| 1 | Mon Mar 31 | vs Blue Jays | W9-2 | 1-0 | 1.000 | Tropicana Field · St. Petersburg, FL |
| 2 | Tue Apr 1 | vs Blue Jays | L2-4 | 1-1 | .500 | Tropicana Field · St. Petersburg, FL |
| 3 | Wed Apr 2 | vs Blue Jays | L0-3 | 1-2 | .333 | Tropicana Field · St. Petersburg, FL |
| 4 | Thu Apr 3 | vs Blue Jays | W7-2 | 2-2 | .500 | Tropicana Field · St. Petersburg, FL |
| 5 | Fri Apr 4 | vs Rangers | W8-1 | 3-2 | .600 | Tropicana Field · St. Petersburg, FL |
| 6 | Sat Apr 5 | vs Rangers | W5-4 | 4-2 | .667 | Tropicana Field · St. Petersburg, FL |
| 7 | Sun Apr 6 | vs Rangers | L0-3 | 4-3 | .571 | Tropicana Field · St. Petersburg, FL |
| 8 | Mon Apr 7 | at Royals | L2-4 | 4-4 | .500 | Kauffman Stadium · Kansas City, MO |
| 9 | Tue Apr 8 | at Royals | W1-0 | 5-4 | .556 | Kauffman Stadium · Kansas City, MO |
| 10 | Wed Apr 9 | at Royals | L3-7 | 5-5 | .500 | Kauffman Stadium · Kansas City, MO |
| 11 | Fri Apr 11 | at Reds | W2-1 | 6-5 | .545 | Great American Ball Park · Cincinnati, OH |
| 12 | Sat Apr 12 | at Reds | W1-0 | 7-5 | .583 | Great American Ball Park · Cincinnati, OH |
| 13 | Sun Apr 13 | at Reds | L4-12 | 7-6 | .538 | Great American Ball Park · Cincinnati, OH |
| 14 | Mon Apr 14 | at Orioles | L1-7 | 7-7 | .500 | Camden Yards · Baltimore, MD |
| 15 | Wed Apr 16 | at Orioles | L0-3 | 7-8 | .467 | Camden Yards · Baltimore, MD |
| 16 | Thu Apr 17 | vs Yankees | L2-10 | 7-9 | .438 | Tropicana Field · St. Petersburg, FL |
| 17 | Fri Apr 18 | vs Yankees | W11-5 | 8-9 | .471 | Tropicana Field · St. Petersburg, FL |
| 18 | Sat Apr 19 | vs Yankees | W16-1 | 9-9 | .500 | Tropicana Field · St. Petersburg, FL |
| 19 | Sun Apr 20 | vs Yankees | L1-5 (12) | 9-10 | .474 | Tropicana Field · St. Petersburg, FL |
| 20 | Tue Apr 22 | vs Twins | W7-3 | 10-10 | .500 | Tropicana Field · St. Petersburg, FL |
| 21 | Wed Apr 23 | vs Twins | L4-6 (12) | 10-11 | .476 | Tropicana Field · St. Petersburg, FL |
| 22 | Thu Apr 24 | vs Twins | L7-9 | 10-12 | .455 | Tropicana Field · St. Petersburg, FL |
| 23 | Fri Apr 25 | at White Sox | L6-9 | 10-13 | .435 | Guaranteed Rate Field · Chicago, IL |
| 24 | Sat Apr 26 | at White Sox | W4-0 | 11-13 | .458 | Guaranteed Rate Field · Chicago, IL |
| 25 | Sun Apr 27 | at White Sox | L2-9 | 11-14 | .440 | Guaranteed Rate Field · Chicago, IL |
| 26 | Mon Apr 28 | at White Sox | L3-7 | 11-15 | .423 | Guaranteed Rate Field · Chicago, IL |
| 27 | Tue Apr 29 | at Red Sox | L4-7 | 11-16 | .407 | Fenway Park · Boston, MA |
| 28 | Thu May 1 | at Red Sox | W2-1 | 12-16 | .429 | Fenway Park · Boston, MA |
| 29 | Thu May 1 | at Red Sox | W6-5 | 13-16 | .448 | Fenway Park · Boston, MA |
| 30 | Fri May 2 | at Yankees | W10-5 (14) | 14-16 | .467 | Yankee Stadium · The Bronx, NY |
| 31 | Sat May 3 | at Yankees | L3-9 | 14-17 | .452 | Yankee Stadium · The Bronx, NY |
| 32 | Sun May 4 | at Yankees | W5-1 | 15-17 | .469 | Yankee Stadium · The Bronx, NY |
| 33 | Tue May 6 | vs Orioles | L3-5 | 15-18 | .455 | Tropicana Field · St. Petersburg, FL |
