| 1 | Sun Mar 30 | vs Dodgers | W3-1 | 1-0 | 1.000 | Petco Park · San Diego, CA |
| 2 | Tue Apr 1 | vs Dodgers | L2-3 | 1-1 | .500 | Petco Park · San Diego, CA |
| 3 | Wed Apr 2 | vs Dodgers | L1-5 | 1-2 | .333 | Petco Park · San Diego, CA |
| 4 | Fri Apr 4 | at Marlins | L2-8 | 1-3 | .250 | LoanDepot Park · Miami, FL |
| 5 | Sat Apr 5 | at Marlins | L0-5 | 1-4 | .200 | LoanDepot Park · Miami, FL |
| 6 | Sun Apr 6 | at Marlins | W4-2 | 2-4 | .333 | LoanDepot Park · Miami, FL |
| 7 | Tue Apr 8 | at Guardians | L6-8 | 2-5 | .286 | Progressive Field · Cleveland, OH |
| 8 | Wed Apr 9 | at Guardians | L0-2 | 2-6 | .250 | Progressive Field · Cleveland, OH |
| 9 | Wed Apr 9 | at Guardians | W2-1 | 3-6 | .333 | Progressive Field · Cleveland, OH |
| 10 | Fri Apr 11 | vs Tigers | W6-0 | 4-6 | .400 | Petco Park · San Diego, CA |
| 11 | Sat Apr 12 | vs Tigers | L2-6 | 4-7 | .364 | Petco Park · San Diego, CA |
| 12 | Sun Apr 13 | vs Tigers | W5-1 | 5-7 | .417 | Petco Park · San Diego, CA |
| 13 | Mon Apr 14 | vs Rockies | W5-4 | 6-7 | .462 | Petco Park · San Diego, CA |
| 14 | Tue Apr 15 | vs Rockies | L2-3 | 6-8 | .429 | Petco Park · San Diego, CA |
| 15 | Wed Apr 16 | vs Rockies | W4-2 | 7-8 | .467 | Petco Park · San Diego, CA |
| 16 | Thu Apr 17 | vs Rockies | L1-3 | 7-9 | .438 | Petco Park · San Diego, CA |
| 17 | Fri Apr 18 | vs Giants | W2-1 | 8-9 | .471 | Petco Park · San Diego, CA |
| 18 | Sat Apr 19 | vs Giants | W3-1 | 9-9 | .500 | Petco Park · San Diego, CA |
| 19 | Sun Apr 20 | vs Giants | L3-4 | 9-10 | .474 | Petco Park · San Diego, CA |
| 20 | Mon Apr 21 | at Brewers | L3-4 | 9-11 | .450 | American Family Field · Milwaukee, WI |
| 21 | Tue Apr 22 | at Brewers | W2-1 (12) | 10-11 | .476 | American Family Field · Milwaukee, WI |
| 22 | Wed Apr 23 | at Brewers | L2-5 | 10-12 | .455 | American Family Field · Milwaukee, WI |
| 23 | Thu Apr 24 | at Nationals | W4-3 (12) | 11-12 | .478 | Nationals Park · Washington, D.C. |
| 24 | Fri Apr 25 | at Nationals | L1-11 | 11-13 | .458 | Nationals Park · Washington, D.C. |
| 25 | Sat Apr 26 | at Nationals | L0-4 | 11-14 | .440 | Nationals Park · Washington, D.C. |
| 26 | Sun Apr 27 | at Nationals | W4-2 | 12-14 | .462 | Nationals Park · Washington, D.C. |
| 27 | Mon Apr 28 | at Giants | W6-4 | 13-14 | .481 | Oracle Park · San Francisco, CA |
| 28 | Tue Apr 29 | at Giants | L0-6 | 13-15 | .464 | Oracle Park · San Francisco, CA |
| 29 | Wed Apr 30 | at Giants | L2-3 | 13-16 | .448 | Oracle Park · San Francisco, CA |
| 30 | Fri May 2 | vs D-backs | L0-2 | 13-17 | .433 | Petco Park · San Diego, CA |
| 31 | Sat May 3 | vs D-backs | L3-4 | 13-18 | .419 | Petco Park · San Diego, CA |
| 32 | Sun May 4 | vs D-backs | W4-3 | 14-18 | .438 | Petco Park · San Diego, CA |
