| 1 | Fri Apr 1 | vs Orioles | L1-4 | 0-1 | .000 | Tropicana Field · St. Petersburg, FL |
| 2 | Sat Apr 2 | vs Orioles | L1-3 | 0-2 | .000 | Tropicana Field · St. Petersburg, FL |
| 3 | Sun Apr 3 | vs Orioles | L1-5 | 0-3 | .000 | Tropicana Field · St. Petersburg, FL |
| 4 | Tue Apr 5 | vs Angels | L3-5 | 0-4 | .000 | Tropicana Field · St. Petersburg, FL |
| 5 | Wed Apr 6 | vs Angels | L1-5 | 0-5 | .000 | Tropicana Field · St. Petersburg, FL |
| 6 | Thu Apr 7 | at White Sox | L1-5 | 0-6 | .000 | Guaranteed Rate Field · Chicago, IL |
| 7 | Fri Apr 8 | at White Sox | W9-7 | 1-6 | .143 | Guaranteed Rate Field · Chicago, IL |
| 8 | Sat Apr 9 | at White Sox | L2-4 | 1-7 | .125 | Guaranteed Rate Field · Chicago, IL |
| 9 | Sun Apr 10 | at White Sox | L1-6 | 1-8 | .111 | Guaranteed Rate Field · Chicago, IL |
| 10 | Mon Apr 11 | at Red Sox | W16-5 | 2-8 | .200 | Fenway Park · Boston, MA |
| 11 | Tue Apr 12 | at Red Sox | W3-2 | 3-8 | .273 | Fenway Park · Boston, MA |
| 12 | Thu Apr 14 | vs Twins | W4-3 (10) | 4-8 | .333 | Tropicana Field · St. Petersburg, FL |
| 13 | Fri Apr 15 | vs Twins | W5-2 | 5-8 | .385 | Tropicana Field · St. Petersburg, FL |
| 14 | Sat Apr 16 | vs Twins | W4-3 | 6-8 | .429 | Tropicana Field · St. Petersburg, FL |
| 15 | Sun Apr 17 | vs Twins | L2-4 | 6-9 | .400 | Tropicana Field · St. Petersburg, FL |
| 16 | Mon Apr 18 | vs White Sox | W5-0 | 7-9 | .438 | Tropicana Field · St. Petersburg, FL |
| 17 | Tue Apr 19 | vs White Sox | W2-1 | 8-9 | .471 | Tropicana Field · St. Petersburg, FL |
| 18 | Wed Apr 20 | vs White Sox | W4-1 | 9-9 | .500 | Tropicana Field · St. Petersburg, FL |
| 19 | Thu Apr 21 | vs White Sox | L2-9 | 9-10 | .474 | Tropicana Field · St. Petersburg, FL |
| 20 | Fri Apr 22 | at Blue Jays | L4-6 (11) | 9-11 | .450 | Rogers Centre · Toronto, ON |
| 21 | Sat Apr 23 | at Blue Jays | W6-4 | 10-11 | .476 | Rogers Centre · Toronto, ON |
| 22 | Sun Apr 24 | at Blue Jays | W2-0 | 11-11 | .500 | Rogers Centre · Toronto, ON |
| 23 | Wed Apr 27 | at Twins | W8-2 | 12-11 | .522 | Target Field · Minneapolis, MN |
| 24 | Thu Apr 28 | at Twins | W15-3 | 13-11 | .542 | Target Field · Minneapolis, MN |
| 25 | Thu Apr 28 | at Twins | W6-1 | 14-11 | .560 | Target Field · Minneapolis, MN |
| 26 | Fri Apr 29 | vs Angels | L5-8 | 14-12 | .538 | Tropicana Field · St. Petersburg, FL |
| 27 | Sat Apr 30 | vs Angels | W2-1 (10) | 15-12 | .556 | Tropicana Field · St. Petersburg, FL |
| 28 | Sun May 1 | vs Angels | L5-6 | 15-13 | .536 | Tropicana Field · St. Petersburg, FL |
