21 | vs Guardians | L0-3 | 7-8 | .467 | Guaranteed Rate Field · Chicago, IL |
| 16 | Sat Apr 22 | vs Guardians | L0-7 | 7-9 | .438 | Guaranteed Rate Field · Chicago, IL |
| 17 | Sun Apr 23 | vs Guardians | W6-2 | 8-9 | .471 | Guaranteed Rate Field · Chicago, IL |
| 18 | Mon Apr 24 | vs Royals | W12-1 | 9-9 | .500 | Guaranteed Rate Field · Chicago, IL |
| 19 | Tue Apr 25 | vs Royals | W10-5 | 10-9 | .526 | Guaranteed Rate Field · Chicago, IL |
| 20 | Wed Apr 26 | vs Royals | W5-2 | 11-9 | .550 | Guaranteed Rate Field · Chicago, IL |
| 21 | Fri Apr 28 | at Tigers | W7-3 | 12-9 | .571 | Comerica Park · Detroit, MI |
| 22 | Sat Apr 29 | at Tigers | W6-4 (10) | 13-9 | .591 | Comerica Park · Detroit, MI |
| 23 | Sun Apr 30 | at Tigers | L3-7 | 13-10 | .565 | Comerica Park · Detroit, MI |
| 24 | Mon May 1 | at Royals | L1-6 | 13-11 | .542 | Kauffman Stadium · Kansas City, MO |
| 25 | Tue May 2 | at Royals | W6-0 | 14-11 | .560 | Kauffman Stadium · Kansas City, MO |
| 26 | Wed May 3 | at Royals | L1-6 | 14-12 | .538 | Kauffman Stadium · Kansas City, MO |
| 27 | Thu May 4 | at Royals | W8-3 | 15-12 | .556 | Kauffman Stadium · Kansas City, MO |
| 28 | Fri May 5 | at Orioles | L2-4 | 15-13 | .536 | Camden Yards · Baltimore, MD |
| 29 | Sat May 6 | at Orioles | L5-6 | 15-14 | .517 | Camden Yards · Baltimore, MD |
| 30 | Sun May 7 | at Orioles | L0-4 | 15-15 | .500 | Camden Yards · Baltimore, MD |
| 31 | Tue May 9 | vs Twins | L2-7 | 15-16 | .484 | Guaranteed Rate Field · Chicago, IL |
| 32 | Thu May 11 | vs Twins | L6-7 | 15-17 | .469 | Guaranteed Rate Field · Chicago, IL |
| 33 | Fri May 12 | vs Padres | L3-6 | 15-18 | .455 | Guaranteed Rate Field · Chicago, IL |
| 34 | Sat May 13 | vs Padres | W5-4 | 16-18 | .471 | Guaranteed Rate Field · Chicago, IL |
| 35 | Sun May 14 | vs Padres | W9-3 | 17-18 | .486 | Guaranteed Rate Field · Chicago, IL |
| 36 | Mon May 15 | at Angels | L3-5 | 17-19 | .472 | Angel Stadium · Anaheim, CA |
| 37 | Tue May 16 | at Angels | L6-7 (11) | 17-20 | .459 | Angel Stadium · Anaheim, CA |
| 38 | Wed May 17 | at Angels | L8-12 | 17-21 | .447 | Angel Stadium · Anaheim, CA |
| 39 | Thu May 18 | at Mariners | L4-5 | 17-22 | .436 | T-Mobile Park · Seattle, WA |
| 40 | Fri May 19 | at Mariners | W2-1 (10) | 18-22 | .450 | T-Mobile Park · Seattle, WA |
| 41 | Sat May 20 | at Mariners | W16-1 | 19-22 | .463 | T-Mobile Park · Seattle, WA |
| 42 | Sun May 21 | at Mariners | W8-1 | 20-22 | .476 | T-Mobile Park · Seattle, WA |
| 43 | Mon May 22 | at D-backs | L1-5 | 20-23 | .465 | Chase Field · Phoenix, AZ |
| 44 | Tue May 23 | at D-backs | L4-5 | 20-24 | .455 | Chase Field · Phoenix, AZ |
