| 1 | Fri Aug 30 | vs Utah State | W38-35 | 1-0 | 1.000 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 2 | Fri Sep 6 | atRice | W41-21 | 2-0 | 1.000 | Rice Stadium · Houston, TX |
| 3 | Fri Sep 13 | vsUNC | W24-18 | 3-0 | 1.000 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 4 | Sat Sep 21 | vsElon | W49-7 | 4-0 | 1.000 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 5 | Sat Sep 28 | atBoston College | W27-24 | 5-0 | 1.000 | Alumni Stadium (Chestnut Hill, MA) · Chestnut Hill, MA |
| 6 | Sat Oct 12 | vsLouisville | L59-62 | 5-1 | .833 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 7 | Sat Oct 19 | vsFlorida St | W22-20 | 6-1 | .857 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 8 | Sat Nov 2 | vsNC State | W44-10 | 7-1 | .875 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 9 | Sat Nov 9 | atVirginia Tech | L17-36 | 7-2 | .778 | Lane Stadium · Blacksburg, VA |
| 10 | Sat Nov 16 | at#3Clemson | L3-52 | 7-3 | .700 | Memorial Stadium · Clemson, SC |
| 11 | Sat Nov 23 | vsDuke | W39-27 | 8-3 | .727 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 12 | Sat Nov 30 | atSyracuse | L30-39 (OT) | 8-4 | .667 | JMA Wireless Dome · Syracuse, NY |
| BOWLS | Fri Dec 27 | vsMichigan St | L21-27 | 8-5 | .615 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
