| 1 | Thu Apr 7 | at D-backs | L2-4 | 0-1 | .000 | Chase Field · Phoenix, AZ |
| 2 | Fri Apr 8 | at D-backs | W3-0 | 1-1 | .500 | Chase Field · Phoenix, AZ |
| 3 | Sat Apr 9 | at D-backs | W5-2 | 2-1 | .667 | Chase Field · Phoenix, AZ |
| 4 | Sun Apr 10 | at D-backs | W10-5 | 3-1 | .750 | Chase Field · Phoenix, AZ |
| 5 | Mon Apr 11 | at Giants | W4-2 | 4-1 | .800 | Oracle Park · San Francisco, CA |
| 6 | Tue Apr 12 | at Giants | L2-13 | 4-2 | .667 | Oracle Park · San Francisco, CA |
| 7 | Wed Apr 13 | at Giants | L1-2 | 4-3 | .571 | Oracle Park · San Francisco, CA |
| 8 | Thu Apr 14 | vs Braves | W12-1 | 5-3 | .625 | Petco Park · San Diego, CA |
| 9 | Fri Apr 15 | vs Braves | L2-5 | 5-4 | .556 | Petco Park · San Diego, CA |
| 10 | Sat Apr 16 | vs Braves | L2-5 | 5-5 | .500 | Petco Park · San Diego, CA |
| 11 | Sun Apr 17 | vs Braves | W2-1 | 6-5 | .545 | Petco Park · San Diego, CA |
| 12 | Mon Apr 18 | vs Reds | W4-1 | 7-5 | .583 | Petco Park · San Diego, CA |
| 13 | Tue Apr 19 | vs Reds | W6-2 | 8-5 | .615 | Petco Park · San Diego, CA |
| 14 | Wed Apr 20 | vs Reds | W6-0 | 9-5 | .643 | Petco Park · San Diego, CA |
| 15 | Fri Apr 22 | vs Dodgers | L1-6 | 9-6 | .600 | Petco Park · San Diego, CA |
| 16 | Sat Apr 23 | vs Dodgers | W3-2 (10) | 10-6 | .625 | Petco Park · San Diego, CA |
| 17 | Sun Apr 24 | vs Dodgers | L2-10 | 10-7 | .588 | Petco Park · San Diego, CA |
| 18 | Tue Apr 26 | at Reds | W9-6 | 11-7 | .611 | Great American Ball Park · Cincinnati, OH |
| 19 | Wed Apr 27 | at Reds | W8-5 | 12-7 | .632 | Great American Ball Park · Cincinnati, OH |
| 20 | Thu Apr 28 | at Reds | W7-5 | 13-7 | .650 | Great American Ball Park · Cincinnati, OH |
| 21 | Fri Apr 29 | at Pirates | W7-3 | 14-7 | .667 | PNC Park · Pittsburgh, PA |
| 22 | Sat Apr 30 | at Pirates | L6-7 (10) | 14-8 | .636 | PNC Park · Pittsburgh, PA |
| 23 | Sun May 1 | at Pirates | W5-2 | 15-8 | .652 | PNC Park · Pittsburgh, PA |
| 24 | Wed May 4 | at Guardians | W5-4 | 16-8 | .667 | Progressive Field · Cleveland, OH |
| 25 | Wed May 4 | at Guardians | L5-6 (10) | 16-9 | .640 | Progressive Field · Cleveland, OH |
| 26 | Thu May 5 | vs Marlins | W2-1 | 17-9 | .654 | Petco Park · San Diego, CA |
| 27 | Fri May 6 | vs Marlins | W3-2 | 18-9 | .667 | Petco Park · San Diego, CA |
| 28 | Sat May 7 | vs Marlins | L0-8 | 18-10 | .643 | Petco Park · San Diego, CA |
| 29 | Sun May 8 | vs Marlins | W3-2 | 19-10 | .655 | Petco Park · San Diego, CA |
| 30 | Mon May 9 | vs Cubs | L0-6 | 19-11 | .633 | Petco Park · San Diego, CA |
