| 1 | Mon Apr 6 | vs Orioles | L2-6 | 0-1 | .000 | Tropicana Field · St. Petersburg, FL |
| 2 | Tue Apr 7 | vs Orioles | L5-6 | 0-2 | .000 | Tropicana Field · St. Petersburg, FL |
| 3 | Wed Apr 8 | vs Orioles | W2-0 | 1-2 | .333 | Tropicana Field · St. Petersburg, FL |
| 4 | Fri Apr 10 | at Marlins | L9-10 (10) | 1-3 | .250 | LoanDepot Park · Miami, FL |
| 5 | Sat Apr 11 | at Marlins | W2-0 | 2-3 | .400 | LoanDepot Park · Miami, FL |
| 6 | Sun Apr 12 | at Marlins | W8-5 | 3-3 | .500 | LoanDepot Park · Miami, FL |
| 7 | Mon Apr 13 | at Blue Jays | W2-1 | 4-3 | .571 | Rogers Centre · Toronto, ON |
| 8 | Tue Apr 14 | at Blue Jays | W3-2 | 5-3 | .625 | Rogers Centre · Toronto, ON |
| 9 | Wed Apr 15 | at Blue Jays | L7-12 | 5-4 | .556 | Rogers Centre · Toronto, ON |
| 10 | Thu Apr 16 | at Blue Jays | W4-2 | 6-4 | .600 | Rogers Centre · Toronto, ON |
| 11 | Fri Apr 17 | vs Yankees | L4-5 | 6-5 | .545 | Tropicana Field · St. Petersburg, FL |
| 12 | Sat Apr 18 | vs Yankees | L0-9 | 6-6 | .500 | Tropicana Field · St. Petersburg, FL |
| 13 | Sun Apr 19 | vs Yankees | L3-5 | 6-7 | .462 | Tropicana Field · St. Petersburg, FL |
| 14 | Tue Apr 21 | vs Red Sox | L0-1 | 6-8 | .429 | Tropicana Field · St. Petersburg, FL |
| 15 | Wed Apr 22 | vs Red Sox | W7-5 | 7-8 | .467 | Tropicana Field · St. Petersburg, FL |
| 16 | Thu Apr 23 | vs Red Sox | W2-1 | 8-8 | .500 | Tropicana Field · St. Petersburg, FL |
| 17 | Fri Apr 24 | vs Blue Jays | W12-3 | 9-8 | .529 | Tropicana Field · St. Petersburg, FL |
| 18 | Sat Apr 25 | vs Blue Jays | W4-2 | 10-8 | .556 | Tropicana Field · St. Petersburg, FL |
| 19 | Sun Apr 26 | vs Blue Jays | W5-1 | 11-8 | .579 | Tropicana Field · St. Petersburg, FL |
| 20 | Mon Apr 27 | at Yankees | L1-4 | 11-9 | .550 | Yankee Stadium · The Bronx, NY |
| 21 | Tue Apr 28 | at Yankees | L2-4 | 11-10 | .524 | Yankee Stadium · The Bronx, NY |
| 22 | Wed Apr 29 | at Yankees | W3-2 (13) | 12-10 | .545 | Yankee Stadium · The Bronx, NY |
| 23 | Fri May 1 | at Orioles | W2-0 | 13-10 | .565 | Tropicana Field · St. Petersburg, FL |
| 24 | Sat May 2 | at Orioles | L0-4 | 13-11 | .542 | Tropicana Field · St. Petersburg, FL |
| 25 | Sun May 3 | at Orioles | L2-4 | 13-12 | .520 | Tropicana Field · St. Petersburg, FL |
| 26 | Mon May 4 | at Red Sox | W5-1 | 14-12 | .538 | Fenway Park · Boston, MA |
| 27 | Tue May 5 | at Red Sox | L0-2 | 14-13 | .519 | Fenway Park · Boston, MA |
| 28 | Wed May 6 | at Red Sox | W5-3 | 15-13 | .536 | Fenway Park · Boston, MA |
| 29 | Thu May 7 | vs Rangers | L4-5 | 15-14 | .517 | Tropicana Field · St. Petersburg, FL |
| 30 | Fri May 8 | vs Rangers | W8-2 | 16-14 | .533 | Tropicana Field · St. Petersburg, FL |
| 31 | Sat May 9 | vs Rangers | W7-2 | 17-14 | .548 | Tropicana Field · St. Petersburg, FL |
| 32 | Sun May 10 | vs Rangers | L1-2 | 17-15 | .531 | Tropicana Field · St. Petersburg, FL |
| 33 | Mon May 11 | vs Yankees | L5-11 | 17-16 | .515 | Tropicana Field · St. Petersburg, FL |
