| 1 | Sun Apr 3 | vs Blue Jays | L3-5 | 0-1 | .000 | Tropicana Field · St. Petersburg, FL |
| 2 | Mon Apr 4 | vs Blue Jays | L3-5 | 0-2 | .000 | Tropicana Field · St. Petersburg, FL |
| 3 | Tue Apr 5 | vs Blue Jays | W3-2 | 1-2 | .333 | Tropicana Field · St. Petersburg, FL |
| 4 | Wed Apr 6 | vs Blue Jays | W5-3 | 2-2 | .500 | Tropicana Field · St. Petersburg, FL |
| 5 | Fri Apr 8 | at Orioles | L1-6 | 2-3 | .400 | Camden Yards · Baltimore, MD |
| 6 | Sun Apr 10 | at Orioles | L3-5 | 2-4 | .333 | Camden Yards · Baltimore, MD |
| 7 | Tue Apr 12 | vs Guardians | W5-1 | 3-4 | .429 | Tropicana Field · St. Petersburg, FL |
| 8 | Wed Apr 13 | vs Guardians | L1-4 | 3-5 | .375 | Tropicana Field · St. Petersburg, FL |
| 9 | Thu Apr 14 | vs Guardians | L0-6 | 3-6 | .333 | Tropicana Field · St. Petersburg, FL |
| 10 | Fri Apr 15 | vs White Sox | L0-1 | 3-7 | .300 | Tropicana Field · St. Petersburg, FL |
| 11 | Sat Apr 16 | vs White Sox | W7-2 | 4-7 | .364 | Tropicana Field · St. Petersburg, FL |
| 12 | Sun Apr 17 | vs White Sox | W3-2 | 5-7 | .417 | Tropicana Field · St. Petersburg, FL |
| 13 | Tue Apr 19 | at Red Sox | W3-0 (10) | 6-7 | .462 | Fenway Park · Boston, MA |
| 14 | Wed Apr 20 | at Red Sox | L3-7 | 6-8 | .429 | Fenway Park · Boston, MA |
| 15 | Thu Apr 21 | at Red Sox | W12-8 | 7-8 | .467 | Fenway Park · Boston, MA |
| 16 | Fri Apr 22 | at Yankees | L3-6 | 7-9 | .438 | Yankee Stadium · The Bronx, NY |
| 17 | Sat Apr 23 | at Yankees | L2-3 | 7-10 | .412 | Yankee Stadium · The Bronx, NY |
| 18 | Sun Apr 24 | at Yankees | W8-1 | 8-10 | .444 | Yankee Stadium · The Bronx, NY |
| 19 | Mon Apr 25 | vs Orioles | W2-0 | 9-10 | .474 | Tropicana Field · St. Petersburg, FL |
| 20 | Tue Apr 26 | vs Orioles | W3-1 | 10-10 | .500 | Tropicana Field · St. Petersburg, FL |
| 21 | Wed Apr 27 | vs Orioles | L1-3 | 10-11 | .476 | Tropicana Field · St. Petersburg, FL |
| 22 | Fri Apr 29 | vs Blue Jays | L1-6 | 10-12 | .455 | Tropicana Field · St. Petersburg, FL |
| 23 | Sat Apr 30 | vs Blue Jays | W4-3 | 11-12 | .478 | Tropicana Field · St. Petersburg, FL |
| 24 | Sun May 1 | vs Blue Jays | L1-5 | 11-13 | .458 | Tropicana Field · St. Petersburg, FL |
| 25 | Tue May 3 | vs Dodgers | L5-10 | 11-14 | .440 | Tropicana Field · St. Petersburg, FL |
| 26 | Wed May 4 | vs Dodgers | W8-5 | 12-14 | .462 | Tropicana Field · St. Petersburg, FL |
| 27 | Fri May 6 | at Angels | W5-2 | 13-14 | .481 | Angel Stadium · Anaheim, CA |
| 28 | Sat May 7 | at Angels | W4-2 | 14-14 | .500 | Angel Stadium · Anaheim, CA |
| 29 | Sun May 8 | at Angels | W3-1 | 15-14 | .517 | Angel Stadium · Anaheim, CA |
| 30 | Mon May 9 | at Mariners | L2-5 | 15-15 | .500 | T-Mobile Park · Seattle, WA |
| 31 | Tue May 10 | at Mariners | L4-6 | 15-16 | .484 | T-Mobile Park · Seattle, WA |
| 32 | Wed May 11 | at Mariners | L5-6 (11) | 15-17 | .469 | T-Mobile Park · Seattle, WA |
| 33 | Fri May 13 | vs Athletics | L3-6 | 15-18 | .455 | Tropicana Field · St. Petersburg, FL |
