| 1 | Thu Mar 30 | vs Rockies | L2-7 | 0-1 | .000 | Petco Park · San Diego, CA |
| 2 | Fri Mar 31 | vs Rockies | L1-4 | 0-2 | .000 | Petco Park · San Diego, CA |
| 3 | Sat Apr 1 | vs Rockies | W8-4 | 1-2 | .333 | Petco Park · San Diego, CA |
| 4 | Sun Apr 2 | vs Rockies | W3-1 | 2-2 | .500 | Petco Park · San Diego, CA |
| 5 | Mon Apr 3 | vs D-backs | W5-4 | 3-2 | .600 | Petco Park · San Diego, CA |
| 6 | Tue Apr 4 | vs D-backs | L6-8 | 3-3 | .500 | Petco Park · San Diego, CA |
| 7 | Thu Apr 6 | at Braves | L6-7 | 3-4 | .429 | Truist Park · Cumberland, GA |
| 8 | Fri Apr 7 | at Braves | W5-4 | 4-4 | .500 | Truist Park · Cumberland, GA |
| 9 | Sat Apr 8 | at Braves | W4-1 | 5-4 | .556 | Truist Park · Cumberland, GA |
| 10 | Sun Apr 9 | at Braves | W10-2 | 6-4 | .600 | Truist Park · Cumberland, GA |
| 11 | Mon Apr 10 | at Mets | L0-5 | 6-5 | .545 | Citi Field · Queens, NY |
| 12 | Tue Apr 11 | at Mets | W4-2 | 7-5 | .583 | Citi Field · Queens, NY |
| 13 | Wed Apr 12 | at Mets | L2-5 | 7-6 | .538 | Citi Field · Queens, NY |
| 14 | Thu Apr 13 | vs Brewers | L3-4 (10) | 7-7 | .500 | Petco Park · San Diego, CA |
| 15 | Fri Apr 14 | vs Brewers | L2-11 | 7-8 | .467 | Petco Park · San Diego, CA |
| 16 | Sat Apr 15 | vs Brewers | W10-3 | 8-8 | .500 | Petco Park · San Diego, CA |
| 17 | Sun Apr 16 | vs Brewers | L0-1 | 8-9 | .471 | Petco Park · San Diego, CA |
| 18 | Mon Apr 17 | vs Braves | L0-2 | 8-10 | .444 | Petco Park · San Diego, CA |
| 19 | Tue Apr 18 | vs Braves | L1-8 | 8-11 | .421 | Petco Park · San Diego, CA |
| 20 | Wed Apr 19 | vs Braves | W1-0 | 9-11 | .450 | Petco Park · San Diego, CA |
| 21 | Thu Apr 20 | at D-backs | W7-5 | 10-11 | .476 | Chase Field · Phoenix, AZ |
| 22 | Fri Apr 21 | at D-backs | L0-9 | 10-12 | .455 | Chase Field · Phoenix, AZ |
| 23 | Sat Apr 22 | at D-backs | W5-3 | 11-12 | .478 | Chase Field · Phoenix, AZ |
| 24 | Sun Apr 23 | at D-backs | W7-5 | 12-12 | .500 | Chase Field · Phoenix, AZ |
| 25 | Tue Apr 25 | at Cubs | L0-6 | 12-13 | .480 | Wrigley Field · Chicago, IL |
| 26 | Wed Apr 26 | at Cubs | W5-3 | 13-13 | .500 | Wrigley Field · Chicago, IL |
| 27 | Thu Apr 27 | at Cubs | L2-5 | 13-14 | .481 | Wrigley Field · Chicago, IL |
| 28 | Sat Apr 29 | vs Giants | W16-11 | 14-14 | .500 | Estadio Alfredo Harp Helu · Mexico City, CDMX |
| 29 | Sun Apr 30 | vs Giants | W6-4 | 15-14 | .517 | Estadio Alfredo Harp Helu · Mexico City, CDMX |
| 30 | Mon May 1 | vs Reds | W8-3 | 16-14 | .533 | Petco Park · San Diego, CA |
| 31 | Tue May 2 | vs Reds | L1-2 (10) | 16-15 | .516 | Petco Park · San Diego, CA |
| 32 | Wed May 3 | vs Reds | W7-1 | 17-15 | .531 | Petco Park · San Diego, CA |
| 33 | Fri May 5 | vs Dodgers | W5-2 | 18-15 | .545 | Petco Park · San Diego, CA |
| 34 | Sat May 6 | vs Dodgers | L1-2 | 18-16 | .529 | Petco Park · San Diego, CA |