| 31 | Tue May 10 | vs Cubs | W5-4 | 20-11 | .645 | Petco Park · San Diego, CA |
| 32 | Wed May 11 | vs Cubs | L5-7 | 20-12 | .625 | Petco Park · San Diego, CA |
| 33 | Fri May 13 | at Braves | W11-6 | 21-12 | .636 | Truist Park · Cumberland, GA |
| 34 | Sat May 14 | at Braves | L5-6 | 21-13 | .618 | Truist Park · Cumberland, GA |
| 35 | Sun May 15 | at Braves | W7-3 (11) | 22-13 | .629 | Truist Park · Cumberland, GA |
| 36 | Tue May 17 | at Phillies | W3-0 | 23-13 | .639 | Citizens Bank Park · Philadelphi, PA |
| 37 | Wed May 18 | at Phillies | L0-3 | 23-14 | .622 | Citizens Bank Park · Philadelphi, PA |
| 38 | Thu May 19 | at Phillies | W2-0 | 24-14 | .632 | Citizens Bank Park · Philadelphi, PA |
| 39 | Fri May 20 | at Giants | W8-7 (10) | 25-14 | .641 | Oracle Park · San Francisco, CA |
| 40 | Sat May 21 | at Giants | W2-1 | 26-14 | .650 | Oracle Park · San Francisco, CA |
| 41 | Sun May 22 | at Giants | W10-1 | 27-14 | .659 | Oracle Park · San Francisco, CA |
| 42 | Mon May 23 | vs Brewers | W3-2 (10) | 28-14 | .667 | Petco Park · San Diego, CA |
| 43 | Tue May 24 | vs Brewers | L1-4 | 28-15 | .651 | Petco Park · San Diego, CA |
| 44 | Wed May 25 | vs Brewers | L1-2 | 28-16 | .636 | Petco Park · San Diego, CA |
| 45 | Fri May 27 | vs Pirates | W4-3 | 29-16 | .644 | Petco Park · San Diego, CA |
| 46 | Sat May 28 | vs Pirates | L2-4 | 29-17 | .630 | Petco Park · San Diego, CA |
| 47 | Sun May 29 | vs Pirates | W4-2 (10) | 30-17 | .638 | Petco Park · San Diego, CA |
| 48 | Mon May 30 | at Cardinals | L3-6 | 30-18 | .625 | Busch Stadium · St. Louis, MO |
| 49 | Tue May 31 | at Cardinals | L2-3 (10) | 30-19 | .612 | Busch Stadium · St. Louis, MO |
| 50 | Wed Jun 1 | at Cardinals | L2-5 | 30-20 | .600 | Busch Stadium · St. Louis, MO |
| 51 | Thu Jun 2 | at Brewers | L4-5 | 30-21 | .588 | American Family Field · Milwaukee, WI |
| 52 | Fri Jun 3 | at Brewers | W7-0 | 31-21 | .596 | American Family Field · Milwaukee, WI |
| 53 | Sat Jun 4 | at Brewers | W4-0 | 32-21 | .604 | American Family Field · Milwaukee, WI |
| 54 | Sun Jun 5 | at Brewers | W6-4 (10) | 33-21 | .611 | American Family Field · Milwaukee, WI |
| 55 | Mon Jun 6 | vs Mets | L5-11 | 33-22 | .600 | Petco Park · San Diego, CA |
| 56 | Tue Jun 7 | vs Mets | W7-0 | 34-22 | .607 | Petco Park · San Diego, CA |
| 57 | Wed Jun 8 | vs Mets | W13-2 | 35-22 | .614 | Petco Park · San Diego, CA |
| 58 | Fri Jun 10 | vs Rockies | W9-0 | 36-22 | .621 | Petco Park · San Diego, CA |