| 34 | Sat May 14 | vs Athletics | W6-0 | 16-18 | .471 | Tropicana Field · St. Petersburg, FL |
| 35 | Sun May 15 | vs Athletics | L6-7 | 16-19 | .457 | Tropicana Field · St. Petersburg, FL |
| 36 | Mon May 16 | at Blue Jays | W13-2 | 17-19 | .472 | Rogers Centre · Toronto, ON |
| 37 | Tue May 17 | at Blue Jays | W12-2 | 18-19 | .486 | Rogers Centre · Toronto, ON |
| 38 | Wed May 18 | at Blue Jays | W6-3 | 19-19 | .500 | Rogers Centre · Toronto, ON |
| 39 | Fri May 20 | at Tigers | W7-5 | 20-19 | .513 | Comerica Park · Detroit, MI |
| 40 | Sat May 21 | at Tigers | L4-5 | 20-20 | .500 | Comerica Park · Detroit, MI |
| 41 | Sun May 22 | at Tigers | L4-9 | 20-21 | .488 | Comerica Park · Detroit, MI |
| 42 | Mon May 23 | at Marlins | L6-7 | 20-22 | .476 | LoanDepot Park · Miami, FL |
| 43 | Tue May 24 | at Marlins | W4-3 | 21-22 | .488 | LoanDepot Park · Miami, FL |
| 44 | Wed May 25 | vs Marlins | L3-4 | 21-23 | .477 | Tropicana Field · St. Petersburg, FL |
| 45 | Thu May 26 | vs Marlins | L1-9 | 21-24 | .467 | Tropicana Field · St. Petersburg, FL |
| 46 | Fri May 27 | vs Yankees | L1-4 | 21-25 | .457 | Tropicana Field · St. Petersburg, FL |
| 47 | Sat May 28 | vs Yankees | W9-5 | 22-25 | .468 | Tropicana Field · St. Petersburg, FL |
| 48 | Sun May 29 | vs Yankees | L1-2 | 22-26 | .458 | Tropicana Field · St. Petersburg, FL |
| 49 | Mon May 30 | at Royals | L2-6 | 22-27 | .449 | Kauffman Stadium · Kansas City, MO |
| 50 | Tue May 31 | at Royals | L5-10 | 22-28 | .440 | Kauffman Stadium · Kansas City, MO |
| 51 | Wed Jun 1 | at Royals | L3-6 | 22-29 | .431 | Kauffman Stadium · Kansas City, MO |
| 52 | Thu Jun 2 | at Twins | L4-6 | 22-30 | .423 | Target Field · Minneapolis, MN |
| 53 | Fri Jun 3 | at Twins | W4-2 | 23-30 | .434 | Target Field · Minneapolis, MN |
| 54 | Sat Jun 4 | at Twins | W7-4 | 24-30 | .444 | Target Field · Minneapolis, MN |
| 55 | Sun Jun 5 | at Twins | W7-5 | 25-30 | .455 | Target Field · Minneapolis, MN |
| 56 | Mon Jun 6 | at D-backs | W6-4 | 26-30 | .464 | Chase Field · Phoenix, AZ |
| 57 | Tue Jun 7 | at D-backs | L0-5 | 26-31 | .456 | Chase Field · Phoenix, AZ |
| 58 | Wed Jun 8 | at D-backs | W6-3 | 27-31 | .466 | Chase Field · Phoenix, AZ |
| 59 | Fri Jun 10 | vs Astros | W4-3 | 28-31 | .475 | Tropicana Field · St. Petersburg, FL |
| 60 | Sat Jun 11 | vs Astros | L3-4 | 28-32 | .467 | Tropicana Field · St. Petersburg, FL |
| 61 | Sun Jun 12 | vs Astros | W5-0 | 29-32 | .475 | Tropicana Field · St. Petersburg, FL |
| 62 | Tue Jun 14 | vs Mariners | W8-7 | 30-32 | .484 | Tropicana Field · St. Petersburg, FL |
| 63 | Wed Jun 15 | vs Mariners | W3-2 (13) | 31-32 | .492 | Tropicana Field · St. Petersburg, FL |
| 64 | Thu Jun 16 | vs Mariners | L4-6 | 31-33 | .484 | Tropicana Field · St. Petersburg, FL |
| 65 | Fri Jun 17 | vs Giants | L1-5 | 31-34 | .477 | Tropicana Field · St. Petersburg, FL |
| 66 | Sat Jun 18 | vs Giants | L4-6 | 31-35 | .470 | Tropicana Field · St. Petersburg, FL |