| 35 | Sun May 7 | vs Dodgers | L2-5 (10) | 18-17 | .514 | Petco Park · San Diego, CA |
| 36 | Tue May 9 | at Twins | W6-1 | 19-17 | .528 | Target Field · Minneapolis, MN |
| 37 | Wed May 10 | at Twins | L3-4 (11) | 19-18 | .514 | Target Field · Minneapolis, MN |
| 38 | Thu May 11 | at Twins | L3-5 | 19-19 | .500 | Target Field · Minneapolis, MN |
| 39 | Fri May 12 | at Dodgers | L2-4 | 19-20 | .487 | Dodger Stadium · Los Angeles, CA |
| 40 | Sat May 13 | at Dodgers | L2-4 | 19-21 | .475 | Dodger Stadium · Los Angeles, CA |
| 41 | Sun May 14 | at Dodgers | L0-4 | 19-22 | .463 | Dodger Stadium · Los Angeles, CA |
| 42 | Mon May 15 | vs Royals | W4-0 | 20-22 | .476 | Petco Park · San Diego, CA |
| 43 | Tue May 16 | vs Royals | L4-5 | 20-23 | .465 | Petco Park · San Diego, CA |
| 44 | Wed May 17 | vs Royals | L3-4 | 20-24 | .455 | Petco Park · San Diego, CA |
| 45 | Fri May 19 | vs Red Sox | L1-6 | 20-25 | .444 | Petco Park · San Diego, CA |
| 46 | Sat May 20 | vs Red Sox | L2-4 | 20-26 | .435 | Petco Park · San Diego, CA |
| 47 | Sun May 21 | vs Red Sox | W7-0 | 21-26 | .447 | Petco Park · San Diego, CA |
| 48 | Tue May 23 | at Nationals | W7-4 | 22-26 | .458 | Nationals Park · Washington, D.C. |
| 49 | Wed May 24 | at Nationals | L3-5 | 22-27 | .449 | Nationals Park · Washington, D.C. |
| 50 | Thu May 25 | at Nationals | W8-6 | 23-27 | .460 | Nationals Park · Washington, D.C. |
| 51 | Fri May 26 | at Yankees | W5-1 | 24-27 | .471 | Yankee Stadium · The Bronx, NY |
| 52 | Sat May 27 | at Yankees | L2-3 (10) | 24-28 | .462 | Yankee Stadium · The Bronx, NY |
| 53 | Sun May 28 | at Yankees | L7-10 | 24-29 | .453 | Yankee Stadium · The Bronx, NY |
| 54 | Tue May 30 | at Marlins | W9-4 | 25-29 | .463 | LoanDepot Park · Miami, FL |
| 55 | Wed May 31 | at Marlins | L1-2 | 25-30 | .455 | LoanDepot Park · Miami, FL |
| 56 | Thu Jun 1 | at Marlins | W10-1 | 26-30 | .464 | LoanDepot Park · Miami, FL |
| 57 | Fri Jun 2 | vs Cubs | L1-2 | 26-31 | .456 | Petco Park · San Diego, CA |
| 58 | Sat Jun 3 | vs Cubs | W6-0 | 27-31 | .466 | Petco Park · San Diego, CA |
| 59 | Sun Jun 4 | vs Cubs | L1-7 | 27-32 | .458 | Petco Park · San Diego, CA |
| 60 | Mon Jun 5 | vs Cubs | W5-0 | 28-32 | .467 | Petco Park · San Diego, CA |
| 61 | Tue Jun 6 | vs Mariners | L1-4 | 28-33 | .459 | Petco Park · San Diego, CA |
| 62 | Wed Jun 7 | vs Mariners | W10-3 | 29-33 | .468 | Petco Park · San Diego, CA |
| 63 | Fri Jun 9 | at Rockies | W9-6 | 30-33 | .476 | Coors Field · Denver, CO |
| 64 | Sat Jun 10 | at Rockies | W3-2 | 31-33 | .484 | Coors Field · Denver, CO |
| 65 | Sun Jun 11 | at Rockies | L4-5 | 31-34 | .477 | Coors Field · Denver, CO |
| 66 | Tue Jun 13 | vs Guardians | W6-3 | 32-34 | .485 | Petco Park · San Diego, CA |
