| 1 | Fri Apr 6 | vs Yankees | W7-6 | 1-0 | 1.000 | Tropicana Field · St. Petersburg, FL |
| 2 | Sat Apr 7 | vs Yankees | W8-6 | 2-0 | 1.000 | Tropicana Field · St. Petersburg, FL |
| 3 | Sun Apr 8 | vs Yankees | W3-0 | 3-0 | 1.000 | Tropicana Field · St. Petersburg, FL |
| 4 | Tue Apr 10 | at Tigers | L2-5 | 3-1 | .750 | Comerica Park · Detroit, MI |
| 5 | Wed Apr 11 | at Tigers | W4-2 | 4-1 | .800 | Comerica Park · Detroit, MI |
| 6 | Thu Apr 12 | at Tigers | L2-7 | 4-2 | .667 | Comerica Park · Detroit, MI |
| 7 | Fri Apr 13 | at Red Sox | L2-12 | 4-3 | .571 | Fenway Park · Boston, MA |
| 8 | Sat Apr 14 | at Red Sox | L5-13 | 4-4 | .500 | Fenway Park · Boston, MA |
| 9 | Sun Apr 15 | at Red Sox | L4-6 | 4-5 | .444 | Fenway Park · Boston, MA |
| 10 | Mon Apr 16 | at Red Sox | W1-0 | 5-5 | .500 | Fenway Park · Boston, MA |
| 11 | Tue Apr 17 | at Blue Jays | L3-7 | 5-6 | .455 | Rogers Centre · Toronto, ON |
| 12 | Wed Apr 18 | at Blue Jays | W12-2 | 6-6 | .500 | Rogers Centre · Toronto, ON |
| 13 | Thu Apr 19 | at Blue Jays | W9-4 | 7-6 | .538 | Rogers Centre · Toronto, ON |
| 14 | Fri Apr 20 | vs Twins | L4-5 | 7-7 | .500 | Tropicana Field · St. Petersburg, FL |
| 15 | Sat Apr 21 | vs Twins | W4-1 | 8-7 | .533 | Tropicana Field · St. Petersburg, FL |
| 16 | Sun Apr 22 | vs Twins | W6-2 | 9-7 | .563 | Tropicana Field · St. Petersburg, FL |
| 17 | Tue Apr 24 | vs Angels | W5-0 | 10-7 | .588 | Tropicana Field · St. Petersburg, FL |
| 18 | Wed Apr 25 | vs Angels | W3-2 | 11-7 | .611 | Tropicana Field · St. Petersburg, FL |
| 19 | Thu Apr 26 | vs Angels | W4-3 | 12-7 | .632 | Tropicana Field · St. Petersburg, FL |
| 20 | Fri Apr 27 | at Rangers | W8-4 | 13-7 | .650 | Globe Life Field · Arlington, TX |
| 21 | Sat Apr 28 | at Rangers | L2-7 | 13-8 | .619 | Globe Life Field · Arlington, TX |
| 22 | Sun Apr 29 | at Rangers | W5-2 | 14-8 | .636 | Globe Life Field · Arlington, TX |
| 23 | Mon Apr 30 | vs Mariners | W3-2 (12) | 15-8 | .652 | Tropicana Field · St. Petersburg, FL |
| 24 | Tue May 1 | vs Mariners | W3-1 | 16-8 | .667 | Tropicana Field · St. Petersburg, FL |
| 25 | Wed May 2 | vs Mariners | W5-4 | 17-8 | .680 | Tropicana Field · St. Petersburg, FL |
| 26 | Thu May 3 | vs Mariners | W4-3 | 18-8 | .692 | Tropicana Field · St. Petersburg, FL |
| 27 | Fri May 4 | vs Athletics | W7-2 | 19-8 | .704 | Tropicana Field · St. Petersburg, FL |
| 28 | Sat May 5 | vs Athletics | L3-4 (12) | 19-9 | .679 | Tropicana Field · St. Petersburg, FL |
| 29 | Sun May 6 | vs Athletics | L5-9 | 19-10 | .655 | Tropicana Field · St. Petersburg, FL |
| 30 | Tue May 8 | at Yankees | L3-5 | 19-11 | .633 | Yankee Stadium · The Bronx, NY |
| 31 | Wed May 9 | at Yankees | W4-1 | 20-11 | .645 | Yankee Stadium · The Bronx, NY |
| 32 | Thu May 10 | at Yankees | L3-5 | 20-12 | .625 | Yankee Stadium · The Bronx, NY |
| 33 | Fri May 11 | at Orioles | L3-4 | 20-13 | .606 | Camden Yards · Baltimore, MD |