| 34 | Wed May 7 | vs Orioles | L3-4 | 15-19 | .441 | Tropicana Field · St. Petersburg, FL |
| 35 | Thu May 8 | vs Orioles | L1-3 | 15-20 | .429 | Tropicana Field · St. Petersburg, FL |
| 36 | Fri May 9 | vs Guardians | L3-6 | 15-21 | .417 | Tropicana Field · St. Petersburg, FL |
| 37 | Sat May 10 | vs Guardians | W7-1 | 16-21 | .432 | Tropicana Field · St. Petersburg, FL |
| 38 | Sun May 11 | vs Guardians | L5-6 | 16-22 | .421 | Tropicana Field · St. Petersburg, FL |
| 39 | Mon May 12 | at Mariners | L5-12 | 16-23 | .410 | T-Mobile Park · Seattle, WA |
| 40 | Tue May 13 | at Mariners | W2-1 | 17-23 | .425 | T-Mobile Park · Seattle, WA |
| 41 | Wed May 14 | at Mariners | W2-0 | 18-23 | .439 | T-Mobile Park · Seattle, WA |
| 42 | Thu May 15 | at Angels | L5-6 | 18-24 | .429 | Angel Stadium · Anaheim, CA |
| 43 | Fri May 16 | at Angels | W3-0 | 19-24 | .442 | Angel Stadium · Anaheim, CA |
| 44 | Sat May 17 | at Angels | L0-6 | 19-25 | .432 | Angel Stadium · Anaheim, CA |
| 45 | Sun May 18 | at Angels | L2-6 | 19-26 | .422 | Angel Stadium · Anaheim, CA |
| 46 | Tue May 20 | vs Athletics | L0-3 | 19-27 | .413 | Tropicana Field · St. Petersburg, FL |
| 47 | Wed May 21 | vs Athletics | L2-3 | 19-28 | .404 | Tropicana Field · St. Petersburg, FL |
| 48 | Thu May 22 | vs Athletics | W5-2 (11) | 20-28 | .417 | Tropicana Field · St. Petersburg, FL |
| 49 | Fri May 23 | vs Red Sox | W1-0 | 21-28 | .429 | Tropicana Field · St. Petersburg, FL |
| 50 | Sat May 24 | vs Red Sox | W6-5 (15) | 22-28 | .440 | Tropicana Field · St. Petersburg, FL |
| 51 | Sun May 25 | vs Red Sox | W8-5 | 23-28 | .451 | Tropicana Field · St. Petersburg, FL |
| 52 | Mon May 26 | at Blue Jays | L5-10 | 23-29 | .442 | Rogers Centre · Toronto, ON |
| 53 | Tue May 27 | at Blue Jays | L6-9 | 23-30 | .434 | Rogers Centre · Toronto, ON |
| 54 | Wed May 28 | at Blue Jays | L2-3 | 23-31 | .426 | Rogers Centre · Toronto, ON |
| 55 | Fri May 30 | at Red Sox | L2-3 (10) | 23-32 | .418 | Fenway Park · Boston, MA |
| 56 | Sat May 31 | at Red Sox | L1-7 | 23-33 | .411 | Fenway Park · Boston, MA |
| 57 | Sun Jun 1 | at Red Sox | L0-4 | 23-34 | .404 | Fenway Park · Boston, MA |
| 58 | Mon Jun 2 | at Marlins | L1-3 | 23-35 | .397 | LoanDepot Park · Miami, FL |
| 59 | Tue Jun 3 | at Marlins | L0-1 | 23-36 | .390 | LoanDepot Park · Miami, FL |
| 60 | Wed Jun 4 | vs Marlins | L4-5 | 23-37 | .383 | Tropicana Field · St. Petersburg, FL |
| 61 | Thu Jun 5 | vs Marlins | L6-11 | 23-38 | .377 | Tropicana Field · St. Petersburg, FL |
| 62 | Fri Jun 6 | vs Mariners | W4-0 | 24-38 | .387 | Tropicana Field · St. Petersburg, FL |
| 63 | Sat Jun 7 | vs Mariners | L4-7 | 24-39 | .381 | Tropicana Field · St. Petersburg, FL |
| 64 | Sun Jun 8 | vs Mariners | L0-5 | 24-40 | .375 | Tropicana Field · St. Petersburg, FL |
| 65 | Mon Jun 9 | vs Mariners | L0-3 | 24-41 | .369 | Tropicana Field · St. Petersburg, FL |