| 33 | Mon May 5 | vs Royals | W6-5 (12) | 15-18 | .455 | Petco Park · San Diego, CA |
| 34 | Tue May 6 | vs Royals | L1-3 (11) | 15-19 | .441 | Petco Park · San Diego, CA |
| 35 | Wed May 7 | vs Royals | L0-8 | 15-20 | .429 | Petco Park · San Diego, CA |
| 36 | Thu May 8 | vs Marlins | L1-3 (11) | 15-21 | .417 | Petco Park · San Diego, CA |
| 37 | Fri May 9 | vs Marlins | W10-1 | 16-21 | .432 | Petco Park · San Diego, CA |
| 38 | Sat May 10 | vs Marlins | W9-3 | 17-21 | .447 | Petco Park · San Diego, CA |
| 39 | Sun May 11 | vs Marlins | W5-4 | 18-21 | .462 | Petco Park · San Diego, CA |
| 40 | Tue May 13 | at Reds | W2-1 | 19-21 | .475 | Great American Ball Park · Cincinnati, OH |
| 41 | Thu May 15 | at Reds | L0-5 | 19-22 | .463 | Great American Ball Park · Cincinnati, OH |
| 42 | Thu May 15 | at Reds | W6-1 | 20-22 | .476 | Great American Ball Park · Cincinnati, OH |
| 43 | Fri May 16 | at Rockies | L1-3 | 20-23 | .465 | Coors Field · Denver, CO |
| 44 | Sat May 17 | at Rockies | W8-5 | 21-23 | .477 | Coors Field · Denver, CO |
| 45 | Sun May 18 | at Rockies | L6-8 (10) | 21-24 | .467 | Coors Field · Denver, CO |
| 46 | Tue May 20 | vs Twins | L3-5 | 21-25 | .457 | Petco Park · San Diego, CA |
| 47 | Wed May 21 | vs Twins | L0-2 | 21-26 | .447 | Petco Park · San Diego, CA |
| 48 | Thu May 22 | vs Cubs | L1-5 | 21-27 | .438 | Petco Park · San Diego, CA |
| 49 | Fri May 23 | vs Cubs | W11-1 | 22-27 | .449 | Petco Park · San Diego, CA |
| 50 | Sat May 24 | vs Cubs | L2-3 | 22-28 | .440 | Petco Park · San Diego, CA |
| 51 | Sun May 25 | vs Cubs | W4-3 | 23-28 | .451 | Petco Park · San Diego, CA |
| 52 | Mon May 26 | at D-backs | L5-7 | 23-29 | .442 | Chase Field · Phoenix, AZ |
| 53 | Tue May 27 | at D-backs | W4-3 | 24-29 | .453 | Chase Field · Phoenix, AZ |
| 54 | Wed May 28 | at D-backs | L6-12 | 24-30 | .444 | Chase Field · Phoenix, AZ |
| 55 | Fri May 30 | at White Sox | W4-1 | 25-30 | .455 | Guaranteed Rate Field · Chicago, IL |
| 56 | Sat May 31 | at White Sox | W4-2 | 26-30 | .464 | Guaranteed Rate Field · Chicago, IL |
| 57 | Sun Jun 1 | at White Sox | L1-4 | 26-31 | .456 | Guaranteed Rate Field · Chicago, IL |
| 58 | Mon Jun 2 | vs Pirates | L3-10 | 26-32 | .448 | Petco Park · San Diego, CA |
| 59 | Tue Jun 3 | vs Pirates | L1-4 | 26-33 | .441 | Petco Park · San Diego, CA |
| 60 | Wed Jun 4 | vs Pirates | W3-2 | 27-33 | .450 | Petco Park · San Diego, CA |
| 61 | Fri Jun 6 | vs Nationals | L0-6 | 27-34 | .443 | Petco Park · San Diego, CA |
| 62 | Sat Jun 7 | vs Nationals | W4-3 (11) | 28-34 | .452 | Petco Park · San Diego, CA |
| 63 | Sun Jun 8 | vs Nationals | L0-6 | 28-35 | .444 | Petco Park · San Diego, CA |
| 64 | Tue Jun 10 | at Phillies | L2-5 | 28-36 | .438 | Citizens Bank Park · Philadelphi, PA |
| 65 | Wed Jun 11 | at Phillies | L0-3 | 28-37 | .431 | Citizens Bank Park · Philadelphi, PA |