| 67 | Sun Jun 19 | vs Giants | L1-5 | 31-36 | .463 | Tropicana Field · St. Petersburg, FL |
| 68 | Mon Jun 20 | at Guardians | L4-7 | 31-37 | .456 | Progressive Field · Cleveland, OH |
| 69 | Tue Jun 21 | at Guardians | L0-6 | 31-38 | .449 | Progressive Field · Cleveland, OH |
| 70 | Wed Jun 22 | at Guardians | L1-6 | 31-39 | .443 | Progressive Field · Cleveland, OH |
| 71 | Fri Jun 24 | at Orioles | L3-6 | 31-40 | .437 | Camden Yards · Baltimore, MD |
| 72 | Sat Jun 25 | at Orioles | L0-5 | 31-41 | .431 | Camden Yards · Baltimore, MD |
| 73 | Sat Jun 25 | at Orioles | L6-8 | 31-42 | .425 | Camden Yards · Baltimore, MD |
| 74 | Sun Jun 26 | at Orioles | L5-12 | 31-43 | .419 | Camden Yards · Baltimore, MD |
| 75 | Mon Jun 27 | vs Red Sox | W13-7 | 32-43 | .427 | Tropicana Field · St. Petersburg, FL |
| 76 | Tue Jun 28 | vs Red Sox | L2-8 | 32-44 | .421 | Tropicana Field · St. Petersburg, FL |
| 77 | Wed Jun 29 | vs Red Sox | W4-0 | 33-44 | .429 | Tropicana Field · St. Petersburg, FL |
| 78 | Thu Jun 30 | vs Tigers | L7-10 | 33-45 | .423 | Tropicana Field · St. Petersburg, FL |
| 79 | Fri Jul 1 | vs Tigers | L2-10 | 33-46 | .418 | Tropicana Field · St. Petersburg, FL |
| 80 | Sat Jul 2 | vs Tigers | L2-3 | 33-47 | .412 | Tropicana Field · St. Petersburg, FL |
| 81 | Sun Jul 3 | vs Tigers | L1-5 | 33-48 | .407 | Tropicana Field · St. Petersburg, FL |
| 82 | Mon Jul 4 | vs Angels | W4-2 | 34-48 | .415 | Tropicana Field · St. Petersburg, FL |
| 83 | Tue Jul 5 | vs Angels | L5-13 | 34-49 | .410 | Tropicana Field · St. Petersburg, FL |
| 84 | Wed Jul 6 | vs Angels | L2-7 | 34-50 | .405 | Tropicana Field · St. Petersburg, FL |
| 85 | Thu Jul 7 | vs Angels | L1-5 | 34-51 | .400 | Tropicana Field · St. Petersburg, FL |
| 86 | Fri Jul 8 | at Red Sox | L5-6 | 34-52 | .395 | Fenway Park · Boston, MA |
| 87 | Sat Jul 9 | at Red Sox | L1-4 | 34-53 | .391 | Fenway Park · Boston, MA |
| 88 | Sun Jul 10 | at Red Sox | L0-4 | 34-54 | .386 | Fenway Park · Boston, MA |
| 89 | Fri Jul 15 | vs Orioles | L3-4 | 34-55 | .382 | Tropicana Field · St. Petersburg, FL |
| 90 | Sat Jul 16 | vs Orioles | L1-2 | 34-56 | .378 | Tropicana Field · St. Petersburg, FL |
| 91 | Sun Jul 17 | vs Orioles | W5-2 | 35-56 | .385 | Tropicana Field · St. Petersburg, FL |
| 92 | Mon Jul 18 | at Rockies | L4-7 | 35-57 | .380 | Coors Field · Denver, CO |
| 93 | Tue Jul 19 | at Rockies | W10-1 | 36-57 | .387 | Coors Field · Denver, CO |
| 94 | Wed Jul 20 | at Rockies | W11-3 | 37-57 | .394 | Coors Field · Denver, CO |
| 95 | Thu Jul 21 | at Athletics | W7-3 | 38-57 | .400 | RingCentral Coliseum · Oakland, CA |
| 96 | Fri Jul 22 | at Athletics | L0-1 (13) | 38-58 | .396 | RingCentral Coliseum · Oakland, CA |
| 97 | Sat Jul 23 | at Athletics | L3-4 | 38-59 | .392 | RingCentral Coliseum · Oakland, CA |
| 98 | Sun Jul 24 | at Athletics | L2-3 | 38-60 | .388 | RingCentral Coliseum · Oakland, CA |