| 34 | Tue May 12 | vs Yankees | W4-2 | 18-16 | .529 | Tropicana Field · St. Petersburg, FL |
| 35 | Wed May 13 | vs Yankees | W3-2 | 19-16 | .543 | Tropicana Field · St. Petersburg, FL |
| 36 | Thu May 14 | vs Yankees | W6-1 | 20-16 | .556 | Tropicana Field · St. Petersburg, FL |
| 37 | Fri May 15 | at Twins | L2-3 | 20-17 | .541 | Target Field · Minneapolis, MN |
| 38 | Sat May 16 | at Twins | L4-6 | 20-18 | .526 | Target Field · Minneapolis, MN |
| 39 | Sun May 17 | at Twins | W11-3 | 21-18 | .538 | Target Field · Minneapolis, MN |
| 40 | Tue May 19 | at Braves | W5-3 | 22-18 | .550 | Truist Park · Cumberland, GA |
| 41 | Wed May 20 | at Braves | L1-2 | 22-19 | .537 | Truist Park · Cumberland, GA |
| 42 | Thu May 21 | vs Athletics | W3-0 | 23-19 | .548 | Tropicana Field · St. Petersburg, FL |
| 43 | Fri May 22 | vs Athletics | W5-2 | 24-19 | .558 | Tropicana Field · St. Petersburg, FL |
| 44 | Sat May 23 | vs Athletics | L0-5 | 24-20 | .545 | Tropicana Field · St. Petersburg, FL |
| 45 | Sun May 24 | vs Athletics | L2-7 | 24-21 | .533 | Tropicana Field · St. Petersburg, FL |
| 46 | Mon May 25 | vs Mariners | L1-4 | 24-22 | .522 | Tropicana Field · St. Petersburg, FL |
| 47 | Tue May 26 | vs Mariners | L6-7 (10) | 24-23 | .511 | Tropicana Field · St. Petersburg, FL |
| 48 | Wed May 27 | vs Mariners | L0-3 | 24-24 | .500 | Tropicana Field · St. Petersburg, FL |
| 49 | Fri May 29 | at Orioles | L1-2 | 24-25 | .490 | Camden Yards · Baltimore, MD |
| 50 | Sat May 30 | at Orioles | W3-0 | 25-25 | .500 | Camden Yards · Baltimore, MD |
| 51 | Sun May 31 | at Orioles | W9-5 | 26-25 | .510 | Camden Yards · Baltimore, MD |
| 52 | Mon Jun 1 | at Angels | L3-7 | 26-26 | .500 | Angel Stadium · Anaheim, CA |
| 53 | Tue Jun 2 | at Angels | W6-1 | 27-26 | .509 | Angel Stadium · Anaheim, CA |
| 54 | Wed Jun 3 | at Angels | W6-5 (10) | 28-26 | .519 | Angel Stadium · Anaheim, CA |
| 55 | Thu Jun 4 | at Mariners | W2-1 | 29-26 | .527 | T-Mobile Park · Seattle, WA |
| 56 | Fri Jun 5 | at Mariners | W1-0 | 30-26 | .536 | T-Mobile Park · Seattle, WA |
| 57 | Sat Jun 6 | at Mariners | L1-2 | 30-27 | .526 | T-Mobile Park · Seattle, WA |
| 58 | Sun Jun 7 | at Mariners | W3-1 | 31-27 | .534 | T-Mobile Park · Seattle, WA |
| 59 | Tue Jun 9 | vs Angels | L2-8 | 31-28 | .525 | Tropicana Field · St. Petersburg, FL |
| 60 | Wed Jun 10 | vs Angels | W4-2 | 32-28 | .533 | Tropicana Field · St. Petersburg, FL |
| 61 | Thu Jun 11 | vs Angels | L2-6 | 32-29 | .525 | Tropicana Field · St. Petersburg, FL |
| 62 | Fri Jun 12 | vs White Sox | W7-5 | 33-29 | .532 | Tropicana Field · St. Petersburg, FL |
| 63 | Sat Jun 13 | vs White Sox | W5-4 | 34-29 | .540 | Tropicana Field · St. Petersburg, FL |
| 64 | Sun Jun 14 | vs White Sox | W2-1 | 35-29 | .547 | Tropicana Field · St. Petersburg, FL |
| 65 | Mon Jun 15 | vs Nationals | W6-1 | 36-29 | .554 | Tropicana Field · St. Petersburg, FL |
| 66 | Tue Jun 16 | vs Nationals | L4-16 | 36-30 | .545 | Tropicana Field · St. Petersburg, FL |