| 59 | Sat Jun 11 | vs Rockies | W2-1 (10) | 37-22 | .627 | Petco Park · San Diego, CA |
| 60 | Sat Jun 11 | vs Rockies | L2-6 | 37-23 | .617 | Petco Park · San Diego, CA |
| 61 | Sun Jun 12 | vs Rockies | L2-4 | 37-24 | .607 | Petco Park · San Diego, CA |
| 62 | Mon Jun 13 | at Cubs | W4-1 | 38-24 | .613 | Wrigley Field · Chicago, IL |
| 63 | Tue Jun 14 | at Cubs | W12-5 | 39-24 | .619 | Wrigley Field · Chicago, IL |
| 64 | Wed Jun 15 | at Cubs | W19-5 | 40-24 | .625 | Wrigley Field · Chicago, IL |
| 65 | Thu Jun 16 | at Cubs | W6-4 | 41-24 | .631 | Wrigley Field · Chicago, IL |
| 66 | Fri Jun 17 | at Rockies | L4-10 | 41-25 | .621 | Coors Field · Denver, CO |
| 67 | Sat Jun 18 | at Rockies | L4-5 | 41-26 | .612 | Coors Field · Denver, CO |
| 68 | Sun Jun 19 | at Rockies | L3-8 | 41-27 | .603 | Coors Field · Denver, CO |
| 69 | Mon Jun 20 | vs D-backs | W4-1 | 42-27 | .609 | Petco Park · San Diego, CA |
| 70 | Tue Jun 21 | vs D-backs | W3-2 (11) | 43-27 | .614 | Petco Park · San Diego, CA |
| 71 | Wed Jun 22 | vs D-backs | W10-4 | 44-27 | .620 | Petco Park · San Diego, CA |
| 72 | Thu Jun 23 | vs Phillies | L2-6 | 44-28 | .611 | Petco Park · San Diego, CA |
| 73 | Fri Jun 24 | vs Phillies | W1-0 | 45-28 | .616 | Petco Park · San Diego, CA |
| 74 | Sat Jun 25 | vs Phillies | L2-4 | 45-29 | .608 | Petco Park · San Diego, CA |
| 75 | Sun Jun 26 | vs Phillies | L5-8 | 45-30 | .600 | Petco Park · San Diego, CA |
| 76 | Tue Jun 28 | at D-backs | L6-7 | 45-31 | .592 | Chase Field · Phoenix, AZ |
| 77 | Wed Jun 29 | at D-backs | W4-0 | 46-31 | .597 | Chase Field · Phoenix, AZ |
| 78 | Thu Jun 30 | at Dodgers | L1-3 | 46-32 | .590 | Dodger Stadium · Los Angeles, CA |
| 79 | Fri Jul 1 | at Dodgers | L1-5 | 46-33 | .582 | Dodger Stadium · Los Angeles, CA |
| 80 | Sat Jul 2 | at Dodgers | L2-7 | 46-34 | .575 | Dodger Stadium · Los Angeles, CA |
| 81 | Sun Jul 3 | at Dodgers | W4-2 | 47-34 | .580 | Dodger Stadium · Los Angeles, CA |
| 82 | Mon Jul 4 | vs Mariners | L2-8 | 47-35 | .573 | Petco Park · San Diego, CA |
| 83 | Tue Jul 5 | vs Mariners | L2-6 | 47-36 | .566 | Petco Park · San Diego, CA |
| 84 | Thu Jul 7 | vs Giants | W2-1 (10) | 48-36 | .571 | Petco Park · San Diego, CA |
| 85 | Fri Jul 8 | vs Giants | W6-3 | 49-36 | .576 | Petco Park · San Diego, CA |
| 86 | Sat Jul 9 | vs Giants | L1-3 | 49-37 | .570 | Petco Park · San Diego, CA |
| 87 | Sun Jul 10 | vs Giants | L0-12 | 49-38 | .563 | Petco Park · San Diego, CA |