| 34 | Sat May 12 | at Orioles | L3-5 | 20-14 | .588 | Camden Yards · Baltimore, MD |
| 35 | Sun May 13 | at Orioles | W9-8 | 21-14 | .600 | Camden Yards · Baltimore, MD |
| 36 | Mon May 14 | at Blue Jays | W7-1 | 22-14 | .611 | Rogers Centre · Toronto, ON |
| 37 | Tue May 15 | at Blue Jays | W4-3 | 23-14 | .622 | Rogers Centre · Toronto, ON |
| 38 | Wed May 16 | vs Red Sox | W2-1 | 24-14 | .632 | Tropicana Field · St. Petersburg, FL |
| 39 | Thu May 17 | vs Red Sox | L3-5 | 24-15 | .615 | Tropicana Field · St. Petersburg, FL |
| 40 | Fri May 18 | vs Braves | L3-5 | 24-16 | .600 | Tropicana Field · St. Petersburg, FL |
| 41 | Sat May 19 | vs Braves | W5-2 | 25-16 | .610 | Tropicana Field · St. Petersburg, FL |
| 42 | Sun May 20 | vs Braves | L0-2 | 25-17 | .595 | Tropicana Field · St. Petersburg, FL |
| 43 | Mon May 21 | vs Blue Jays | L2-6 | 25-18 | .581 | Tropicana Field · St. Petersburg, FL |
| 44 | Tue May 22 | vs Blue Jays | W8-5 | 26-18 | .591 | Tropicana Field · St. Petersburg, FL |
| 45 | Wed May 23 | vs Blue Jays | W5-4 (11) | 27-18 | .600 | Tropicana Field · St. Petersburg, FL |
| 46 | Fri May 25 | at Red Sox | W7-4 | 28-18 | .609 | Fenway Park · Boston, MA |
| 47 | Sat May 26 | at Red Sox | L2-3 | 28-19 | .596 | Fenway Park · Boston, MA |
| 48 | Sun May 27 | at Red Sox | W4-3 | 29-19 | .604 | Fenway Park · Boston, MA |
| 49 | Mon May 28 | vs White Sox | L1-2 | 29-20 | .592 | Tropicana Field · St. Petersburg, FL |
| 50 | Tue May 29 | vs White Sox | L2-7 | 29-21 | .580 | Tropicana Field · St. Petersburg, FL |
| 51 | Wed May 30 | vs White Sox | L3-4 | 29-22 | .569 | Tropicana Field · St. Petersburg, FL |
| 52 | Fri Jun 1 | vs Orioles | W5-0 | 30-22 | .577 | Tropicana Field · St. Petersburg, FL |
| 53 | Sat Jun 2 | vs Orioles | L1-2 | 30-23 | .566 | Tropicana Field · St. Petersburg, FL |
| 54 | Sun Jun 3 | vs Orioles | W8-4 | 31-23 | .574 | Tropicana Field · St. Petersburg, FL |
| 55 | Tue Jun 5 | at Yankees | L0-7 | 31-24 | .564 | Yankee Stadium · The Bronx, NY |
| 56 | Wed Jun 6 | at Yankees | L1-4 | 31-25 | .554 | Yankee Stadium · The Bronx, NY |
| 57 | Thu Jun 7 | at Yankees | W7-3 | 32-25 | .561 | Yankee Stadium · The Bronx, NY |
| 58 | Fri Jun 8 | at Marlins | W5-1 | 33-25 | .569 | LoanDepot Park · Miami, FL |
| 59 | Sat Jun 9 | at Marlins | W13-4 | 34-25 | .576 | LoanDepot Park · Miami, FL |
| 60 | Sun Jun 10 | at Marlins | W4-2 | 35-25 | .583 | LoanDepot Park · Miami, FL |
| 61 | Tue Jun 12 | vs Mets | L2-11 | 35-26 | .574 | Tropicana Field · St. Petersburg, FL |
| 62 | Wed Jun 13 | vs Mets | L1-9 | 35-27 | .565 | Tropicana Field · St. Petersburg, FL |
| 63 | Thu Jun 14 | vs Mets | L6-9 | 35-28 | .556 | Tropicana Field · St. Petersburg, FL |
| 64 | Fri Jun 15 | vs Marlins | W11-0 | 36-28 | .563 | Tropicana Field · St. Petersburg, FL |
| 65 | Sat Jun 16 | vs Marlins | L3-4 (15) | 36-29 | .554 | Tropicana Field · St. Petersburg, FL |
| 66 | Sun Jun 17 | vs Marlins | W3-0 | 37-29 | .561 | Tropicana Field · St. Petersburg, FL |