| 67 | Wed Jun 17 | at Nationals | W5-0 | 37-30 | .552 | Nationals Park · Washington, D.C. |
| 68 | Thu Jun 18 | at Nationals | W5-3 | 38-30 | .559 | Nationals Park · Washington, D.C. |
| 69 | Fri Jun 19 | at Guardians | W4-1 | 39-30 | .565 | Progressive Field · Cleveland, OH |
| 70 | Sat Jun 20 | at Guardians | W4-1 | 40-30 | .571 | Progressive Field · Cleveland, OH |
| 71 | Sun Jun 21 | at Guardians | L0-1 | 40-31 | .563 | Progressive Field · Cleveland, OH |
| 72 | Mon Jun 22 | vs Blue Jays | L5-8 | 40-32 | .556 | Tropicana Field · St. Petersburg, FL |
| 73 | Tue Jun 23 | vs Blue Jays | W4-3 | 41-32 | .562 | Tropicana Field · St. Petersburg, FL |
| 74 | Wed Jun 24 | vs Blue Jays | L0-1 (12) | 41-33 | .554 | Tropicana Field · St. Petersburg, FL |
| 75 | Fri Jun 26 | vs Red Sox | L3-4 (10) | 41-34 | .547 | Tropicana Field · St. Petersburg, FL |
| 76 | Sat Jun 27 | vs Red Sox | W4-1 | 42-34 | .553 | Tropicana Field · St. Petersburg, FL |
| 77 | Sun Jun 28 | vs Red Sox | L3-5 | 42-35 | .545 | Tropicana Field · St. Petersburg, FL |
| 78 | Mon Jun 29 | vs Guardians | L1-7 | 42-36 | .538 | Tropicana Field · St. Petersburg, FL |
| 79 | Tue Jun 30 | vs Guardians | L2-6 | 42-37 | .532 | Tropicana Field · St. Petersburg, FL |
| 80 | Wed Jul 1 | vs Guardians | L1-8 | 42-38 | .525 | Tropicana Field · St. Petersburg, FL |
| 81 | Thu Jul 2 | vs Guardians | L4-5 (10) | 42-39 | .519 | Tropicana Field · St. Petersburg, FL |
| 82 | Fri Jul 3 | at Yankees | L5-7 (12) | 42-40 | .512 | Yankee Stadium · The Bronx, NY |
| 83 | Sat Jul 4 | at Yankees | L2-3 | 42-41 | .506 | Yankee Stadium · The Bronx, NY |
| 84 | Sun Jul 5 | at Yankees | W8-1 | 43-41 | .512 | Yankee Stadium · The Bronx, NY |
| 85 | Tue Jul 7 | at Royals | L5-9 | 43-42 | .506 | Kauffman Stadium · Kansas City, MO |
| 86 | Tue Jul 7 | at Royals | L1-7 | 43-43 | .500 | Kauffman Stadium · Kansas City, MO |
| 87 | Wed Jul 8 | at Royals | L7-9 | 43-44 | .494 | Kauffman Stadium · Kansas City, MO |
| 88 | Thu Jul 9 | at Royals | L3-8 | 43-45 | .489 | Kauffman Stadium · Kansas City, MO |
| 89 | Fri Jul 10 | vs Astros | W3-1 | 44-45 | .494 | Tropicana Field · St. Petersburg, FL |
| 90 | Sat Jul 11 | vs Astros | W3-0 | 45-45 | .500 | Tropicana Field · St. Petersburg, FL |
| 91 | Sun Jul 12 | vs Astros | W4-3 | 46-45 | .505 | Tropicana Field · St. Petersburg, FL |
| 92 | Fri Jul 17 | at Blue Jays | L2-6 | 46-46 | .500 | Rogers Centre · Toronto, ON |
| 93 | Sat Jul 18 | at Blue Jays | W3-2 | 47-46 | .505 | Rogers Centre · Toronto, ON |
| 94 | Sun Jul 19 | at Blue Jays | L0-4 | 47-47 | .500 | Rogers Centre · Toronto, ON |
| 95 | Mon Jul 20 | at Phillies | L3-5 | 47-48 | .495 | Citizens Bank Park · Philadelphi, PA |
| 96 | Tue Jul 21 | at Phillies | W1-0 | 48-48 | .500 | Citizens Bank Park · Philadelphi, PA |
| 97 | Wed Jul 22 | at Phillies | L4-5 (10) | 48-49 | .495 | Citizens Bank Park · Philadelphi, PA |