| 45 | Wed May 24 | at D-backs | L6-8 | 20-25 | .444 | Chase Field · Phoenix, AZ |
| 46 | Fri May 26 | vs Tigers | W8-2 | 21-25 | .457 | Guaranteed Rate Field · Chicago, IL |
| 47 | Sat May 27 | vs Tigers | W3-0 | 22-25 | .468 | Guaranteed Rate Field · Chicago, IL |
| 48 | Sat May 27 | vs Tigers | L3-4 | 22-26 | .458 | Guaranteed Rate Field · Chicago, IL |
| 49 | Sun May 28 | vs Tigers | W7-3 | 23-26 | .469 | Guaranteed Rate Field · Chicago, IL |
| 50 | Mon May 29 | vs Red Sox | W5-4 | 24-26 | .480 | Guaranteed Rate Field · Chicago, IL |
| 51 | Tue May 30 | vs Red Sox | L7-13 | 24-27 | .471 | Guaranteed Rate Field · Chicago, IL |
| 52 | Wed May 31 | vs Red Sox | L1-4 | 24-28 | .462 | Guaranteed Rate Field · Chicago, IL |
| 53 | Fri Jun 2 | at Tigers | L5-15 | 24-29 | .453 | Comerica Park · Detroit, MI |
| 54 | Sat Jun 3 | at Tigers | L1-10 | 24-30 | .444 | Comerica Park · Detroit, MI |
| 55 | Sun Jun 4 | at Tigers | L4-7 | 24-31 | .436 | Comerica Park · Detroit, MI |
| 56 | Tue Jun 6 | at Rays | W4-2 | 25-31 | .446 | Tropicana Field · St. Petersburg, FL |
| 57 | Wed Jun 7 | at Rays | L1-3 | 25-32 | .439 | Tropicana Field · St. Petersburg, FL |
| 58 | Thu Jun 8 | at Rays | L5-7 | 25-33 | .431 | Tropicana Field · St. Petersburg, FL |
| 59 | Fri Jun 9 | at Guardians | L3-7 | 25-34 | .424 | Progressive Field · Cleveland, OH |
| 60 | Sat Jun 10 | at Guardians | W5-3 | 26-34 | .433 | Progressive Field · Cleveland, OH |
| 61 | Sun Jun 11 | at Guardians | L2-4 | 26-35 | .426 | Progressive Field · Cleveland, OH |
| 62 | Mon Jun 12 | vs Orioles | W10-7 | 27-35 | .435 | Guaranteed Rate Field · Chicago, IL |
| 63 | Tue Jun 13 | vs Orioles | W6-1 | 28-35 | .444 | Guaranteed Rate Field · Chicago, IL |
| 64 | Wed Jun 14 | vs Orioles | L6-10 | 28-36 | .438 | Guaranteed Rate Field · Chicago, IL |
| 65 | Thu Jun 15 | vs Orioles | W5-2 | 29-36 | .446 | Guaranteed Rate Field · Chicago, IL |
| 66 | Fri Jun 16 | at Blue Jays | W11-4 | 30-36 | .455 | Rogers Centre · Toronto, ON |
| 67 | Sat Jun 17 | at Blue Jays | W5-2 | 31-36 | .463 | Rogers Centre · Toronto, ON |
| 68 | Sun Jun 18 | at Blue Jays | L3-7 | 31-37 | .456 | Rogers Centre · Toronto, ON |
| 69 | Tue Jun 20 | at Twins | L7-9 | 31-38 | .449 | Target Field · Minneapolis, MN |
| 70 | Wed Jun 21 | at Twins | L2-4 | 31-39 | .443 | Target Field · Minneapolis, MN |
| 71 | Thu Jun 22 | at Twins | W9-0 | 32-39 | .451 | Target Field · Minneapolis, MN |
| 72 | Fri Jun 23 | vs Athletics | L0-3 | 32-40 | .444 | Guaranteed Rate Field · Chicago, IL |
| 73 | Sat Jun 24 | vs Athletics | L2-10 | 32-41 | .438 | Guaranteed Rate Field · Chicago, IL |
| 74 | Sun Jun 25 | vs Athletics | L3-5 | 32-42 | .432 | Guaranteed Rate Field · Chicago, IL |
