| 1 | Tue Apr 2 | vs Orioles | L4-7 | 0-1 | .000 | Tropicana Field · St. Petersburg, FL |
| 2 | Wed Apr 3 | vs Orioles | W8-7 | 1-1 | .500 | Tropicana Field · St. Petersburg, FL |
| 3 | Thu Apr 4 | vs Orioles | L3-6 | 1-2 | .333 | Tropicana Field · St. Petersburg, FL |
| 4 | Fri Apr 5 | vs Guardians | W4-0 | 2-2 | .500 | Tropicana Field · St. Petersburg, FL |
| 5 | Sat Apr 6 | vs Guardians | W6-0 | 3-2 | .600 | Tropicana Field · St. Petersburg, FL |
| 6 | Sun Apr 7 | vs Guardians | L0-13 | 3-3 | .500 | Tropicana Field · St. Petersburg, FL |
| 7 | Mon Apr 8 | at Rangers | L4-5 | 3-4 | .429 | Globe Life Field · Arlington, TX |
| 8 | Tue Apr 9 | at Rangers | L1-6 | 3-5 | .375 | Globe Life Field · Arlington, TX |
| 9 | Wed Apr 10 | at Rangers | W2-0 | 4-5 | .444 | Globe Life Field · Arlington, TX |
| 10 | Sat Apr 13 | at Red Sox | L1-2 (10) | 4-6 | .400 | Fenway Park · Boston, MA |
| 11 | Sun Apr 14 | at Red Sox | L0-5 | 4-7 | .364 | Fenway Park · Boston, MA |
| 12 | Mon Apr 15 | at Red Sox | L2-3 | 4-8 | .333 | Fenway Park · Boston, MA |
| 13 | Tue Apr 16 | at Orioles | L4-5 | 4-9 | .308 | Camden Yards · Baltimore, MD |
| 14 | Wed Apr 17 | at Orioles | W6-2 | 5-9 | .357 | Camden Yards · Baltimore, MD |
| 15 | Thu Apr 18 | at Orioles | L6-10 (10) | 5-10 | .333 | Camden Yards · Baltimore, MD |
| 16 | Fri Apr 19 | vs Athletics | W8-3 | 6-10 | .375 | Tropicana Field · St. Petersburg, FL |
| 17 | Sat Apr 20 | vs Athletics | W1-0 | 7-10 | .412 | Tropicana Field · St. Petersburg, FL |
| 18 | Sun Apr 21 | vs Athletics | W8-1 | 8-10 | .444 | Tropicana Field · St. Petersburg, FL |
| 19 | Mon Apr 22 | vs Yankees | W5-1 | 9-10 | .474 | Tropicana Field · St. Petersburg, FL |
| 20 | Tue Apr 23 | vs Yankees | L3-4 | 9-11 | .450 | Tropicana Field · St. Petersburg, FL |
| 21 | Wed Apr 24 | vs Yankees | W3-0 | 10-11 | .476 | Tropicana Field · St. Petersburg, FL |
| 22 | Thu Apr 25 | at White Sox | L2-5 | 10-12 | .455 | Guaranteed Rate Field · Chicago, IL |
| 23 | Fri Apr 26 | at White Sox | L4-5 | 10-13 | .435 | Guaranteed Rate Field · Chicago, IL |
| 24 | Sat Apr 27 | at White Sox | W10-4 | 11-13 | .458 | Guaranteed Rate Field · Chicago, IL |
| 25 | Sun Apr 28 | at White Sox | W8-3 | 12-13 | .480 | Guaranteed Rate Field · Chicago, IL |
| 26 | Tue Apr 30 | at Royals | L2-8 | 12-14 | .462 | Kauffman Stadium · Kansas City, MO |
| 27 | Wed May 1 | at Royals | L8-9 | 12-15 | .444 | Kauffman Stadium · Kansas City, MO |
| 28 | Fri May 3 | at Rockies | W7-4 (10) | 13-15 | .464 | Coors Field · Denver, CO |