| 29 | Tue May 3 | vs Blue Jays | W3-2 | 16-13 | .552 | Tropicana Field · St. Petersburg, FL |
| 30 | Wed May 4 | vs Blue Jays | L2-3 | 16-14 | .533 | Tropicana Field · St. Petersburg, FL |
| 31 | Thu May 5 | vs Blue Jays | W3-1 | 17-14 | .548 | Tropicana Field · St. Petersburg, FL |
| 32 | Fri May 6 | at Orioles | W6-2 | 18-14 | .563 | Camden Yards · Baltimore, MD |
| 33 | Sat May 7 | at Orioles | W8-2 | 19-14 | .576 | Camden Yards · Baltimore, MD |
| 34 | Sun May 8 | at Orioles | W5-3 | 20-14 | .588 | Camden Yards · Baltimore, MD |
| 35 | Tue May 10 | at Guardians | L4-5 | 20-15 | .571 | Progressive Field · Cleveland, OH |
| 36 | Wed May 11 | at Guardians | W8-2 | 21-15 | .583 | Progressive Field · Cleveland, OH |
| 37 | Thu May 12 | at Guardians | W7-4 | 22-15 | .595 | Progressive Field · Cleveland, OH |
| 38 | Fri May 13 | vs Orioles | W3-0 | 23-15 | .605 | Tropicana Field · St. Petersburg, FL |
| 39 | Sat May 14 | vs Orioles | L0-6 | 23-16 | .590 | Tropicana Field · St. Petersburg, FL |
| 40 | Sun May 15 | vs Orioles | L3-9 | 23-17 | .575 | Tropicana Field · St. Petersburg, FL |
| 41 | Mon May 16 | vs Yankees | W6-5 | 24-17 | .585 | Tropicana Field · St. Petersburg, FL |
| 42 | Tue May 17 | vs Yankees | L2-6 | 24-18 | .571 | Tropicana Field · St. Petersburg, FL |
| 43 | Wed May 18 | at Blue Jays | W6-5 | 25-18 | .581 | Rogers Centre · Toronto, ON |
| 44 | Thu May 19 | at Blue Jays | L2-3 | 25-19 | .568 | Rogers Centre · Toronto, ON |
| 45 | Fri May 20 | at Marlins | L3-5 | 25-20 | .556 | MVP Arena · Albany, NY |
| 46 | Sat May 21 | at Marlins | L3-5 | 25-21 | .543 | MVP Arena · Albany, NY |
| 47 | Sun May 22 | at Marlins | W4-0 | 26-21 | .553 | MVP Arena · Albany, NY |
| 48 | Mon May 23 | at Tigers | L3-6 | 26-22 | .542 | Comerica Park · Detroit, MI |
| 49 | Tue May 24 | at Tigers | L6-7 | 26-23 | .531 | Comerica Park · Detroit, MI |
| 50 | Fri May 27 | vs Guardians | W5-0 | 27-23 | .540 | Tropicana Field · St. Petersburg, FL |
| 51 | Sat May 28 | vs Guardians | L3-7 | 27-24 | .529 | Tropicana Field · St. Petersburg, FL |
| 52 | Sun May 29 | vs Guardians | W7-0 | 28-24 | .538 | Tropicana Field · St. Petersburg, FL |
| 53 | Mon May 30 | vs Rangers | L5-11 | 28-25 | .528 | Tropicana Field · St. Petersburg, FL |
| 54 | Tue May 31 | vs Rangers | W5-4 | 29-25 | .537 | Tropicana Field · St. Petersburg, FL |
| 55 | Wed Jun 1 | vs Rangers | L0-3 | 29-26 | .527 | Tropicana Field · St. Petersburg, FL |
| 56 | Thu Jun 2 | at Mariners | L2-8 | 29-27 | .518 | T-Mobile Park · Seattle, WA |