| 98 | Fri Jul 24 | vs Orioles | W3-1 | 49-49 | .500 | Tropicana Field · St. Petersburg, FL |
| 99 | Sat Jul 25 | vs Orioles | L1-5 | 49-50 | .495 | Tropicana Field · St. Petersburg, FL |
| 100 | Sun Jul 26 | vs Orioles | L2-5 | 49-51 | .490 | Tropicana Field · St. Petersburg, FL |
| 101 | Mon Jul 27 | vs Tigers | W5-2 | 50-51 | .495 | Tropicana Field · St. Petersburg, FL |
| 102 | Tue Jul 28 | vs Tigers | W10-2 | 51-51 | .500 | Tropicana Field · St. Petersburg, FL |
| 103 | Wed Jul 29 | vs Tigers | L1-2 | 51-52 | .495 | Tropicana Field · St. Petersburg, FL |
| 104 | Fri Jul 31 | at Red Sox | L5-7 | 51-53 | .490 | Fenway Park · Boston, MA |
| 105 | Sat Aug 1 | at Red Sox | L7-11 | 51-54 | .486 | Fenway Park · Boston, MA |
| 106 | Sun Aug 2 | at Red Sox | W4-3 | 52-54 | .491 | Fenway Park · Boston, MA |
| 107 | Mon Aug 3 | at White Sox | W5-4 | 53-54 | .495 | Guaranteed Rate Field · Chicago, IL |
| 108 | Tue Aug 4 | at White Sox | W11-3 | 54-54 | .500 | Guaranteed Rate Field · Chicago, IL |
| 109 | Wed Aug 5 | at White Sox | L5-6 (10) | 54-55 | .495 | Guaranteed Rate Field · Chicago, IL |
| 110 | Fri Aug 7 | vs Mets | L3-4 | 54-56 | .491 | Tropicana Field · St. Petersburg, FL |
| 111 | Sat Aug 8 | vs Mets | W5-4 | 55-56 | .495 | Tropicana Field · St. Petersburg, FL |
| 112 | Sun Aug 9 | vs Mets | W4-3 | 56-56 | .500 | Tropicana Field · St. Petersburg, FL |
| 113 | Tue Aug 11 | vs Braves | W2-0 | 57-56 | .504 | Tropicana Field · St. Petersburg, FL |
| 114 | Wed Aug 12 | vs Braves | W9-6 | 58-56 | .509 | Tropicana Field · St. Petersburg, FL |
| 115 | Fri Aug 14 | at Rangers | L3-5 | 58-57 | .504 | Globe Life Field · Arlington, TX |
| 116 | Sat Aug 15 | at Rangers | L4-12 | 58-58 | .500 | Globe Life Field · Arlington, TX |
| 117 | Sun Aug 16 | at Rangers | L3-5 | 58-59 | .496 | Globe Life Field · Arlington, TX |
| 118 | Mon Aug 17 | at Astros | W9-2 | 59-59 | .500 | Minute Maid Park · Houston, TX |
| 119 | Tue Aug 18 | at Astros | L2-3 (10) | 59-60 | .496 | Minute Maid Park · Houston, TX |
| 120 | Wed Aug 19 | at Astros | L2-3 (13) | 59-61 | .492 | Minute Maid Park · Houston, TX |
| 121 | Thu Aug 20 | at Astros | W1-0 | 60-61 | .496 | Minute Maid Park · Houston, TX |
| 122 | Fri Aug 21 | at Athletics | W2-1 | 61-61 | .500 | RingCentral Coliseum · Oakland, CA |
| 123 | Sat Aug 22 | at Athletics | W5-4 | 62-61 | .504 | RingCentral Coliseum · Oakland, CA |
| 124 | Sun Aug 23 | at Athletics | L2-8 | 62-62 | .500 | RingCentral Coliseum · Oakland, CA |
| 125 | Tue Aug 25 | vs Twins | L7-11 | 62-63 | .496 | Tropicana Field · St. Petersburg, FL |
| 126 | Wed Aug 26 | vs Twins | L3-5 | 62-64 | .492 | Tropicana Field · St. Petersburg, FL |
| 127 | Thu Aug 27 | vs Twins | W5-4 | 63-64 | .496 | Tropicana Field · St. Petersburg, FL |
| 128 | Fri Aug 28 | vs Royals | L2-3 | 63-65 | .492 | Tropicana Field · St. Petersburg, FL |
| 129 | Sat Aug 29 | vs Royals | L3-6 | 63-66 | .488 | Tropicana Field · St. Petersburg, FL |