| 75 | Mon Jun 26 | vs Yankees | L5-6 | 32-43 | .427 | Guaranteed Rate Field · Chicago, IL |
| 76 | Tue Jun 27 | vs Yankees | W4-3 | 33-43 | .434 | Guaranteed Rate Field · Chicago, IL |
| 77 | Wed Jun 28 | vs Yankees | L3-12 | 33-44 | .429 | Guaranteed Rate Field · Chicago, IL |
| 78 | Thu Jun 29 | vs Yankees | W4-3 | 34-44 | .436 | Guaranteed Rate Field · Chicago, IL |
| 79 | Fri Jun 30 | vs Rangers | W8-7 | 35-44 | .443 | Guaranteed Rate Field · Chicago, IL |
| 80 | Sat Jul 1 | vs Rangers | L4-10 | 35-45 | .438 | Guaranteed Rate Field · Chicago, IL |
| 81 | Sun Jul 2 | vs Rangers | W6-5 | 36-45 | .444 | Guaranteed Rate Field · Chicago, IL |
| 82 | Mon Jul 3 | at Athletics | W7-2 | 37-45 | .451 | RingCentral Coliseum · Oakland, CA |
| 83 | Tue Jul 4 | at Athletics | L6-7 | 37-46 | .446 | RingCentral Coliseum · Oakland, CA |
| 84 | Wed Jul 5 | at Athletics | L4-7 | 37-47 | .440 | RingCentral Coliseum · Oakland, CA |
| 85 | Fri Jul 7 | at Rockies | L4-12 | 37-48 | .435 | Coors Field · Denver, CO |
| 86 | Sat Jul 8 | at Rockies | W5-4 | 38-48 | .442 | Coors Field · Denver, CO |
| 87 | Sun Jul 9 | at Rockies | L0-10 | 38-49 | .437 | Coors Field · Denver, CO |
| 88 | Fri Jul 14 | vs Mariners | L2-4 | 38-50 | .432 | Guaranteed Rate Field · Chicago, IL |
| 89 | Sat Jul 15 | vs Mariners | L3-4 | 38-51 | .427 | Guaranteed Rate Field · Chicago, IL |
| 90 | Sun Jul 16 | vs Mariners | L6-7 (10) | 38-52 | .422 | Guaranteed Rate Field · Chicago, IL |
| 91 | Tue Jul 18 | vs Dodgers | L0-1 | 38-53 | .418 | Guaranteed Rate Field · Chicago, IL |
| 92 | Wed Jul 19 | vs Dodgers | L1-9 | 38-54 | .413 | Guaranteed Rate Field · Chicago, IL |
| 93 | Fri Jul 21 | at Royals | L6-7 (10) | 38-55 | .409 | Kauffman Stadium · Kansas City, MO |
| 94 | Sat Jul 22 | at Royals | L2-7 | 38-56 | .404 | Kauffman Stadium · Kansas City, MO |
| 95 | Sun Jul 23 | at Royals | L4-5 | 38-57 | .400 | Kauffman Stadium · Kansas City, MO |
| 96 | Mon Jul 24 | at Cubs | W3-1 | 39-57 | .406 | Wrigley Field · Chicago, IL |
| 97 | Tue Jul 25 | at Cubs | L2-7 | 39-58 | .402 | Wrigley Field · Chicago, IL |
| 98 | Wed Jul 26 | vs Cubs | L3-8 | 39-59 | .398 | Guaranteed Rate Field · Chicago, IL |
| 99 | Thu Jul 27 | vs Cubs | L3-6 | 39-60 | .394 | Guaranteed Rate Field · Chicago, IL |
| 100 | Fri Jul 28 | vs Guardians | L3-9 | 39-61 | .390 | Guaranteed Rate Field · Chicago, IL |
| 101 | Sat Jul 29 | vs Guardians | L4-5 | 39-62 | .386 | Guaranteed Rate Field · Chicago, IL |
| 102 | Sun Jul 30 | vs Guardians | W3-1 | 40-62 | .392 | Guaranteed Rate Field · Chicago, IL |
| 103 | Mon Jul 31 | vs Blue Jays | W7-6 | 41-62 | .398 | Guaranteed Rate Field · Chicago, IL |