| 57 | Fri Jun 3 | at Mariners | L0-7 | 29-28 | .509 | T-Mobile Park · Seattle, WA |
| 58 | Sat Jun 4 | at Mariners | W3-2 | 30-28 | .517 | T-Mobile Park · Seattle, WA |
| 59 | Sun Jun 5 | at Mariners | L6-9 | 30-29 | .508 | T-Mobile Park · Seattle, WA |
| 60 | Mon Jun 6 | at Angels | W5-1 | 31-29 | .517 | Angel Stadium · Anaheim, CA |
| 61 | Tue Jun 7 | at Angels | W4-1 | 32-29 | .525 | Angel Stadium · Anaheim, CA |
| 62 | Wed Jun 8 | at Angels | W4-3 (10) | 33-29 | .532 | Angel Stadium · Anaheim, CA |
| 63 | Fri Jun 10 | at Orioles | L0-7 | 33-30 | .524 | Camden Yards · Baltimore, MD |
| 64 | Sat Jun 11 | at Orioles | W7-5 (11) | 34-30 | .531 | Camden Yards · Baltimore, MD |
| 65 | Sun Jun 12 | at Orioles | W9-6 | 35-30 | .538 | Camden Yards · Baltimore, MD |
| 66 | Mon Jun 13 | at Tigers | L1-2 (10) | 35-31 | .530 | Comerica Park · Detroit, MI |
| 67 | Tue Jun 14 | vs Red Sox | W4-0 | 36-31 | .537 | Tropicana Field · St. Petersburg, FL |
| 68 | Wed Jun 15 | vs Red Sox | L0-3 | 36-32 | .529 | Tropicana Field · St. Petersburg, FL |
| 69 | Thu Jun 16 | vs Red Sox | L2-4 | 36-33 | .522 | Tropicana Field · St. Petersburg, FL |
| 70 | Fri Jun 17 | vs Marlins | W5-1 | 37-33 | .529 | Tropicana Field · St. Petersburg, FL |
| 71 | Sat Jun 18 | vs Marlins | W7-4 | 38-33 | .535 | Tropicana Field · St. Petersburg, FL |
| 72 | Sun Jun 19 | vs Marlins | W2-1 | 39-33 | .542 | Tropicana Field · St. Petersburg, FL |
| 73 | Mon Jun 20 | at Brewers | W8-4 | 40-33 | .548 | American Family Field · Milwaukee, WI |
| 74 | Tue Jun 21 | at Brewers | L1-5 | 40-34 | .541 | American Family Field · Milwaukee, WI |
| 75 | Wed Jun 22 | at Brewers | W6-3 | 41-34 | .547 | American Family Field · Milwaukee, WI |
| 76 | Fri Jun 24 | at Astros | W5-1 | 42-34 | .553 | Minute Maid Park · Houston, TX |
| 77 | Sat Jun 25 | at Astros | W7-2 | 43-34 | .558 | Minute Maid Park · Houston, TX |
| 78 | Sun Jun 26 | at Astros | W14-10 | 44-34 | .564 | Minute Maid Park · Houston, TX |
| 79 | Mon Jun 27 | vs Reds | L0-5 | 44-35 | .557 | Tropicana Field · St. Petersburg, FL |
| 80 | Tue Jun 28 | vs Reds | W4-3 | 45-35 | .563 | Tropicana Field · St. Petersburg, FL |
| 81 | Wed Jun 29 | vs Reds | L3-4 | 45-36 | .556 | Tropicana Field · St. Petersburg, FL |
| 82 | Fri Jul 1 | vs Cardinals | L3-5 | 45-37 | .549 | Tropicana Field · St. Petersburg, FL |
| 83 | Sat Jul 2 | vs Cardinals | W5-1 | 46-37 | .554 | Tropicana Field · St. Petersburg, FL |
| 84 | Sun Jul 3 | vs Cardinals | W8-3 | 47-37 | .560 | Tropicana Field · St. Petersburg, FL |