| 66 | Thu Jun 12 | at Phillies | L3-7 | 28-38 | .424 | Citizens Bank Park · Philadelphi, PA |
| 67 | Fri Jun 13 | at Mets | L2-6 | 28-39 | .418 | Citi Field · Queens, NY |
| 68 | Sat Jun 14 | at Mets | W5-0 | 29-39 | .426 | Citi Field · Queens, NY |
| 69 | Sun Jun 15 | at Mets | L1-3 | 29-40 | .420 | Citi Field · Queens, NY |
| 70 | Mon Jun 16 | at Mariners | L1-5 | 29-41 | .414 | T-Mobile Park · Seattle, WA |
| 71 | Tue Jun 17 | at Mariners | L1-6 | 29-42 | .408 | T-Mobile Park · Seattle, WA |
| 72 | Wed Jun 18 | vs Mariners | W2-1 | 30-42 | .417 | Petco Park · San Diego, CA |
| 73 | Thu Jun 19 | vs Mariners | W4-1 | 31-42 | .425 | Petco Park · San Diego, CA |
| 74 | Fri Jun 20 | vs Dodgers | W6-5 | 32-42 | .432 | Petco Park · San Diego, CA |
| 75 | Sat Jun 21 | vs Dodgers | L2-4 | 32-43 | .427 | Petco Park · San Diego, CA |
| 76 | Sun Jun 22 | vs Dodgers | L1-2 | 32-44 | .421 | Petco Park · San Diego, CA |
| 77 | Mon Jun 23 | at Giants | W6-0 | 33-44 | .429 | Oracle Park · San Francisco, CA |
| 78 | Tue Jun 24 | at Giants | W7-2 | 34-44 | .436 | Oracle Park · San Francisco, CA |
| 79 | Wed Jun 25 | at Giants | L0-4 | 34-45 | .430 | Oracle Park · San Francisco, CA |
| 80 | Fri Jun 27 | vs D-backs | L1-2 | 34-46 | .425 | Petco Park · San Diego, CA |
| 81 | Sat Jun 28 | vs D-backs | L1-3 | 34-47 | .420 | Petco Park · San Diego, CA |
| 82 | Sun Jun 29 | vs D-backs | W2-1 | 35-47 | .427 | Petco Park · San Diego, CA |
| 83 | Mon Jun 30 | vs Reds | W1-0 | 36-47 | .434 | Petco Park · San Diego, CA |
| 84 | Tue Jul 1 | vs Reds | W8-2 | 37-47 | .440 | Petco Park · San Diego, CA |
| 85 | Wed Jul 2 | vs Reds | W3-0 | 38-47 | .447 | Petco Park · San Diego, CA |
| 86 | Fri Jul 4 | vs Giants | W2-0 | 39-47 | .453 | Petco Park · San Diego, CA |
| 87 | Sat Jul 5 | vs Giants | L3-5 (10) | 39-48 | .448 | Petco Park · San Diego, CA |
| 88 | Sun Jul 6 | vs Giants | L3-5 | 39-49 | .443 | Petco Park · San Diego, CA |
| 89 | Mon Jul 7 | at Rockies | W6-1 | 40-49 | .449 | Coors Field · Denver, CO |
| 90 | Tue Jul 8 | at Rockies | L1-2 | 40-50 | .444 | Coors Field · Denver, CO |
| 91 | Wed Jul 9 | at Rockies | L3-6 | 40-51 | .440 | Coors Field · Denver, CO |
| 92 | Thu Jul 10 | at Dodgers | L1-2 | 40-52 | .435 | Dodger Stadium · Los Angeles, CA |
| 93 | Fri Jul 11 | at Dodgers | W6-3 | 41-52 | .441 | Dodger Stadium · Los Angeles, CA |
| 94 | Sat Jul 12 | at Dodgers | L0-1 | 41-53 | .436 | Dodger Stadium · Los Angeles, CA |
| 95 | Sun Jul 13 | at Dodgers | L0-1 | 41-54 | .432 | Dodger Stadium · Los Angeles, CA |
| 96 | Fri Jul 18 | vs Mets | L4-5 | 41-55 | .427 | Petco Park · San Diego, CA |
| 97 | Sat Jul 19 | vs Mets | W6-0 | 42-55 | .433 | Petco Park · San Diego, CA |
| 98 | Sun Jul 20 | vs Mets | W2-1 | 43-55 | .439 | Petco Park · San Diego, CA |