| 88 | Mon Jul 11 | at Rockies | W6-5 | 50-38 | .568 | Coors Field · Denver, CO |
| 89 | Tue Jul 12 | at Rockies | L3-5 | 50-39 | .562 | Coors Field · Denver, CO |
| 90 | Wed Jul 13 | at Rockies | L6-10 | 50-40 | .556 | Coors Field · Denver, CO |
| 91 | Thu Jul 14 | at Rockies | L5-8 | 50-41 | .549 | Coors Field · Denver, CO |
| 92 | Fri Jul 15 | vs D-backs | W5-3 | 51-41 | .554 | Petco Park · San Diego, CA |
| 93 | Sat Jul 16 | vs D-backs | W4-3 | 52-41 | .559 | Petco Park · San Diego, CA |
| 94 | Sun Jul 17 | vs D-backs | L1-3 | 52-42 | .553 | Petco Park · San Diego, CA |
| 95 | Fri Jul 22 | at Mets | W4-1 | 53-42 | .558 | Citi Field · Queens, NY |
| 96 | Sat Jul 23 | at Mets | W2-1 | 54-42 | .563 | Citi Field · Queens, NY |
| 97 | Sun Jul 24 | at Mets | L5-8 | 54-43 | .557 | Citi Field · Queens, NY |
| 98 | Mon Jul 25 | at Tigers | L4-12 | 54-44 | .551 | Comerica Park · Detroit, MI |
| 99 | Tue Jul 26 | at Tigers | W6-4 (10) | 55-44 | .556 | Comerica Park · Detroit, MI |
| 100 | Wed Jul 27 | at Tigers | L3-4 | 55-45 | .550 | Comerica Park · Detroit, MI |
| 101 | Fri Jul 29 | vs Twins | W10-1 | 56-45 | .554 | Petco Park · San Diego, CA |
| 102 | Sat Jul 30 | vs Twins | L4-7 | 56-46 | .549 | Petco Park · San Diego, CA |
| 103 | Sun Jul 31 | vs Twins | W3-2 | 57-46 | .553 | Petco Park · San Diego, CA |
| 104 | Mon Aug 1 | vs Rockies | W4-1 | 58-46 | .558 | Petco Park · San Diego, CA |
| 105 | Tue Aug 2 | vs Rockies | W13-5 | 59-46 | .562 | Petco Park · San Diego, CA |
| 106 | Tue Aug 2 | vs Rockies | W3-2 | 60-46 | .566 | Petco Park · San Diego, CA |
| 107 | Wed Aug 3 | vs Rockies | W9-1 | 61-46 | .570 | Petco Park · San Diego, CA |
| 108 | Thu Aug 4 | vs Rockies | L3-7 | 61-47 | .565 | Petco Park · San Diego, CA |
| 109 | Fri Aug 5 | at Dodgers | L1-8 | 61-48 | .560 | Dodger Stadium · Los Angeles, CA |
| 110 | Sat Aug 6 | at Dodgers | L3-8 | 61-49 | .555 | Dodger Stadium · Los Angeles, CA |
| 111 | Sun Aug 7 | at Dodgers | L0-4 | 61-50 | .550 | Dodger Stadium · Los Angeles, CA |
| 112 | Mon Aug 8 | vs Giants | L0-1 | 61-51 | .545 | Petco Park · San Diego, CA |
| 113 | Tue Aug 9 | vs Giants | W7-4 | 62-51 | .549 | Petco Park · San Diego, CA |
| 114 | Wed Aug 10 | vs Giants | W13-7 | 63-51 | .553 | Petco Park · San Diego, CA |
| 115 | Fri Aug 12 | at Nationals | W10-5 | 64-51 | .557 | Nationals Park · Washington, D.C. |
| 116 | Sat Aug 13 | at Nationals | L3-4 | 64-52 | .552 | Nationals Park · Washington, D.C. |
| 117 | Sun Aug 14 | at Nationals | W6-0 | 65-52 | .556 | Nationals Park · Washington, D.C. |