| 104 | Tue Aug 1 | vs Blue Jays | L4-8 | 41-63 | .394 | Guaranteed Rate Field · Chicago, IL |
| 105 | Wed Aug 2 | vs Blue Jays | L1-5 | 41-64 | .390 | Guaranteed Rate Field · Chicago, IL |
| 106 | Thu Aug 3 | at Red Sox | L5-9 | 41-65 | .387 | Fenway Park · Boston, MA |
| 107 | Fri Aug 4 | at Red Sox | L2-3 (11) | 41-66 | .383 | Fenway Park · Boston, MA |
| 108 | Sat Aug 5 | at Red Sox | L1-4 | 41-67 | .380 | Fenway Park · Boston, MA |
| 109 | Sun Aug 6 | at Red Sox | L3-6 | 41-68 | .376 | Fenway Park · Boston, MA |
| 110 | Tue Aug 8 | vs Astros | W8-5 | 42-68 | .382 | Guaranteed Rate Field · Chicago, IL |
| 111 | Wed Aug 9 | vs Astros | W7-1 | 43-68 | .387 | Guaranteed Rate Field · Chicago, IL |
| 112 | Thu Aug 10 | vs Astros | W3-2 (11) | 44-68 | .393 | Guaranteed Rate Field · Chicago, IL |
| 113 | Fri Aug 11 | vs Royals | W6-3 | 45-68 | .398 | Guaranteed Rate Field · Chicago, IL |
| 114 | Sat Aug 12 | vs Royals | L4-5 | 45-69 | .395 | Guaranteed Rate Field · Chicago, IL |
| 115 | Sun Aug 13 | vs Royals | L6-14 | 45-70 | .391 | Guaranteed Rate Field · Chicago, IL |
| 116 | Tue Aug 15 | at Dodgers | L1-6 | 45-71 | .388 | Dodger Stadium · Los Angeles, CA |
| 117 | Wed Aug 16 | at Dodgers | L4-5 | 45-72 | .385 | Dodger Stadium · Los Angeles, CA |
| 118 | Thu Aug 17 | at Rangers | L8-9 | 45-73 | .381 | Globe Life Field · Arlington, TX |
| 119 | Fri Aug 18 | at Rangers | W4-3 | 46-73 | .387 | Globe Life Field · Arlington, TX |
| 120 | Sat Aug 19 | at Rangers | L7-17 | 46-74 | .383 | Globe Life Field · Arlington, TX |
| 121 | Sun Aug 20 | at Rangers | W3-2 | 47-74 | .388 | Globe Life Field · Arlington, TX |
| 122 | Mon Aug 21 | vs Twins | W7-6 | 48-74 | .393 | Guaranteed Rate Field · Chicago, IL |
| 123 | Mon Aug 21 | vs Twins | L2-10 | 48-75 | .390 | Guaranteed Rate Field · Chicago, IL |
| 124 | Tue Aug 22 | vs Twins | L1-4 | 48-76 | .387 | Guaranteed Rate Field · Chicago, IL |
| 125 | Wed Aug 23 | vs Twins | W4-3 | 49-76 | .392 | Guaranteed Rate Field · Chicago, IL |
| 126 | Thu Aug 24 | vs Twins | W5-1 | 50-76 | .397 | Guaranteed Rate Field · Chicago, IL |
| 127 | Fri Aug 25 | vs Tigers | W3-2 | 51-76 | .402 | Guaranteed Rate Field · Chicago, IL |
| 128 | Sat Aug 26 | vs Tigers | L3-6 | 51-77 | .398 | Guaranteed Rate Field · Chicago, IL |
| 129 | Sun Aug 27 | vs Tigers | W7-1 | 52-77 | .403 | Guaranteed Rate Field · Chicago, IL |
| 130 | Tue Aug 29 | at Twins | L4-6 | 52-78 | .400 | Target Field · Minneapolis, MN |
| 131 | Wed Aug 30 | at Twins | L1-11 | 52-79 | .397 | Target Field · Minneapolis, MN |
| 132 | Thu Aug 31 | at Twins | L4-5 | 52-80 | .394 | Target Field · Minneapolis, MN |
| 133 | Fri Sep 1 | vs Rays | L1-3 | 52-81 | .391 | Guaranteed Rate Field · Chicago, IL |