| 85 | Mon Jul 4 | at Twins | L0-7 | 47-38 | .553 | Target Field · Minneapolis, MN |
| 86 | Tue Jul 5 | at Twins | L2-3 | 47-39 | .547 | Target Field · Minneapolis, MN |
| 87 | Wed Jul 6 | at Twins | W12-5 | 48-39 | .552 | Target Field · Minneapolis, MN |
| 88 | Thu Jul 7 | at Yankees | W5-1 | 49-39 | .557 | Yankee Stadium · The Bronx, NY |
| 89 | Sat Jul 9 | at Yankees | L4-5 | 49-40 | .551 | Yankee Stadium · The Bronx, NY |
| 90 | Sun Jul 10 | at Yankees | L0-1 | 49-41 | .544 | Yankee Stadium · The Bronx, NY |
| 91 | Fri Jul 15 | vs Red Sox | W9-6 | 50-41 | .549 | Tropicana Field · St. Petersburg, FL |
| 92 | Sat Jul 16 | vs Red Sox | L5-9 | 50-42 | .543 | Tropicana Field · St. Petersburg, FL |
| 93 | Sun Jul 17 | vs Red Sox | L0-1 (16) | 50-43 | .538 | Tropicana Field · St. Petersburg, FL |
| 94 | Mon Jul 18 | vs Yankees | L4-5 | 50-44 | .532 | Tropicana Field · St. Petersburg, FL |
| 95 | Tue Jul 19 | vs Yankees | W3-2 | 51-44 | .537 | Tropicana Field · St. Petersburg, FL |
| 96 | Wed Jul 20 | vs Yankees | L0-4 | 51-45 | .531 | Tropicana Field · St. Petersburg, FL |
| 97 | Thu Jul 21 | vs Yankees | W2-1 | 52-45 | .536 | Tropicana Field · St. Petersburg, FL |
| 98 | Fri Jul 22 | at Royals | L4-10 | 52-46 | .531 | Kauffman Stadium · Kansas City, MO |
| 99 | Sat Jul 23 | at Royals | L4-5 (10) | 52-47 | .525 | Kauffman Stadium · Kansas City, MO |
| 100 | Sun Jul 24 | at Royals | W5-0 | 53-47 | .530 | Kauffman Stadium · Kansas City, MO |
| 101 | Mon Jul 25 | at Athletics | L5-7 | 53-48 | .525 | RingCentral Coliseum · Oakland, CA |
| 102 | Tue Jul 26 | at Athletics | L1-6 | 53-49 | .520 | RingCentral Coliseum · Oakland, CA |
| 103 | Wed Jul 27 | at Athletics | L4-13 | 53-50 | .515 | RingCentral Coliseum · Oakland, CA |
| 104 | Thu Jul 28 | at Athletics | W10-8 | 54-50 | .519 | RingCentral Coliseum · Oakland, CA |
| 105 | Fri Jul 29 | at Mariners | W8-0 | 55-50 | .524 | T-Mobile Park · Seattle, WA |
| 106 | Sat Jul 30 | at Mariners | L2-3 | 55-51 | .519 | T-Mobile Park · Seattle, WA |
| 107 | Sun Jul 31 | at Mariners | W8-1 | 56-51 | .523 | T-Mobile Park · Seattle, WA |
| 108 | Tue Aug 2 | vs Blue Jays | L1-3 | 56-52 | .519 | Tropicana Field · St. Petersburg, FL |
| 109 | Wed Aug 3 | vs Blue Jays | W9-1 | 57-52 | .523 | Tropicana Field · St. Petersburg, FL |
| 110 | Thu Aug 4 | vs Blue Jays | W7-6 (12) | 58-52 | .527 | Tropicana Field · St. Petersburg, FL |
| 111 | Fri Aug 5 | vs Athletics | W8-4 | 59-52 | .532 | Tropicana Field · St. Petersburg, FL |