| 67 | Tue Jun 19 | at Nationals | W5-4 | 38-29 | .567 | Nationals Park · Washington, D.C. |
| 68 | Wed Jun 20 | at Nationals | L2-3 | 38-30 | .559 | Nationals Park · Washington, D.C. |
| 69 | Thu Jun 21 | at Nationals | L2-5 | 38-31 | .551 | Nationals Park · Washington, D.C. |
| 70 | Sat Jun 23 | at Phillies | L6-7 | 38-32 | .543 | Citizens Bank Park · Philadelphi, PA |
| 71 | Sun Jun 24 | at Phillies | W3-2 | 39-32 | .549 | Citizens Bank Park · Philadelphi, PA |
| 72 | Sun Jun 24 | at Phillies | W7-3 | 40-32 | .556 | Citizens Bank Park · Philadelphi, PA |
| 73 | Mon Jun 25 | at Royals | L0-8 | 40-33 | .548 | Kauffman Stadium · Kansas City, MO |
| 74 | Tue Jun 26 | at Royals | L2-8 | 40-34 | .541 | Kauffman Stadium · Kansas City, MO |
| 75 | Wed Jun 27 | at Royals | L4-5 | 40-35 | .533 | Kauffman Stadium · Kansas City, MO |
| 76 | Thu Jun 28 | vs Tigers | L2-5 | 40-36 | .526 | Tropicana Field · St. Petersburg, FL |
| 77 | Fri Jun 29 | vs Tigers | W4-2 | 41-36 | .532 | Tropicana Field · St. Petersburg, FL |
| 78 | Sat Jun 30 | vs Tigers | L2-6 | 41-37 | .526 | Tropicana Field · St. Petersburg, FL |
| 79 | Sun Jul 1 | vs Tigers | L3-5 | 41-38 | .519 | Tropicana Field · St. Petersburg, FL |
| 80 | Mon Jul 2 | vs Yankees | W4-3 | 42-38 | .525 | Tropicana Field · St. Petersburg, FL |
| 81 | Tue Jul 3 | vs Yankees | W7-4 | 43-38 | .531 | Tropicana Field · St. Petersburg, FL |
| 82 | Wed Jul 4 | vs Yankees | L3-4 | 43-39 | .524 | Tropicana Field · St. Petersburg, FL |
| 83 | Thu Jul 5 | at Guardians | L1-3 | 43-40 | .518 | Progressive Field · Cleveland, OH |
| 84 | Fri Jul 6 | at Guardians | W10-3 | 44-40 | .524 | Progressive Field · Cleveland, OH |
| 85 | Sat Jul 7 | at Guardians | L3-7 | 44-41 | .518 | Progressive Field · Cleveland, OH |
| 86 | Sun Jul 8 | at Guardians | W7-6 | 45-41 | .523 | Progressive Field · Cleveland, OH |
| 87 | Fri Jul 13 | vs Red Sox | L1-3 | 45-42 | .517 | Tropicana Field · St. Petersburg, FL |
| 88 | Sat Jul 14 | vs Red Sox | W5-3 | 46-42 | .523 | Tropicana Field · St. Petersburg, FL |
| 89 | Sun Jul 15 | vs Red Sox | L3-7 | 46-43 | .517 | Tropicana Field · St. Petersburg, FL |
| 90 | Mon Jul 16 | vs Guardians | L2-3 | 46-44 | .511 | Tropicana Field · St. Petersburg, FL |
| 91 | Tue Jul 17 | vs Guardians | W4-2 | 47-44 | .516 | Tropicana Field · St. Petersburg, FL |
| 92 | Wed Jul 18 | vs Guardians | L6-10 | 47-45 | .511 | Tropicana Field · St. Petersburg, FL |
| 93 | Thu Jul 19 | vs Guardians | W6-0 | 48-45 | .516 | Tropicana Field · St. Petersburg, FL |
| 94 | Fri Jul 20 | vs Mariners | W4-3 (14) | 49-45 | .521 | Tropicana Field · St. Petersburg, FL |
| 95 | Sat Jul 21 | vs Mariners | L1-2 | 49-46 | .516 | Tropicana Field · St. Petersburg, FL |
| 96 | Sun Jul 22 | vs Mariners | L1-2 | 49-47 | .510 | Tropicana Field · St. Petersburg, FL |
| 97 | Tue Jul 24 | at Orioles | W3-1 | 50-47 | .515 | Camden Yards · Baltimore, MD |
| 98 | Wed Jul 25 | at Orioles | W10-1 | 51-47 | .520 | Camden Yards · Baltimore, MD |
