| 1 | Fri Jul 24 | vs D-backs | W7-2 | 1-0 | 1.000 | Petco Park · San Diego, CA |
| 2 | Sat Jul 25 | vsD-backs | W5-1 | 2-0 | 1.000 | Petco Park · San Diego, CA |
| 3 | Sun Jul 26 | vsD-backs | L3-4 | 2-1 | .667 | Petco Park · San Diego, CA |
| 4 | Mon Jul 27 | vsD-backs | W6-2 | 3-1 | .750 | Petco Park · San Diego, CA |
| 5 | Tue Jul 28 | at Giants | W5-3 | 4-1 | .800 | Oracle Park · San Francisco, CA |
| 6 | Wed Jul 29 | atGiants | L6-7 | 4-2 | .667 | Oracle Park · San Francisco, CA |
| 7 | Thu Jul 30 | atGiants | W12-7 (10) | 5-2 | .714 | Oracle Park · San Francisco, CA |
| 8 | Fri Jul 31 | at Rockies | W8-7 | 6-2 | .750 | Coors Field · Denver, CO |
| 9 | Sat Aug 1 | atRockies | L1-6 | 6-3 | .667 | Coors Field · Denver, CO |
| 10 | Sun Aug 2 | atRockies | L6-9 | 6-4 | .600 | Coors Field · Denver, CO |
| 11 | Mon Aug 3 | vs Dodgers | W5-4 | 7-4 | .636 | Petco Park · San Diego, CA |
| 12 | Tue Aug 4 | vsDodgers | L2-5 | 7-5 | .583 | Petco Park · San Diego, CA |
| 13 | Wed Aug 5 | vsDodgers | L6-7 | 7-6 | .538 | Petco Park · San Diego, CA |
| 14 | Fri Aug 7 | vsD-backs | W3-0 | 8-6 | .571 | Petco Park · San Diego, CA |
| 15 | Sat Aug 8 | vsD-backs | L2-3 | 8-7 | .533 | Petco Park · San Diego, CA |
| 16 | Sun Aug 9 | vsD-backs | W9-5 | 9-7 | .563 | Petco Park · San Diego, CA |
| 17 | Mon Aug 10 | atDodgers | W2-1 | 10-7 | .588 | Dodger Stadium · Los Angeles, CA |
| 18 | Tue Aug 11 | atDodgers | W6-2 | 11-7 | .611 | Dodger Stadium · Los Angeles, CA |
| 19 | Wed Aug 12 | atDodgers | L0-6 | 11-8 | .579 | Dodger Stadium · Los Angeles, CA |
| 20 | Thu Aug 13 | atDodgers | L2-11 | 11-9 | .550 | Dodger Stadium · Los Angeles, CA |
| 21 | Fri Aug 14 | atD-backs | L1-5 | 11-10 | .524 | Chase Field · Phoenix, AZ |
| 22 | Sat Aug 15 | atD-backs | L6-7 | 11-11 | .500 | Chase Field · Phoenix, AZ |
| 23 | Sun Aug 16 | atD-backs | L4-5 | 11-12 | .478 | Chase Field · Phoenix, AZ |
| 24 | Mon Aug 17 | at Rangers | W14-4 | 12-12 | .500 | Globe Life Field · Arlington, TX |
| 25 | Tue Aug 18 | atRangers | W6-4 | 13-12 | .520 | Globe Life Field · Arlington, TX |
| 26 | Wed Aug 19 | vsRangers | W6-3 (10) | 14-12 | .538 | Petco Park · San Diego, CA |
| 27 | Thu Aug 20 | vsRangers | W8-7 (10) | 15-12 | .556 | Petco Park · San Diego, CA |
| 28 | Fri Aug 21 | vs Astros | W4-3 | 16-12 | .571 | Petco Park · San Diego, CA |
| 29 | Sat Aug 22 | vsAstros | W13-2 | 17-12 | .586 | Petco Park · San Diego, CA |
| 30 | Sun Aug 23 | vsAstros | W5-3 | 18-12 | .600 | Petco Park · San Diego, CA |
| 31 | Tue Aug 25 | vs Mariners | L3-8 | 18-13 | .581 | Petco Park · San Diego, CA |
| 32 | Thu Aug 27 | vsMariners | W10-7 | 19-13 | .594 | Petco Park · San Diego, CA |
| 33 | Thu Aug 27 | vsMariners | L3-8 | 19-14 | .576 | Petco Park · San Diego, CA |