| 112 | Sat Aug 6 | vs Athletics | L0-8 | 59-53 | .527 | Tropicana Field · St. Petersburg, FL |
| 113 | Sun Aug 7 | vs Athletics | L4-5 (10) | 59-54 | .522 | Tropicana Field · St. Petersburg, FL |
| 114 | Mon Aug 8 | vs Royals | W2-1 | 60-54 | .526 | Tropicana Field · St. Petersburg, FL |
| 115 | Tue Aug 9 | vs Royals | W4-0 | 61-54 | .530 | Tropicana Field · St. Petersburg, FL |
| 116 | Wed Aug 10 | vs Royals | W8-7 | 62-54 | .534 | Tropicana Field · St. Petersburg, FL |
| 117 | Thu Aug 11 | vs Royals | W4-1 | 63-54 | .538 | Tropicana Field · St. Petersburg, FL |
| 118 | Fri Aug 12 | at Yankees | W5-1 | 64-54 | .542 | Yankee Stadium · The Bronx, NY |
| 119 | Sat Aug 13 | at Yankees | L2-9 | 64-55 | .538 | Yankee Stadium · The Bronx, NY |
| 120 | Tue Aug 16 | at Red Sox | L1-3 | 64-56 | .533 | Fenway Park · Boston, MA |
| 121 | Tue Aug 16 | at Red Sox | W6-2 | 65-56 | .537 | Fenway Park · Boston, MA |
| 122 | Wed Aug 17 | at Red Sox | W4-0 | 66-56 | .541 | Fenway Park · Boston, MA |
| 123 | Fri Aug 19 | vs Mariners | W3-2 | 67-56 | .545 | Tropicana Field · St. Petersburg, FL |
| 124 | Sat Aug 20 | vs Mariners | W8-0 | 68-56 | .548 | Tropicana Field · St. Petersburg, FL |
| 125 | Sun Aug 21 | vs Mariners | W8-7 | 69-56 | .552 | Tropicana Field · St. Petersburg, FL |
| 126 | Mon Aug 22 | vs Tigers | L2-5 | 69-57 | .548 | Tropicana Field · St. Petersburg, FL |
| 127 | Tue Aug 23 | vs Tigers | L1-2 | 69-58 | .543 | Tropicana Field · St. Petersburg, FL |
| 128 | Wed Aug 24 | vs Tigers | W3-2 (10) | 70-58 | .547 | Tropicana Field · St. Petersburg, FL |
| 129 | Thu Aug 25 | vs Tigers | L0-2 | 70-59 | .543 | Tropicana Field · St. Petersburg, FL |
| 130 | Fri Aug 26 | at Blue Jays | W6-1 | 71-59 | .546 | Rogers Centre · Toronto, ON |
| 131 | Sat Aug 27 | at Blue Jays | W6-5 | 72-59 | .550 | Rogers Centre · Toronto, ON |
| 132 | Sun Aug 28 | at Blue Jays | W12-0 | 73-59 | .553 | Rogers Centre · Toronto, ON |
| 133 | Mon Aug 29 | at Blue Jays | L3-7 | 73-60 | .549 | Rogers Centre · Toronto, ON |
| 134 | Tue Aug 30 | at Rangers | L0-2 | 73-61 | .545 | Globe Life Field · Arlington, TX |
| 135 | Wed Aug 31 | at Rangers | W4-1 | 74-61 | .548 | Globe Life Field · Arlington, TX |
| 136 | Thu Sep 1 | at Rangers | L2-7 | 74-62 | .544 | Globe Life Field · Arlington, TX |
| 137 | Fri Sep 2 | vs Orioles | L2-3 | 74-63 | .540 | Tropicana Field · St. Petersburg, FL |
| 138 | Sat Sep 3 | vs Orioles | W6-3 | 75-63 | .543 | Tropicana Field · St. Petersburg, FL |