| 66 | Tue Jun 10 | vs Cardinals | L0-1 | 24-42 | .364 | Tropicana Field · St. Petersburg, FL |
| 67 | Wed Jun 11 | vs Cardinals | W6-3 | 25-42 | .373 | Tropicana Field · St. Petersburg, FL |
| 68 | Fri Jun 13 | at Astros | W6-1 | 26-42 | .382 | Minute Maid Park · Houston, TX |
| 69 | Sat Jun 14 | at Astros | L3-7 | 26-43 | .377 | Minute Maid Park · Houston, TX |
| 70 | Sun Jun 15 | at Astros | W4-3 | 27-43 | .386 | Minute Maid Park · Houston, TX |
| 71 | Mon Jun 16 | vs Orioles | W5-4 | 28-43 | .394 | Tropicana Field · St. Petersburg, FL |
| 72 | Tue Jun 17 | vs Orioles | L5-7 | 28-44 | .389 | Tropicana Field · St. Petersburg, FL |
| 73 | Wed Jun 18 | vs Orioles | L0-2 | 28-45 | .384 | Tropicana Field · St. Petersburg, FL |
| 74 | Thu Jun 19 | vs Astros | W5-0 | 29-45 | .392 | Tropicana Field · St. Petersburg, FL |
| 75 | Fri Jun 20 | vs Astros | L1-3 | 29-46 | .387 | Tropicana Field · St. Petersburg, FL |
| 76 | Sat Jun 21 | vs Astros | W8-0 | 30-46 | .395 | Tropicana Field · St. Petersburg, FL |
| 77 | Sun Jun 22 | vs Astros | W5-2 | 31-46 | .403 | Tropicana Field · St. Petersburg, FL |
| 78 | Mon Jun 23 | vs Pirates | L1-8 | 31-47 | .397 | Tropicana Field · St. Petersburg, FL |
| 79 | Tue Jun 24 | vs Pirates | L5-6 | 31-48 | .392 | Tropicana Field · St. Petersburg, FL |
| 80 | Wed Jun 25 | vs Pirates | W5-1 | 32-48 | .400 | Tropicana Field · St. Petersburg, FL |
| 81 | Fri Jun 27 | at Orioles | W5-2 | 33-48 | .407 | Camden Yards · Baltimore, MD |
| 82 | Fri Jun 27 | at Orioles | L1-4 | 33-49 | .402 | Camden Yards · Baltimore, MD |
| 83 | Sat Jun 28 | at Orioles | W5-4 | 34-49 | .410 | Camden Yards · Baltimore, MD |
| 84 | Sun Jun 29 | at Orioles | W12-7 | 35-49 | .417 | Camden Yards · Baltimore, MD |
| 85 | Mon Jun 30 | at Yankees | W4-3 (12) | 36-49 | .424 | Yankee Stadium · The Bronx, NY |
| 86 | Tue Jul 1 | at Yankees | W2-1 | 37-49 | .430 | Yankee Stadium · The Bronx, NY |
| 87 | Wed Jul 2 | at Yankees | W6-3 | 38-49 | .437 | Yankee Stadium · The Bronx, NY |
| 88 | Thu Jul 3 | at Tigers | L1-8 | 38-50 | .432 | Comerica Park · Detroit, MI |
| 89 | Fri Jul 4 | at Tigers | W6-3 | 39-50 | .438 | Comerica Park · Detroit, MI |
| 90 | Sat Jul 5 | at Tigers | W7-2 | 40-50 | .444 | Comerica Park · Detroit, MI |
| 91 | Sun Jul 6 | at Tigers | W7-3 | 41-50 | .451 | Comerica Park · Detroit, MI |
| 92 | Mon Jul 7 | vs Royals | L0-6 | 41-51 | .446 | Tropicana Field · St. Petersburg, FL |
| 93 | Tue Jul 8 | vs Royals | W4-3 | 42-51 | .452 | Tropicana Field · St. Petersburg, FL |
| 94 | Wed Jul 9 | vs Royals | L4-5 | 42-52 | .447 | Tropicana Field · St. Petersburg, FL |
| 95 | Fri Jul 11 | vs Blue Jays | L5-8 | 42-53 | .442 | Tropicana Field · St. Petersburg, FL |
| 96 | Sat Jul 12 | vs Blue Jays | W10-3 | 43-53 | .448 | Tropicana Field · St. Petersburg, FL |
| 97 | Sun Jul 13 | vs Blue Jays | W3-0 | 44-53 | .454 | Tropicana Field · St. Petersburg, FL |
| 98 | Fri Jul 18 | at Twins | W6-2 | 45-53 | .459 | Target Field · Minneapolis, MN |