| 29 | Sat May 4 | at Rockies | L3-9 | 13-16 | .448 | Coors Field · Denver, CO |
| 30 | Sun May 5 | at Rockies | W8-3 | 14-16 | .467 | Coors Field · Denver, CO |
| 31 | Mon May 6 | vs Blue Jays | L7-8 | 14-17 | .452 | Tropicana Field · St. Petersburg, FL |
| 32 | Tue May 7 | vs Blue Jays | L4-6 | 14-18 | .438 | Tropicana Field · St. Petersburg, FL |
| 33 | Wed May 8 | vs Blue Jays | W10-4 | 15-18 | .455 | Tropicana Field · St. Petersburg, FL |
| 34 | Thu May 9 | vs Blue Jays | W5-4 (10) | 16-18 | .471 | Tropicana Field · St. Petersburg, FL |
| 35 | Fri May 10 | vs Padres | W6-3 | 17-18 | .486 | Tropicana Field · St. Petersburg, FL |
| 36 | Sat May 11 | vs Padres | W8-7 | 18-18 | .500 | Tropicana Field · St. Petersburg, FL |
| 37 | Sun May 12 | vs Padres | W4-2 | 19-18 | .514 | Tropicana Field · St. Petersburg, FL |
| 38 | Tue May 14 | vs Red Sox | W5-3 | 20-18 | .526 | Tropicana Field · St. Petersburg, FL |
| 39 | Wed May 15 | vs Red Sox | L2-9 | 20-19 | .513 | Tropicana Field · St. Petersburg, FL |
| 40 | Thu May 16 | vs Red Sox | L3-4 | 20-20 | .500 | Tropicana Field · St. Petersburg, FL |
| 41 | Fri May 17 | at Orioles | W12-10 | 21-20 | .512 | Camden Yards · Baltimore, MD |
| 42 | Sat May 18 | at Orioles | W10-6 | 22-20 | .524 | Camden Yards · Baltimore, MD |
| 43 | Sun May 19 | at Orioles | W3-1 | 23-20 | .535 | Camden Yards · Baltimore, MD |
| 44 | Mon May 20 | at Blue Jays | L5-7 | 23-21 | .523 | Rogers Centre · Toronto, ON |
| 45 | Tue May 21 | at Blue Jays | W4-3 | 24-21 | .533 | Rogers Centre · Toronto, ON |
| 46 | Wed May 22 | at Blue Jays | L3-4 (10) | 24-22 | .522 | Rogers Centre · Toronto, ON |
| 47 | Fri May 24 | vs Yankees | L4-9 | 24-23 | .511 | Tropicana Field · St. Petersburg, FL |
| 48 | Sat May 25 | vs Yankees | L3-4 (11) | 24-24 | .500 | Tropicana Field · St. Petersburg, FL |
| 49 | Sun May 26 | vs Yankees | W8-3 | 25-24 | .510 | Tropicana Field · St. Petersburg, FL |
| 50 | Mon May 27 | vs Marlins | W10-6 | 26-24 | .520 | Tropicana Field · St. Petersburg, FL |
| 51 | Tue May 28 | vs Marlins | W7-6 | 27-24 | .529 | Tropicana Field · St. Petersburg, FL |
| 52 | Wed May 29 | at Marlins | W3-1 | 28-24 | .538 | LoanDepot Park · Miami, FL |
| 53 | Thu May 30 | at Marlins | W5-2 | 29-24 | .547 | LoanDepot Park · Miami, FL |
| 54 | Fri May 31 | at Guardians | W9-2 | 30-24 | .556 | Progressive Field · Cleveland, OH |
| 55 | Sat Jun 1 | at Guardians | L0-5 | 30-25 | .545 | Progressive Field · Cleveland, OH |
| 56 | Sun Jun 2 | at Guardians | W11-3 | 31-25 | .554 | Progressive Field · Cleveland, OH |
