| 1 | Mon Nov 3 | at Duquesne | L63-83 | 0-1 | .000 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 2 | Sat Nov 8 | atBinghamton | W67-59 | 1-1 | .500 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 3 | Mon Nov 10 | vsDelaware St | W68-57 | 2-1 | .667 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 4 | Mon Nov 17 | atLe Moyne | L68-74 | 2-2 | .500 | - | | Ted Grant Court · Syracuse, NY |
| 5 | Fri Nov 21 | at5Duke | L42-100 | 2-3 | .400 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 6 | Sat Nov 22 | atHoward | L70-80 | 2-4 | .333 | - | ACC Extra | Cameron Indoor Stadium · Durham, NC |
| 7 | Sat Nov 29 | vsDetroit Mercy | L66-70 | 2-5 | .286 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 8 | Fri Dec 5 | atSiena | L54-83 | 2-6 | .250 | - | ESPN+ | MVP Arena · Albany, NY |
| 9 | Sun Dec 7 | atSaint Peter's | L43-71 | 2-7 | .222 | - | ESPN+ | Yanitelli Center · Jersey City, NJ |
| 10 | Sat Dec 13 | atMorgan St | L73-81 | 2-8 | .200 | - | | Hill Field House · Baltimore, MD |
| 11 | Mon Dec 15 | atVCU | L58-84 | 2-9 | .182 | - | ESPN+ | Stuart C. Siegel Center · Richmond, VA |
| 12 | Sat Dec 20 | vsTBD | W81-58 | 3-9 | .250 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 13 | Fri Jan 2 | vsSacred Heart | W64-61 | 4-9 | .308 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 14 | Sun Jan 4 | vsFairfield | L75-83 | 4-10 | .286 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 15 | Fri Jan 9 | atIona | L53-71 | 4-11 | .267 | - | ESPN+ | Hynes Athletics Center · New Rochelle, NY |
| 16 | Sun Jan 11 | atManhattan | L70-79 | 4-12 | .250 | - | ESPN+ | Draddy Gymnasium · Riverdale, NY |
| 17 | Wed Jan 14 | atCanisius | W59-54 | 5-12 | .294 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 18 | Mon Jan 19 | vsMount St Mary | L58-68 | 5-13 | .278 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 19 | Thu Jan 22 | atFairfield | L61-62 | 5-14 | .263 | - | ESPN+ | Leo D. Mahoney Arena · Fairfield, CT |
| 20 | Sat Jan 24 | atSacred Heart | L70-71 | 5-15 | .250 | - | ESPN+ | William H. Pitt Center · Fairfield, CT |
| 21 | Fri Jan 30 | vsSiena | L79-82 | 5-16 | .238 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 22 | Sun Feb 1 | vsMarist | L46-58 | 5-17 | .227 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 23 | Tue Feb 3 | vsCanisius | W65-56 | 6-17 | .261 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 24 | Sat Feb 7 | atQuinnipiac | L55-56 | 6-18 | .250 | - | ESPN+ | M&T Bank Arena · Hamden, CT |
| 25 | Fri Feb 13 | vsManhattan | L69-76 | 6-19 | .240 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 26 | Sun Feb 15 | vsIona | W70-68 | 7-19 | .269 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 27 | Fri Feb 20 | atMount St Mary | L63-76 | 7-20 | .259 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 28 | Sun Feb 22 | atRider | L62-67 | 7-21 | .250 | - | ESPN+ | Alumni Gymnasium (Rider) · Lawrenceville, NJ |
| 29 | Fri Feb 27 | vsQuinnipiac | W78-76 (OT) | 8-21 | .276 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 30 | Sun Mar 1 | vsMerrimack | L66-73 | 8-22 | .267 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