| 130 | Sun Aug 30 | vs Royals | W3-2 | 64-66 | .492 | Tropicana Field · St. Petersburg, FL |
| 131 | Mon Aug 31 | at Orioles | W6-3 | 65-66 | .496 | Camden Yards · Baltimore, MD |
| 132 | Tue Sep 1 | at Orioles | W11-2 | 66-66 | .500 | Camden Yards · Baltimore, MD |
| 133 | Wed Sep 2 | at Orioles | L6-7 (11) | 66-67 | .496 | Camden Yards · Baltimore, MD |
| 134 | Fri Sep 4 | at Yankees | L2-5 | 66-68 | .493 | Yankee Stadium · The Bronx, NY |
| 135 | Sat Sep 5 | at Yankees | W3-2 | 67-68 | .496 | Yankee Stadium · The Bronx, NY |
| 136 | Sun Sep 6 | at Yankees | L4-6 | 67-69 | .493 | Yankee Stadium · The Bronx, NY |
| 137 | Mon Sep 7 | at Tigers | L4-5 | 67-70 | .489 | Comerica Park · Detroit, MI |
| 138 | Tue Sep 8 | at Tigers | L7-8 (13) | 67-71 | .486 | Comerica Park · Detroit, MI |
| 139 | Wed Sep 9 | at Tigers | W8-0 | 68-71 | .489 | Comerica Park · Detroit, MI |
| 140 | Fri Sep 11 | vs Red Sox | W8-4 | 69-71 | .493 | Tropicana Field · St. Petersburg, FL |
| 141 | Sat Sep 12 | vs Red Sox | L4-10 | 69-72 | .489 | Tropicana Field · St. Petersburg, FL |
| 142 | Sun Sep 13 | vs Red Sox | L0-2 (13) | 69-73 | .486 | Tropicana Field · St. Petersburg, FL |
| 143 | Mon Sep 14 | vs Yankees | L1-4 | 69-74 | .483 | Tropicana Field · St. Petersburg, FL |
| 144 | Tue Sep 15 | vs Yankees | W6-3 | 70-74 | .486 | Tropicana Field · St. Petersburg, FL |
| 145 | Wed Sep 16 | vs Yankees | L1-3 | 70-75 | .483 | Tropicana Field · St. Petersburg, FL |
| 146 | Thu Sep 17 | vs Orioles | L3-4 | 70-76 | .479 | Tropicana Field · St. Petersburg, FL |
| 147 | Fri Sep 18 | vs Orioles | W8-6 | 71-76 | .483 | Tropicana Field · St. Petersburg, FL |
| 148 | Sat Sep 19 | vs Orioles | L1-2 | 71-77 | .480 | Tropicana Field · St. Petersburg, FL |
| 149 | Sun Sep 20 | vs Orioles | W7-6 | 72-77 | .483 | Tropicana Field · St. Petersburg, FL |
| 150 | Mon Sep 21 | at Red Sox | L7-8 | 72-78 | .480 | Fenway Park · Boston, MA |
| 151 | Tue Sep 22 | at Red Sox | W5-2 | 73-78 | .483 | Fenway Park · Boston, MA |
| 152 | Wed Sep 23 | at Red Sox | W6-2 | 74-78 | .487 | Fenway Park · Boston, MA |
| 153 | Thu Sep 24 | at Red Sox | W4-2 | 75-78 | .490 | Fenway Park · Boston, MA |
| 154 | Fri Sep 25 | at Blue Jays | L3-5 | 75-79 | .487 | Rogers Centre · Toronto, ON |
| 155 | Sat Sep 26 | at Blue Jays | L8-10 | 75-80 | .484 | Rogers Centre · Toronto, ON |
| 156 | Sun Sep 27 | at Blue Jays | L4-5 | 75-81 | .481 | Rogers Centre · Toronto, ON |
| 157 | Tue Sep 29 | vs Marlins | W4-2 | 76-81 | .484 | Tropicana Field · St. Petersburg, FL |
| 158 | Wed Sep 30 | vs Marlins | W6-4 | 77-81 | .487 | Tropicana Field · St. Petersburg, FL |
| 159 | Thu Oct 1 | vs Marlins | W4-1 | 78-81 | .491 | Tropicana Field · St. Petersburg, FL |
| 160 | Fri Oct 2 | vs Blue Jays | L4-8 | 78-82 | .487 | Tropicana Field · St. Petersburg, FL |
| 161 | Sat Oct 3 | vs Blue Jays | W4-3 | 79-82 | .491 | Tropicana Field · St. Petersburg, FL |
| 162 | Sun Oct 4 | vs Blue Jays | W12-3 | 80-82 | .494 | Tropicana Field · St. Petersburg, FL |