| Sat Dec 9 | vs LAFC | W2-1 | 16-9-9 | 57 PTS | Lower.com Field · Columbus, OH |
| Sat Dec 2 | at Cincinnati | W3-2 | 16-9-9 | 57 PTS | TQL Stadium · Cincinnati, OH |
| Sat Nov 25 | at Orlando | W2-0 | 16-9-9 | 57 PTS | Exploria Stadium · Orlando, FL |
| Sun Nov 12 | vs Atlanta | W4-2 | 16-9-9 | 57 PTS | Lower.com Field · Columbus, OH |
| Tue Nov 7 | atAtlanta | L2-4 | 16-9-9 | 57 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| Wed Nov 1 | vsAtlanta | W2-0 | 16-9-9 | 57 PTS | Lower.com Field · Columbus, OH |
| Sat Oct 21 | vs Montreal | W2-1 | 16-9-9 | 57 PTS | Lower.com Field · Columbus, OH |
| Sat Oct 7 | atAtlanta | D1-1 | 15-9-9 | 54 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| Wed Oct 4 | at New England | W2-1 | 15-9-8 | 53 PTS | Gillette Stadium · Foxborough, MA |
| Sat Sep 30 | vs Philadelphia | D1-1 | 14-9-8 | 50 PTS | Lower.com Field · Columbus, OH |
| Sat Sep 23 | at Dallas | D1-1 | 14-9-7 | 49 PTS | Toyota Stadium · Frisco, TX |
| Wed Sep 20 | vs Chicago | W3-0 | 14-9-6 | 48 PTS | Lower.com Field · Columbus, OH |
| Sat Sep 16 | atOrlando | L3-4 | 13-9-6 | 45 PTS | Exploria Stadium · Orlando, FL |
| Sat Sep 2 | atMontreal | W4-2 | 13-8-6 | 45 PTS | Stade Saputo · Montreal, QC |
| Wed Aug 30 | at Houston | L0-2 | 12-8-6 | 42 PTS | Shell Energy Stadium · Houston, TX |
| Sat Aug 26 | vs Toronto | W2-0 | 12-7-6 | 42 PTS | Lower.com Field · Columbus, OH |
| Sun Aug 20 | vsCincinnati | W3-0 | 11-7-6 | 39 PTS | Lower.com Field · Columbus, OH |
| Sat Jul 15 | at Portland | L2-3 | 10-7-6 | 36 PTS | Providence Park · Portland, OR |
| Sat Jul 8 | vs NYCFC | D1-1 | 10-6-6 | 36 PTS | Lower.com Field · Columbus, OH |
| Tue Jul 4 | at Miami | D2-2 | 10-6-5 | 35 PTS | DRV PNK Stadium · Fort Lauderdale, FL |
| Sat Jul 1 | vs New York | W2-1 | 10-6-4 | 34 PTS | Lower.com Field · Columbus, OH |
| Sat Jun 24 | vs Nashville | W2-0 | 9-6-4 | 31 PTS | Lower.com Field · Columbus, OH |
| Sat Jun 17 | atNYCFC | D1-1 | 8-6-4 | 28 PTS | Yankee Stadium · New York City, NY |
| Sat Jun 10 | atChicago | W2-1 | 8-6-3 | 27 PTS | Soldier Field · Chicago, IL |
| Sat Jun 3 | vs Charlotte | W4-2 | 7-6-3 | 24 PTS | Lower.com Field · Columbus, OH |
| Wed May 31 | vs Colorado | W3-2 | 6-6-3 | 21 PTS | Lower.com Field · Columbus, OH |
| Sun May 28 | atNashville | L1-3 | 5-6-3 | 18 PTS | GEODIS Park · Nashville, TN |
| Sat May 20 | atCincinnati | L2-3 | 5-5-3 | 18 PTS | TQL Stadium · Cincinnati, OH |
| Wed May 17 | vs LA Galaxy | W2-0 | 5-4-3 | 18 PTS | Lower.com Field · Columbus, OH |
| Sat May 13 | vsOrlando | D2-2 | 4-4-3 | 15 PTS | Lower.com Field · Columbus, OH |
| Sat Apr 29 | vsMiami | L1-2 | 4-4-2 | 14 PTS | Lower.com Field · Columbus, OH |
| Sat Apr 22 | atCharlotte | L0-1 | 4-3-2 | 14 PTS | Bank of America Stadium · Charlotte, NC |
| Sat Apr 15 | vsNew England | D1-1 | 4-2-2 | 14 PTS | Lower.com Field · Columbus, OH |
| Sat Apr 8 | at D.C. United | W2-0 | 4-2-1 | 13 PTS | Audi Field · Washington, D.C. |
| Sat Apr 1 | vs Salt Lake | W4-0 | 3-2-1 | 10 PTS | Lower.com Field · Columbus, OH |
| Sat Mar 25 | vsAtlanta | W6-1 | 2-2-1 | 7 PTS | Lower.com Field · Columbus, OH |
| Sat Mar 18 | atNew York | L1-2 | 1-2-1 | 4 PTS | Red Bull Arena · Harrison, NJ |
| Sat Mar 11 | atToronto | D1-1 | 1-1-1 | 4 PTS | BMO Field · Toronto, ON |
| Sat Mar 4 | vsD.C. United | W2-0 | 1-1-0 | 3 PTS | Lower.com Field · Columbus, OH |
| Sat Feb 25 | atPhiladelphia | L1-4 | 0-1-0 | 0 PTS | Subaru Park · Chester, PA |
