| 1 | Tue Nov 4 | at West Virginia | L54-70 | 0-1 | .000 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 2 | Fri Nov 7 | vsBucknell | L62-73 | 0-2 | .000 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 3 | Tue Nov 11 | atSt Francis PA | W74-66 | 1-2 | .333 | - | | DeGol Arena · Loretto, PA |
| 4 | Sun Nov 16 | atCincinnati | L55-72 | 1-3 | .250 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 5 | Wed Nov 19 | atMaryland | L90-95 (OT) | 1-4 | .200 | - | B1G+ | XFINITY Center · College Park, MD |
| 6 | Sun Nov 23 | atW Michigan | L60-83 | 1-5 | .167 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 7 | Tue Nov 25 | atOhio State | L60-113 | 1-6 | .143 | - | BTN | Value City Arena · Columbus, OH |
| 8 | Sat Nov 29 | vsHoward | W79-75 | 2-6 | .250 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 9 | Wed Dec 3 | vsSacred Heart | L80-87 | 2-7 | .222 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 10 | Fri Dec 5 | atMarist | L56-64 | 2-8 | .200 | - | ESPN+ | McCann Arena · Poughkeepsie, NY |
| 11 | Sat Dec 13 | atLoyola MD | W81-73 | 3-8 | .273 | - | ESPN+ | Reitz Arena · Baltimore, MD |
| 12 | Fri Dec 19 | atDrexel | L67-75 | 3-9 | .250 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 13 | Sun Dec 21 | vsTBD | W73-42 | 4-9 | .308 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 14 | Mon Dec 29 | vsIona | W66-59 | 5-9 | .357 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 15 | Fri Jan 2 | atMerrimack | L65-75 | 5-10 | .333 | - | ESPN+ | placeholder · sf, ca |
| 16 | Sun Jan 4 | atQuinnipiac | L69-80 | 5-11 | .313 | - | ESPN+ | M&T Bank Arena · Hamden, CT |
| 17 | Fri Jan 9 | vsSaint Peter's | W70-65 | 6-11 | .353 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 18 | Sun Jan 11 | vsSiena | L50-67 | 6-12 | .333 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 19 | Sat Jan 17 | atCanisius | W78-68 | 7-12 | .368 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 20 | Mon Jan 19 | atNiagara | W68-58 | 8-12 | .400 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 21 | Thu Jan 22 | vsQuinnipiac | L62-77 | 8-13 | .381 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 22 | Sat Jan 24 | vsRider | W71-61 | 9-13 | .409 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 23 | Fri Jan 30 | atSaint Peter's | L58-66 | 9-14 | .391 | - | ESPNU | Yanitelli Center · Jersey City, NJ |
| 24 | Sun Feb 1 | vsManhattan | W72-65 | 10-14 | .417 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 25 | Thu Feb 5 | vsMerrimack | L70-87 | 10-15 | .400 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 26 | Sat Feb 7 | atIona | W83-76 | 11-15 | .423 | - | ESPN+ | Hynes Athletics Center · New Rochelle, NY |
| 27 | Fri Feb 13 | atRider | W65-55 | 12-15 | .444 | - | ESPN+ | Alumni Gymnasium (Rider) · Lawrenceville, NJ |
| 28 | Fri Feb 20 | vsNiagara | W76-63 | 13-15 | .464 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 29 | Sun Feb 22 | vsCanisius | W68-47 | 14-15 | .483 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 30 | Fri Feb 27 | atSacred Heart | L69-77 | 14-16 | .467 | - | ESPN+ | William H. Pitt Center · Fairfield, CT |
| 31 | Sun Mar 1 | atFairfield | W69-47 | 15-16 | .484 | - | ESPN+ | Leo D. Mahoney Arena · Fairfield, CT |