| 99 | Thu Jul 26 | at Orioles | L2-6 | 51-48 | .515 | Camden Yards · Baltimore, MD |
| 100 | Fri Jul 27 | at Angels | L1-3 | 51-49 | .510 | Angel Stadium · Anaheim, CA |
| 101 | Sat Jul 28 | at Angels | W3-0 | 52-49 | .515 | Angel Stadium · Anaheim, CA |
| 102 | Sun Jul 29 | at Angels | W2-0 | 53-49 | .520 | Angel Stadium · Anaheim, CA |
| 103 | Mon Jul 30 | at Athletics | L3-4 (15) | 53-50 | .515 | RingCentral Coliseum · Oakland, CA |
| 104 | Tue Jul 31 | at Athletics | W8-0 | 54-50 | .519 | RingCentral Coliseum · Oakland, CA |
| 105 | Wed Aug 1 | at Athletics | W4-1 | 55-50 | .524 | RingCentral Coliseum · Oakland, CA |
| 106 | Fri Aug 3 | vs Orioles | W2-0 | 56-50 | .528 | Tropicana Field · St. Petersburg, FL |
| 107 | Sat Aug 4 | vs Orioles | L0-4 | 56-51 | .523 | Tropicana Field · St. Petersburg, FL |
| 108 | Sun Aug 5 | vs Orioles | L0-1 (10) | 56-52 | .519 | Tropicana Field · St. Petersburg, FL |
| 109 | Tue Aug 7 | vs Blue Jays | W4-1 | 57-52 | .523 | Tropicana Field · St. Petersburg, FL |
| 110 | Wed Aug 8 | vs Blue Jays | W3-2 | 58-52 | .527 | Tropicana Field · St. Petersburg, FL |
| 111 | Thu Aug 9 | vs Blue Jays | W7-1 | 59-52 | .532 | Tropicana Field · St. Petersburg, FL |
| 112 | Fri Aug 10 | at Twins | W12-6 | 60-52 | .536 | Target Field · Minneapolis, MN |
| 113 | Sat Aug 11 | at Twins | W4-2 | 61-52 | .540 | Target Field · Minneapolis, MN |
| 114 | Sun Aug 12 | at Twins | W7-3 (10) | 62-52 | .544 | Target Field · Minneapolis, MN |
| 115 | Mon Aug 13 | at Mariners | W4-1 | 63-52 | .548 | T-Mobile Park · Seattle, WA |
| 116 | Tue Aug 14 | at Mariners | L2-3 | 63-53 | .543 | T-Mobile Park · Seattle, WA |
| 117 | Wed Aug 15 | at Mariners | L0-1 | 63-54 | .538 | T-Mobile Park · Seattle, WA |
| 118 | Thu Aug 16 | at Angels | W7-0 | 64-54 | .542 | Angel Stadium · Anaheim, CA |
| 119 | Fri Aug 17 | at Angels | W12-3 | 65-54 | .546 | Angel Stadium · Anaheim, CA |
| 120 | Sat Aug 18 | at Angels | W10-8 | 66-54 | .550 | Angel Stadium · Anaheim, CA |
| 121 | Sun Aug 19 | at Angels | W8-3 | 67-54 | .554 | Angel Stadium · Anaheim, CA |
| 122 | Mon Aug 20 | vs Royals | W5-1 | 68-54 | .557 | Tropicana Field · St. Petersburg, FL |
| 123 | Tue Aug 21 | vs Royals | L0-1 (10) | 68-55 | .553 | Tropicana Field · St. Petersburg, FL |
| 124 | Wed Aug 22 | vs Royals | W5-3 | 69-55 | .556 | Tropicana Field · St. Petersburg, FL |
| 125 | Thu Aug 23 | vs Athletics | W5-0 | 70-55 | .560 | Tropicana Field · St. Petersburg, FL |
| 126 | Fri Aug 24 | vs Athletics | L4-5 | 70-56 | .556 | Tropicana Field · St. Petersburg, FL |
| 127 | Sat Aug 25 | vs Athletics | L2-4 | 70-57 | .551 | Tropicana Field · St. Petersburg, FL |
| 128 | Mon Aug 27 | at Rangers | L5-6 | 70-58 | .547 | Globe Life Field · Arlington, TX |
| 129 | Tue Aug 28 | at Rangers | L0-1 | 70-59 | .543 | Globe Life Field · Arlington, TX |
| 130 | Wed Aug 29 | at Rangers | W8-4 | 71-59 | .546 | Globe Life Field · Arlington, TX |