| 99 | Tue Jul 22 | at Cubs | L0-6 | 43-56 | .434 | Wrigley Field · Chicago, IL |
| 100 | Wed Jul 23 | at Cubs | W8-3 | 44-56 | .440 | Wrigley Field · Chicago, IL |
| 101 | Thu Jul 24 | at Cubs | W13-3 | 45-56 | .446 | Wrigley Field · Chicago, IL |
| 102 | Fri Jul 25 | at Braves | W5-2 | 46-56 | .451 | Truist Park · Cumberland, GA |
| 103 | Sat Jul 26 | at Braves | L3-5 | 46-57 | .447 | Truist Park · Cumberland, GA |
| 104 | Sun Jul 27 | at Braves | L3-8 | 46-58 | .442 | Truist Park · Cumberland, GA |
| 105 | Mon Jul 28 | at Braves | L0-2 | 46-59 | .438 | Truist Park · Cumberland, GA |
| 106 | Tue Jul 29 | vs Cardinals | W3-1 | 47-59 | .443 | Petco Park · San Diego, CA |
| 107 | Wed Jul 30 | vs Cardinals | W12-1 | 48-59 | .449 | Petco Park · San Diego, CA |
| 108 | Thu Jul 31 | vs Cardinals | L2-6 | 48-60 | .444 | Petco Park · San Diego, CA |
| 109 | Fri Aug 1 | vs Braves | W10-1 | 49-60 | .450 | Petco Park · San Diego, CA |
| 110 | Sat Aug 2 | vs Braves | W3-2 (12) | 50-60 | .455 | Petco Park · San Diego, CA |
| 111 | Sun Aug 3 | vs Braves | W4-3 (10) | 51-60 | .459 | Petco Park · San Diego, CA |
| 112 | Tue Aug 5 | at Twins | L1-3 | 51-61 | .455 | Target Field · Minneapolis, MN |
| 113 | Wed Aug 6 | at Twins | W5-4 (10) | 52-61 | .460 | Target Field · Minneapolis, MN |
| 114 | Fri Aug 8 | at Pirates | L1-2 | 52-62 | .456 | PNC Park · Pittsburgh, PA |
| 115 | Sat Aug 9 | at Pirates | W2-1 | 53-62 | .461 | PNC Park · Pittsburgh, PA |
| 116 | Sun Aug 10 | at Pirates | W8-2 | 54-62 | .466 | PNC Park · Pittsburgh, PA |
| 117 | Mon Aug 11 | vs Rockies | W4-3 | 55-62 | .470 | Petco Park · San Diego, CA |
| 118 | Tue Aug 12 | vs Rockies | W4-1 | 56-62 | .475 | Petco Park · San Diego, CA |
| 119 | Wed Aug 13 | vs Rockies | W5-3 | 57-62 | .479 | Petco Park · San Diego, CA |
| 120 | Thu Aug 14 | at Cardinals | L3-4 | 57-63 | .475 | Busch Stadium · St. Louis, MO |
| 121 | Fri Aug 15 | at Cardinals | L2-4 | 57-64 | .471 | Busch Stadium · St. Louis, MO |
| 122 | Sat Aug 16 | at Cardinals | W9-5 | 58-64 | .475 | Busch Stadium · St. Louis, MO |
| 123 | Sun Aug 17 | at Cardinals | L6-7 | 58-65 | .472 | Busch Stadium · St. Louis, MO |
| 124 | Tue Aug 19 | at Dodgers | L6-8 | 58-66 | .468 | Dodger Stadium · Los Angeles, CA |
| 125 | Wed Aug 20 | at Dodgers | W4-1 | 59-66 | .472 | Dodger Stadium · Los Angeles, CA |
| 126 | Thu Aug 21 | at Dodgers | L1-2 | 59-67 | .468 | Dodger Stadium · Los Angeles, CA |
| 127 | Fri Aug 22 | at D-backs | L1-5 | 59-68 | .465 | Chase Field · Phoenix, AZ |
| 128 | Sat Aug 23 | at D-backs | L2-5 | 59-69 | .461 | Chase Field · Phoenix, AZ |
| 129 | Sun Aug 24 | at D-backs | W7-4 | 60-69 | .465 | Chase Field · Phoenix, AZ |
| 130 | Mon Aug 25 | vs Brewers | L1-10 | 60-70 | .462 | Petco Park · San Diego, CA |