| 99 | Sat Jul 19 | at Twins | W5-1 | 46-53 | .465 | Target Field · Minneapolis, MN |
| 100 | Sun Jul 20 | at Twins | W5-3 | 47-53 | .470 | Target Field · Minneapolis, MN |
| 101 | Tue Jul 22 | at Cardinals | W7-2 | 48-53 | .475 | Busch Stadium · St. Louis, MO |
| 102 | Wed Jul 23 | at Cardinals | W3-0 | 49-53 | .480 | Busch Stadium · St. Louis, MO |
| 103 | Fri Jul 25 | vs Red Sox | W6-4 | 50-53 | .485 | Tropicana Field · St. Petersburg, FL |
| 104 | Sat Jul 26 | vs Red Sox | W3-0 | 51-53 | .490 | Tropicana Field · St. Petersburg, FL |
| 105 | Sun Jul 27 | vs Red Sox | L2-3 | 51-54 | .486 | Tropicana Field · St. Petersburg, FL |
| 106 | Mon Jul 28 | vs Brewers | W2-1 | 52-54 | .491 | Tropicana Field · St. Petersburg, FL |
| 107 | Tue Jul 29 | vs Brewers | W5-1 | 53-54 | .495 | Tropicana Field · St. Petersburg, FL |
| 108 | Wed Jul 30 | vs Brewers | L0-5 | 53-55 | .491 | Tropicana Field · St. Petersburg, FL |
| 109 | Fri Aug 1 | vs Angels | L3-5 | 53-56 | .486 | Tropicana Field · St. Petersburg, FL |
| 110 | Sat Aug 2 | vs Angels | W10-3 | 54-56 | .491 | Tropicana Field · St. Petersburg, FL |
| 111 | Sun Aug 3 | vs Angels | L5-7 | 54-57 | .486 | Tropicana Field · St. Petersburg, FL |
| 112 | Mon Aug 4 | at Athletics | L2-3 (10) | 54-58 | .482 | RingCentral Coliseum · Oakland, CA |
| 113 | Tue Aug 5 | at Athletics | L0-3 | 54-59 | .478 | RingCentral Coliseum · Oakland, CA |
| 114 | Wed Aug 6 | at Athletics | W7-3 | 55-59 | .482 | RingCentral Coliseum · Oakland, CA |
| 115 | Fri Aug 8 | at Cubs | W4-3 (10) | 56-59 | .487 | Wrigley Field · Chicago, IL |
| 116 | Sat Aug 9 | at Cubs | W4-0 | 57-59 | .491 | Wrigley Field · Chicago, IL |
| 117 | Sun Aug 10 | at Cubs | L2-3 (12) | 57-60 | .487 | Wrigley Field · Chicago, IL |
| 118 | Mon Aug 11 | at Rangers | W7-0 | 58-60 | .492 | Globe Life Field · Arlington, TX |
| 119 | Tue Aug 12 | at Rangers | L2-3 (14) | 58-61 | .487 | Globe Life Field · Arlington, TX |
| 120 | Wed Aug 13 | at Rangers | W10-1 | 59-61 | .492 | Globe Life Field · Arlington, TX |
| 121 | Thu Aug 14 | at Rangers | W6-3 | 60-61 | .496 | Globe Life Field · Arlington, TX |
| 122 | Fri Aug 15 | vs Yankees | W5-0 | 61-61 | .500 | Tropicana Field · St. Petersburg, FL |
| 123 | Sat Aug 16 | vs Yankees | L2-3 | 61-62 | .496 | Tropicana Field · St. Petersburg, FL |
| 124 | Sun Aug 17 | vs Yankees | L2-4 | 61-63 | .492 | Tropicana Field · St. Petersburg, FL |
| 125 | Tue Aug 19 | vs Tigers | L6-8 (11) | 61-64 | .488 | Tropicana Field · St. Petersburg, FL |
| 126 | Wed Aug 20 | vs Tigers | L0-6 | 61-65 | .484 | Tropicana Field · St. Petersburg, FL |
| 127 | Thu Aug 21 | vs Tigers | W1-0 | 62-65 | .488 | Tropicana Field · St. Petersburg, FL |
| 128 | Fri Aug 22 | at Blue Jays | W8-0 | 63-65 | .492 | Rogers Centre · Toronto, ON |
| 129 | Sat Aug 23 | at Blue Jays | L4-5 (10) | 63-66 | .488 | Rogers Centre · Toronto, ON |
| 130 | Sun Aug 24 | at Blue Jays | W2-1 (10) | 64-66 | .492 | Rogers Centre · Toronto, ON |