| 134 | Sat Sep 2 | vs Rays | W5-4 | 53-81 | .396 | Guaranteed Rate Field · Chicago, IL |
| 135 | Sun Sep 3 | vs Rays | W6-2 | 54-81 | .400 | Guaranteed Rate Field · Chicago, IL |
| 136 | Mon Sep 4 | vs Guardians | L3-5 | 54-82 | .397 | Guaranteed Rate Field · Chicago, IL |
| 137 | Tue Sep 5 | vs Guardians | L4-9 | 54-83 | .394 | Guaranteed Rate Field · Chicago, IL |
| 138 | Wed Sep 6 | vs Guardians | L1-5 | 54-84 | .391 | Guaranteed Rate Field · Chicago, IL |
| 139 | Thu Sep 7 | vs Guardians | L2-11 | 54-85 | .388 | Guaranteed Rate Field · Chicago, IL |
| 140 | Fri Sep 8 | vs Giants | L2-9 | 54-86 | .386 | Guaranteed Rate Field · Chicago, IL |
| 141 | Sat Sep 9 | vs Giants | W13-1 | 55-86 | .390 | Guaranteed Rate Field · Chicago, IL |
| 142 | Sun Sep 10 | vs Giants | W8-1 | 56-86 | .394 | Guaranteed Rate Field · Chicago, IL |
| 143 | Mon Sep 11 | at Royals | W11-3 | 57-86 | .399 | Kauffman Stadium · Kansas City, MO |
| 144 | Tue Sep 12 | at Royals | L3-4 | 57-87 | .396 | Kauffman Stadium · Kansas City, MO |
| 145 | Wed Sep 13 | at Royals | W5-3 | 58-87 | .400 | Kauffman Stadium · Kansas City, MO |
| 146 | Thu Sep 14 | at Tigers | W17-7 | 59-87 | .404 | Comerica Park · Detroit, MI |
| 147 | Fri Sep 15 | at Tigers | L2-3 | 59-88 | .401 | Comerica Park · Detroit, MI |
| 148 | Sat Sep 16 | at Tigers | W10-4 | 60-88 | .405 | Comerica Park · Detroit, MI |
| 149 | Sun Sep 17 | at Tigers | L0-12 | 60-89 | .403 | Comerica Park · Detroit, MI |
| 150 | Tue Sep 19 | at Astros | L1-3 | 60-90 | .400 | Minute Maid Park · Houston, TX |
| 151 | Wed Sep 20 | at Astros | L3-4 | 60-91 | .397 | Minute Maid Park · Houston, TX |
| 152 | Thu Sep 21 | at Astros | W3-1 | 61-91 | .401 | Minute Maid Park · Houston, TX |
| 153 | Fri Sep 22 | vs Royals | W7-6 | 62-91 | .405 | Guaranteed Rate Field · Chicago, IL |
| 154 | Sat Sep 23 | vs Royals | L2-8 | 62-92 | .403 | Guaranteed Rate Field · Chicago, IL |
| 155 | Sun Sep 24 | vs Royals | W8-1 | 63-92 | .406 | Guaranteed Rate Field · Chicago, IL |
| 156 | Mon Sep 25 | vs Angels | W4-2 | 64-92 | .410 | Guaranteed Rate Field · Chicago, IL |
| 157 | Tue Sep 26 | vs Angels | L3-9 | 64-93 | .408 | Guaranteed Rate Field · Chicago, IL |
| 158 | Wed Sep 27 | vs Angels | W6-4 (10) | 65-93 | .411 | Guaranteed Rate Field · Chicago, IL |
| 159 | Thu Sep 28 | vs Angels | W5-4 | 66-93 | .415 | Guaranteed Rate Field · Chicago, IL |
| 160 | Fri Sep 29 | at Guardians | L1-10 | 66-94 | .412 | Progressive Field · Cleveland, OH |
| 161 | Sat Sep 30 | at Guardians | W2-1 | 67-94 | .416 | Progressive Field · Cleveland, OH |
| 162 | Sun Oct 1 | at Guardians | L1-3 | 67-95 | .414 | Progressive Field · Cleveland, OH |