| 118 | Mon Aug 15 | at Marlins | L0-3 | 65-53 | .551 | LoanDepot Park · Miami, FL |
| 119 | Tue Aug 16 | at Marlins | L3-4 | 65-54 | .546 | LoanDepot Park · Miami, FL |
| 120 | Wed Aug 17 | at Marlins | W10-3 | 66-54 | .550 | LoanDepot Park · Miami, FL |
| 121 | Thu Aug 18 | vs Nationals | L1-3 | 66-55 | .545 | Petco Park · San Diego, CA |
| 122 | Fri Aug 19 | vs Nationals | L3-6 | 66-56 | .541 | Petco Park · San Diego, CA |
| 123 | Sat Aug 20 | vs Nationals | W2-1 | 67-56 | .545 | Petco Park · San Diego, CA |
| 124 | Sun Aug 21 | vs Nationals | W2-1 | 68-56 | .548 | Petco Park · San Diego, CA |
| 125 | Tue Aug 23 | vs Guardians | L1-3 | 68-57 | .544 | Petco Park · San Diego, CA |
| 126 | Wed Aug 24 | vs Guardians | L0-7 | 68-58 | .540 | Petco Park · San Diego, CA |
| 127 | Fri Aug 26 | at Royals | W13-5 | 69-58 | .543 | Kauffman Stadium · Kansas City, MO |
| 128 | Sat Aug 27 | at Royals | W4-3 | 70-58 | .547 | Kauffman Stadium · Kansas City, MO |
| 129 | Sun Aug 28 | at Royals | L7-15 | 70-59 | .543 | Kauffman Stadium · Kansas City, MO |
| 130 | Mon Aug 29 | at Giants | W6-5 | 71-59 | .546 | Oracle Park · San Francisco, CA |
| 131 | Tue Aug 30 | at Giants | W4-3 | 72-59 | .550 | Oracle Park · San Francisco, CA |
| 132 | Wed Aug 31 | at Giants | W5-4 | 73-59 | .553 | Oracle Park · San Francisco, CA |
| 133 | Fri Sep 2 | at Dodgers | W7-1 | 74-59 | .556 | Dodger Stadium · Los Angeles, CA |
| 134 | Sat Sep 3 | at Dodgers | L1-12 | 74-60 | .552 | Dodger Stadium · Los Angeles, CA |
| 135 | Sun Sep 4 | at Dodgers | L4-9 | 74-61 | .548 | Dodger Stadium · Los Angeles, CA |
| 136 | Mon Sep 5 | vs D-backs | L0-5 | 74-62 | .544 | Petco Park · San Diego, CA |
| 137 | Tue Sep 6 | vs D-backs | W6-5 | 75-62 | .547 | Petco Park · San Diego, CA |
| 138 | Wed Sep 7 | vs D-backs | W6-3 | 76-62 | .551 | Petco Park · San Diego, CA |
| 139 | Fri Sep 9 | vs Dodgers | W5-4 (10) | 77-62 | .554 | Petco Park · San Diego, CA |
| 140 | Sat Sep 10 | vs Dodgers | L4-8 | 77-63 | .550 | Petco Park · San Diego, CA |
| 141 | Sun Sep 11 | vs Dodgers | L2-11 | 77-64 | .546 | Petco Park · San Diego, CA |
| 142 | Tue Sep 13 | at Mariners | W2-0 | 78-64 | .549 | T-Mobile Park · Seattle, WA |
| 143 | Wed Sep 14 | at Mariners | L1-6 | 78-65 | .545 | T-Mobile Park · Seattle, WA |
| 144 | Thu Sep 15 | at D-backs | L0-4 | 78-66 | .542 | Chase Field · Phoenix, AZ |
| 145 | Fri Sep 16 | at D-backs | W12-3 | 79-66 | .545 | Chase Field · Phoenix, AZ |