| 131 | Mon Aug 25 | at Orioles | L1-9 | 64-67 | .489 | Camden Yards · Baltimore, MD |
| 132 | Tue Aug 26 | at Orioles | L2-4 | 64-68 | .485 | Camden Yards · Baltimore, MD |
| 133 | Wed Aug 27 | at Orioles | W3-1 | 65-68 | .489 | Camden Yards · Baltimore, MD |
| 134 | Thu Aug 28 | at Orioles | L4-5 | 65-69 | .485 | Camden Yards · Baltimore, MD |
| 135 | Fri Aug 29 | vs Red Sox | L4-8 | 65-70 | .481 | Tropicana Field · St. Petersburg, FL |
| 136 | Sat Aug 30 | vs Red Sox | W7-0 | 66-70 | .485 | Tropicana Field · St. Petersburg, FL |
| 137 | Sun Aug 31 | vs Red Sox | L0-3 | 66-71 | .482 | Tropicana Field · St. Petersburg, FL |
| 138 | Mon Sep 1 | vs Red Sox | W4-3 (10) | 67-71 | .486 | Tropicana Field · St. Petersburg, FL |
| 139 | Tue Sep 2 | vs Blue Jays | L2-8 | 67-72 | .482 | Tropicana Field · St. Petersburg, FL |
| 140 | Wed Sep 3 | vs Blue Jays | L4-7 | 67-73 | .479 | Tropicana Field · St. Petersburg, FL |
| 141 | Thu Sep 4 | vs Blue Jays | L0-1 (10) | 67-74 | .475 | Tropicana Field · St. Petersburg, FL |
| 142 | Fri Sep 5 | vs Orioles | W3-0 | 68-74 | .479 | Tropicana Field · St. Petersburg, FL |
| 143 | Sat Sep 6 | vs Orioles | W3-2 | 69-74 | .483 | Tropicana Field · St. Petersburg, FL |
| 144 | Sun Sep 7 | vs Orioles | L5-7 (11) | 69-75 | .479 | Tropicana Field · St. Petersburg, FL |
| 145 | Tue Sep 9 | at Yankees | W4-3 | 70-75 | .483 | Yankee Stadium · The Bronx, NY |
| 146 | Wed Sep 10 | at Yankees | L5-8 | 70-76 | .479 | Yankee Stadium · The Bronx, NY |
| 147 | Thu Sep 11 | at Yankees | L4-5 | 70-77 | .476 | Yankee Stadium · The Bronx, NY |
| 148 | Fri Sep 12 | at Blue Jays | W1-0 | 71-77 | .480 | Rogers Centre · Toronto, ON |
| 149 | Sat Sep 13 | at Blue Jays | L3-6 | 71-78 | .477 | Rogers Centre · Toronto, ON |
| 150 | Sun Sep 14 | at Blue Jays | W6-5 (10) | 72-78 | .480 | Rogers Centre · Toronto, ON |
| 151 | Mon Sep 15 | vs Yankees | W1-0 | 73-78 | .483 | Tropicana Field · St. Petersburg, FL |
| 152 | Tue Sep 16 | vs Yankees | W6-1 | 74-78 | .487 | Tropicana Field · St. Petersburg, FL |
| 153 | Wed Sep 17 | vs Yankees | L2-3 | 74-79 | .484 | Tropicana Field · St. Petersburg, FL |
| 154 | Fri Sep 19 | vs White Sox | L3-4 | 74-80 | .481 | Tropicana Field · St. Petersburg, FL |
| 155 | Sat Sep 20 | vs White Sox | W3-1 | 75-80 | .484 | Tropicana Field · St. Petersburg, FL |
| 156 | Sun Sep 21 | vs White Sox | L5-10 | 75-81 | .481 | Tropicana Field · St. Petersburg, FL |
| 157 | Tue Sep 23 | at Red Sox | W6-2 | 76-81 | .484 | Fenway Park · Boston, MA |
| 158 | Wed Sep 24 | at Red Sox | L3-11 | 76-82 | .481 | Fenway Park · Boston, MA |
| 159 | Thu Sep 25 | at Red Sox | L1-11 | 76-83 | .478 | Fenway Park · Boston, MA |
| 160 | Fri Sep 26 | at Guardians | L0-1 | 76-84 | .475 | Progressive Field · Cleveland, OH |
| 161 | Sat Sep 27 | at Guardians | W2-0 | 77-84 | .478 | Progressive Field · Cleveland, OH |
| 162 | Sun Sep 28 | at Guardians | L2-7 | 77-85 | .475 | Progressive Field · Cleveland, OH |