| 131 | Thu Aug 30 | at Blue Jays | L0-2 | 71-60 | .542 | Rogers Centre · Toronto, ON |
| 132 | Fri Aug 31 | at Blue Jays | L1-2 | 71-61 | .538 | Rogers Centre · Toronto, ON |
| 133 | Sat Sep 1 | at Blue Jays | W5-4 | 72-61 | .541 | Rogers Centre · Toronto, ON |
| 134 | Sun Sep 2 | at Blue Jays | W9-4 | 73-61 | .545 | Rogers Centre · Toronto, ON |
| 135 | Mon Sep 3 | vs Yankees | W4-3 | 74-61 | .548 | Tropicana Field · St. Petersburg, FL |
| 136 | Tue Sep 4 | vs Yankees | W5-2 | 75-61 | .551 | Tropicana Field · St. Petersburg, FL |
| 137 | Wed Sep 5 | vs Yankees | L4-6 | 75-62 | .547 | Tropicana Field · St. Petersburg, FL |
| 138 | Fri Sep 7 | vs Rangers | W3-1 (11) | 76-62 | .551 | Tropicana Field · St. Petersburg, FL |
| 139 | Sat Sep 8 | vs Rangers | L2-4 (10) | 76-63 | .547 | Tropicana Field · St. Petersburg, FL |
| 140 | Sun Sep 9 | vs Rangers | W6-0 | 77-63 | .550 | Tropicana Field · St. Petersburg, FL |
| 141 | Tue Sep 11 | at Orioles | L2-9 | 77-64 | .546 | Camden Yards · Baltimore, MD |
| 142 | Wed Sep 12 | at Orioles | L2-3 | 77-65 | .542 | Camden Yards · Baltimore, MD |
| 143 | Thu Sep 13 | at Orioles | L2-3 (14) | 77-66 | .538 | Camden Yards · Baltimore, MD |
| 144 | Fri Sep 14 | at Yankees | W6-4 | 78-66 | .542 | Yankee Stadium · The Bronx, NY |
| 145 | Sat Sep 15 | at Yankees | L3-5 | 78-67 | .538 | Yankee Stadium · The Bronx, NY |
| 146 | Sun Sep 16 | at Yankees | L4-6 | 78-68 | .534 | Yankee Stadium · The Bronx, NY |
| 147 | Mon Sep 17 | vs Red Sox | L2-5 | 78-69 | .531 | Tropicana Field · St. Petersburg, FL |
| 148 | Tue Sep 18 | vs Red Sox | L5-7 | 78-70 | .527 | Tropicana Field · St. Petersburg, FL |
| 149 | Wed Sep 19 | vs Red Sox | W13-3 | 79-70 | .530 | Tropicana Field · St. Petersburg, FL |
| 150 | Thu Sep 20 | vs Red Sox | W7-4 | 80-70 | .533 | Tropicana Field · St. Petersburg, FL |
| 151 | Fri Sep 21 | vs Blue Jays | W12-1 | 81-70 | .536 | Tropicana Field · St. Petersburg, FL |
| 152 | Sat Sep 22 | vs Blue Jays | W11-5 | 82-70 | .539 | Tropicana Field · St. Petersburg, FL |
| 153 | Sun Sep 23 | vs Blue Jays | W3-0 | 83-70 | .542 | Tropicana Field · St. Petersburg, FL |
| 154 | Tue Sep 25 | at Red Sox | W5-2 | 84-70 | .545 | Fenway Park · Boston, MA |
| 155 | Wed Sep 26 | at Red Sox | W4-2 | 85-70 | .548 | Fenway Park · Boston, MA |
| 156 | Thu Sep 27 | at White Sox | W3-2 | 86-70 | .551 | Guaranteed Rate Field · Chicago, IL |
| 157 | Fri Sep 28 | at White Sox | L1-3 | 86-71 | .548 | Guaranteed Rate Field · Chicago, IL |
| 158 | Sat Sep 29 | at White Sox | W10-4 | 87-71 | .551 | Guaranteed Rate Field · Chicago, IL |
| 159 | Sun Sep 30 | at White Sox | W6-2 | 88-71 | .553 | Guaranteed Rate Field · Chicago, IL |
| 160 | Mon Oct 1 | vs Orioles | W5-3 | 89-71 | .556 | Tropicana Field · St. Petersburg, FL |
| 161 | Tue Oct 2 | vs Orioles | L0-1 | 89-72 | .553 | Tropicana Field · St. Petersburg, FL |
| 162 | Wed Oct 3 | vs Orioles | W4-1 | 90-72 | .556 | Tropicana Field · St. Petersburg, FL |