| 1 | Mon Nov 4 | vs TBD | W100-65 | 1-0 | 1.000 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 2 | Thu Nov 7 | atMichigan St | L60-96 | 1-1 | .500 | - | BTN | Breslin Center · East Lansing, MI |
| 3 | Sun Nov 10 | atDetroit Mercy | L78-84 (OT) | 1-2 | .333 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 4 | Tue Nov 19 | atBowling Green | L68-76 | 1-3 | .250 | - | ESPN+ | Stroh Center · Bowling Green, OH |
| 5 | Thu Nov 21 | atKent State | L73-76 | 1-4 | .200 | - | ESPN+ | M.A.C. Center · Kent, OH |
| 6 | Fri Nov 29 | atBinghamton | W65-62 | 2-4 | .333 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 7 | Sat Nov 30 | atLafayette | L47-59 | 2-5 | .286 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 8 | Sun Dec 1 | vsLong Island | W60-52 | 3-5 | .375 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 9 | Fri Dec 6 | vsSiena | W69-68 | 4-5 | .444 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 10 | Sun Dec 8 | vsMerrimack | L62-80 | 4-6 | .400 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 11 | Sat Dec 14 | vsSt Francis PA | W69-66 | 5-6 | .455 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 12 | Sat Dec 21 | atSt Bonaventure | L52-71 | 5-7 | .417 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 13 | Sun Dec 29 | vsLe Moyne | W88-69 | 6-7 | .462 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 14 | Sun Jan 5 | atMount St Mary | L62-68 | 6-8 | .429 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 15 | Fri Jan 10 | vsSaint Peter's | W70-60 | 7-8 | .467 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 16 | Sun Jan 12 | vsRider | L65-68 | 7-9 | .438 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 17 | Thu Jan 16 | atFairfield | L66-70 | 7-10 | .412 | - | ESPN+ | Leo D. Mahoney Arena · Fairfield, CT |
| 18 | Sat Jan 18 | atManhattan | L65-72 | 7-11 | .389 | - | ESPN+ | Draddy Gymnasium · Riverdale, NY |
| 19 | Thu Jan 23 | vsMarist | L65-67 (OT) | 7-12 | .368 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 20 | Sat Jan 25 | vsSacred Heart | L77-86 | 7-13 | .350 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 21 | Fri Jan 31 | atCanisius | W64-63 | 8-13 | .381 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 22 | Thu Feb 6 | atMerrimack | L59-64 | 8-14 | .364 | - | ESPN+ | placeholder · sf, ca |
| 23 | Sat Feb 8 | atQuinnipiac | W76-75 | 9-14 | .391 | - | ESPN+ | M&T Bank Arena · Hamden, CT |
| 24 | Wed Feb 12 | vsCanisius | W71-60 | 10-14 | .417 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 25 | Fri Feb 14 | vsMount St Mary | L83-84 | 10-15 | .400 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 26 | Fri Feb 21 | atSiena | L60-94 | 10-16 | .385 | - | ESPN+ | MVP Arena · Albany, NY |
| 27 | Sun Feb 23 | atMarist | L61-64 | 10-17 | .370 | - | ESPN+ | McCann Arena · Poughkeepsie, NY |
| 28 | Fri Feb 28 | vsIona | L63-65 | 10-18 | .357 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 29 | Sun Mar 2 | vsManhattan | L70-85 | 10-19 | .345 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 30 | Thu Mar 6 | atSaint Peter's | W78-68 (OT) | 11-19 | .367 | - | ESPN+ | Yanitelli Center · Jersey City, NJ |
| 31 | Sat Mar 8 | atRider | L76-77 | 11-20 | .355 | - | ESPN+ | Alumni Gymnasium (Rider) · Lawrenceville, NJ |