| 57 | Tue Jun 4 | at Tigers | L1-10 | 31-26 | .544 | Comerica Park · Detroit, MI |
| 58 | Wed Jun 5 | at Tigers | W3-0 | 32-26 | .552 | Comerica Park · Detroit, MI |
| 59 | Thu Jun 6 | at Tigers | L2-5 | 32-27 | .542 | Comerica Park · Detroit, MI |
| 60 | Fri Jun 7 | vs Orioles | W2-1 | 33-27 | .550 | Tropicana Field · St. Petersburg, FL |
| 61 | Sat Jun 8 | vs Orioles | W8-0 | 34-27 | .557 | Tropicana Field · St. Petersburg, FL |
| 62 | Sun Jun 9 | vs Orioles | L7-10 | 34-28 | .548 | Tropicana Field · St. Petersburg, FL |
| 63 | Mon Jun 10 | vs Red Sox | L8-10 (14) | 34-29 | .540 | Tropicana Field · St. Petersburg, FL |
| 64 | Tue Jun 11 | vs Red Sox | W8-3 | 35-29 | .547 | Tropicana Field · St. Petersburg, FL |
| 65 | Wed Jun 12 | vs Red Sox | L1-2 | 35-30 | .538 | Tropicana Field · St. Petersburg, FL |
| 66 | Thu Jun 13 | vs Royals | L1-10 | 35-31 | .530 | Tropicana Field · St. Petersburg, FL |
| 67 | Fri Jun 14 | vs Royals | L2-7 | 35-32 | .522 | Tropicana Field · St. Petersburg, FL |
| 68 | Sat Jun 15 | vs Royals | W5-3 | 36-32 | .529 | Tropicana Field · St. Petersburg, FL |
| 69 | Sun Jun 16 | vs Royals | L3-5 | 36-33 | .522 | Tropicana Field · St. Petersburg, FL |
| 70 | Tue Jun 18 | at Red Sox | L1-5 | 36-34 | .514 | Fenway Park · Boston, MA |
| 71 | Tue Jun 18 | at Red Sox | L1-3 | 36-35 | .507 | Fenway Park · Boston, MA |
| 72 | Wed Jun 19 | at Red Sox | W6-2 | 37-35 | .514 | Fenway Park · Boston, MA |
| 73 | Thu Jun 20 | at Yankees | W8-3 | 38-35 | .521 | Yankee Stadium · The Bronx, NY |
| 74 | Fri Jun 21 | at Yankees | L2-6 | 38-36 | .514 | Yankee Stadium · The Bronx, NY |
| 75 | Sat Jun 22 | at Yankees | L5-7 | 38-37 | .507 | Yankee Stadium · The Bronx, NY |
| 76 | Sun Jun 23 | at Yankees | W3-1 | 39-37 | .513 | Yankee Stadium · The Bronx, NY |
| 77 | Mon Jun 24 | vs Blue Jays | W4-1 | 40-37 | .519 | Tropicana Field · St. Petersburg, FL |
| 78 | Tue Jun 25 | vs Blue Jays | W5-1 | 41-37 | .526 | Tropicana Field · St. Petersburg, FL |
| 79 | Wed Jun 26 | vs Blue Jays | L0-3 | 41-38 | .519 | Tropicana Field · St. Petersburg, FL |
| 80 | Fri Jun 28 | vs Tigers | L3-6 | 41-39 | .512 | Tropicana Field · St. Petersburg, FL |
| 81 | Sat Jun 29 | vs Tigers | W4-3 (10) | 42-39 | .519 | Tropicana Field · St. Petersburg, FL |
| 82 | Sun Jun 30 | vs Tigers | W3-1 | 43-39 | .524 | Tropicana Field · St. Petersburg, FL |
| 83 | Mon Jul 1 | at Astros | W12-0 | 44-39 | .530 | Minute Maid Park · Houston, TX |
| 84 | Tue Jul 2 | at Astros | W8-0 | 45-39 | .536 | Minute Maid Park · Houston, TX |
