| 1 | Sat Sep 26 | vs NC State | W45-24 | 1-0 | 1.000 | Lane Stadium · Blacksburg, VA |
| 2 | Sat Oct 3 | atDuke | W38-31 | 2-0 | 1.000 | Wallace Wade Stadium · Durham, NC |
| 3 | Sat Oct 10 | at#8UNC | L45-56 | 2-1 | .667 | Kenan Stadium · Chapel Hill, NC |
| 4 | Sat Oct 17 | vsBoston College | W40-14 | 3-1 | .750 | Lane Stadium · Blacksburg, VA |
| 5 | Sat Oct 24 | atWake Forest | L16-23 | 3-2 | .600 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 6 | Sat Oct 31 | atLouisville | W42-35 | 4-2 | .667 | Cardinal Stadium · Louisville, KY |
| 7 | Sat Nov 7 | vs#25Liberty | L35-38 | 4-3 | .571 | Lane Stadium · Blacksburg, VA |
| 8 | Sat Nov 14 | vs#9Miami | L24-25 | 4-4 | .500 | Lane Stadium · Blacksburg, VA |
| 9 | Sat Nov 21 | atPitt | L14-47 | 4-5 | .444 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sat Dec 5 | vs#3Clemson | L10-45 | 4-6 | .400 | Lane Stadium · Blacksburg, VA |
| 11 | Sat Dec 12 | vsVirginia | W33-15 | 5-6 | .455 | Lane Stadium · Blacksburg, VA |