| 67 | Wed Jun 14 | vs Guardians | W5-0 | 33-34 | .493 | Petco Park · San Diego, CA |
| 68 | Thu Jun 15 | vs Guardians | L6-8 | 33-35 | .485 | Petco Park · San Diego, CA |
| 69 | Fri Jun 16 | vs Rays | L2-6 | 33-36 | .478 | Petco Park · San Diego, CA |
| 70 | Sat Jun 17 | vs Rays | W2-0 | 34-36 | .486 | Petco Park · San Diego, CA |
| 71 | Sun Jun 18 | vs Rays | W5-4 | 35-36 | .493 | Petco Park · San Diego, CA |
| 72 | Mon Jun 19 | at Giants | L4-7 (10) | 35-37 | .486 | Oracle Park · San Francisco, CA |
| 73 | Tue Jun 20 | at Giants | L3-4 | 35-38 | .479 | Oracle Park · San Francisco, CA |
| 74 | Wed Jun 21 | at Giants | L2-4 | 35-39 | .473 | Oracle Park · San Francisco, CA |
| 75 | Thu Jun 22 | at Giants | W10-0 | 36-39 | .480 | Oracle Park · San Francisco, CA |
| 76 | Fri Jun 23 | vs Nationals | W13-3 | 37-39 | .487 | Petco Park · San Diego, CA |
| 77 | Sat Jun 24 | vs Nationals | L0-2 | 37-40 | .481 | Petco Park · San Diego, CA |
| 78 | Sun Jun 25 | vs Nationals | L3-8 | 37-41 | .474 | Petco Park · San Diego, CA |
| 79 | Tue Jun 27 | at Pirates | L4-9 | 37-42 | .468 | PNC Park · Pittsburgh, PA |
| 80 | Wed Jun 28 | at Pirates | L1-7 | 37-43 | .463 | PNC Park · Pittsburgh, PA |
| 81 | Thu Jun 29 | at Pirates | L4-5 | 37-44 | .457 | PNC Park · Pittsburgh, PA |
| 82 | Fri Jun 30 | at Reds | L5-7 (11) | 37-45 | .451 | Great American Ball Park · Cincinnati, OH |
| 83 | Sat Jul 1 | at Reds | W12-5 | 38-45 | .458 | Great American Ball Park · Cincinnati, OH |
| 84 | Sun Jul 2 | at Reds | L3-4 | 38-46 | .452 | Great American Ball Park · Cincinnati, OH |
| 85 | Mon Jul 3 | vs Angels | W10-3 | 39-46 | .459 | Petco Park · San Diego, CA |
| 86 | Tue Jul 4 | vs Angels | W8-5 | 40-46 | .465 | Petco Park · San Diego, CA |
| 87 | Wed Jul 5 | vs Angels | W5-3 | 41-46 | .471 | Petco Park · San Diego, CA |
| 88 | Fri Jul 7 | vs Mets | L5-7 (10) | 41-47 | .466 | Petco Park · San Diego, CA |
| 89 | Sat Jul 8 | vs Mets | W3-1 | 42-47 | .472 | Petco Park · San Diego, CA |
| 90 | Sun Jul 9 | vs Mets | W6-2 | 43-47 | .478 | Petco Park · San Diego, CA |
| 91 | Fri Jul 14 | at Phillies | W8-3 | 44-47 | .484 | Citizens Bank Park · Philadelphi, PA |
| 92 | Sat Jul 15 | at Phillies | L4-6 | 44-48 | .478 | Citizens Bank Park · Philadelphi, PA |
| 93 | Sat Jul 15 | at Phillies | L4-9 | 44-49 | .473 | Citizens Bank Park · Philadelphi, PA |
| 94 | Sun Jul 16 | at Phillies | L6-7 (12) | 44-50 | .468 | Citizens Bank Park · Philadelphi, PA |
| 95 | Tue Jul 18 | at Blue Jays | W9-1 | 45-50 | .474 | Rogers Centre · Toronto, ON |
| 96 | Wed Jul 19 | at Blue Jays | W2-0 | 46-50 | .479 | Rogers Centre · Toronto, ON |
| 97 | Thu Jul 20 | at Blue Jays | L0-4 | 46-51 | .474 | Rogers Centre · Toronto, ON |
| 98 | Fri Jul 21 | at Tigers | W5-4 | 47-51 | .480 | Comerica Park · Detroit, MI |