| 131 | Tue Aug 26 | vs Brewers | W4-1 | 61-70 | .466 | Petco Park · San Diego, CA |
| 132 | Wed Aug 27 | vs Brewers | W3-2 (10) | 62-70 | .470 | Petco Park · San Diego, CA |
| 133 | Fri Aug 29 | vs Dodgers | W3-2 (12) | 63-70 | .474 | Petco Park · San Diego, CA |
| 134 | Sat Aug 30 | vs Dodgers | W2-1 (10) | 64-70 | .478 | Petco Park · San Diego, CA |
| 135 | Sun Aug 31 | vs Dodgers | L1-7 | 64-71 | .474 | Petco Park · San Diego, CA |
| 136 | Mon Sep 1 | vs D-backs | W3-1 | 65-71 | .478 | Petco Park · San Diego, CA |
| 137 | Tue Sep 2 | vs D-backs | W2-1 | 66-71 | .482 | Petco Park · San Diego, CA |
| 138 | Wed Sep 3 | vs D-backs | L1-6 | 66-72 | .478 | Petco Park · San Diego, CA |
| 139 | Thu Sep 4 | vs D-backs | L1-5 | 66-73 | .475 | Petco Park · San Diego, CA |
| 140 | Fri Sep 5 | at Rockies | L0-3 | 66-74 | .471 | Coors Field · Denver, CO |
| 141 | Sat Sep 6 | at Rockies | L6-7 (12) | 66-75 | .468 | Coors Field · Denver, CO |
| 142 | Sun Sep 7 | at Rockies | L0-6 | 66-76 | .465 | Coors Field · Denver, CO |
| 143 | Mon Sep 8 | at Dodgers | L4-9 | 66-77 | .462 | Dodger Stadium · Los Angeles, CA |
| 144 | Tue Sep 9 | at Dodgers | W6-3 | 67-77 | .465 | Dodger Stadium · Los Angeles, CA |
| 145 | Wed Sep 10 | at Dodgers | L0-4 | 67-78 | .462 | Dodger Stadium · Los Angeles, CA |
| 146 | Fri Sep 12 | at D-backs | W6-5 | 68-78 | .466 | Chase Field · Phoenix, AZ |
| 147 | Sat Sep 13 | at D-backs | L4-10 | 68-79 | .463 | Chase Field · Phoenix, AZ |
| 148 | Sun Sep 14 | at D-backs | L6-8 | 68-80 | .459 | Chase Field · Phoenix, AZ |
| 149 | Mon Sep 15 | vs Phillies | W1-0 | 69-80 | .463 | Petco Park · San Diego, CA |
| 150 | Tue Sep 16 | vs Phillies | W5-4 | 70-80 | .467 | Petco Park · San Diego, CA |
| 151 | Wed Sep 17 | vs Phillies | L2-5 | 70-81 | .464 | Petco Park · San Diego, CA |
| 152 | Thu Sep 18 | vs Phillies | W7-3 | 71-81 | .467 | Petco Park · San Diego, CA |
| 153 | Fri Sep 19 | vs Giants | W5-0 | 72-81 | .471 | Petco Park · San Diego, CA |
| 154 | Sat Sep 20 | vs Giants | W3-2 | 73-81 | .474 | Petco Park · San Diego, CA |
| 155 | Sun Sep 21 | vs Giants | W8-2 | 74-81 | .477 | Petco Park · San Diego, CA |
| 156 | Mon Sep 22 | vs Rockies | W1-0 | 75-81 | .481 | Petco Park · San Diego, CA |
| 157 | Tue Sep 23 | vs Rockies | L2-3 | 75-82 | .478 | Petco Park · San Diego, CA |
| 158 | Wed Sep 24 | vs Rockies | W4-3 | 76-82 | .481 | Petco Park · San Diego, CA |
| 159 | Thu Sep 25 | at Giants | L8-9 | 76-83 | .478 | Oracle Park · San Francisco, CA |
| 160 | Fri Sep 26 | at Giants | W4-1 | 77-83 | .481 | Oracle Park · San Francisco, CA |
| 161 | Sat Sep 27 | at Giants | L1-3 | 77-84 | .478 | Oracle Park · San Francisco, CA |
| 162 | Sun Sep 28 | at Giants | L3-9 | 77-85 | .475 | Oracle Park · San Francisco, CA |