| Sun Nov 3 | at New York | L2-2 (4-5) | 1-0-2 | 5 PTS | Red Bull Arena · Harrison, NJ |
| Tue Oct 29 | vsNew York | L0-1 | 2-0-0 | 6 PTS | Lower.com Field · Columbus, OH |
| Sat Oct 19 | atNew York | W3-2 | 17-6-9 | 60 PTS | Red Bull Arena · Harrison, NJ |
| Sat Oct 12 | vs New England | W4-0 | 17-6-9 | 60 PTS | Lower.com Field · Columbus, OH |
| Sat Oct 5 | vs Philadelphia | W3-2 | 17-6-9 | 60 PTS | Lower.com Field · Columbus, OH |
| Wed Oct 2 | vs Miami | L2-3 | 16-7-9 | 57 PTS | Lower.com Field · Columbus, OH |
| Sat Sep 28 | at D.C. United | D2-2 | 16-5-10 | 58 PTS | Audi Field · Washington, D.C. |
| Sat Sep 21 | vs Orlando | W4-3 | 17-5-8 | 59 PTS | Lower.com Field · Columbus, OH |
| Wed Sep 18 | at Toronto | W2-0 | 16-5-8 | 56 PTS | BMO Field · Toronto, ON |
| Sat Sep 14 | at Cincinnati | D0-0 | 14-5-9 | 51 PTS | TQL Stadium · Cincinnati, OH |
| Sat Sep 7 | vs Seattle | L0-4 | 14-6-7 | 49 PTS | Lower.com Field · Columbus, OH |
| Sat Aug 31 | vs NYCFC | W4-2 | 15-4-7 | 52 PTS | Lower.com Field · Columbus, OH |
| Wed Aug 28 | atPhiladelphia | W1-0 | 14-4-7 | 49 PTS | Subaru Park · Chester, PA |
| Sat Jul 20 | at Atlanta | L1-2 | 12-5-7 | 43 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| Wed Jul 17 | vs Charlotte | D1-1 | 12-3-8 | 44 PTS | Lower.com Field · Columbus, OH |
| Sat Jul 13 | at LAFC | W5-1 | 13-3-6 | 45 PTS | BMO Stadium · Los Angeles, CA |
| Sat Jul 6 | vsToronto | W4-0 | 12-3-6 | 42 PTS | Lower.com Field · Columbus, OH |
| Wed Jul 3 | vs Nashville | W2-0 | 11-3-6 | 39 PTS | Lower.com Field · Columbus, OH |
| Sat Jun 29 | atNew England | W5-1 | 10-3-6 | 36 PTS | Gillette Stadium · Foxborough, MA |
| Sat Jun 22 | vs Kansas City | W4-0 | 9-3-6 | 33 PTS | Lower.com Field · Columbus, OH |
| Wed Jun 19 | atMiami | L1-2 | 7-4-6 | 27 PTS | DRV PNK Stadium · Fort Lauderdale, FL |
| Fri Jun 14 | atNYCFC | W3-2 | 8-2-6 | 30 PTS | Yankee Stadium · New York City, NY |
| Sat May 25 | atOrlando | W2-0 | 7-2-6 | 27 PTS | Exploria Stadium · Orlando, FL |
| Sat May 18 | at Chicago | W3-1 | 6-2-6 | 24 PTS | Soldier Field · Chicago, IL |
| Wed May 15 | at Montreal | W3-1 | 5-2-6 | 21 PTS | Stade Saputo · Montreal, QC |
| Sat May 11 | vsCincinnati | L1-2 | 3-3-6 | 15 PTS | Lower.com Field · Columbus, OH |
| Sat Apr 27 | vsMontreal | D0-0 | 3-1-7 | 16 PTS | Lower.com Field · Columbus, OH |
| Sat Apr 20 | vs Portland | D2-2 | 3-1-6 | 15 PTS | Lower.com Field · Columbus, OH |
| Sat Apr 13 | at Salt Lake | D0-0 | 3-1-5 | 14 PTS | America First Field · Sandy, UT |
| Sat Apr 6 | vsD.C. United | D1-1 | 3-1-4 | 13 PTS | Lower.com Field · Columbus, OH |
| Sat Mar 30 | atNashville | D2-2 | 3-1-3 | 12 PTS | GEODIS Park · Nashville, TN |
| Sat Mar 23 | atCharlotte | L0-2 | 3-2-1 | 10 PTS | Bank of America Stadium · Charlotte, NC |
| Sat Mar 16 | vsNew York | W3-0 | 4-0-1 | 13 PTS | Lower.com Field · Columbus, OH |
| Sat Mar 9 | vsChicago | W2-1 | 3-0-1 | 10 PTS | Lower.com Field · Columbus, OH |
| Sat Mar 2 | at Minnesota | D1-1 | 1-0-2 | 5 PTS | Allianz Field · Saint Paul, MN |
| Sat Feb 24 | vsAtlanta | W1-0 | 2-0-0 | 6 PTS | Lower.com Field · Columbus, OH |
