| 1 | Tue Nov 5 | vs TBD | W100-62 | 1-0 | 1.000 | - | | William Nicks Building · Prairie View, TX |
| 2 | Sat Nov 9 | at UCF | L69-73 | 1-1 | .500 | - | | Addition Financial Arena · Orlando, FL |
| 3 | Tue Nov 12 | at Texas St | L48-75 | 1-2 | .333 | - | | Strahan Arena at the University Events Center · San Marcos, TX |
| 4 | Fri Nov 15 | at Texas | L56-70 | 1-3 | .250 | - | LHN | Moody Center · Austin, TX |
| 5 | Mon Nov 18 | at California | L50-54 | 1-4 | .200 | - | | Haas Pavilion · Berkeley, CA |
| 6 | Fri Nov 22 | vs Georgia St | L74-83 | 1-5 | .167 | - | | William Nicks Building · Prairie View, TX |
| 7 | Sat Nov 23 | at C Arkansas | W78-72 (OT) | 2-5 | .286 | - | | Farris Center · Conway, AR |
| 8 | Sat Nov 30 | at UTSA | W79-72 | 3-5 | .375 | - | | UTSA Convocation Center · San Antonio, TX |
| 9 | Wed Dec 11 | at Arizona St | L79-88 | 3-6 | .333 | - | PACN | Desert Financial Arena · Tempe, AZ |
| 10 | Fri Dec 13 | at LMU | L76-79 | 3-7 | .300 | - | | Gersten Pavilion · Los Angeles, CA |
| 11 | Thu Dec 19 | at Colorado | L64-83 | 3-8 | .273 | - | PACN | CU Events Center · Boulder, CO |
| 12 | Sun Dec 22 | at Seton Hall | L55-75 | 3-9 | .250 | - | FS1 | Prudential Center · Newark, NJ |
| 13 | Mon Dec 30 | vsTBD | W92-77 | 4-9 | .308 | - | | William Nicks Building · Prairie View, TX |
| 14 | Sat Jan 4 | vs Alcorn St | W84-70 | 5-9 | .357 | - | | William Nicks Building · Prairie View, TX |
| 15 | Mon Jan 6 | vs Southern | W64-54 | 6-9 | .400 | - | ESPNU | William Nicks Building · Prairie View, TX |
| 16 | Sat Jan 11 | at Texas So | L67-71 | 6-10 | .375 | - | | H&PE Arena · Houston, TX |
| 17 | Sat Jan 18 | at Grambling | W64-57 | 7-10 | .412 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 18 | Mon Jan 20 | at Jackson St | W74-60 | 8-10 | .444 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 19 | Sat Jan 25 | vs AR-Pine Bluff | W67-54 | 9-10 | .474 | - | | William Nicks Building · Prairie View, TX |
| 20 | Mon Jan 27 | vs Miss Valley St | W102-83 | 10-10 | .500 | - | | William Nicks Building · Prairie View, TX |
| 21 | Sat Feb 1 | at Alabama St | L49-52 | 10-11 | .476 | - | | Dunn-Oliver Acadome · Montgomery, AL |
| 22 | Mon Feb 3 | at Alabama A&M | W69-54 | 11-11 | .500 | - | | T.M. Elmore Gymnasium · Normal, AL |
| 23 | Sat Feb 8 | vsTexas So | W69-59 | 12-11 | .522 | - | | William Nicks Building · Prairie View, TX |
| 24 | Sat Feb 15 | vsGrambling | W75-69 | 13-11 | .542 | - | | William Nicks Building · Prairie View, TX |
| 25 | Mon Feb 17 | vsJackson St | W70-61 | 14-11 | .560 | - | ESPNU | William Nicks Building · Prairie View, TX |
| 26 | Sat Feb 22 | atAR-Pine Bluff | W69-61 | 15-11 | .577 | - | | H. O. Clemmons Arena · Pine Bluff, AR |
| 27 | Mon Feb 24 | atMiss Valley St | W88-69 | 16-11 | .593 | - | | Robert W. Harrison HPER Complex · Itta Bena, MS |
| 28 | Sat Feb 29 | vsAlabama St | W65-58 | 17-11 | .607 | - | | William Nicks Building · Prairie View, TX |
| 29 | Mon Mar 2 | vsAlabama A&M | W73-62 | 18-11 | .621 | - | | William Nicks Building · Prairie View, TX |
| 30 | Thu Mar 5 | atAlcorn St | L71-80 | 18-12 | .600 | - | | Davey L. Whitney Complex · Lorman, MS |
| 31 | Sat Mar 7 | atSouthern | L80-89 (OT) | 18-13 | .581 | - | | F. G. Clark Activity Center · Baton Rouge, LA |
| 32 | Tue Mar 10 | vsAlabama A&M | W82-60 | 19-13 | .594 | - | | William Nicks Building · Prairie View, TX |