| 139 | Sun Sep 4 | vs Orioles | W8-1 | 76-63 | .547 | Tropicana Field · St. Petersburg, FL |
| 140 | Mon Sep 5 | vs Rangers | W5-1 | 77-63 | .550 | Tropicana Field · St. Petersburg, FL |
| 141 | Tue Sep 6 | vs Rangers | L0-8 | 77-64 | .546 | Tropicana Field · St. Petersburg, FL |
| 142 | Wed Sep 7 | vs Rangers | W5-4 (10) | 78-64 | .549 | Tropicana Field · St. Petersburg, FL |
| 143 | Fri Sep 9 | vs Red Sox | W7-2 | 79-64 | .552 | Tropicana Field · St. Petersburg, FL |
| 144 | Sat Sep 10 | vs Red Sox | W6-5 (11) | 80-64 | .556 | Tropicana Field · St. Petersburg, FL |
| 145 | Sun Sep 11 | vs Red Sox | W9-1 | 81-64 | .559 | Tropicana Field · St. Petersburg, FL |
| 146 | Mon Sep 12 | at Orioles | W5-2 | 82-64 | .562 | Camden Yards · Baltimore, MD |
| 147 | Tue Sep 13 | at Orioles | L2-4 | 82-65 | .558 | Camden Yards · Baltimore, MD |
| 148 | Wed Sep 14 | at Orioles | L2-6 | 82-66 | .554 | Camden Yards · Baltimore, MD |
| 149 | Thu Sep 15 | at Red Sox | W9-2 | 83-66 | .557 | Fenway Park · Boston, MA |
| 150 | Fri Sep 16 | at Red Sox | L3-4 | 83-67 | .553 | Fenway Park · Boston, MA |
| 151 | Sat Sep 17 | at Red Sox | W4-3 | 84-67 | .556 | Fenway Park · Boston, MA |
| 152 | Sun Sep 18 | at Red Sox | W8-5 | 85-67 | .559 | Fenway Park · Boston, MA |
| 153 | Tue Sep 20 | at Yankees | L0-5 | 85-68 | .556 | Yankee Stadium · The Bronx, NY |
| 154 | Wed Sep 21 | at Yankees | L2-4 | 85-69 | .552 | Yankee Stadium · The Bronx, NY |
| 155 | Wed Sep 21 | at Yankees | L2-4 | 85-70 | .548 | Yankee Stadium · The Bronx, NY |
| 156 | Thu Sep 22 | at Yankees | W15-8 | 86-70 | .551 | Yankee Stadium · The Bronx, NY |
| 157 | Fri Sep 23 | vs Blue Jays | L1-5 | 86-71 | .548 | Tropicana Field · St. Petersburg, FL |
| 158 | Sat Sep 24 | vs Blue Jays | W6-2 | 87-71 | .551 | Tropicana Field · St. Petersburg, FL |
| 159 | Sun Sep 25 | vs Blue Jays | W5-2 | 88-71 | .553 | Tropicana Field · St. Petersburg, FL |
| 160 | Mon Sep 26 | vs Yankees | W5-2 | 89-71 | .556 | Tropicana Field · St. Petersburg, FL |
| 161 | Tue Sep 27 | vs Yankees | W5-3 | 90-71 | .559 | Tropicana Field · St. Petersburg, FL |
| 162 | Wed Sep 28 | vs Yankees | W8-7 (12) | 91-71 | .562 | Tropicana Field · St. Petersburg, FL |
| 163 | Fri Sep 30 | at Rangers | W9-0 | 1-0 | 1.000 | Globe Life Field · Arlington, TX |
| 164 | Sat Oct 1 | at Rangers | L6-8 | 1-1 | .500 | Globe Life Field · Arlington, TX |
| 165 | Mon Oct 3 | vs Rangers | L3-4 | 1-2 | .333 | Tropicana Field · St. Petersburg, FL |
| 166 | Tue Oct 4 | vs Rangers | L3-4 | 1-3 | .250 | Tropicana Field · St. Petersburg, FL |