| 99 | Sat Jul 22 | at Tigers | W14-3 | 48-51 | .485 | Comerica Park · Detroit, MI |
| 100 | Sun Jul 23 | at Tigers | L1-3 | 48-52 | .480 | Comerica Park · Detroit, MI |
| 101 | Mon Jul 24 | vs Pirates | L4-8 | 48-53 | .475 | Petco Park · San Diego, CA |
| 102 | Tue Jul 25 | vs Pirates | W5-1 | 49-53 | .480 | Petco Park · San Diego, CA |
| 103 | Wed Jul 26 | vs Pirates | L2-3 | 49-54 | .476 | Petco Park · San Diego, CA |
| 104 | Fri Jul 28 | vs Rangers | W7-1 | 50-54 | .481 | Petco Park · San Diego, CA |
| 105 | Sat Jul 29 | vs Rangers | W4-0 | 51-54 | .486 | Petco Park · San Diego, CA |
| 106 | Sun Jul 30 | vs Rangers | W5-3 | 52-54 | .491 | Petco Park · San Diego, CA |
| 107 | Mon Jul 31 | at Rockies | L3-4 (10) | 52-55 | .486 | Coors Field · Denver, CO |
| 108 | Tue Aug 1 | at Rockies | W8-5 | 53-55 | .491 | Coors Field · Denver, CO |
| 109 | Wed Aug 2 | at Rockies | W11-1 | 54-55 | .495 | Coors Field · Denver, CO |
| 110 | Fri Aug 4 | vs Dodgers | L5-10 | 54-56 | .491 | Petco Park · San Diego, CA |
| 111 | Sat Aug 5 | vs Dodgers | W8-3 | 55-56 | .495 | Petco Park · San Diego, CA |
| 112 | Sun Aug 6 | vs Dodgers | L2-8 | 55-57 | .491 | Petco Park · San Diego, CA |
| 113 | Mon Aug 7 | vs Dodgers | L7-13 | 55-58 | .487 | Petco Park · San Diego, CA |
| 114 | Tue Aug 8 | at Mariners | L0-2 | 55-59 | .482 | T-Mobile Park · Seattle, WA |
| 115 | Wed Aug 9 | at Mariners | L1-6 | 55-60 | .478 | T-Mobile Park · Seattle, WA |
| 116 | Fri Aug 11 | at D-backs | W10-5 | 56-60 | .483 | Chase Field · Phoenix, AZ |
| 117 | Sat Aug 12 | at D-backs | L0-3 | 56-61 | .479 | Chase Field · Phoenix, AZ |
| 118 | Sun Aug 13 | at D-backs | L4-5 | 56-62 | .475 | Chase Field · Phoenix, AZ |
| 119 | Mon Aug 14 | vs Orioles | L1-4 | 56-63 | .471 | Petco Park · San Diego, CA |
| 120 | Tue Aug 15 | vs Orioles | W10-3 | 57-63 | .475 | Petco Park · San Diego, CA |
| 121 | Wed Aug 16 | vs Orioles | W5-2 | 58-63 | .479 | Petco Park · San Diego, CA |
| 122 | Thu Aug 17 | vs D-backs | L1-3 | 58-64 | .475 | Petco Park · San Diego, CA |
| 123 | Fri Aug 18 | vs D-backs | W4-0 | 59-64 | .480 | Petco Park · San Diego, CA |
| 124 | Sat Aug 19 | vs D-backs | L4-6 | 59-65 | .476 | Petco Park · San Diego, CA |
| 125 | Sat Aug 19 | vs D-backs | L1-8 | 59-66 | .472 | Petco Park · San Diego, CA |
| 126 | Mon Aug 21 | vs Marlins | W6-2 | 60-66 | .476 | Petco Park · San Diego, CA |
| 127 | Tue Aug 22 | vs Marlins | L0-3 | 60-67 | .472 | Petco Park · San Diego, CA |
| 128 | Wed Aug 23 | vs Marlins | W4-0 | 61-67 | .477 | Petco Park · San Diego, CA |
| 129 | Fri Aug 25 | at Brewers | L3-7 | 61-68 | .473 | American Family Field · Milwaukee, WI |
| 130 | Sat Aug 26 | at Brewers | L4-5 | 61-69 | .469 | American Family Field · Milwaukee, WI |
| 131 | Sun Aug 27 | at Brewers | L6-10 | 61-70 | .466 | American Family Field · Milwaukee, WI |