| 85 | Wed Jul 3 | at Astros | L1-4 | 45-40 | .529 | Minute Maid Park · Houston, TX |
| 86 | Thu Jul 4 | at Astros | W7-5 (11) | 46-40 | .535 | Minute Maid Park · Houston, TX |
| 87 | Fri Jul 5 | vs White Sox | W8-3 | 47-40 | .540 | Tropicana Field · St. Petersburg, FL |
| 88 | Sat Jul 6 | vs White Sox | W3-0 | 48-40 | .545 | Tropicana Field · St. Petersburg, FL |
| 89 | Sun Jul 7 | vs White Sox | W3-1 | 49-40 | .551 | Tropicana Field · St. Petersburg, FL |
| 90 | Mon Jul 8 | vs Twins | W7-4 | 50-40 | .556 | Tropicana Field · St. Petersburg, FL |
| 91 | Tue Jul 9 | vs Twins | W4-1 | 51-40 | .560 | Tropicana Field · St. Petersburg, FL |
| 92 | Wed Jul 10 | vs Twins | W4-3 (13) | 52-40 | .565 | Tropicana Field · St. Petersburg, FL |
| 93 | Thu Jul 11 | vs Twins | W4-3 | 53-40 | .570 | Tropicana Field · St. Petersburg, FL |
| 94 | Fri Jul 12 | vs Astros | L1-2 | 53-41 | .564 | Tropicana Field · St. Petersburg, FL |
| 95 | Sat Jul 13 | vs Astros | W4-3 | 54-41 | .568 | Tropicana Field · St. Petersburg, FL |
| 96 | Sun Jul 14 | vs Astros | W5-0 | 55-41 | .573 | Tropicana Field · St. Petersburg, FL |
| 97 | Fri Jul 19 | at Blue Jays | W8-5 | 56-41 | .577 | Rogers Centre · Toronto, ON |
| 98 | Sat Jul 20 | at Blue Jays | W4-3 | 57-41 | .582 | Rogers Centre · Toronto, ON |
| 99 | Sun Jul 21 | at Blue Jays | W4-3 | 58-41 | .586 | Rogers Centre · Toronto, ON |
| 100 | Mon Jul 22 | at Red Sox | W3-0 | 59-41 | .590 | Fenway Park · Boston, MA |
| 101 | Tue Jul 23 | at Red Sox | L2-6 | 59-42 | .584 | Fenway Park · Boston, MA |
| 102 | Wed Jul 24 | at Red Sox | W5-1 | 60-42 | .588 | Fenway Park · Boston, MA |
| 103 | Fri Jul 26 | at Yankees | W10-6 | 61-42 | .592 | Yankee Stadium · The Bronx, NY |
| 104 | Sat Jul 27 | at Yankees | W1-0 | 62-42 | .596 | Yankee Stadium · The Bronx, NY |
| 105 | Sun Jul 28 | at Yankees | L5-6 | 62-43 | .590 | Yankee Stadium · The Bronx, NY |
| 106 | Mon Jul 29 | at Red Sox | W2-1 | 63-43 | .594 | Fenway Park · Boston, MA |
| 107 | Tue Jul 30 | vs D-backs | W5-2 | 64-43 | .598 | Tropicana Field · St. Petersburg, FL |
| 108 | Wed Jul 31 | vs D-backs | L0-7 | 64-44 | .593 | Tropicana Field · St. Petersburg, FL |
| 109 | Fri Aug 2 | vs Giants | L1-4 | 64-45 | .587 | Tropicana Field · St. Petersburg, FL |
| 110 | Sat Aug 3 | vs Giants | W2-1 (10) | 65-45 | .591 | Tropicana Field · St. Petersburg, FL |
| 111 | Sun Aug 4 | vs Giants | W4-3 | 66-45 | .595 | Tropicana Field · St. Petersburg, FL |
| 112 | Tue Aug 6 | at D-backs | L1-6 | 66-46 | .589 | Chase Field · Phoenix, AZ |