| 34 | Fri Aug 28 | atRockies | W10-4 | 20-14 | .588 | Coors Field · Denver, CO |
| 35 | Sat Aug 29 | atRockies | L3-4 | 20-15 | .571 | Coors Field · Denver, CO |
| 36 | Sun Aug 30 | atRockies | W13-2 | 21-15 | .583 | Coors Field · Denver, CO |
| 37 | Mon Aug 31 | atRockies | W6-0 | 22-15 | .595 | Coors Field · Denver, CO |
| 38 | Wed Sep 2 | at Angels | W11-4 | 23-15 | .605 | Angel Stadium · Anaheim, CA |
| 39 | Thu Sep 3 | atAngels | L0-2 | 23-16 | .590 | Angel Stadium · Anaheim, CA |
| 40 | Fri Sep 4 | at Athletics | W7-0 | 24-16 | .600 | RingCentral Coliseum · Oakland, CA |
| 41 | Sat Sep 5 | atAthletics | L4-8 | 24-17 | .585 | RingCentral Coliseum · Oakland, CA |
| 42 | Sun Sep 6 | atAthletics | W5-3 | 25-17 | .595 | RingCentral Coliseum · Oakland, CA |
| 43 | Mon Sep 7 | vsRockies | W1-0 | 26-17 | .605 | Petco Park · San Diego, CA |
| 44 | Tue Sep 8 | vsRockies | W14-5 | 27-17 | .614 | Petco Park · San Diego, CA |
| 45 | Wed Sep 9 | vsRockies | W5-3 | 28-17 | .622 | Petco Park · San Diego, CA |
| 46 | Thu Sep 10 | vsGiants | W6-1 | 29-17 | .630 | Petco Park · San Diego, CA |
| 47 | Sun Sep 13 | vsGiants | W6-0 | 30-17 | .638 | Petco Park · San Diego, CA |
| 48 | Sun Sep 13 | vsGiants | W3-1 | 31-17 | .646 | Petco Park · San Diego, CA |
| 49 | Mon Sep 14 | vsDodgers | W7-2 | 32-17 | .653 | Petco Park · San Diego, CA |
| 50 | Tue Sep 15 | vsDodgers | L1-3 | 32-18 | .640 | Petco Park · San Diego, CA |
| 51 | Wed Sep 16 | vsDodgers | L5-7 | 32-19 | .627 | Petco Park · San Diego, CA |
| 52 | Fri Sep 18 | atMariners | W6-1 | 33-19 | .635 | Petco Park · San Diego, CA |
| 53 | Sat Sep 19 | atMariners | L1-4 | 33-20 | .623 | Petco Park · San Diego, CA |
| 54 | Sun Sep 20 | atMariners | W7-4 (11) | 34-20 | .630 | Petco Park · San Diego, CA |
| 55 | Tue Sep 22 | vsAngels | L2-4 | 34-21 | .618 | Petco Park · San Diego, CA |
| 56 | Wed Sep 23 | vsAngels | L2-5 | 34-22 | .607 | Petco Park · San Diego, CA |
| 57 | Fri Sep 25 | atGiants | L4-5 | 34-23 | .596 | Oracle Park · San Francisco, CA |
| 58 | Fri Sep 25 | vsGiants | W6-5 | 35-23 | .603 | Oracle Park · San Francisco, CA |
| 59 | Sat Sep 26 | atGiants | W6-2 | 36-23 | .610 | Oracle Park · San Francisco, CA |
| 60 | Sun Sep 27 | atGiants | W5-4 | 37-23 | .617 | Oracle Park · San Francisco, CA |
| 61 | Wed Sep 30 | vs Cardinals | L4-7 | 0-1 | .000 | Petco Park · San Diego, CA |
| 62 | Thu Oct 1 | vsCardinals | W11-9 | 1-1 | .500 | Petco Park · San Diego, CA |
| 63 | Fri Oct 2 | vsCardinals | W4-0 | 2-1 | .667 | Petco Park · San Diego, CA |
| 64 | Tue Oct 6 | atDodgers | L1-5 | 0-1 | .000 | Globe Life Field · Arlington, TX |
| 65 | Wed Oct 7 | atDodgers | L5-6 | 0-2 | .000 | Globe Life Field · Arlington, TX |
| 66 | Thu Oct 8 | vsDodgers | L3-12 | 0-3 | .000 | Globe Life Field · Arlington, TX |