| 132 | Mon Aug 28 | at Cardinals | W4-1 | 62-70 | .470 | Busch Stadium · St. Louis, MO |
| 133 | Tue Aug 29 | at Cardinals | L5-6 (10) | 62-71 | .466 | Busch Stadium · St. Louis, MO |
| 134 | Wed Aug 30 | at Cardinals | L4-5 | 62-72 | .463 | Busch Stadium · St. Louis, MO |
| 135 | Thu Aug 31 | vs Giants | L2-7 | 62-73 | .459 | Petco Park · San Diego, CA |
| 136 | Fri Sep 1 | vs Giants | W7-3 | 63-73 | .463 | Petco Park · San Diego, CA |
| 137 | Sat Sep 2 | vs Giants | W6-1 | 64-73 | .467 | Petco Park · San Diego, CA |
| 138 | Sun Sep 3 | vs Giants | W4-0 | 65-73 | .471 | Petco Park · San Diego, CA |
| 139 | Mon Sep 4 | vs Phillies | L7-9 | 65-74 | .468 | Petco Park · San Diego, CA |
| 140 | Tue Sep 5 | vs Phillies | W8-0 | 66-74 | .471 | Petco Park · San Diego, CA |
| 141 | Wed Sep 6 | vs Phillies | L1-5 | 66-75 | .468 | Petco Park · San Diego, CA |
| 142 | Fri Sep 8 | at Astros | W11-2 | 67-75 | .472 | Minute Maid Park · Houston, TX |
| 143 | Sat Sep 9 | at Astros | L5-7 | 67-76 | .469 | Minute Maid Park · Houston, TX |
| 144 | Sun Sep 10 | at Astros | L2-12 | 67-77 | .465 | Minute Maid Park · Houston, TX |
| 145 | Mon Sep 11 | at Dodgers | W11-8 | 68-77 | .469 | Dodger Stadium · Los Angeles, CA |
| 146 | Tue Sep 12 | at Dodgers | L2-11 | 68-78 | .466 | Dodger Stadium · Los Angeles, CA |
| 147 | Wed Sep 13 | at Dodgers | W6-1 | 69-78 | .469 | Dodger Stadium · Los Angeles, CA |
| 148 | Fri Sep 15 | at Athletics | W8-3 | 70-78 | .473 | RingCentral Coliseum · Oakland, CA |
| 149 | Sat Sep 16 | at Athletics | W5-2 | 71-78 | .477 | RingCentral Coliseum · Oakland, CA |
| 150 | Sun Sep 17 | at Athletics | W10-1 | 72-78 | .480 | RingCentral Coliseum · Oakland, CA |
| 151 | Mon Sep 18 | vs Rockies | W11-9 | 73-78 | .483 | Petco Park · San Diego, CA |
| 152 | Tue Sep 19 | vs Rockies | W2-0 | 74-78 | .487 | Petco Park · San Diego, CA |
| 153 | Wed Sep 20 | vs Rockies | W3-2 | 75-78 | .490 | Petco Park · San Diego, CA |
| 154 | Fri Sep 22 | vs Cardinals | W4-2 | 76-78 | .494 | Petco Park · San Diego, CA |
| 155 | Sat Sep 23 | vs Cardinals | L2-5 (11) | 76-79 | .490 | Petco Park · San Diego, CA |
| 156 | Sun Sep 24 | vs Cardinals | W12-2 | 77-79 | .494 | Petco Park · San Diego, CA |
| 157 | Mon Sep 25 | at Giants | L1-2 | 77-80 | .490 | Oracle Park · San Francisco, CA |
| 158 | Tue Sep 26 | at Giants | W4-0 | 78-80 | .494 | Oracle Park · San Francisco, CA |
| 159 | Wed Sep 27 | at Giants | W5-2 (10) | 79-80 | .497 | Oracle Park · San Francisco, CA |
| 160 | Fri Sep 29 | at White Sox | W3-2 | 80-80 | .500 | Guaranteed Rate Field · Chicago, IL |
| 161 | Sat Sep 30 | at White Sox | W6-1 | 81-80 | .503 | Guaranteed Rate Field · Chicago, IL |
| 162 | Sun Oct 1 | at White Sox | W2-1 (11) | 82-80 | .506 | Guaranteed Rate Field · Chicago, IL |