| 113 | Wed Aug 7 | at D-backs | L8-9 | 66-47 | .584 | Chase Field · Phoenix, AZ |
| 114 | Fri Aug 9 | at Dodgers | L6-7 | 66-48 | .579 | Dodger Stadium · Los Angeles, CA |
| 115 | Sat Aug 10 | at Dodgers | L0-5 | 66-49 | .574 | Dodger Stadium · Los Angeles, CA |
| 116 | Sun Aug 11 | at Dodgers | L2-8 | 66-50 | .569 | Dodger Stadium · Los Angeles, CA |
| 117 | Tue Aug 13 | vs Mariners | L4-5 | 66-51 | .564 | Tropicana Field · St. Petersburg, FL |
| 118 | Wed Aug 14 | vs Mariners | W5-4 | 67-51 | .568 | Tropicana Field · St. Petersburg, FL |
| 119 | Thu Aug 15 | vs Mariners | W7-1 | 68-51 | .571 | Tropicana Field · St. Petersburg, FL |
| 120 | Fri Aug 16 | vs Blue Jays | W5-4 | 69-51 | .575 | Tropicana Field · St. Petersburg, FL |
| 121 | Sat Aug 17 | vs Blue Jays | L2-6 | 69-52 | .570 | Tropicana Field · St. Petersburg, FL |
| 122 | Sun Aug 18 | vs Blue Jays | W2-1 (10) | 70-52 | .574 | Tropicana Field · St. Petersburg, FL |
| 123 | Mon Aug 19 | at Orioles | W4-3 | 71-52 | .577 | Camden Yards · Baltimore, MD |
| 124 | Tue Aug 20 | at Orioles | W7-4 | 72-52 | .581 | Camden Yards · Baltimore, MD |
| 125 | Wed Aug 21 | at Orioles | L2-4 | 72-53 | .576 | Camden Yards · Baltimore, MD |
| 126 | Fri Aug 23 | vs Yankees | W7-2 | 73-53 | .579 | Tropicana Field · St. Petersburg, FL |
| 127 | Sat Aug 24 | vs Yankees | W4-2 | 74-53 | .583 | Tropicana Field · St. Petersburg, FL |
| 128 | Sun Aug 25 | vs Yankees | L2-3 (11) | 74-54 | .578 | Tropicana Field · St. Petersburg, FL |
| 129 | Mon Aug 26 | at Royals | L1-11 | 74-55 | .574 | Kauffman Stadium · Kansas City, MO |
| 130 | Tue Aug 27 | vs Angels | L5-6 | 74-56 | .569 | Tropicana Field · St. Petersburg, FL |
| 131 | Wed Aug 28 | vs Angels | W4-1 | 75-56 | .573 | Tropicana Field · St. Petersburg, FL |
| 132 | Thu Aug 29 | vs Angels | L0-2 | 75-57 | .568 | Tropicana Field · St. Petersburg, FL |
| 133 | Fri Aug 30 | at Athletics | L3-4 | 75-58 | .564 | RingCentral Coliseum · Oakland, CA |
| 134 | Sat Aug 31 | at Athletics | L1-2 | 75-59 | .560 | RingCentral Coliseum · Oakland, CA |
| 135 | Sun Sep 1 | at Athletics | L1-5 | 75-60 | .556 | RingCentral Coliseum · Oakland, CA |
| 136 | Mon Sep 2 | at Angels | L2-11 | 75-61 | .551 | Angel Stadium · Anaheim, CA |
| 137 | Tue Sep 3 | at Angels | W7-1 | 76-61 | .555 | Angel Stadium · Anaheim, CA |
| 138 | Wed Sep 4 | at Angels | W3-1 | 77-61 | .558 | Angel Stadium · Anaheim, CA |
| 139 | Thu Sep 5 | at Angels | L2-6 | 77-62 | .554 | Angel Stadium · Anaheim, CA |
| 140 | Fri Sep 6 | at Mariners | L4-6 | 77-63 | .550 | T-Mobile Park · Seattle, WA |