| 99 | Tue Jul 26 | at Dodgers | L2-3 | 38-61 | .384 | Dodger Stadium · Los Angeles, CA |
| 100 | Wed Jul 27 | at Dodgers | W3-1 | 39-61 | .390 | Dodger Stadium · Los Angeles, CA |
| 101 | Fri Jul 29 | vs Yankees | W5-1 | 40-61 | .396 | Tropicana Field · St. Petersburg, FL |
| 102 | Sat Jul 30 | vs Yankees | W6-3 | 41-61 | .402 | Tropicana Field · St. Petersburg, FL |
| 103 | Sun Jul 31 | vs Yankees | W5-3 | 42-61 | .408 | Tropicana Field · St. Petersburg, FL |
| 104 | Mon Aug 1 | vs Royals | L0-3 | 42-62 | .404 | Tropicana Field · St. Petersburg, FL |
| 105 | Tue Aug 2 | vs Royals | L2-3 | 42-63 | .400 | Tropicana Field · St. Petersburg, FL |
| 106 | Wed Aug 3 | vs Royals | W12-0 | 43-63 | .406 | Tropicana Field · St. Petersburg, FL |
| 107 | Thu Aug 4 | vs Royals | W3-2 | 44-63 | .411 | Tropicana Field · St. Petersburg, FL |
| 108 | Fri Aug 5 | vs Twins | L2-6 | 44-64 | .407 | Tropicana Field · St. Petersburg, FL |
| 109 | Sat Aug 6 | vs Twins | W7-3 | 45-64 | .413 | Tropicana Field · St. Petersburg, FL |
| 110 | Sun Aug 7 | vs Twins | L3-6 | 45-65 | .409 | Tropicana Field · St. Petersburg, FL |
| 111 | Mon Aug 8 | at Blue Jays | L5-7 | 45-66 | .405 | Rogers Centre · Toronto, ON |
| 112 | Tue Aug 9 | at Blue Jays | W9-2 | 46-66 | .411 | Rogers Centre · Toronto, ON |
| 113 | Wed Aug 10 | at Blue Jays | L0-7 | 46-67 | .407 | Rogers Centre · Toronto, ON |
| 114 | Fri Aug 12 | at Yankees | L3-6 | 46-68 | .404 | Yankee Stadium · The Bronx, NY |
| 115 | Sat Aug 13 | at Yankees | L4-8 | 46-69 | .400 | Yankee Stadium · The Bronx, NY |
| 116 | Sun Aug 14 | at Yankees | W12-3 | 47-69 | .405 | Yankee Stadium · The Bronx, NY |
| 117 | Mon Aug 15 | vs Padres | W8-2 | 48-69 | .410 | Tropicana Field · St. Petersburg, FL |
| 118 | Tue Aug 16 | vs Padres | W15-1 | 49-69 | .415 | Tropicana Field · St. Petersburg, FL |
| 119 | Wed Aug 17 | vs Padres | W2-0 | 50-69 | .420 | Tropicana Field · St. Petersburg, FL |
| 120 | Fri Aug 19 | vs Rangers | L2-6 | 50-70 | .417 | Tropicana Field · St. Petersburg, FL |
| 121 | Sat Aug 20 | vs Rangers | W8-2 | 51-70 | .421 | Tropicana Field · St. Petersburg, FL |
| 122 | Sun Aug 21 | vs Rangers | W8-4 | 52-70 | .426 | Tropicana Field · St. Petersburg, FL |
| 123 | Mon Aug 22 | vs Red Sox | L2-6 | 52-71 | .423 | Tropicana Field · St. Petersburg, FL |
| 124 | Tue Aug 23 | vs Red Sox | L1-2 | 52-72 | .419 | Tropicana Field · St. Petersburg, FL |
| 125 | Wed Aug 24 | vs Red Sox | W4-3 (11) | 53-72 | .424 | Tropicana Field · St. Petersburg, FL |
| 126 | Thu Aug 25 | vs Red Sox | W2-1 | 54-72 | .429 | Tropicana Field · St. Petersburg, FL |
| 127 | Fri Aug 26 | at Astros | L4-5 | 54-73 | .425 | Minute Maid Park · Houston, TX |
| 128 | Sat Aug 27 | at Astros | L2-6 | 54-74 | .422 | Minute Maid Park · Houston, TX |
| 129 | Sun Aug 28 | at Astros | W10-4 | 55-74 | .426 | Minute Maid Park · Houston, TX |
| 130 | Mon Aug 29 | at Red Sox | L4-9 | 55-75 | .423 | Fenway Park · Boston, MA |