| 146 | Sat Sep 17 | at D-backs | W2-0 | 80-66 | .548 | Chase Field · Phoenix, AZ |
| 147 | Sun Sep 18 | at D-backs | W6-1 | 81-66 | .551 | Chase Field · Phoenix, AZ |
| 148 | Tue Sep 20 | vs Cardinals | W5-0 | 82-66 | .554 | Petco Park · San Diego, CA |
| 149 | Wed Sep 21 | vs Cardinals | W1-0 | 83-66 | .557 | Petco Park · San Diego, CA |
| 150 | Thu Sep 22 | vs Cardinals | L4-5 | 83-67 | .553 | Petco Park · San Diego, CA |
| 151 | Fri Sep 23 | at Rockies | L3-4 (10) | 83-68 | .550 | Coors Field · Denver, CO |
| 152 | Sat Sep 24 | at Rockies | W9-3 | 84-68 | .553 | Coors Field · Denver, CO |
| 153 | Sun Sep 25 | at Rockies | W13-6 | 85-68 | .556 | Coors Field · Denver, CO |
| 154 | Tue Sep 27 | vs Dodgers | W4-3 (10) | 86-68 | .558 | Petco Park · San Diego, CA |
| 155 | Wed Sep 28 | vs Dodgers | L0-1 (10) | 86-69 | .555 | Petco Park · San Diego, CA |
| 156 | Thu Sep 29 | vs Dodgers | L2-5 | 86-70 | .551 | Petco Park · San Diego, CA |
| 157 | Fri Sep 30 | vs White Sox | L1-3 | 86-71 | .548 | Petco Park · San Diego, CA |
| 158 | Sat Oct 1 | vs White Sox | W5-2 | 87-71 | .551 | Petco Park · San Diego, CA |
| 159 | Sun Oct 2 | vs White Sox | L1-2 | 87-72 | .547 | Petco Park · San Diego, CA |
| 160 | Mon Oct 3 | vs Giants | W7-4 | 88-72 | .550 | Petco Park · San Diego, CA |
| 161 | Tue Oct 4 | vs Giants | W6-2 | 89-72 | .553 | Petco Park · San Diego, CA |
| 162 | Wed Oct 5 | vs Giants | L1-8 | 89-73 | .549 | Petco Park · San Diego, CA |
| 163 | Fri Oct 7 | at Mets | W7-1 | 1-0 | 1.000 | Citi Field · Queens, NY |
| 164 | Sat Oct 8 | at Mets | L3-7 | 1-1 | .500 | Citi Field · Queens, NY |
| 165 | Sun Oct 9 | at Mets | W6-0 | 2-1 | .667 | Citi Field · Queens, NY |
| 166 | Tue Oct 11 | at Dodgers | L3-5 | 0-1 | .000 | Dodger Stadium · Los Angeles, CA |
| 167 | Wed Oct 12 | at Dodgers | W5-3 | 1-1 | .500 | Dodger Stadium · Los Angeles, CA |
| 168 | Fri Oct 14 | vs Dodgers | W2-1 | 2-1 | .667 | Petco Park · San Diego, CA |
| 169 | Sat Oct 15 | vs Dodgers | W5-3 | 3-1 | .750 | Petco Park · San Diego, CA |
| 170 | Tue Oct 18 | vs Phillies | L0-2 | 0-1 | .000 | Petco Park · San Diego, CA |
| 171 | Wed Oct 19 | vs Phillies | W8-5 | 1-1 | .500 | Petco Park · San Diego, CA |
| 172 | Fri Oct 21 | at Phillies | L2-4 | 1-2 | .333 | Citizens Bank Park · Philadelphi, PA |
| 173 | Sat Oct 22 | at Phillies | L6-10 | 1-3 | .250 | Citizens Bank Park · Philadelphi, PA |
| 174 | Sun Oct 23 | at Phillies | L3-4 | 1-4 | .200 | Citizens Bank Park · Philadelphi, PA |