| 141 | Sat Sep 7 | at Mariners | L2-6 | 77-64 | .546 | T-Mobile Park · Seattle, WA |
| 142 | Sun Sep 8 | at Mariners | W4-1 | 78-64 | .549 | T-Mobile Park · Seattle, WA |
| 143 | Tue Sep 10 | vs Red Sox | L0-2 | 78-65 | .545 | Tropicana Field · St. Petersburg, FL |
| 144 | Wed Sep 11 | vs Red Sox | L3-7 (10) | 78-66 | .542 | Tropicana Field · St. Petersburg, FL |
| 145 | Thu Sep 12 | vs Red Sox | W4-3 | 79-66 | .545 | Tropicana Field · St. Petersburg, FL |
| 146 | Fri Sep 13 | at Twins | W3-0 | 80-66 | .548 | Target Field · Minneapolis, MN |
| 147 | Sat Sep 14 | at Twins | W7-0 | 81-66 | .551 | Target Field · Minneapolis, MN |
| 148 | Sun Sep 15 | at Twins | L4-6 | 81-67 | .547 | Target Field · Minneapolis, MN |
| 149 | Mon Sep 16 | vs Rangers | W6-2 | 82-67 | .550 | Tropicana Field · St. Petersburg, FL |
| 150 | Tue Sep 17 | vs Rangers | L1-7 | 82-68 | .547 | Tropicana Field · St. Petersburg, FL |
| 151 | Wed Sep 18 | vs Rangers | W4-3 (12) | 83-68 | .550 | Tropicana Field · St. Petersburg, FL |
| 152 | Thu Sep 19 | vs Rangers | L2-8 | 83-69 | .546 | Tropicana Field · St. Petersburg, FL |
| 153 | Fri Sep 20 | vs Orioles | W5-4 (18) | 84-69 | .549 | Tropicana Field · St. Petersburg, FL |
| 154 | Sat Sep 21 | vs Orioles | W5-1 | 85-69 | .552 | Tropicana Field · St. Petersburg, FL |
| 155 | Sun Sep 22 | vs Orioles | W3-1 | 86-69 | .555 | Tropicana Field · St. Petersburg, FL |
| 156 | Mon Sep 23 | vs Orioles | W5-4 | 87-69 | .558 | Tropicana Field · St. Petersburg, FL |
| 157 | Tue Sep 24 | at Yankees | W7-0 | 88-69 | .561 | Yankee Stadium · The Bronx, NY |
| 158 | Wed Sep 25 | at Yankees | W8-3 | 89-69 | .563 | Yankee Stadium · The Bronx, NY |
| 159 | Thu Sep 26 | at Yankees | W4-0 | 90-69 | .566 | Yankee Stadium · The Bronx, NY |
| 160 | Fri Sep 27 | at Blue Jays | L3-6 | 90-70 | .563 | Rogers Centre · Toronto, ON |
| 161 | Sat Sep 28 | at Blue Jays | L2-7 | 90-71 | .559 | Rogers Centre · Toronto, ON |
| 162 | Sun Sep 29 | at Blue Jays | W7-6 | 91-71 | .562 | Rogers Centre · Toronto, ON |
| 163 | Mon Sep 30 | at Rangers | W5-2 | 92-71 | .564 | Globe Life Field · Arlington, TX |
| 164 | Wed Oct 2 | at Guardians | W4-0 | 1-0 | 1.000 | Progressive Field · Cleveland, OH |
| 165 | Fri Oct 4 | at Red Sox | L2-12 | 0-1 | .000 | Fenway Park · Boston, MA |
| 166 | Sat Oct 5 | at Red Sox | L4-7 | 0-2 | .000 | Fenway Park · Boston, MA |
| 167 | Mon Oct 7 | vs Red Sox | W5-4 | 1-2 | .333 | Tropicana Field · St. Petersburg, FL |
| 168 | Tue Oct 8 | vs Red Sox | L1-3 | 1-3 | .250 | Tropicana Field · St. Petersburg, FL |