| 131 | Tue Aug 30 | at Red Sox | W4-3 | 56-75 | .427 | Fenway Park · Boston, MA |
| 132 | Wed Aug 31 | at Red Sox | L6-8 | 56-76 | .424 | Fenway Park · Boston, MA |
| 133 | Fri Sep 2 | vs Blue Jays | W8-3 | 57-76 | .429 | Tropicana Field · St. Petersburg, FL |
| 134 | Sat Sep 3 | vs Blue Jays | W7-5 | 58-76 | .433 | Tropicana Field · St. Petersburg, FL |
| 135 | Sun Sep 4 | vs Blue Jays | L3-5 | 58-77 | .430 | Tropicana Field · St. Petersburg, FL |
| 136 | Mon Sep 5 | vs Orioles | L3-7 | 58-78 | .426 | Tropicana Field · St. Petersburg, FL |
| 137 | Tue Sep 6 | vs Orioles | L2-11 | 58-79 | .423 | Tropicana Field · St. Petersburg, FL |
| 138 | Wed Sep 7 | vs Orioles | W7-6 | 59-79 | .428 | Tropicana Field · St. Petersburg, FL |
| 139 | Thu Sep 8 | at Yankees | L4-5 | 59-80 | .424 | Yankee Stadium · The Bronx, NY |
| 140 | Fri Sep 9 | at Yankees | L5-7 | 59-81 | .421 | Yankee Stadium · The Bronx, NY |
| 141 | Sat Sep 10 | at Yankees | L1-5 | 59-82 | .418 | Yankee Stadium · The Bronx, NY |
| 142 | Sun Sep 11 | at Yankees | W4-2 | 60-82 | .423 | Yankee Stadium · The Bronx, NY |
| 143 | Mon Sep 12 | at Blue Jays | L2-3 | 60-83 | .420 | Rogers Centre · Toronto, ON |
| 144 | Tue Sep 13 | at Blue Jays | W6-2 | 61-83 | .424 | Rogers Centre · Toronto, ON |
| 145 | Wed Sep 14 | at Blue Jays | W8-1 | 62-83 | .428 | Rogers Centre · Toronto, ON |
| 146 | Thu Sep 15 | at Orioles | W7-6 | 63-83 | .432 | Camden Yards · Baltimore, MD |
| 147 | Fri Sep 16 | at Orioles | L4-5 | 63-84 | .429 | Camden Yards · Baltimore, MD |
| 148 | Sat Sep 17 | at Orioles | W5-2 | 64-84 | .432 | Camden Yards · Baltimore, MD |
| 149 | Sun Sep 18 | at Orioles | L1-2 | 64-85 | .430 | Camden Yards · Baltimore, MD |
| 150 | Tue Sep 20 | vs Yankees | L3-5 | 64-86 | .427 | Tropicana Field · St. Petersburg, FL |
| 151 | Wed Sep 21 | vs Yankees | L5-11 | 64-87 | .424 | Tropicana Field · St. Petersburg, FL |
| 152 | Thu Sep 22 | vs Yankees | W2-0 | 65-87 | .428 | Tropicana Field · St. Petersburg, FL |
| 153 | Fri Sep 23 | vs Red Sox | L1-2 | 65-88 | .425 | Tropicana Field · St. Petersburg, FL |
| 154 | Sat Sep 24 | vs Red Sox | L4-6 | 65-89 | .422 | Tropicana Field · St. Petersburg, FL |
| 155 | Sun Sep 25 | vs Red Sox | L2-3 (10) | 65-90 | .419 | Tropicana Field · St. Petersburg, FL |
| 156 | Mon Sep 26 | at White Sox | L1-7 | 65-91 | .417 | Guaranteed Rate Field · Chicago, IL |
| 157 | Tue Sep 27 | at White Sox | L6-13 | 65-92 | .414 | Guaranteed Rate Field · Chicago, IL |
| 158 | Wed Sep 28 | at White Sox | L0-1 | 65-93 | .411 | Guaranteed Rate Field · Chicago, IL |
| 159 | Thu Sep 29 | at White Sox | W5-3 | 66-93 | .415 | Guaranteed Rate Field · Chicago, IL |
| 160 | Fri Sep 30 | at Rangers | L1-3 | 66-94 | .412 | Globe Life Field · Arlington, TX |
| 161 | Sat Oct 1 | at Rangers | W4-1 | 67-94 | .416 | Globe Life Field · Arlington, TX |
| 162 | Sun Oct 2 | at Rangers | W6-4 (10) | 68-94 | .420 | Globe Life Field · Arlington, TX |